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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EDEM1
Full Name:
ER degradation-enhancing alpha-mannosidase-like 1
Alias:
Type:
Mass (Da):
73768
Number AA:
657
UniProt ID:
Q92611
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
F
Y
Q
R
F
P
L
S
F
G
F
Q
R
L
R
Site 2
S48
F
G
F
Q
R
L
R
S
P
D
G
P
A
S
P
Site 3
S54
R
S
P
D
G
P
A
S
P
T
S
G
P
V
G
Site 4
T56
P
D
G
P
A
S
P
T
S
G
P
V
G
R
P
Site 5
S57
D
G
P
A
S
P
T
S
G
P
V
G
R
P
G
Site 6
S67
V
G
R
P
G
G
V
S
G
P
S
W
L
Q
P
Site 7
S70
P
G
G
V
S
G
P
S
W
L
Q
P
P
G
T
Site 8
T77
S
W
L
Q
P
P
G
T
G
A
A
Q
S
P
R
Site 9
S82
P
G
T
G
A
A
Q
S
P
R
K
A
P
R
R
Site 10
Y102
C
G
P
A
N
W
G
Y
V
L
G
G
R
G
R
Site 11
Y114
R
G
R
G
P
D
E
Y
E
K
R
Y
S
G
A
Site 12
Y118
P
D
E
Y
E
K
R
Y
S
G
A
F
P
P
Q
Site 13
S119
D
E
Y
E
K
R
Y
S
G
A
F
P
P
Q
L
Site 14
Y142
R
G
M
F
V
F
G
Y
D
N
Y
M
A
H
A
Site 15
Y145
F
V
F
G
Y
D
N
Y
M
A
H
A
F
P
Q
Site 16
S171
G
P
D
R
G
D
P
S
N
L
N
I
N
D
V
Site 17
S219
T
V
S
F
D
K
D
S
T
V
Q
V
F
E
A
Site 18
T220
V
S
F
D
K
D
S
T
V
Q
V
F
E
A
T
Site 19
T242
L
S
A
H
R
I
I
T
D
S
K
Q
P
F
G
Site 20
T252
K
Q
P
F
G
D
M
T
I
K
D
Y
D
N
E
Site 21
Y256
G
D
M
T
I
K
D
Y
D
N
E
L
L
Y
M
Site 22
Y262
D
Y
D
N
E
L
L
Y
M
A
H
D
L
A
V
Site 23
T280
P
A
F
E
N
T
K
T
G
I
P
Y
P
R
V
Site 24
Y284
N
T
K
T
G
I
P
Y
P
R
V
N
L
K
T
Site 25
T291
Y
P
R
V
N
L
K
T
G
V
P
P
D
T
N
Site 26
T297
K
T
G
V
P
P
D
T
N
N
E
T
C
T
A
Site 27
S323
L
S
R
L
L
G
D
S
T
F
E
W
V
A
R
Site 28
T324
S
R
L
L
G
D
S
T
F
E
W
V
A
R
R
Site 29
S341
K
A
L
W
N
L
R
S
N
D
T
G
L
L
G
Site 30
Y373
G
A
G
L
D
S
F
Y
E
Y
L
L
K
S
Y
Site 31
Y396
L
E
M
F
N
A
A
Y
Q
S
I
Q
N
Y
L
Site 32
Y402
A
Y
Q
S
I
Q
N
Y
L
R
R
G
R
E
A
Site 33
Y420
G
E
G
D
P
P
L
Y
V
N
V
N
M
F
S
Site 34
T433
F
S
G
Q
L
M
N
T
W
I
D
S
L
Q
A
Site 35
S497
L
R
P
E
L
V
E
S
T
Y
L
L
Y
Q
A
Site 36
Y499
P
E
L
V
E
S
T
Y
L
L
Y
Q
A
T
K
Site 37
Y502
V
E
S
T
Y
L
L
Y
Q
A
T
K
N
P
F
Site 38
T505
T
Y
L
L
Y
Q
A
T
K
N
P
F
Y
L
H
Site 39
Y510
Q
A
T
K
N
P
F
Y
L
H
V
G
M
D
I
Site 40
S520
V
G
M
D
I
L
Q
S
L
E
K
Y
T
K
V
Site 41
Y524
I
L
Q
S
L
E
K
Y
T
K
V
K
C
G
Y
Site 42
S541
L
H
H
V
I
D
K
S
T
E
D
R
M
E
S
Site 43
T542
H
H
V
I
D
K
S
T
E
D
R
M
E
S
F
Site 44
S548
S
T
E
D
R
M
E
S
F
F
L
S
E
T
C
Site 45
Y559
S
E
T
C
K
Y
L
Y
L
L
F
D
E
D
N
Site 46
Y575
V
H
K
S
G
T
R
Y
M
F
T
T
E
G
H
Site 47
T578
S
G
T
R
Y
M
F
T
T
E
G
H
I
V
S
Site 48
S585
T
T
E
G
H
I
V
S
V
D
E
H
L
R
E
Site 49
S611
G
Q
D
Q
G
G
K
S
V
H
R
P
K
P
H
Site 50
S625
H
E
L
K
V
I
N
S
S
S
N
C
N
R
V
Site 51
S627
L
K
V
I
N
S
S
S
N
C
N
R
V
P
D
Site 52
Y638
R
V
P
D
E
R
R
Y
S
L
P
L
K
S
I
Site 53
S639
V
P
D
E
R
R
Y
S
L
P
L
K
S
I
Y
Site 54
S644
R
Y
S
L
P
L
K
S
I
Y
M
R
Q
I
D
Site 55
Y646
S
L
P
L
K
S
I
Y
M
R
Q
I
D
Q
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation