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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC9A6
Full Name:
Sodium/hydrogen exchanger 6
Alias:
KIAA0267; Na(+)/H(+) exchanger 6; NHE6; NHE-6; SL9A6; Solute carrier family 9 (sodium/hydrogen exchanger) member 6; Solute carrier family 9 member 6
Type:
Mass (Da):
74143
Number AA:
669
UniProt ID:
Q92581
International Prot ID:
IPI00022061
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031901
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0015385
PhosphoSite+
KinaseNET
Biological Process:
GO:0006885
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
P
L
R
R
G
V
G
S
S
P
R
A
R
R
L
Site 2
S18
L
R
R
G
V
G
S
S
P
R
A
R
R
L
M
Site 3
S43
V
F
D
W
A
G
A
S
D
G
G
G
G
E
A
Site 4
S59
A
M
D
E
E
I
V
S
E
K
Q
A
E
E
S
Site 5
S66
S
E
K
Q
A
E
E
S
H
R
Q
D
S
A
N
Site 6
S71
E
E
S
H
R
Q
D
S
A
N
L
L
I
F
I
Site 7
S124
R
Y
G
I
H
V
P
S
D
V
N
N
V
T
L
Site 8
T130
P
S
D
V
N
N
V
T
L
S
C
E
V
Q
S
Site 9
S132
D
V
N
N
V
T
L
S
C
E
V
Q
S
S
P
Site 10
T141
E
V
Q
S
S
P
T
T
L
L
V
T
F
D
P
Site 11
Y165
P
I
I
F
Y
A
G
Y
S
L
K
R
R
H
F
Site 12
Y273
L
S
S
S
I
V
A
Y
Q
P
A
G
D
N
S
Site 13
T282
P
A
G
D
N
S
H
T
F
D
V
T
A
M
F
Site 14
T286
N
S
H
T
F
D
V
T
A
M
F
K
S
I
G
Site 15
Y365
C
G
I
T
Q
A
H
Y
T
Y
N
N
L
S
T
Site 16
S371
H
Y
T
Y
N
N
L
S
T
E
S
Q
H
R
T
Site 17
S374
Y
N
N
L
S
T
E
S
Q
H
R
T
K
Q
L
Site 18
T378
S
T
E
S
Q
H
R
T
K
Q
L
F
E
L
L
Site 19
S442
L
L
N
L
G
R
R
S
K
I
G
S
N
F
Q
Site 20
Y473
A
I
R
D
T
A
T
Y
A
R
Q
M
M
F
S
Site 21
S512
H
I
R
V
G
V
D
S
D
Q
E
H
L
G
V
Site 22
T526
V
P
E
N
E
R
R
T
T
K
A
E
S
A
W
Site 23
T527
P
E
N
E
R
R
T
T
K
A
E
S
A
W
L
Site 24
Y545
W
Y
N
F
D
H
N
Y
L
K
P
L
L
T
H
Site 25
T551
N
Y
L
K
P
L
L
T
H
S
G
P
P
L
T
Site 26
S553
L
K
P
L
L
T
H
S
G
P
P
L
T
T
T
Site 27
T573
G
P
I
A
R
C
L
T
S
P
Q
A
Y
E
N
Site 28
S574
P
I
A
R
C
L
T
S
P
Q
A
Y
E
N
Q
Site 29
Y578
C
L
T
S
P
Q
A
Y
E
N
Q
E
Q
L
K
Site 30
S589
E
Q
L
K
D
D
D
S
D
L
I
L
N
D
G
Site 31
S599
I
L
N
D
G
D
I
S
L
T
Y
G
D
S
T
Site 32
T601
N
D
G
D
I
S
L
T
Y
G
D
S
T
V
N
Site 33
Y602
D
G
D
I
S
L
T
Y
G
D
S
T
V
N
T
Site 34
S605
I
S
L
T
Y
G
D
S
T
V
N
T
E
P
A
Site 35
T606
S
L
T
Y
G
D
S
T
V
N
T
E
P
A
T
Site 36
T609
Y
G
D
S
T
V
N
T
E
P
A
T
S
S
A
Site 37
S614
V
N
T
E
P
A
T
S
S
A
P
R
R
F
M
Site 38
S624
P
R
R
F
M
G
N
S
S
E
D
A
L
D
R
Site 39
S625
R
R
F
M
G
N
S
S
E
D
A
L
D
R
E
Site 40
S654
L
V
L
P
M
D
D
S
E
P
P
L
N
L
L
Site 41
T664
P
L
N
L
L
D
N
T
R
H
G
P
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation