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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FIG4
Full Name:
Polyphosphoinositide phosphatase
Alias:
EC 3.1.3.-; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3
Type:
Uncharacterized
Mass (Da):
103635
Number AA:
907
UniProt ID:
Q92562
International Prot ID:
IPI00022022
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0010008
Uniprot
OncoNet
Molecular Function:
GO:0016787
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Polyphosphoinositide phosphatase pan-specific antibody AB-NN247-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN247-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
S
V
Q
K
L
V
L
Y
E
T
R
A
R
Y
F
Site 2
Y24
L
Y
E
T
R
A
R
Y
F
L
V
G
S
N
N
Site 3
Y36
S
N
N
A
E
T
K
Y
R
V
L
K
I
D
R
Site 4
T44
R
V
L
K
I
D
R
T
E
P
K
D
L
V
I
Site 5
Y58
I
I
D
D
R
H
V
Y
T
Q
Q
E
V
R
E
Site 6
T111
G
Y
Y
I
V
L
I
T
K
R
R
K
M
A
D
Site 7
Y125
D
I
G
G
H
A
I
Y
K
V
E
D
T
N
M
Site 8
Y134
V
E
D
T
N
M
I
Y
I
P
N
D
S
V
R
Site 9
T143
P
N
D
S
V
R
V
T
H
P
D
E
A
R
Y
Site 10
Y150
T
H
P
D
E
A
R
Y
L
R
I
F
Q
N
V
Site 11
Y164
V
D
L
S
S
N
F
Y
F
S
Y
S
Y
D
L
Site 12
S166
L
S
S
N
F
Y
F
S
Y
S
Y
D
L
S
H
Site 13
Y167
S
S
N
F
Y
F
S
Y
S
Y
D
L
S
H
S
Site 14
S168
S
N
F
Y
F
S
Y
S
Y
D
L
S
H
S
L
Site 15
S172
F
S
Y
S
Y
D
L
S
H
S
L
Q
Y
N
L
Site 16
S174
Y
S
Y
D
L
S
H
S
L
Q
Y
N
L
T
V
Site 17
T180
H
S
L
Q
Y
N
L
T
V
L
R
M
P
L
E
Site 18
S191
M
P
L
E
M
L
K
S
E
M
T
Q
N
R
Q
Site 19
T194
E
M
L
K
S
E
M
T
Q
N
R
Q
E
S
F
Site 20
S200
M
T
Q
N
R
Q
E
S
F
D
I
F
E
D
E
Site 21
T211
F
E
D
E
G
L
I
T
Q
G
G
S
G
V
F
Site 22
Y228
C
S
E
P
Y
M
K
Y
V
W
N
G
E
L
L
Site 23
S240
E
L
L
D
I
I
K
S
T
V
H
R
D
W
L
Site 24
Y263
G
Q
S
K
L
L
I
Y
G
R
P
V
Y
V
T
Site 25
Y268
L
I
Y
G
R
P
V
Y
V
T
L
I
A
R
R
Site 26
T270
Y
G
R
P
V
Y
V
T
L
I
A
R
R
S
S
Site 27
S276
V
T
L
I
A
R
R
S
S
K
F
A
G
T
R
Site 28
S277
T
L
I
A
R
R
S
S
K
F
A
G
T
R
F
Site 29
S319
S
F
T
A
G
S
Y
S
S
Y
V
Q
V
R
G
Site 30
S320
F
T
A
G
S
Y
S
S
Y
V
Q
V
R
G
S
Site 31
Y321
T
A
G
S
Y
S
S
Y
V
Q
V
R
G
S
V
Site 32
S327
S
Y
V
Q
V
R
G
S
V
P
L
Y
W
S
Q
Site 33
Y331
V
R
G
S
V
P
L
Y
W
S
Q
D
I
S
T
Site 34
T338
Y
W
S
Q
D
I
S
T
M
M
P
K
P
P
I
Site 35
T346
M
M
P
K
P
P
I
T
L
D
Q
A
D
P
F
Site 36
S391
R
K
H
E
R
I
L
S
E
E
L
V
A
A
V
Site 37
T410
Q
F
L
P
P
E
H
T
I
V
Y
I
P
W
D
Site 38
Y413
P
P
E
H
T
I
V
Y
I
P
W
D
M
A
K
Site 39
Y421
I
P
W
D
M
A
K
Y
T
K
S
K
L
C
N
Site 40
S453
F
F
V
N
R
P
D
S
Y
C
S
I
L
R
P
Site 41
Y454
F
V
N
R
P
D
S
Y
C
S
I
L
R
P
D
Site 42
T479
I
P
T
G
R
L
Q
T
G
I
L
R
T
N
C
Site 43
T495
D
C
L
D
R
T
N
T
A
Q
F
M
V
G
K
Site 44
T524
K
P
N
L
Q
F
D
T
D
A
V
R
L
F
E
Site 45
Y534
V
R
L
F
E
E
L
Y
E
D
H
G
D
T
L
Site 46
T540
L
Y
E
D
H
G
D
T
L
S
L
Q
Y
G
G
Site 47
S542
E
D
H
G
D
T
L
S
L
Q
Y
G
G
S
Q
Site 48
S548
L
S
L
Q
Y
G
G
S
Q
L
V
H
R
V
K
Site 49
T556
Q
L
V
H
R
V
K
T
Y
R
K
I
A
P
W
Site 50
T573
H
S
K
D
I
M
Q
T
L
S
R
Y
Y
S
N
Site 51
Y577
I
M
Q
T
L
S
R
Y
Y
S
N
A
F
S
D
Site 52
Y578
M
Q
T
L
S
R
Y
Y
S
N
A
F
S
D
A
Site 53
S579
Q
T
L
S
R
Y
Y
S
N
A
F
S
D
A
D
Site 54
S583
R
Y
Y
S
N
A
F
S
D
A
D
R
Q
D
S
Site 55
S590
S
D
A
D
R
Q
D
S
I
N
L
F
L
G
V
Site 56
T621
F
Y
L
H
H
K
N
T
M
R
L
L
P
T
R
Site 57
T627
N
T
M
R
L
L
P
T
R
R
S
Y
T
Y
W
Site 58
Y631
L
L
P
T
R
R
S
Y
T
Y
W
W
T
P
E
Site 59
T632
L
P
T
R
R
S
Y
T
Y
W
W
T
P
E
V
Site 60
Y633
P
T
R
R
S
Y
T
Y
W
W
T
P
E
V
I
Site 61
Y667
I
V
K
K
F
H
K
Y
E
E
E
I
D
I
H
Site 62
Y681
H
N
E
F
F
R
P
Y
E
L
S
S
F
D
D
Site 63
S685
F
R
P
Y
E
L
S
S
F
D
D
T
F
C
L
Site 64
T705
A
R
D
F
M
P
K
T
V
G
I
D
P
S
P
Site 65
S711
K
T
V
G
I
D
P
S
P
F
T
V
R
K
P
Site 66
T714
G
I
D
P
S
P
F
T
V
R
K
P
D
E
T
Site 67
T721
T
V
R
K
P
D
E
T
G
K
S
V
L
G
N
Site 68
S724
K
P
D
E
T
G
K
S
V
L
G
N
K
S
N
Site 69
S730
K
S
V
L
G
N
K
S
N
R
E
E
A
V
L
Site 70
T741
E
A
V
L
Q
R
K
T
A
A
S
A
P
P
P
Site 71
S744
L
Q
R
K
T
A
A
S
A
P
P
P
P
S
E
Site 72
S750
A
S
A
P
P
P
P
S
E
E
A
V
S
S
S
Site 73
S755
P
P
S
E
E
A
V
S
S
S
S
E
D
D
S
Site 74
S756
P
S
E
E
A
V
S
S
S
S
E
D
D
S
G
Site 75
S757
S
E
E
A
V
S
S
S
S
E
D
D
S
G
T
Site 76
S758
E
E
A
V
S
S
S
S
E
D
D
S
G
T
D
Site 77
S762
S
S
S
S
E
D
D
S
G
T
D
R
E
E
E
Site 78
T764
S
S
E
D
D
S
G
T
D
R
E
E
E
G
S
Site 79
S771
T
D
R
E
E
E
G
S
V
S
Q
R
S
T
P
Site 80
S773
R
E
E
E
G
S
V
S
Q
R
S
T
P
V
K
Site 81
S776
E
G
S
V
S
Q
R
S
T
P
V
K
M
T
D
Site 82
T777
G
S
V
S
Q
R
S
T
P
V
K
M
T
D
A
Site 83
S787
K
M
T
D
A
G
D
S
A
K
V
T
E
N
V
Site 84
T791
A
G
D
S
A
K
V
T
E
N
V
V
Q
P
M
Site 85
Y802
V
Q
P
M
K
E
L
Y
G
I
N
L
S
D
G
Site 86
S807
E
L
Y
G
I
N
L
S
D
G
L
S
E
E
D
Site 87
S811
I
N
L
S
D
G
L
S
E
E
D
F
S
I
Y
Site 88
S816
G
L
S
E
E
D
F
S
I
Y
S
R
F
V
Q
Site 89
Y818
S
E
E
D
F
S
I
Y
S
R
F
V
Q
L
G
Site 90
S827
R
F
V
Q
L
G
Q
S
Q
H
K
Q
D
K
N
Site 91
S840
K
N
S
Q
Q
P
C
S
R
C
S
D
G
V
I
Site 92
S843
Q
Q
P
C
S
R
C
S
D
G
V
I
K
L
T
Site 93
Y861
A
F
S
Q
D
N
I
Y
E
V
Q
P
P
R
V
Site 94
S872
P
P
R
V
D
R
K
S
T
E
I
F
Q
A
H
Site 95
T873
P
R
V
D
R
K
S
T
E
I
F
Q
A
H
I
Site 96
S895
Q
P
L
G
K
E
D
S
S
M
Y
R
E
Y
I
Site 97
S896
P
L
G
K
E
D
S
S
M
Y
R
E
Y
I
R
Site 98
Y901
D
S
S
M
Y
R
E
Y
I
R
N
R
Y
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation