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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMG7
Full Name:
Protein SMG7
Alias:
Breast cancer-associated antigen SGA-56M; C1orf16; EST1 telomerase component C; EST1C; EST1-like C; EST1-like protein C; Ever shorter telomeres 1C; KIAA0250; SGA56M; SMG-7; SMG-7 homolog; Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); Smg-7, nonsense mediated mRNA decay factor
Type:
Adaptor/scaffold
Mass (Da):
127282
Number AA:
1137
UniProt ID:
Q92540
International Prot ID:
IPI00217494
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051721
PhosphoSite+
KinaseNET
Biological Process:
GO:0006406
GO:0000184
GO:0035303
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
L
Q
S
A
Q
Y
L
R
Q
A
E
V
L
Site 2
T20
E
V
L
K
A
D
M
T
D
S
K
L
G
P
A
Site 3
S22
L
K
A
D
M
T
D
S
K
L
G
P
A
E
V
Site 4
T31
L
G
P
A
E
V
W
T
S
R
Q
A
L
Q
D
Site 5
Y40
R
Q
A
L
Q
D
L
Y
Q
K
M
L
V
T
D
Site 6
Y50
M
L
V
T
D
L
E
Y
A
L
D
K
K
V
E
Site 7
S130
S
S
Q
L
G
I
I
S
N
K
Q
T
H
T
S
Site 8
T134
G
I
I
S
N
K
Q
T
H
T
S
A
I
V
K
Site 9
S137
S
N
K
Q
T
H
T
S
A
I
V
K
P
Q
S
Site 10
Y149
P
Q
S
S
S
C
S
Y
I
C
Q
H
C
L
V
Site 11
T168
I
A
R
Y
R
N
Q
T
S
Q
A
E
S
Y
Y
Site 12
S169
A
R
Y
R
N
Q
T
S
Q
A
E
S
Y
Y
R
Site 13
S173
N
Q
T
S
Q
A
E
S
Y
Y
R
H
A
A
Q
Site 14
Y174
Q
T
S
Q
A
E
S
Y
Y
R
H
A
A
Q
L
Site 15
T204
S
S
K
G
D
H
L
T
T
I
F
Y
Y
C
R
Site 16
S231
T
N
L
Q
K
A
L
S
K
A
L
E
S
R
D
Site 17
T242
E
S
R
D
E
V
K
T
K
W
G
V
S
D
F
Site 18
Y261
I
K
F
H
G
H
V
Y
L
S
K
S
L
E
K
Site 19
S263
F
H
G
H
V
Y
L
S
K
S
L
E
K
L
S
Site 20
S265
G
H
V
Y
L
S
K
S
L
E
K
L
S
P
L
Site 21
S270
S
K
S
L
E
K
L
S
P
L
R
E
K
L
E
Site 22
S291
L
F
Q
K
A
F
N
S
Q
Q
L
V
H
V
T
Site 23
S312
L
H
H
L
R
D
F
S
N
E
T
E
Q
H
T
Site 24
Y320
N
E
T
E
Q
H
T
Y
S
Q
D
E
Q
L
C
Site 25
S351
K
C
P
L
Q
N
E
S
Q
E
E
S
Y
N
A
Site 26
S355
Q
N
E
S
Q
E
E
S
Y
N
A
Y
P
L
P
Site 27
Y359
Q
E
E
S
Y
N
A
Y
P
L
P
A
V
K
V
Site 28
S399
W
L
I
S
L
L
N
S
F
H
P
H
E
E
D
Site 29
S408
H
P
H
E
E
D
L
S
S
I
S
A
T
P
L
Site 30
S409
P
H
E
E
D
L
S
S
I
S
A
T
P
L
P
Site 31
S411
E
E
D
L
S
S
I
S
A
T
P
L
P
E
E
Site 32
T413
D
L
S
S
I
S
A
T
P
L
P
E
E
F
E
Site 33
S430
G
F
L
A
L
R
P
S
F
R
N
L
D
F
S
Site 34
S437
S
F
R
N
L
D
F
S
K
G
H
Q
G
I
T
Site 35
S461
I
R
Q
Q
R
L
I
S
I
G
K
W
I
A
D
Site 36
S498
E
L
I
L
E
D
P
S
E
A
K
E
N
L
I
Site 37
S514
Q
E
T
S
V
I
E
S
L
A
A
D
G
S
P
Site 38
S520
E
S
L
A
A
D
G
S
P
G
L
K
S
V
L
Site 39
S525
D
G
S
P
G
L
K
S
V
L
S
T
S
R
N
Site 40
S528
P
G
L
K
S
V
L
S
T
S
R
N
L
S
N
Site 41
T529
G
L
K
S
V
L
S
T
S
R
N
L
S
N
N
Site 42
S530
L
K
S
V
L
S
T
S
R
N
L
S
N
N
C
Site 43
S534
L
S
T
S
R
N
L
S
N
N
C
D
T
G
E
Site 44
T546
T
G
E
K
P
V
V
T
F
K
E
N
I
K
T
Site 45
T553
T
F
K
E
N
I
K
T
R
E
V
N
R
D
Q
Site 46
S563
V
N
R
D
Q
G
R
S
F
P
P
K
E
V
R
Site 47
Y573
P
K
E
V
R
R
D
Y
S
K
G
I
T
V
T
Site 48
S574
K
E
V
R
R
D
Y
S
K
G
I
T
V
T
K
Site 49
T578
R
D
Y
S
K
G
I
T
V
T
K
N
D
G
K
Site 50
T593
K
D
N
N
K
R
K
T
E
T
K
K
C
T
L
Site 51
S617
N
V
A
V
Q
V
K
S
Q
T
E
L
R
K
T
Site 52
T624
S
Q
T
E
L
R
K
T
P
V
S
E
A
R
K
Site 53
S627
E
L
R
K
T
P
V
S
E
A
R
K
T
P
V
Site 54
T632
P
V
S
E
A
R
K
T
P
V
T
Q
T
P
T
Site 55
T635
E
A
R
K
T
P
V
T
Q
T
P
T
Q
A
S
Site 56
T637
R
K
T
P
V
T
Q
T
P
T
Q
A
S
N
S
Site 57
S642
T
Q
T
P
T
Q
A
S
N
S
Q
F
I
P
I
Site 58
S644
T
P
T
Q
A
S
N
S
Q
F
I
P
I
H
H
Site 59
S660
G
A
F
P
P
L
P
S
R
P
G
F
P
P
P
Site 60
T668
R
P
G
F
P
P
P
T
Y
V
I
P
P
P
V
Site 61
S702
F
L
Q
P
T
A
H
S
P
A
G
N
Q
V
Q
Site 62
Y718
G
K
Q
S
H
I
P
Y
S
Q
Q
R
P
S
G
Site 63
S719
K
Q
S
H
I
P
Y
S
Q
Q
R
P
S
G
P
Site 64
S724
P
Y
S
Q
Q
R
P
S
G
P
G
P
M
N
Q
Site 65
S736
M
N
Q
G
P
Q
Q
S
Q
P
P
S
Q
Q
P
Site 66
S740
P
Q
Q
S
Q
P
P
S
Q
Q
P
L
T
S
L
Site 67
T745
P
P
S
Q
Q
P
L
T
S
L
P
A
Q
P
T
Site 68
S746
P
S
Q
Q
P
L
T
S
L
P
A
Q
P
T
A
Site 69
T752
T
S
L
P
A
Q
P
T
A
Q
S
T
S
Q
L
Site 70
S770
A
L
T
Q
Q
Q
Q
S
P
T
K
A
V
P
A
Site 71
S781
A
V
P
A
L
G
K
S
P
P
H
H
S
G
F
Site 72
S786
G
K
S
P
P
H
H
S
G
F
Q
Q
Y
Q
Q
Site 73
Y791
H
H
S
G
F
Q
Q
Y
Q
Q
A
D
A
S
K
Site 74
Y820
I
M
P
V
K
Q
P
Y
Y
L
Q
T
Q
D
P
Site 75
Y821
M
P
V
K
Q
P
Y
Y
L
Q
T
Q
D
P
I
Site 76
T824
K
Q
P
Y
Y
L
Q
T
Q
D
P
I
K
L
F
Site 77
S834
P
I
K
L
F
E
P
S
L
Q
P
P
V
M
Q
Site 78
S862
E
P
Y
N
H
N
P
S
E
V
K
V
P
E
F
Site 79
Y870
E
V
K
V
P
E
F
Y
W
D
S
S
Y
S
M
Site 80
Y875
E
F
Y
W
D
S
S
Y
S
M
A
D
N
R
S
Site 81
S897
I
D
R
R
G
K
R
S
P
G
V
F
R
P
E
Site 82
S916
P
R
M
P
F
E
K
S
L
L
E
K
P
S
E
Site 83
S922
K
S
L
L
E
K
P
S
E
L
M
S
H
S
S
Site 84
S926
E
K
P
S
E
L
M
S
H
S
S
S
F
L
S
Site 85
S928
P
S
E
L
M
S
H
S
S
S
F
L
S
L
T
Site 86
S929
S
E
L
M
S
H
S
S
S
F
L
S
L
T
G
Site 87
S933
S
H
S
S
S
F
L
S
L
T
G
F
S
L
N
Site 88
T935
S
S
S
F
L
S
L
T
G
F
S
L
N
Q
E
Site 89
Y944
F
S
L
N
Q
E
R
Y
P
N
N
S
M
F
N
Site 90
S962
G
K
N
L
T
S
S
S
K
A
E
L
S
P
S
Site 91
S967
S
S
S
K
A
E
L
S
P
S
M
A
P
Q
E
Site 92
S969
S
K
A
E
L
S
P
S
M
A
P
Q
E
T
S
Site 93
S976
S
M
A
P
Q
E
T
S
L
Y
S
L
F
E
G
Site 94
Y978
A
P
Q
E
T
S
L
Y
S
L
F
E
G
T
P
Site 95
S979
P
Q
E
T
S
L
Y
S
L
F
E
G
T
P
W
Site 96
T984
L
Y
S
L
F
E
G
T
P
W
S
P
S
L
P
Site 97
S987
L
F
E
G
T
P
W
S
P
S
L
P
A
S
S
Site 98
S989
E
G
T
P
W
S
P
S
L
P
A
S
S
D
H
Site 99
S993
W
S
P
S
L
P
A
S
S
D
H
S
T
P
A
Site 100
S994
S
P
S
L
P
A
S
S
D
H
S
T
P
A
S
Site 101
S997
L
P
A
S
S
D
H
S
T
P
A
S
Q
S
P
Site 102
T998
P
A
S
S
D
H
S
T
P
A
S
Q
S
P
H
Site 103
S1001
S
D
H
S
T
P
A
S
Q
S
P
H
S
S
N
Site 104
S1003
H
S
T
P
A
S
Q
S
P
H
S
S
N
P
S
Site 105
S1006
P
A
S
Q
S
P
H
S
S
N
P
S
S
L
P
Site 106
S1007
A
S
Q
S
P
H
S
S
N
P
S
S
L
P
S
Site 107
S1010
S
P
H
S
S
N
P
S
S
L
P
S
S
P
P
Site 108
S1011
P
H
S
S
N
P
S
S
L
P
S
S
P
P
T
Site 109
S1014
S
N
P
S
S
L
P
S
S
P
P
T
H
N
H
Site 110
S1015
N
P
S
S
L
P
S
S
P
P
T
H
N
H
N
Site 111
T1018
S
L
P
S
S
P
P
T
H
N
H
N
S
V
P
Site 112
S1023
P
P
T
H
N
H
N
S
V
P
F
S
N
F
G
Site 113
S1027
N
H
N
S
V
P
F
S
N
F
G
P
I
G
T
Site 114
T1034
S
N
F
G
P
I
G
T
P
D
N
R
D
R
R
Site 115
T1042
P
D
N
R
D
R
R
T
A
D
R
W
K
T
D
Site 116
T1048
R
T
A
D
R
W
K
T
D
K
P
A
M
G
G
Site 117
S1062
G
F
G
I
D
Y
L
S
A
T
S
S
S
E
S
Site 118
T1064
G
I
D
Y
L
S
A
T
S
S
S
E
S
S
W
Site 119
S1065
I
D
Y
L
S
A
T
S
S
S
E
S
S
W
H
Site 120
S1066
D
Y
L
S
A
T
S
S
S
E
S
S
W
H
Q
Site 121
S1067
Y
L
S
A
T
S
S
S
E
S
S
W
H
Q
A
Site 122
S1069
S
A
T
S
S
S
E
S
S
W
H
Q
A
S
T
Site 123
S1070
A
T
S
S
S
E
S
S
W
H
Q
A
S
T
P
Site 124
S1075
E
S
S
W
H
Q
A
S
T
P
S
G
T
W
T
Site 125
T1076
S
S
W
H
Q
A
S
T
P
S
G
T
W
T
G
Site 126
S1078
W
H
Q
A
S
T
P
S
G
T
W
T
G
H
G
Site 127
T1082
S
T
P
S
G
T
W
T
G
H
G
P
S
M
E
Site 128
S1087
T
W
T
G
H
G
P
S
M
E
D
S
S
A
V
Site 129
S1091
H
G
P
S
M
E
D
S
S
A
V
L
M
E
S
Site 130
S1092
G
P
S
M
E
D
S
S
A
V
L
M
E
S
L
Site 131
S1104
E
S
L
K
S
I
W
S
S
S
M
M
H
P
G
Site 132
S1105
S
L
K
S
I
W
S
S
S
M
M
H
P
G
P
Site 133
S1106
L
K
S
I
W
S
S
S
M
M
H
P
G
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation