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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM38A
Full Name:
Protein PIEZO1
Alias:
Membrane protein induced by beta-amyloid treatment; Protein FAM38A: Membrane protein induced by beta-amyloid treatment
Type:
Unknown function
Mass (Da):
233171
Number AA:
2036
UniProt ID:
Q92508
International Prot ID:
IPI00797210
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033116
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
L
R
P
E
L
P
T
T
L
G
P
V
S
L
Site 2
T10
L
R
P
E
L
P
T
T
L
G
P
V
S
L
R
Site 3
T24
R
Q
L
G
L
E
H
T
R
Y
P
C
L
D
L
Site 4
Y26
L
G
L
E
H
T
R
Y
P
C
L
D
L
G
A
Site 5
T76
A
D
T
E
P
T
R
T
Q
T
L
L
Q
S
L
Site 6
T78
T
E
P
T
R
T
Q
T
L
L
Q
S
L
G
E
Site 7
S82
R
T
Q
T
L
L
Q
S
L
G
E
L
V
K
G
Site 8
Y170
Q
F
Q
D
F
P
A
Y
W
R
N
L
T
G
F
Site 9
T175
P
A
Y
W
R
N
L
T
G
F
T
D
E
Q
L
Site 10
S191
D
L
G
L
E
Q
F
S
V
S
E
L
F
S
S
Site 11
T224
H
R
P
F
M
Q
L
T
D
M
E
H
V
S
L
Site 12
S230
L
T
D
M
E
H
V
S
L
P
G
T
R
L
P
Site 13
T234
E
H
V
S
L
P
G
T
R
L
P
R
W
A
H
Site 14
S247
A
H
R
Q
D
A
V
S
G
T
P
L
L
R
E
Site 15
T249
R
Q
D
A
V
S
G
T
P
L
L
R
E
E
Q
Site 16
S273
E
E
E
E
E
E
D
S
R
D
E
G
L
G
V
Site 17
T282
D
E
G
L
G
V
A
T
P
H
Q
A
T
Q
V
Site 18
T287
V
A
T
P
H
Q
A
T
Q
V
P
E
G
A
A
Site 19
S370
P
R
F
R
P
M
A
S
C
L
S
T
V
W
T
Site 20
S399
V
N
P
Q
E
Y
S
S
N
C
T
E
P
F
P
Site 21
T402
Q
E
Y
S
S
N
C
T
E
P
F
P
N
S
T
Site 22
S408
C
T
E
P
F
P
N
S
T
N
L
L
P
T
E
Site 23
S417
N
L
L
P
T
E
I
S
Q
S
L
L
Y
R
G
Site 24
S419
L
P
T
E
I
S
Q
S
L
L
Y
R
G
P
V
Site 25
Y422
E
I
S
Q
S
L
L
Y
R
G
P
V
D
P
A
Site 26
Y443
K
G
F
P
N
L
G
Y
I
Q
N
H
L
Q
V
Site 27
Y461
L
V
F
E
A
I
V
Y
R
R
Q
E
H
Y
R
Site 28
Y467
V
Y
R
R
Q
E
H
Y
R
R
Q
H
Q
L
A
Site 29
S611
D
F
F
R
A
P
N
S
T
N
L
I
S
D
F
Site 30
T636
Q
V
F
S
A
E
R
T
E
E
W
Q
R
M
A
Site 31
T647
Q
R
M
A
G
V
N
T
D
R
L
E
P
L
R
Site 32
T723
T
A
L
L
Q
R
D
T
R
A
R
L
V
L
W
Site 33
Y778
L
V
C
T
V
K
G
Y
Y
D
P
K
E
M
M
Site 34
Y779
V
C
T
V
K
G
Y
Y
D
P
K
E
M
M
D
Site 35
Y821
R
R
V
F
L
S
H
Y
Y
L
H
V
R
A
D
Site 36
Y843
A
S
R
G
F
A
L
Y
N
A
A
N
L
K
S
Site 37
S861
H
R
R
I
E
E
K
S
L
A
Q
L
K
R
Q
Site 38
S887
R
Q
G
R
V
D
R
S
R
P
Q
D
T
L
G
Site 39
T892
D
R
S
R
P
Q
D
T
L
G
P
K
D
P
G
Site 40
S906
G
L
E
P
G
P
D
S
P
G
G
S
S
P
P
Site 41
S910
G
P
D
S
P
G
G
S
S
P
P
R
R
Q
W
Site 42
S911
P
D
S
P
G
G
S
S
P
P
R
R
Q
W
W
Site 43
Y933
T
V
I
H
S
G
D
Y
F
L
F
E
S
D
S
Site 44
S938
G
D
Y
F
L
F
E
S
D
S
E
E
E
E
E
Site 45
S940
Y
F
L
F
E
S
D
S
E
E
E
E
E
A
V
Site 46
S954
V
P
E
D
P
R
P
S
A
Q
S
A
F
Q
L
Site 47
S957
D
P
R
P
S
A
Q
S
A
F
Q
L
A
Y
Q
Site 48
S999
L
P
T
G
G
G
P
S
Q
E
V
E
P
A
E
Site 49
T1041
Q
A
L
V
D
E
L
T
R
W
L
Q
E
F
T
Site 50
T1053
E
F
T
R
H
H
G
T
M
S
D
V
L
R
A
Site 51
S1055
T
R
H
H
G
T
M
S
D
V
L
R
A
E
R
Site 52
Y1063
D
V
L
R
A
E
R
Y
L
L
T
Q
E
L
L
Site 53
Y1084
R
G
V
L
D
Q
L
Y
T
S
Q
A
E
A
T
Site 54
S1086
V
L
D
Q
L
Y
T
S
Q
A
E
A
T
L
P
Site 55
S1103
T
E
A
P
N
A
P
S
T
V
S
S
G
L
G
Site 56
T1104
E
A
P
N
A
P
S
T
V
S
S
G
L
G
A
Site 57
S1107
N
A
P
S
T
V
S
S
G
L
G
A
E
E
P
Site 58
S1116
L
G
A
E
E
P
L
S
S
M
T
D
D
M
G
Site 59
S1117
G
A
E
E
P
L
S
S
M
T
D
D
M
G
S
Site 60
S1124
S
M
T
D
D
M
G
S
P
L
S
T
G
Y
H
Site 61
S1127
D
D
M
G
S
P
L
S
T
G
Y
H
T
R
S
Site 62
T1128
D
M
G
S
P
L
S
T
G
Y
H
T
R
S
G
Site 63
Y1130
G
S
P
L
S
T
G
Y
H
T
R
S
G
S
E
Site 64
T1132
P
L
S
T
G
Y
H
T
R
S
G
S
E
E
A
Site 65
S1136
G
Y
H
T
R
S
G
S
E
E
A
V
T
D
P
Site 66
T1141
S
G
S
E
E
A
V
T
D
P
G
E
R
E
A
Site 67
S1151
G
E
R
E
A
G
A
S
L
Y
Q
G
L
M
R
Site 68
T1159
L
Y
Q
G
L
M
R
T
A
S
E
L
L
L
D
Site 69
S1161
Q
G
L
M
R
T
A
S
E
L
L
L
D
R
R
Site 70
Y1278
S
H
V
V
L
R
R
Y
E
N
K
P
Y
F
P
Site 71
Y1283
R
R
Y
E
N
K
P
Y
F
P
P
R
I
L
G
Site 72
T1294
R
I
L
G
L
E
K
T
D
G
Y
I
K
Y
D
Site 73
Y1297
G
L
E
K
T
D
G
Y
I
K
Y
D
L
V
Q
Site 74
Y1300
K
T
D
G
Y
I
K
Y
D
L
V
Q
L
M
A
Site 75
S1327
L
W
D
H
E
E
D
S
P
S
K
E
H
D
K
Site 76
S1329
D
H
E
E
D
S
P
S
K
E
H
D
K
S
G
Site 77
S1335
P
S
K
E
H
D
K
S
G
E
E
E
Q
G
A
Site 78
T1369
R
V
G
P
T
D
G
T
P
E
P
Q
V
E
L
Site 79
T1381
V
E
L
R
P
R
D
T
R
R
I
S
L
R
F
Site 80
S1385
P
R
D
T
R
R
I
S
L
R
F
R
R
R
K
Site 81
S1429
T
G
R
E
K
R
P
S
R
S
G
G
R
V
R
Site 82
S1431
R
E
K
R
P
S
R
S
G
G
R
V
R
A
A
Site 83
S1448
R
L
Q
G
F
C
L
S
L
A
Q
G
T
Y
R
Site 84
T1453
C
L
S
L
A
Q
G
T
Y
R
P
L
R
R
F
Site 85
Y1469
H
D
I
L
H
T
K
Y
R
A
A
T
D
V
Y
Site 86
T1473
H
T
K
Y
R
A
A
T
D
V
Y
A
L
M
F
Site 87
T1504
F
G
K
H
S
A
A
T
D
I
T
S
S
L
S
Site 88
T1507
H
S
A
A
T
D
I
T
S
S
L
S
D
D
Q
Site 89
S1509
A
A
T
D
I
T
S
S
L
S
D
D
Q
V
P
Site 90
S1511
T
D
I
T
S
S
L
S
D
D
Q
V
P
E
A
Site 91
Y1600
A
Y
Q
I
R
C
G
Y
P
T
R
I
L
G
N
Site 92
T1610
R
I
L
G
N
F
L
T
K
K
Y
N
H
L
N
Site 93
Y1613
G
N
F
L
T
K
K
Y
N
H
L
N
L
F
L
Site 94
S1649
T
D
T
T
L
S
L
S
S
W
M
C
V
E
D
Site 95
T1670
I
I
K
C
S
R
E
T
E
K
K
Y
P
Q
P
Site 96
Y1674
S
R
E
T
E
K
K
Y
P
Q
P
K
G
Q
K
Site 97
T1739
G
G
Y
E
P
L
F
T
M
S
A
Q
Q
P
S
Site 98
S1746
T
M
S
A
Q
Q
P
S
I
I
P
F
T
A
Q
Site 99
S1773
P
L
A
M
Q
F
I
S
Q
Y
S
P
E
D
I
Site 100
S1776
M
Q
F
I
S
Q
Y
S
P
E
D
I
V
T
A
Site 101
T1782
Y
S
P
E
D
I
V
T
A
Q
I
E
G
S
S
Site 102
S1796
S
G
A
L
W
R
I
S
P
P
S
R
A
Q
M
Site 103
S1799
L
W
R
I
S
P
P
S
R
A
Q
M
K
R
E
Site 104
Y1808
A
Q
M
K
R
E
L
Y
N
G
T
A
D
I
T
Site 105
T1848
L
A
L
A
P
N
S
T
A
R
R
Q
L
A
S
Site 106
S1855
T
A
R
R
Q
L
A
S
L
L
E
G
T
S
D
Site 107
Y1874
I
P
N
L
F
P
K
Y
I
R
A
P
N
G
P
Site 108
Y1897
Q
P
N
E
E
A
D
Y
L
G
V
R
I
Q
L
Site 109
T1928
I
E
L
Q
E
C
R
T
D
C
N
L
L
P
M
Site 110
S1946
S
D
K
V
S
P
P
S
L
G
F
L
A
G
Y
Site 111
T2005
D
I
F
L
V
R
E
T
R
E
L
E
L
E
E
Site 112
S2024
K
L
I
F
L
Y
R
S
P
E
T
M
I
K
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation