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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ST8SIA4
Full Name:
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Alias:
Alpha-2,8-sialyltransferase 8D;Polysialyltransferase-1;Sialyltransferase 8D;Sialytransferase St8Sia IV
Type:
Mass (Da):
41295
Number AA:
359
UniProt ID:
Q92187
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
K
T
K
E
I
A
R
T
E
E
H
Q
E
T
Q
Site 2
T34
R
T
E
E
H
Q
E
T
Q
L
I
G
D
G
E
Site 3
S45
G
D
G
E
L
S
L
S
R
S
L
V
N
S
S
Site 4
S47
G
E
L
S
L
S
R
S
L
V
N
S
S
D
K
Site 5
S51
L
S
R
S
L
V
N
S
S
D
K
I
I
R
K
Site 6
S62
I
I
R
K
A
G
S
S
I
F
Q
H
N
V
E
Site 7
S76
E
G
W
K
I
N
S
S
L
V
L
E
I
R
K
Site 8
S96
L
D
A
E
R
D
V
S
V
V
K
S
S
F
K
Site 9
S100
R
D
V
S
V
V
K
S
S
F
K
P
G
D
V
Site 10
Y110
K
P
G
D
V
I
H
Y
V
L
D
R
R
R
T
Site 11
T117
Y
V
L
D
R
R
R
T
L
N
I
S
H
D
L
Site 12
S121
R
R
R
T
L
N
I
S
H
D
L
H
S
L
L
Site 13
S126
N
I
S
H
D
L
H
S
L
L
P
E
V
S
P
Site 14
S132
H
S
L
L
P
E
V
S
P
M
K
N
R
R
F
Site 15
T141
M
K
N
R
R
F
K
T
C
A
V
V
G
N
S
Site 16
S154
N
S
G
I
L
L
D
S
E
C
G
K
E
I
D
Site 17
S185
A
A
D
V
G
T
K
S
D
F
I
T
M
N
P
Site 18
T189
G
T
K
S
D
F
I
T
M
N
P
S
V
V
Q
Site 19
S206
F
G
G
F
R
N
E
S
D
R
E
K
F
V
H
Site 20
S216
E
K
F
V
H
R
L
S
M
L
N
D
S
V
L
Site 21
T253
K
N
K
L
K
V
R
T
A
Y
P
S
L
R
L
Site 22
Y255
K
L
K
V
R
T
A
Y
P
S
L
R
L
I
H
Site 23
T270
A
V
R
G
Y
W
L
T
N
K
V
P
I
K
R
Site 24
S279
K
V
P
I
K
R
P
S
T
G
L
L
M
Y
T
Site 25
Y314
L
N
G
K
A
V
K
Y
H
Y
Y
D
D
L
K
Site 26
Y316
G
K
A
V
K
Y
H
Y
Y
D
D
L
K
Y
R
Site 27
Y317
K
A
V
K
Y
H
Y
Y
D
D
L
K
Y
R
Y
Site 28
Y322
H
Y
Y
D
D
L
K
Y
R
Y
F
S
N
A
S
Site 29
Y324
Y
D
D
L
K
Y
R
Y
F
S
N
A
S
P
H
Site 30
S326
D
L
K
Y
R
Y
F
S
N
A
S
P
H
R
M
Site 31
S329
Y
R
Y
F
S
N
A
S
P
H
R
M
P
L
E
Site 32
T339
R
M
P
L
E
F
K
T
L
N
V
L
H
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation