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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAPGEF4
Full Name:
Rap guanine nucleotide exchange factor 4
Alias:
CAMP-GEFII; CAMP-regulated guanine nucleotide exchange factor II; CGEF2; Epac 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Rap guanine nucleotide exchange factor (GEF) 4; RAP guanine-nucleotide-exchange factor (GEF) 4; RPGF4
Type:
Guanine nucleotide exchange factor, Ras
Mass (Da):
115522
Number AA:
1011
UniProt ID:
Q8WZA2
International Prot ID:
IPI00329560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005952
GO:0019898
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0008603
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0001932
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
A
A
H
A
A
H
S
S
S
S
A
E
W
I
Site 2
S27
D
K
R
P
L
E
R
S
S
E
D
V
D
I
I
Site 3
S28
K
R
P
L
E
R
S
S
E
D
V
D
I
I
F
Site 4
Y60
H
Q
I
C
L
C
G
Y
Y
E
N
L
E
K
G
Site 5
Y61
Q
I
C
L
C
G
Y
Y
E
N
L
E
K
G
I
Site 6
T69
E
N
L
E
K
G
I
T
L
F
R
Q
G
D
I
Site 7
S93
G
S
L
D
V
K
V
S
E
T
S
S
H
Q
D
Site 8
S97
V
K
V
S
E
T
S
S
H
Q
D
A
V
T
I
Site 9
T121
G
E
S
I
L
D
N
T
P
R
H
A
T
I
V
Site 10
T126
D
N
T
P
R
H
A
T
I
V
T
R
E
S
S
Site 11
S132
A
T
I
V
T
R
E
S
S
E
L
L
R
I
E
Site 12
S133
T
I
V
T
R
E
S
S
E
L
L
R
I
E
Q
Site 13
Y150
F
K
A
L
W
E
K
Y
R
Q
Y
M
A
G
L
Site 14
Y153
L
W
E
K
Y
R
Q
Y
M
A
G
L
L
A
P
Site 15
S169
Y
G
V
M
E
T
G
S
N
N
D
R
I
P
D
Site 16
T180
R
I
P
D
K
E
N
T
P
L
I
E
P
H
V
Site 17
T194
V
P
L
R
P
A
N
T
I
T
K
V
P
S
E
Site 18
T196
L
R
P
A
N
T
I
T
K
V
P
S
E
K
I
Site 19
S216
I
L
R
N
A
I
L
S
R
A
P
H
M
I
R
Site 20
Y227
H
M
I
R
D
R
K
Y
H
L
K
T
Y
R
Q
Site 21
Y284
E
H
H
F
Q
D
K
Y
L
F
Y
R
F
L
D
Site 22
T315
C
D
E
E
L
Q
D
T
M
L
L
L
S
Q
M
Site 23
S320
Q
D
T
M
L
L
L
S
Q
M
G
P
D
A
H
Site 24
T340
R
K
P
P
G
Q
R
T
V
D
D
L
E
I
I
Site 25
S361
I
K
A
L
S
H
L
S
T
T
V
K
R
E
L
Site 26
T362
K
A
L
S
H
L
S
T
T
V
K
R
E
L
A
Site 27
T363
A
L
S
H
L
S
T
T
V
K
R
E
L
A
G
Site 28
Y395
G
E
E
G
T
S
W
Y
I
I
L
K
G
S
V
Site 29
S435
N
D
A
P
R
A
A
S
I
V
L
R
E
D
N
Site 30
T464
L
R
D
V
E
A
N
T
V
R
L
K
E
H
D
Site 31
S487
V
P
A
G
N
R
A
S
N
Q
G
N
S
Q
P
Site 32
S492
R
A
S
N
Q
G
N
S
Q
P
Q
Q
K
Y
T
Site 33
Y498
N
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
Site 34
T499
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Site 35
T504
K
Y
T
V
M
S
G
T
P
E
K
I
L
E
H
Site 36
S559
A
H
Y
H
A
Q
P
S
Q
G
T
E
Q
E
K
Site 37
Y569
T
E
Q
E
K
M
D
Y
A
L
N
N
K
R
R
Site 38
S608
F
L
E
E
F
Y
V
S
V
S
D
D
A
R
M
Site 39
S610
E
E
F
Y
V
S
V
S
D
D
A
R
M
I
A
Site 40
S634
E
K
I
V
K
Q
I
S
E
D
A
K
A
P
Q
Site 41
T653
V
L
L
Q
Q
F
N
T
G
D
E
R
A
Q
K
Site 42
S667
K
R
Q
P
I
R
G
S
D
E
V
L
F
K
V
Site 43
T680
K
V
Y
C
M
D
H
T
Y
T
T
I
R
V
P
Site 44
Y681
V
Y
C
M
D
H
T
Y
T
T
I
R
V
P
V
Site 45
T682
Y
C
M
D
H
T
Y
T
T
I
R
V
P
V
A
Site 46
T683
C
M
D
H
T
Y
T
T
I
R
V
P
V
A
T
Site 47
S750
C
P
R
E
Q
F
D
S
L
T
P
L
P
E
Q
Site 48
T752
R
E
Q
F
D
S
L
T
P
L
P
E
Q
E
G
Site 49
T761
L
P
E
Q
E
G
P
T
V
G
T
V
G
T
F
Site 50
S772
V
G
T
F
E
L
M
S
S
K
D
L
A
Y
Q
Site 51
S773
G
T
F
E
L
M
S
S
K
D
L
A
Y
Q
M
Site 52
Y778
M
S
S
K
D
L
A
Y
Q
M
T
I
Y
D
W
Site 53
Y798
V
H
E
L
E
L
I
Y
H
T
F
G
R
H
N
Site 54
T800
E
L
E
L
I
Y
H
T
F
G
R
H
N
F
K
Site 55
T809
G
R
H
N
F
K
K
T
T
A
N
L
D
L
F
Site 56
T810
R
H
N
F
K
K
T
T
A
N
L
D
L
F
L
Site 57
Y857
I
A
A
H
C
K
E
Y
K
N
L
N
S
F
F
Site 58
T881
A
V
S
R
L
A
L
T
W
E
K
L
P
S
K
Site 59
S887
L
T
W
E
K
L
P
S
K
F
K
K
F
Y
A
Site 60
Y893
P
S
K
F
K
K
F
Y
A
E
F
E
S
L
M
Site 61
S898
K
F
Y
A
E
F
E
S
L
M
D
P
S
R
N
Site 62
Y909
P
S
R
N
H
R
A
Y
R
L
T
V
A
K
L
Site 63
T912
N
H
R
A
Y
R
L
T
V
A
K
L
E
P
P
Site 64
T932
P
L
L
I
K
D
M
T
F
T
H
E
G
N
K
Site 65
T940
F
T
H
E
G
N
K
T
F
I
D
N
L
V
N
Site 66
Y963
N
T
A
R
T
V
R
Y
Y
R
S
Q
P
F
N
Site 67
Y964
T
A
R
T
V
R
Y
Y
R
S
Q
P
F
N
P
Site 68
S966
R
T
V
R
Y
Y
R
S
Q
P
F
N
P
D
A
Site 69
S985
K
N
H
Q
D
V
R
S
Y
V
R
Q
L
N
V
Site 70
Y986
N
H
Q
D
V
R
S
Y
V
R
Q
L
N
V
I
Site 71
T998
N
V
I
D
N
Q
R
T
L
S
Q
M
S
H
R
Site 72
S1000
I
D
N
Q
R
T
L
S
Q
M
S
H
R
L
E
Site 73
S1003
Q
R
T
L
S
Q
M
S
H
R
L
E
P
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation