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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARAP2
Full Name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Alias:
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2; Centaurin-delta 1; CENTD1; Cnt-d1; KIAA0580; PARX
Type:
GTPase-activating protein for G protein, ARF
Mass (Da):
193424
Number AA:
1704
UniProt ID:
Q8WZ64
International Prot ID:
IPI00292471
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005547
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
M
S
I
N
L
E
Q
Y
L
L
H
F
H
E
S
Site 2
S52
L
L
Q
K
I
G
I
S
P
T
G
H
R
R
R
Site 3
S69
K
Q
L
Q
I
I
L
S
K
M
Q
D
I
P
I
Site 4
Y77
K
M
Q
D
I
P
I
Y
A
N
V
H
K
T
K
Site 5
S90
T
K
K
N
D
D
P
S
K
D
Y
H
V
P
S
Site 6
Y93
N
D
D
P
S
K
D
Y
H
V
P
S
S
D
Q
Site 7
S107
Q
N
I
C
I
E
L
S
N
S
G
S
V
Q
T
Site 8
S109
I
C
I
E
L
S
N
S
G
S
V
Q
T
S
S
Site 9
S111
I
E
L
S
N
S
G
S
V
Q
T
S
S
P
P
Site 10
S115
N
S
G
S
V
Q
T
S
S
P
P
Q
L
E
T
Site 11
S116
S
G
S
V
Q
T
S
S
P
P
Q
L
E
T
V
Site 12
T122
S
S
P
P
Q
L
E
T
V
R
K
N
L
E
D
Site 13
S130
V
R
K
N
L
E
D
S
D
A
S
V
E
R
S
Site 14
S133
N
L
E
D
S
D
A
S
V
E
R
S
Q
Y
P
Site 15
S137
S
D
A
S
V
E
R
S
Q
Y
P
Q
S
D
D
Site 16
Y139
A
S
V
E
R
S
Q
Y
P
Q
S
D
D
K
L
Site 17
S142
E
R
S
Q
Y
P
Q
S
D
D
K
L
S
P
P
Site 18
S147
P
Q
S
D
D
K
L
S
P
P
K
R
D
F
P
Site 19
S165
E
P
H
L
N
L
G
S
L
N
D
S
L
F
G
Site 20
S169
N
L
G
S
L
N
D
S
L
F
G
S
D
N
I
Site 21
S173
L
N
D
S
L
F
G
S
D
N
I
K
I
E
S
Site 22
S180
S
D
N
I
K
I
E
S
L
I
T
K
K
T
V
Site 23
T183
I
K
I
E
S
L
I
T
K
K
T
V
D
H
T
Site 24
T186
E
S
L
I
T
K
K
T
V
D
H
T
V
E
E
Site 25
T190
T
K
K
T
V
D
H
T
V
E
E
Q
Q
T
E
Site 26
T196
H
T
V
E
E
Q
Q
T
E
K
V
K
L
I
T
Site 27
S207
K
L
I
T
E
N
L
S
K
L
P
N
A
D
S
Site 28
S214
S
K
L
P
N
A
D
S
E
C
L
S
F
V
G
Site 29
S218
N
A
D
S
E
C
L
S
F
V
G
C
S
T
S
Site 30
S225
S
F
V
G
C
S
T
S
G
T
N
S
G
N
G
Site 31
T227
V
G
C
S
T
S
G
T
N
S
G
N
G
T
N
Site 32
S229
C
S
T
S
G
T
N
S
G
N
G
T
N
G
L
Site 33
T233
G
T
N
S
G
N
G
T
N
G
L
L
E
G
S
Site 34
S240
T
N
G
L
L
E
G
S
P
P
S
P
F
F
K
Site 35
S243
L
L
E
G
S
P
P
S
P
F
F
K
F
Q
G
Site 36
Y258
E
M
I
V
N
D
L
Y
V
P
S
S
P
I
L
Site 37
S270
P
I
L
A
P
V
R
S
R
S
K
L
V
S
R
Site 38
S272
L
A
P
V
R
S
R
S
K
L
V
S
R
P
S
Site 39
S276
R
S
R
S
K
L
V
S
R
P
S
R
S
F
L
Site 40
S279
S
K
L
V
S
R
P
S
R
S
F
L
L
R
H
Site 41
S281
L
V
S
R
P
S
R
S
F
L
L
R
H
R
P
Site 42
S295
P
V
P
E
I
P
G
S
T
K
G
V
S
G
S
Site 43
T296
V
P
E
I
P
G
S
T
K
G
V
S
G
S
Y
Site 44
S300
P
G
S
T
K
G
V
S
G
S
Y
F
R
E
R
Site 45
S302
S
T
K
G
V
S
G
S
Y
F
R
E
R
R
N
Site 46
Y303
T
K
G
V
S
G
S
Y
F
R
E
R
R
N
V
Site 47
T312
R
E
R
R
N
V
A
T
S
T
E
K
S
V
A
Site 48
S313
E
R
R
N
V
A
T
S
T
E
K
S
V
A
W
Site 49
S317
V
A
T
S
T
E
K
S
V
A
W
Q
N
S
N
Site 50
S323
K
S
V
A
W
Q
N
S
N
E
E
N
S
S
S
Site 51
S329
N
S
N
E
E
N
S
S
S
I
F
P
Y
G
E
Site 52
S330
S
N
E
E
N
S
S
S
I
F
P
Y
G
E
T
Site 53
Y334
N
S
S
S
I
F
P
Y
G
E
T
F
L
F
Q
Site 54
T337
S
I
F
P
Y
G
E
T
F
L
F
Q
R
L
E
Site 55
S346
L
F
Q
R
L
E
N
S
K
K
R
S
I
K
N
Site 56
S350
L
E
N
S
K
K
R
S
I
K
N
E
F
L
T
Site 57
T357
S
I
K
N
E
F
L
T
Q
G
E
A
L
K
G
Site 58
Y380
F
I
I
K
S
S
I
Y
D
N
R
K
E
K
I
Site 59
S388
D
N
R
K
E
K
I
S
E
D
K
V
E
D
I
Site 60
T409
K
N
N
F
L
I
D
T
A
S
E
S
E
Y
S
Site 61
S411
N
F
L
I
D
T
A
S
E
S
E
Y
S
T
V
Site 62
S413
L
I
D
T
A
S
E
S
E
Y
S
T
V
E
E
Site 63
Y415
D
T
A
S
E
S
E
Y
S
T
V
E
E
C
F
Site 64
S416
T
A
S
E
S
E
Y
S
T
V
E
E
C
F
Q
Site 65
T417
A
S
E
S
E
Y
S
T
V
E
E
C
F
Q
S
Site 66
S424
T
V
E
E
C
F
Q
S
L
R
R
K
N
S
K
Site 67
S430
Q
S
L
R
R
K
N
S
K
A
S
K
S
R
T
Site 68
S433
R
R
K
N
S
K
A
S
K
S
R
T
Q
K
A
Site 69
S435
K
N
S
K
A
S
K
S
R
T
Q
K
A
L
I
Site 70
T437
S
K
A
S
K
S
R
T
Q
K
A
L
I
L
D
Site 71
S445
Q
K
A
L
I
L
D
S
V
N
R
H
S
Y
P
Site 72
S450
L
D
S
V
N
R
H
S
Y
P
L
S
S
T
S
Site 73
Y451
D
S
V
N
R
H
S
Y
P
L
S
S
T
S
G
Site 74
S454
N
R
H
S
Y
P
L
S
S
T
S
G
N
A
D
Site 75
S455
R
H
S
Y
P
L
S
S
T
S
G
N
A
D
S
Site 76
S457
S
Y
P
L
S
S
T
S
G
N
A
D
S
S
A
Site 77
S462
S
T
S
G
N
A
D
S
S
A
V
S
S
Q
A
Site 78
S463
T
S
G
N
A
D
S
S
A
V
S
S
Q
A
I
Site 79
S466
N
A
D
S
S
A
V
S
S
Q
A
I
S
P
Y
Site 80
S467
A
D
S
S
A
V
S
S
Q
A
I
S
P
Y
A
Site 81
Y473
S
S
Q
A
I
S
P
Y
A
C
F
Y
G
A
S
Site 82
Y477
I
S
P
Y
A
C
F
Y
G
A
S
A
K
K
V
Site 83
S486
A
S
A
K
K
V
K
S
G
W
L
D
K
L
S
Site 84
S493
S
G
W
L
D
K
L
S
P
Q
G
K
R
M
F
Site 85
S513
K
F
D
G
L
S
I
S
Y
Y
N
N
E
K
E
Site 86
Y515
D
G
L
S
I
S
Y
Y
N
N
E
K
E
M
Y
Site 87
Y522
Y
N
N
E
K
E
M
Y
S
K
G
I
I
P
L
Site 88
T548
N
K
F
E
V
V
T
T
Q
R
T
F
V
F
R
Site 89
T551
E
V
V
T
T
Q
R
T
F
V
F
R
V
E
K
Site 90
S567
E
E
R
N
D
W
I
S
I
L
L
N
A
L
K
Site 91
S575
I
L
L
N
A
L
K
S
Q
S
L
T
S
Q
S
Site 92
S577
L
N
A
L
K
S
Q
S
L
T
S
Q
S
Q
A
Site 93
T579
A
L
K
S
Q
S
L
T
S
Q
S
Q
A
V
V
Site 94
S580
L
K
S
Q
S
L
T
S
Q
S
Q
A
V
V
T
Site 95
S582
S
Q
S
L
T
S
Q
S
Q
A
V
V
T
P
E
Site 96
T587
S
Q
S
Q
A
V
V
T
P
E
K
C
G
Y
L
Site 97
Y593
V
T
P
E
K
C
G
Y
L
E
L
R
G
Y
K
Site 98
S623
K
N
E
Q
D
F
K
S
G
L
G
I
T
I
I
Site 99
T643
N
V
K
Q
V
D
R
T
V
K
Q
S
F
E
I
Site 100
S647
V
D
R
T
V
K
Q
S
F
E
I
I
T
P
Y
Site 101
T652
K
Q
S
F
E
I
I
T
P
Y
R
S
F
S
F
Site 102
Y654
S
F
E
I
I
T
P
Y
R
S
F
S
F
T
A
Site 103
S656
E
I
I
T
P
Y
R
S
F
S
F
T
A
E
T
Site 104
S658
I
T
P
Y
R
S
F
S
F
T
A
E
T
E
K
Site 105
T660
P
Y
R
S
F
S
F
T
A
E
T
E
K
E
K
Site 106
S677
W
I
E
A
V
Q
Q
S
I
A
E
T
L
S
D
Site 107
T681
V
Q
Q
S
I
A
E
T
L
S
D
Y
E
V
A
Site 108
S683
Q
S
I
A
E
T
L
S
D
Y
E
V
A
E
K
Site 109
Y685
I
A
E
T
L
S
D
Y
E
V
A
E
K
I
W
Site 110
S729
K
C
A
G
Q
H
R
S
L
G
P
K
D
S
K
Site 111
S735
R
S
L
G
P
K
D
S
K
V
R
S
L
K
M
Site 112
S739
P
K
D
S
K
V
R
S
L
K
M
D
A
S
I
Site 113
S745
R
S
L
K
M
D
A
S
I
W
S
N
E
L
I
Site 114
S781
D
E
E
L
H
M
D
S
P
V
E
K
R
K
N
Site 115
T791
E
K
R
K
N
F
I
T
Q
K
Y
K
E
G
K
Site 116
Y794
K
N
F
I
T
Q
K
Y
K
E
G
K
F
R
K
Site 117
T802
K
E
G
K
F
R
K
T
L
L
A
S
L
T
K
Site 118
T849
T
G
D
P
V
H
S
T
P
Y
L
L
A
K
K
Site 119
Y867
S
L
Q
M
E
F
L
Y
H
N
K
F
S
D
F
Site 120
S881
F
P
Q
H
D
I
H
S
E
G
V
L
S
Q
E
Site 121
S886
I
H
S
E
G
V
L
S
Q
E
S
S
Q
S
T
Site 122
S890
G
V
L
S
Q
E
S
S
Q
S
T
F
L
C
D
Site 123
S892
L
S
Q
E
S
S
Q
S
T
F
L
C
D
F
L
Site 124
T893
S
Q
E
S
S
Q
S
T
F
L
C
D
F
L
Y
Site 125
S904
D
F
L
Y
Q
A
P
S
A
A
S
K
L
S
S
Site 126
S910
P
S
A
A
S
K
L
S
S
E
K
K
L
L
E
Site 127
S911
S
A
A
S
K
L
S
S
E
K
K
L
L
E
E
Site 128
S932
V
L
E
G
G
F
L
S
Y
Y
E
N
D
K
S
Site 129
Y934
E
G
G
F
L
S
Y
Y
E
N
D
K
S
T
T
Site 130
S939
S
Y
Y
E
N
D
K
S
T
T
P
N
G
T
I
Site 131
T941
Y
E
N
D
K
S
T
T
P
N
G
T
I
N
I
Site 132
Y962
A
I
H
K
E
D
F
Y
L
N
T
G
P
I
F
Site 133
T995
S
Q
A
Q
R
K
W
T
E
A
I
A
K
H
F
Site 134
Y1015
E
N
L
T
E
A
D
Y
D
L
I
G
Q
L
F
Site 135
T1067
L
R
R
L
Q
E
L
T
I
S
T
M
V
Q
N
Site 136
S1069
R
L
Q
E
L
T
I
S
T
M
V
Q
N
G
E
Site 137
T1089
L
L
V
E
K
G
R
T
L
Y
I
H
G
H
T
Site 138
Y1091
V
E
K
G
R
T
L
Y
I
H
G
H
T
K
L
Site 139
S1124
A
L
Q
D
Q
Q
L
S
K
N
D
V
P
I
I
Site 140
Y1148
Q
Y
G
L
G
C
K
Y
I
Y
Q
K
N
G
D
Site 141
Y1150
G
L
G
C
K
Y
I
Y
Q
K
N
G
D
P
L
Site 142
S1160
N
G
D
P
L
H
I
S
E
L
L
E
S
F
K
Site 143
S1165
H
I
S
E
L
L
E
S
F
K
K
D
A
R
S
Site 144
S1172
S
F
K
K
D
A
R
S
F
K
L
R
A
G
K
Site 145
T1186
K
H
Q
L
E
D
V
T
A
V
L
K
S
F
L
Site 146
S1191
D
V
T
A
V
L
K
S
F
L
S
D
I
D
D
Site 147
T1202
D
I
D
D
A
L
L
T
K
E
L
Y
P
Y
W
Site 148
Y1208
L
T
K
E
L
Y
P
Y
W
I
S
A
L
D
T
Site 149
T1215
Y
W
I
S
A
L
D
T
Q
D
D
K
E
R
I
Site 150
Y1225
D
K
E
R
I
K
K
Y
G
A
F
I
R
S
L
Site 151
S1231
K
Y
G
A
F
I
R
S
L
P
G
V
N
R
A
Site 152
Y1248
A
A
I
I
E
H
L
Y
R
V
Q
K
C
S
E
Site 153
T1320
F
I
T
K
W
K
D
T
Q
V
S
Q
A
G
D
Site 154
S1323
K
W
K
D
T
Q
V
S
Q
A
G
D
L
L
I
Site 155
Y1333
G
D
L
L
I
E
V
Y
V
E
R
K
E
P
D
Site 156
S1342
E
R
K
E
P
D
C
S
I
I
I
R
I
S
P
Site 157
T1376
T
K
G
D
I
W
A
T
F
E
V
I
E
N
E
Site 158
S1403
L
E
Q
V
L
R
W
S
S
L
A
E
P
G
S
Site 159
S1404
E
Q
V
L
R
W
S
S
L
A
E
P
G
S
A
Site 160
S1410
S
S
L
A
E
P
G
S
A
Y
L
V
V
K
R
Site 161
T1423
K
R
F
L
T
A
D
T
I
K
H
C
S
D
R
Site 162
S1428
A
D
T
I
K
H
C
S
D
R
S
T
L
G
S
Site 163
S1431
I
K
H
C
S
D
R
S
T
L
G
S
I
K
E
Site 164
T1432
K
H
C
S
D
R
S
T
L
G
S
I
K
E
G
Site 165
S1435
S
D
R
S
T
L
G
S
I
K
E
G
I
L
K
Site 166
S1448
L
K
I
K
E
E
P
S
K
I
L
S
G
N
K
Site 167
S1452
E
E
P
S
K
I
L
S
G
N
K
F
Q
D
R
Site 168
Y1460
G
N
K
F
Q
D
R
Y
F
V
L
R
D
G
F
Site 169
Y1471
R
D
G
F
L
F
L
Y
K
D
V
K
S
S
K
Site 170
S1484
S
K
H
D
K
M
F
S
L
S
S
M
K
F
Y
Site 171
S1486
H
D
K
M
F
S
L
S
S
M
K
F
Y
R
G
Site 172
Y1491
S
L
S
S
M
K
F
Y
R
G
V
K
K
K
M
Site 173
T1502
K
K
K
M
K
P
P
T
S
W
G
L
T
A
Y
Site 174
S1503
K
K
M
K
P
P
T
S
W
G
L
T
A
Y
S
Site 175
T1507
P
P
T
S
W
G
L
T
A
Y
S
E
K
H
H
Site 176
Y1539
I
F
I
A
Q
H
E
Y
D
I
W
P
P
A
G
Site 177
S1552
A
G
K
E
R
K
R
S
I
T
K
N
P
K
I
Site 178
T1554
K
E
R
K
R
S
I
T
K
N
P
K
I
G
G
Site 179
T1574
I
Q
H
E
G
N
A
T
L
A
R
K
N
I
E
Site 180
S1582
L
A
R
K
N
I
E
S
A
R
A
E
L
E
R
Site 181
S1593
E
L
E
R
L
R
L
S
E
K
C
D
K
E
S
Site 182
S1600
S
E
K
C
D
K
E
S
V
D
S
S
L
K
E
Site 183
S1603
C
D
K
E
S
V
D
S
S
L
K
E
R
A
S
Site 184
S1604
D
K
E
S
V
D
S
S
L
K
E
R
A
S
M
Site 185
S1610
S
S
L
K
E
R
A
S
M
V
A
H
C
L
E
Site 186
S1632
N
R
P
R
K
H
R
S
F
N
C
L
E
D
T
Site 187
T1639
S
F
N
C
L
E
D
T
E
P
E
A
P
L
G
Site 188
T1656
K
G
H
K
G
L
K
T
L
R
K
T
E
D
R
Site 189
T1660
G
L
K
T
L
R
K
T
E
D
R
N
S
K
A
Site 190
S1665
R
K
T
E
D
R
N
S
K
A
T
L
D
S
D
Site 191
T1668
E
D
R
N
S
K
A
T
L
D
S
D
H
K
L
Site 192
S1671
N
S
K
A
T
L
D
S
D
H
K
L
P
S
R
Site 193
S1677
D
S
D
H
K
L
P
S
R
V
I
E
E
L
N
Site 194
T1692
V
V
L
Q
R
S
R
T
L
P
K
E
L
Q
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation