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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3R5
Full Name:
Phosphoinositide 3-kinase regulatory subunit 5
Alias:
FOAP-2; P101-PI3K; Phosphoinositide-3-kinase, regulatory subunit 5, p101; PI3R5
Type:
Mass (Da):
97348
Number AA:
880
UniProt ID:
Q8WYR1
International Prot ID:
IPI00292380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
Q
P
G
A
T
T
C
T
E
D
R
I
Q
H
A
Site 2
S25
E
R
C
L
H
G
L
S
L
S
R
R
S
T
S
Site 3
S27
C
L
H
G
L
S
L
S
R
R
S
T
S
W
S
Site 4
S30
G
L
S
L
S
R
R
S
T
S
W
S
A
G
L
Site 5
T31
L
S
L
S
R
R
S
T
S
W
S
A
G
L
C
Site 6
S32
S
L
S
R
R
S
T
S
W
S
A
G
L
C
L
Site 7
S34
S
R
R
S
T
S
W
S
A
G
L
C
L
N
C
Site 8
S49
W
S
L
Q
E
L
V
S
R
D
P
G
H
F
L
Site 9
Y75
E
V
Q
E
K
G
T
Y
D
L
L
T
P
L
A
Site 10
T92
F
Y
S
T
V
L
C
T
P
H
F
P
P
D
S
Site 11
S99
T
P
H
F
P
P
D
S
D
L
L
L
K
A
A
Site 12
Y109
L
L
K
A
A
S
T
Y
H
R
F
L
T
W
P
Site 13
T114
S
T
Y
H
R
F
L
T
W
P
V
P
Y
C
S
Site 14
S121
T
W
P
V
P
Y
C
S
I
C
Q
E
L
L
T
Site 15
Y141
L
K
A
P
G
I
S
Y
Q
R
L
V
R
A
E
Site 16
S155
E
Q
G
L
P
I
R
S
H
R
S
S
T
V
T
Site 17
S183
L
A
V
A
N
K
L
S
T
P
G
H
S
P
H
Site 18
T184
A
V
A
N
K
L
S
T
P
G
H
S
P
H
S
Site 19
S188
K
L
S
T
P
G
H
S
P
H
S
A
Y
T
T
Site 20
S191
T
P
G
H
S
P
H
S
A
Y
T
T
L
L
L
Site 21
T195
S
P
H
S
A
Y
T
T
L
L
L
H
A
F
Q
Site 22
T222
H
C
R
L
Q
A
K
T
L
A
E
L
E
D
I
Site 23
T231
A
E
L
E
D
I
F
T
E
T
A
E
A
Q
E
Site 24
T255
E
A
R
R
W
L
R
T
K
L
Q
A
V
G
E
Site 25
T272
G
F
P
G
V
L
D
T
A
K
P
G
K
L
H
Site 26
Y289
P
I
P
V
A
R
C
Y
T
Y
S
W
S
Q
D
Site 27
T290
I
P
V
A
R
C
Y
T
Y
S
W
S
Q
D
S
Site 28
S297
T
Y
S
W
S
Q
D
S
F
D
I
L
Q
E
I
Site 29
T336
E
V
E
E
D
L
E
T
D
G
H
C
A
E
R
Site 30
S345
G
H
C
A
E
R
D
S
L
L
S
T
S
S
L
Site 31
S348
A
E
R
D
S
L
L
S
T
S
S
L
A
S
H
Site 32
T349
E
R
D
S
L
L
S
T
S
S
L
A
S
H
D
Site 33
S350
R
D
S
L
L
S
T
S
S
L
A
S
H
D
S
Site 34
S351
D
S
L
L
S
T
S
S
L
A
S
H
D
S
T
Site 35
S354
L
S
T
S
S
L
A
S
H
D
S
T
L
S
L
Site 36
S357
S
S
L
A
S
H
D
S
T
L
S
L
A
S
S
Site 37
T358
S
L
A
S
H
D
S
T
L
S
L
A
S
S
Q
Site 38
S360
A
S
H
D
S
T
L
S
L
A
S
S
Q
A
S
Site 39
S363
D
S
T
L
S
L
A
S
S
Q
A
S
G
P
A
Site 40
S367
S
L
A
S
S
Q
A
S
G
P
A
L
S
R
H
Site 41
S372
Q
A
S
G
P
A
L
S
R
H
L
L
T
S
F
Site 42
S384
T
S
F
V
S
G
L
S
D
G
M
D
S
G
Y
Site 43
S389
G
L
S
D
G
M
D
S
G
Y
V
E
D
S
E
Site 44
Y391
S
D
G
M
D
S
G
Y
V
E
D
S
E
E
S
Site 45
S395
D
S
G
Y
V
E
D
S
E
E
S
S
S
E
W
Site 46
S399
V
E
D
S
E
E
S
S
S
E
W
P
W
R
R
Site 47
S400
E
D
S
E
E
S
S
S
E
W
P
W
R
R
G
Site 48
S408
E
W
P
W
R
R
G
S
Q
E
R
R
G
H
R
Site 49
Y425
G
Q
K
F
I
R
I
Y
K
L
F
K
S
T
S
Site 50
S430
R
I
Y
K
L
F
K
S
T
S
Q
L
V
L
R
Site 51
S432
Y
K
L
F
K
S
T
S
Q
L
V
L
R
R
D
Site 52
S440
Q
L
V
L
R
R
D
S
R
S
L
E
G
S
S
Site 53
S442
V
L
R
R
D
S
R
S
L
E
G
S
S
D
T
Site 54
S446
D
S
R
S
L
E
G
S
S
D
T
A
L
P
L
Site 55
S447
S
R
S
L
E
G
S
S
D
T
A
L
P
L
R
Site 56
T449
S
L
E
G
S
S
D
T
A
L
P
L
R
R
A
Site 57
S458
L
P
L
R
R
A
G
S
L
C
S
P
L
D
E
Site 58
S461
R
R
A
G
S
L
C
S
P
L
D
E
P
V
S
Site 59
S468
S
P
L
D
E
P
V
S
P
P
S
R
A
Q
R
Site 60
S471
D
E
P
V
S
P
P
S
R
A
Q
R
S
R
S
Site 61
S476
P
P
S
R
A
Q
R
S
R
S
L
P
Q
P
K
Site 62
S478
S
R
A
Q
R
S
R
S
L
P
Q
P
K
L
G
Site 63
T486
L
P
Q
P
K
L
G
T
Q
L
P
S
W
L
L
Site 64
S497
S
W
L
L
A
P
A
S
R
P
Q
R
R
R
P
Site 65
S507
Q
R
R
R
P
F
L
S
G
D
E
D
P
K
A
Site 66
S528
V
F
G
S
D
R
I
S
G
K
V
A
R
A
Y
Site 67
Y535
S
G
K
V
A
R
A
Y
S
N
L
R
R
L
E
Site 68
S536
G
K
V
A
R
A
Y
S
N
L
R
R
L
E
N
Site 69
Y558
F
F
K
L
Q
F
F
Y
V
P
V
K
R
S
H
Site 70
S564
F
Y
V
P
V
K
R
S
H
G
T
S
P
G
A
Site 71
S568
V
K
R
S
H
G
T
S
P
G
A
C
P
P
P
Site 72
S577
G
A
C
P
P
P
R
S
Q
T
P
S
P
P
T
Site 73
T579
C
P
P
P
R
S
Q
T
P
S
P
P
T
D
S
Site 74
S581
P
P
R
S
Q
T
P
S
P
P
T
D
S
P
R
Site 75
T584
S
Q
T
P
S
P
P
T
D
S
P
R
H
A
S
Site 76
S586
T
P
S
P
P
T
D
S
P
R
H
A
S
P
G
Site 77
S591
T
D
S
P
R
H
A
S
P
G
E
L
G
T
T
Site 78
T598
S
P
G
E
L
G
T
T
P
W
E
E
S
T
N
Site 79
T604
T
T
P
W
E
E
S
T
N
D
I
S
H
Y
L
Site 80
S608
E
E
S
T
N
D
I
S
H
Y
L
G
M
L
D
Site 81
Y610
S
T
N
D
I
S
H
Y
L
G
M
L
D
P
W
Site 82
S648
E
A
Q
A
L
E
G
S
P
T
Q
L
P
I
L
Site 83
T650
Q
A
L
E
G
S
P
T
Q
L
P
I
L
A
D
Site 84
T680
Q
V
Y
Q
T
E
L
T
F
I
T
G
E
K
T
Site 85
T687
T
F
I
T
G
E
K
T
T
E
I
F
I
H
S
Site 86
S700
H
S
L
E
L
G
H
S
A
A
T
R
A
I
K
Site 87
S709
A
T
R
A
I
K
A
S
G
P
G
S
K
R
L
Site 88
S713
I
K
A
S
G
P
G
S
K
R
L
G
I
D
G
Site 89
T728
D
R
E
A
V
P
L
T
L
Q
I
I
Y
S
K
Site 90
S739
I
Y
S
K
G
A
I
S
G
R
S
R
W
S
N
Site 91
S742
K
G
A
I
S
G
R
S
R
W
S
N
L
E
K
Site 92
S745
I
S
G
R
S
R
W
S
N
L
E
K
V
C
T
Site 93
T752
S
N
L
E
K
V
C
T
S
V
N
L
N
K
A
Site 94
S768
R
K
Q
E
E
L
D
S
S
M
E
A
L
T
L
Site 95
S769
K
Q
E
E
L
D
S
S
M
E
A
L
T
L
N
Site 96
T778
E
A
L
T
L
N
L
T
E
V
V
K
R
Q
N
Site 97
S786
E
V
V
K
R
Q
N
S
K
S
K
K
G
F
N
Site 98
S788
V
K
R
Q
N
S
K
S
K
K
G
F
N
Q
I
Site 99
S796
K
K
G
F
N
Q
I
S
T
S
Q
I
K
V
D
Site 100
S798
G
F
N
Q
I
S
T
S
Q
I
K
V
D
K
V
Site 101
S829
D
E
R
K
I
L
Q
S
V
V
R
C
E
V
S
Site 102
S836
S
V
V
R
C
E
V
S
P
C
Y
K
P
E
K
Site 103
Y839
R
C
E
V
S
P
C
Y
K
P
E
K
S
D
L
Site 104
S844
P
C
Y
K
P
E
K
S
D
L
S
S
P
P
Q
Site 105
S847
K
P
E
K
S
D
L
S
S
P
P
Q
T
P
P
Site 106
S848
P
E
K
S
D
L
S
S
P
P
Q
T
P
P
D
Site 107
T852
D
L
S
S
P
P
Q
T
P
P
D
L
P
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation