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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGCR8
Full Name:
Microprocessor complex subunit DGCR8
Alias:
C22orf12; DGCRK6; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; Gy1; Pasha
Type:
RNA processing; RNA binding protein
Mass (Da):
86045
Number AA:
773
UniProt ID:
Q8WYQ5
International Prot ID:
IPI00165970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003725
GO:0005515
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0031053
GO:0006396
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
T
D
E
S
P
S
P
L
P
C
G
Site 2
S8
M
E
T
D
E
S
P
S
P
L
P
C
G
P
A
Site 3
S22
A
G
E
A
V
M
E
S
R
A
R
P
F
Q
A
Site 4
S35
Q
A
L
P
R
E
Q
S
P
P
P
P
L
Q
T
Site 5
S53
A
E
V
M
D
V
G
S
G
G
D
G
Q
S
E
Site 6
S59
G
S
G
G
D
G
Q
S
E
L
P
A
E
D
P
Site 7
Y70
A
E
D
P
F
N
F
Y
G
A
S
L
L
S
K
Site 8
S76
F
Y
G
A
S
L
L
S
K
G
S
F
S
K
G
Site 9
S79
A
S
L
L
S
K
G
S
F
S
K
G
R
L
L
Site 10
S92
L
L
I
D
P
N
C
S
G
H
S
P
R
T
A
Site 11
S95
D
P
N
C
S
G
H
S
P
R
T
A
R
H
A
Site 12
T98
C
S
G
H
S
P
R
T
A
R
H
A
P
A
V
Site 13
S109
A
P
A
V
R
K
F
S
P
D
L
K
L
L
K
Site 14
S123
K
D
V
K
I
S
V
S
F
T
E
S
C
R
S
Site 15
T125
V
K
I
S
V
S
F
T
E
S
C
R
S
K
D
Site 16
S127
I
S
V
S
F
T
E
S
C
R
S
K
D
R
K
Site 17
S130
S
F
T
E
S
C
R
S
K
D
R
K
V
L
Y
Site 18
Y137
S
K
D
R
K
V
L
Y
T
G
A
E
R
D
V
Site 19
T138
K
D
R
K
V
L
Y
T
G
A
E
R
D
V
R
Site 20
Y196
D
Q
E
K
R
V
E
Y
A
V
L
D
E
L
E
Site 21
T206
L
D
E
L
E
D
F
T
D
N
L
E
L
D
E
Site 22
Y239
E
E
A
L
N
F
P
Y
E
D
D
F
D
N
D
Site 23
T263
C
A
P
K
K
R
R
T
E
E
K
Y
G
G
D
Site 24
Y267
K
R
R
T
E
E
K
Y
G
G
D
S
D
H
P
Site 25
S271
E
E
K
Y
G
G
D
S
D
H
P
S
D
G
E
Site 26
S275
G
G
D
S
D
H
P
S
D
G
E
T
S
V
Q
Site 27
T279
D
H
P
S
D
G
E
T
S
V
Q
P
M
M
T
Site 28
S280
H
P
S
D
G
E
T
S
V
Q
P
M
M
T
K
Site 29
T290
P
M
M
T
K
I
K
T
V
L
K
S
R
G
R
Site 30
S294
K
I
K
T
V
L
K
S
R
G
R
P
P
T
E
Site 31
T300
K
S
R
G
R
P
P
T
E
P
L
P
D
G
W
Site 32
Y319
H
N
S
G
V
P
V
Y
L
H
R
E
S
R
V
Site 33
S324
P
V
Y
L
H
R
E
S
R
V
V
T
W
S
R
Site 34
T328
H
R
E
S
R
V
V
T
W
S
R
P
Y
F
L
Site 35
S330
E
S
R
V
V
T
W
S
R
P
Y
F
L
G
T
Site 36
T337
S
R
P
Y
F
L
G
T
G
S
I
R
K
H
D
Site 37
S339
P
Y
F
L
G
T
G
S
I
R
K
H
D
P
P
Site 38
S348
R
K
H
D
P
P
L
S
S
I
P
C
L
H
Y
Site 39
S349
K
H
D
P
P
L
S
S
I
P
C
L
H
Y
K
Site 40
S367
D
N
E
E
R
E
Q
S
S
D
L
T
P
S
G
Site 41
T371
R
E
Q
S
S
D
L
T
P
S
G
D
V
S
P
Site 42
S373
Q
S
S
D
L
T
P
S
G
D
V
S
P
V
K
Site 43
S377
L
T
P
S
G
D
V
S
P
V
K
P
L
S
R
Site 44
S383
V
S
P
V
K
P
L
S
R
S
A
E
L
E
F
Site 45
S385
P
V
K
P
L
S
R
S
A
E
L
E
F
P
L
Site 46
S397
F
P
L
D
E
P
D
S
M
G
A
D
P
G
P
Site 47
S434
V
E
V
C
K
D
E
S
V
D
L
E
E
F
R
Site 48
S442
V
D
L
E
E
F
R
S
Y
L
E
K
R
F
D
Site 49
Y443
D
L
E
E
F
R
S
Y
L
E
K
R
F
D
F
Site 50
T454
R
F
D
F
E
Q
V
T
V
K
K
F
R
T
W
Site 51
T460
V
T
V
K
K
F
R
T
W
A
E
R
R
Q
F
Site 52
S478
M
K
R
K
Q
A
E
S
E
R
P
I
L
P
A
Site 53
T491
P
A
N
Q
K
L
I
T
L
S
V
Q
D
A
P
Site 54
S493
N
Q
K
L
I
T
L
S
V
Q
D
A
P
T
K
Site 55
Y530
V
L
K
V
R
P
V
Y
N
F
F
E
C
E
N
Site 56
S539
F
F
E
C
E
N
P
S
E
P
F
G
A
S
V
Site 57
S555
I
D
G
V
T
Y
G
S
G
T
A
S
S
K
K
Site 58
S559
T
Y
G
S
G
T
A
S
S
K
K
L
A
K
N
Site 59
T572
K
N
K
A
A
R
A
T
L
E
I
L
I
P
D
Site 60
S592
S
E
E
K
P
K
D
S
E
E
L
E
Y
F
N
Site 61
Y597
K
D
S
E
E
L
E
Y
F
N
H
I
S
I
E
Site 62
S602
L
E
Y
F
N
H
I
S
I
E
D
S
R
V
Y
Site 63
S606
N
H
I
S
I
E
D
S
R
V
Y
E
L
T
S
Site 64
Y609
S
I
E
D
S
R
V
Y
E
L
T
S
K
A
G
Site 65
T612
D
S
R
V
Y
E
L
T
S
K
A
G
L
L
S
Site 66
S613
S
R
V
Y
E
L
T
S
K
A
G
L
L
S
P
Site 67
S619
T
S
K
A
G
L
L
S
P
Y
Q
I
L
H
E
Site 68
Y653
G
K
N
Q
K
S
E
Y
V
M
A
C
G
K
H
Site 69
Y698
W
G
S
L
L
R
M
Y
G
R
E
S
S
K
M
Site 70
S702
L
R
M
Y
G
R
E
S
S
K
M
V
K
Q
E
Site 71
S703
R
M
Y
G
R
E
S
S
K
M
V
K
Q
E
T
Site 72
S711
K
M
V
K
Q
E
T
S
D
K
S
V
I
E
L
Site 73
S714
K
Q
E
T
S
D
K
S
V
I
E
L
Q
Q
Y
Site 74
Y721
S
V
I
E
L
Q
Q
Y
A
K
K
N
K
P
N
Site 75
T749
L
A
E
E
R
E
E
T
R
K
K
P
K
M
S
Site 76
S756
T
R
K
K
P
K
M
S
I
V
A
S
A
Q
P
Site 77
S760
P
K
M
S
I
V
A
S
A
Q
P
G
G
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation