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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOT12
Full Name:
Acyl-coenzyme A thioesterase 12
Alias:
ACO12; Acyl-CoA thioester hydrolase 12; Acyl-CoA thioesterase 12; CACH; CACH1; CACH-1; Cytoplasmic acetyl-CoA hydrolase 1; Cytosolic acetyl-CoA hydrolase; EC 3.1.2.1; STARD12; STARD15; StAR-related lipid transfer (START) domain containing 15; START domain-containing protein 12; THEAL
Type:
Hydrolase; Carbohydrate Metabolism - pyruvate; EC 3.1.2.1
Mass (Da):
62034
Number AA:
555
UniProt ID:
Q8WYK0
International Prot ID:
IPI00103729
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003986
GO:0004091
PhosphoSite+
KinaseNET
Biological Process:
GO:0006637
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
A
I
Q
P
A
H
A
T
A
R
G
E
L
S
A
Site 2
S27
A
T
A
R
G
E
L
S
A
G
Q
L
L
K
W
Site 3
S82
A
K
V
T
R
A
F
S
T
S
M
E
I
S
I
Site 4
T83
K
V
T
R
A
F
S
T
S
M
E
I
S
I
K
Site 5
T153
V
R
L
Q
H
E
D
T
F
N
N
L
M
K
E
Site 6
S162
N
N
L
M
K
E
S
S
K
F
D
D
L
I
F
Site 7
S177
D
E
E
E
G
A
V
S
T
R
G
T
S
V
Q
Site 8
T181
G
A
V
S
T
R
G
T
S
V
Q
S
I
E
L
Site 9
S239
M
F
K
F
R
G
P
S
T
V
G
D
R
L
V
Site 10
T240
F
K
F
R
G
P
S
T
V
G
D
R
L
V
F
Site 11
T299
D
D
K
E
N
L
I
T
F
P
R
I
Q
P
I
Site 12
S307
F
P
R
I
Q
P
I
S
K
D
D
F
R
R
Y
Site 13
Y314
S
K
D
D
F
R
R
Y
R
G
A
I
A
R
K
Site 14
Y329
R
I
R
L
G
R
K
Y
V
I
S
H
K
E
E
Site 15
S332
L
G
R
K
Y
V
I
S
H
K
E
E
V
P
L
Site 16
S350
W
D
I
S
K
Q
A
S
L
S
D
S
N
V
E
Site 17
S352
I
S
K
Q
A
S
L
S
D
S
N
V
E
A
L
Site 18
S354
K
Q
A
S
L
S
D
S
N
V
E
A
L
K
K
Site 19
T371
A
K
R
G
W
E
V
T
S
T
V
E
K
I
K
Site 20
T373
R
G
W
E
V
T
S
T
V
E
K
I
K
I
Y
Site 21
S389
L
E
E
H
D
V
L
S
V
W
V
E
K
H
V
Site 22
S398
W
V
E
K
H
V
G
S
P
A
H
L
A
Y
R
Site 23
S408
H
L
A
Y
R
L
L
S
D
F
T
K
R
P
L
Site 24
T411
Y
R
L
L
S
D
F
T
K
R
P
L
W
D
P
Site 25
S456
K
D
L
V
V
L
V
S
R
R
K
P
L
K
D
Site 26
T466
K
P
L
K
D
G
N
T
Y
T
V
A
V
K
S
Site 27
S473
T
Y
T
V
A
V
K
S
V
I
L
P
S
V
P
Site 28
S482
I
L
P
S
V
P
P
S
P
Q
Y
I
R
S
E
Site 29
Y485
S
V
P
P
S
P
Q
Y
I
R
S
E
I
I
C
Site 30
Y509
S
N
S
C
I
V
S
Y
F
N
H
M
S
A
S
Site 31
S531
N
L
G
G
W
S
K
S
I
E
E
T
A
A
S
Site 32
T535
W
S
K
S
I
E
E
T
A
A
S
C
I
Q
F
Site 33
S538
S
I
E
E
T
A
A
S
C
I
Q
F
L
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation