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Updated November 2019
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Protein Info
Short Name:
MYST4
Full Name:
Histone acetyltransferase MYST4
Alias:
KAT6B; KIAA0383; Morf; MORF; MOZ2; MOZ-related factor; MYST histone acetyltransferase (monocytic leukemia) 4; MYST histone acetyltransferase (monocytic leukemia) 4 (MORF); Qkf; Querkopf
Type:
EC 2.3.1.48; EC 2.3.1.-; Acetyltransferase
Mass (Da):
231378
Number AA:
2073
UniProt ID:
Q8WYB5
International Prot ID:
IPI00099433
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070776
GO:0000786
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0016563
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0043966
GO:0016481
GO:0006334
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
K
K
Q
K
Q
R
P
S
E
E
R
I
C
H
A
Site 2
T46
S
H
G
L
D
K
K
T
V
S
E
Q
L
E
L
Site 3
S48
G
L
D
K
K
T
V
S
E
Q
L
E
L
S
V
Site 4
S59
E
L
S
V
Q
D
G
S
V
L
K
V
T
N
K
Site 5
Y71
T
N
K
G
L
A
S
Y
K
D
P
D
N
P
G
Site 6
S81
P
D
N
P
G
R
F
S
S
V
K
P
G
T
F
Site 7
S82
D
N
P
G
R
F
S
S
V
K
P
G
T
F
P
Site 8
T87
F
S
S
V
K
P
G
T
F
P
K
S
A
K
G
Site 9
S91
K
P
G
T
F
P
K
S
A
K
G
S
R
G
S
Site 10
S95
F
P
K
S
A
K
G
S
R
G
S
C
N
D
L
Site 11
S98
S
A
K
G
S
R
G
S
C
N
D
L
R
N
V
Site 12
Y132
S
L
K
N
I
E
K
Y
L
R
S
Q
S
D
L
Site 13
S135
N
I
E
K
Y
L
R
S
Q
S
D
L
T
S
T
Site 14
S137
E
K
Y
L
R
S
Q
S
D
L
T
S
T
T
N
Site 15
S141
R
S
Q
S
D
L
T
S
T
T
N
N
P
A
F
Site 16
Y172
L
L
K
D
G
P
Q
Y
R
V
N
Y
G
S
L
Site 17
Y176
G
P
Q
Y
R
V
N
Y
G
S
L
D
G
K
G
Site 18
S178
Q
Y
R
V
N
Y
G
S
L
D
G
K
G
A
P
Site 19
Y187
D
G
K
G
A
P
Q
Y
P
S
A
F
P
S
S
Site 20
S189
K
G
A
P
Q
Y
P
S
A
F
P
S
S
L
P
Site 21
S193
Q
Y
P
S
A
F
P
S
S
L
P
P
V
S
L
Site 22
S199
P
S
S
L
P
P
V
S
L
L
P
H
E
K
D
Site 23
S217
A
D
P
I
P
I
C
S
F
C
L
G
T
K
E
Site 24
T222
I
C
S
F
C
L
G
T
K
E
S
N
R
E
K
Site 25
S225
F
C
L
G
T
K
E
S
N
R
E
K
K
P
E
Site 26
S236
K
K
P
E
E
L
L
S
C
A
D
C
G
S
S
Site 27
S243
S
C
A
D
C
G
S
S
G
H
P
S
C
L
K
Site 28
S247
C
G
S
S
G
H
P
S
C
L
K
F
C
P
E
Site 29
Y338
A
A
Q
I
K
R
R
Y
A
K
P
I
G
R
P
Site 30
S355
K
L
K
Q
R
L
L
S
V
T
S
D
E
G
S
Site 31
T357
K
Q
R
L
L
S
V
T
S
D
E
G
S
M
N
Site 32
S358
Q
R
L
L
S
V
T
S
D
E
G
S
M
N
A
Site 33
S362
S
V
T
S
D
E
G
S
M
N
A
F
T
G
R
Site 34
T367
E
G
S
M
N
A
F
T
G
R
G
S
P
G
R
Site 35
S371
N
A
F
T
G
R
G
S
P
G
R
G
Q
K
T
Site 36
T378
S
P
G
R
G
Q
K
T
K
V
C
T
T
P
S
Site 37
T382
G
Q
K
T
K
V
C
T
T
P
S
S
G
H
A
Site 38
T383
Q
K
T
K
V
C
T
T
P
S
S
G
H
A
A
Site 39
S386
K
V
C
T
T
P
S
S
G
H
A
A
S
G
K
Site 40
S391
P
S
S
G
H
A
A
S
G
K
D
S
S
S
R
Site 41
S395
H
A
A
S
G
K
D
S
S
S
R
L
A
V
T
Site 42
S396
A
A
S
G
K
D
S
S
S
R
L
A
V
T
D
Site 43
S397
A
S
G
K
D
S
S
S
R
L
A
V
T
D
P
Site 44
T402
S
S
S
R
L
A
V
T
D
P
T
R
P
G
A
Site 45
T411
P
T
R
P
G
A
T
T
K
I
T
T
T
S
T
Site 46
T416
A
T
T
K
I
T
T
T
S
T
Y
I
S
A
S
Site 47
S417
T
T
K
I
T
T
T
S
T
Y
I
S
A
S
T
Site 48
T418
T
K
I
T
T
T
S
T
Y
I
S
A
S
T
L
Site 49
Y419
K
I
T
T
T
S
T
Y
I
S
A
S
T
L
K
Site 50
S421
T
T
T
S
T
Y
I
S
A
S
T
L
K
V
N
Site 51
T439
K
G
L
I
D
G
L
T
K
F
F
T
P
S
P
Site 52
T443
D
G
L
T
K
F
F
T
P
S
P
D
G
R
R
Site 53
S445
L
T
K
F
F
T
P
S
P
D
G
R
R
S
R
Site 54
S451
P
S
P
D
G
R
R
S
R
G
E
I
I
D
F
Site 55
S459
R
G
E
I
I
D
F
S
K
H
Y
R
P
R
K
Site 56
S469
Y
R
P
R
K
K
V
S
Q
K
Q
S
C
T
S
Site 57
S473
K
K
V
S
Q
K
Q
S
C
T
S
H
V
L
A
Site 58
S492
Q
K
L
K
P
P
P
S
S
L
P
P
P
T
P
Site 59
S493
K
L
K
P
P
P
S
S
L
P
P
P
T
P
I
Site 60
T498
P
S
S
L
P
P
P
T
P
I
S
G
Q
S
P
Site 61
S501
L
P
P
P
T
P
I
S
G
Q
S
P
S
S
Q
Site 62
S504
P
T
P
I
S
G
Q
S
P
S
S
Q
K
S
S
Site 63
S506
P
I
S
G
Q
S
P
S
S
Q
K
S
S
T
A
Site 64
S507
I
S
G
Q
S
P
S
S
Q
K
S
S
T
A
T
Site 65
S510
Q
S
P
S
S
Q
K
S
S
T
A
T
S
S
P
Site 66
S511
S
P
S
S
Q
K
S
S
T
A
T
S
S
P
S
Site 67
T512
P
S
S
Q
K
S
S
T
A
T
S
S
P
S
P
Site 68
T514
S
Q
K
S
S
T
A
T
S
S
P
S
P
Q
S
Site 69
S515
Q
K
S
S
T
A
T
S
S
P
S
P
Q
S
S
Site 70
S516
K
S
S
T
A
T
S
S
P
S
P
Q
S
S
S
Site 71
S518
S
T
A
T
S
S
P
S
P
Q
S
S
S
S
Q
Site 72
S521
T
S
S
P
S
P
Q
S
S
S
S
Q
C
S
V
Site 73
S522
S
S
P
S
P
Q
S
S
S
S
Q
C
S
V
P
Site 74
S523
S
P
S
P
Q
S
S
S
S
Q
C
S
V
P
S
Site 75
S524
P
S
P
Q
S
S
S
S
Q
C
S
V
P
S
L
Site 76
S527
Q
S
S
S
S
Q
C
S
V
P
S
L
S
S
L
Site 77
S530
S
S
Q
C
S
V
P
S
L
S
S
L
T
T
N
Site 78
S532
Q
C
S
V
P
S
L
S
S
L
T
T
N
S
Q
Site 79
S533
C
S
V
P
S
L
S
S
L
T
T
N
S
Q
L
Site 80
T536
P
S
L
S
S
L
T
T
N
S
Q
L
K
A
L
Site 81
S538
L
S
S
L
T
T
N
S
Q
L
K
A
L
F
D
Site 82
S548
K
A
L
F
D
G
L
S
H
I
Y
T
T
Q
G
Site 83
Y551
F
D
G
L
S
H
I
Y
T
T
Q
G
Q
S
R
Site 84
T552
D
G
L
S
H
I
Y
T
T
Q
G
Q
S
R
K
Site 85
S564
S
R
K
K
G
H
P
S
Y
A
P
P
K
R
M
Site 86
Y565
R
K
K
G
H
P
S
Y
A
P
P
K
R
M
R
Site 87
T575
P
K
R
M
R
R
K
T
E
L
S
S
T
A
K
Site 88
S578
M
R
R
K
T
E
L
S
S
T
A
K
S
K
A
Site 89
S579
R
R
K
T
E
L
S
S
T
A
K
S
K
A
H
Site 90
T580
R
K
T
E
L
S
S
T
A
K
S
K
A
H
F
Site 91
S583
E
L
S
S
T
A
K
S
K
A
H
F
F
G
K
Site 92
S595
F
G
K
R
D
I
R
S
R
F
I
S
H
S
S
Site 93
S599
D
I
R
S
R
F
I
S
H
S
S
S
S
S
W
Site 94
S601
R
S
R
F
I
S
H
S
S
S
S
S
W
G
M
Site 95
S602
S
R
F
I
S
H
S
S
S
S
S
W
G
M
A
Site 96
S603
R
F
I
S
H
S
S
S
S
S
W
G
M
A
R
Site 97
S605
I
S
H
S
S
S
S
S
W
G
M
A
R
G
S
Site 98
T624
I
A
H
F
K
R
T
T
F
L
K
K
H
R
M
Site 99
Y637
R
M
L
G
R
L
K
Y
K
V
T
P
Q
M
G
Site 100
T640
G
R
L
K
Y
K
V
T
P
Q
M
G
T
P
S
Site 101
T645
K
V
T
P
Q
M
G
T
P
S
P
G
K
G
S
Site 102
S647
T
P
Q
M
G
T
P
S
P
G
K
G
S
L
T
Site 103
T654
S
P
G
K
G
S
L
T
D
G
R
I
K
P
D
Site 104
T666
K
P
D
Q
D
D
D
T
E
I
K
I
N
I
K
Site 105
T689
I
G
N
K
D
V
V
T
E
E
D
L
D
V
F
Site 106
S703
F
K
Q
A
Q
E
L
S
W
E
K
I
E
C
E
Site 107
Y719
G
V
E
D
C
G
R
Y
P
S
V
I
E
F
G
Site 108
S721
E
D
C
G
R
Y
P
S
V
I
E
F
G
K
Y
Site 109
Y728
S
V
I
E
F
G
K
Y
E
I
Q
T
W
Y
S
Site 110
Y734
K
Y
E
I
Q
T
W
Y
S
S
P
Y
P
Q
E
Site 111
S736
E
I
Q
T
W
Y
S
S
P
Y
P
Q
E
Y
A
Site 112
Y738
Q
T
W
Y
S
S
P
Y
P
Q
E
Y
A
R
L
Site 113
Y742
S
S
P
Y
P
Q
E
Y
A
R
L
P
K
L
Y
Site 114
Y757
L
C
E
F
C
L
K
Y
M
K
S
K
N
I
L
Site 115
Y782
H
P
P
A
N
E
I
Y
R
R
K
D
L
S
V
Site 116
S788
I
Y
R
R
K
D
L
S
V
F
E
V
D
G
N
Site 117
T816
K
L
F
L
D
H
K
T
L
Y
Y
D
V
E
P
Site 118
Y818
F
L
D
H
K
T
L
Y
Y
D
V
E
P
F
L
Site 119
Y819
L
D
H
K
T
L
Y
Y
D
V
E
P
F
L
F
Site 120
Y827
D
V
E
P
F
L
F
Y
V
L
T
K
N
D
E
Site 121
T830
P
F
L
F
Y
V
L
T
K
N
D
E
K
G
C
Site 122
Y842
K
G
C
H
L
V
G
Y
F
S
K
E
K
L
C
Site 123
Y853
E
K
L
C
Q
Q
K
Y
N
V
S
C
I
M
I
Site 124
S877
G
R
F
L
I
D
F
S
Y
L
L
S
R
R
E
Site 125
Y878
R
F
L
I
D
F
S
Y
L
L
S
R
R
E
G
Site 126
S881
I
D
F
S
Y
L
L
S
R
R
E
G
Q
A
G
Site 127
S889
R
R
E
G
Q
A
G
S
P
E
K
P
L
S
D
Site 128
S895
G
S
P
E
K
P
L
S
D
L
G
R
L
S
Y
Site 129
S901
L
S
D
L
G
R
L
S
Y
L
A
Y
W
K
S
Site 130
Y902
S
D
L
G
R
L
S
Y
L
A
Y
W
K
S
V
Site 131
Y913
W
K
S
V
I
L
E
Y
L
Y
H
H
H
E
R
Site 132
Y915
S
V
I
L
E
Y
L
Y
H
H
H
E
R
H
I
Site 133
S923
H
H
H
E
R
H
I
S
I
K
A
I
S
R
A
Site 134
S966
R
R
E
K
L
I
L
S
H
M
E
K
L
K
T
Site 135
T973
S
H
M
E
K
L
K
T
C
S
R
A
N
E
L
Site 136
S984
A
N
E
L
D
P
D
S
L
R
W
T
P
I
L
Site 137
T988
D
P
D
S
L
R
W
T
P
I
L
I
S
N
A
Site 138
S1016
E
R
L
M
E
Q
A
S
C
W
E
K
E
E
Q
Site 139
S1027
K
E
E
Q
E
I
L
S
T
R
A
N
S
R
Q
Site 140
T1028
E
E
Q
E
I
L
S
T
R
A
N
S
R
Q
S
Site 141
S1032
I
L
S
T
R
A
N
S
R
Q
S
P
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S
K
Q
S
L
N
G
S
Y
M
R
Site 294
Y2070
K
Q
S
L
N
G
S
Y
M
R
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation