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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THAP4
Full Name:
THAP domain-containing protein 4
Alias:
CGI-36
Type:
Mass (Da):
62890
Number AA:
577
UniProt ID:
Q8WY91
International Prot ID:
IPI00788055
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
K
G
E
K
R
A
V
S
F
H
R
F
P
L
K
Site 2
S32
H
R
F
P
L
K
D
S
K
R
L
I
Q
W
L
Site 3
T48
A
V
Q
R
D
N
W
T
P
T
K
Y
S
F
L
Site 4
Y52
D
N
W
T
P
T
K
Y
S
F
L
C
S
E
H
Site 5
S57
T
K
Y
S
F
L
C
S
E
H
F
T
K
D
S
Site 6
T61
F
L
C
S
E
H
F
T
K
D
S
F
S
K
R
Site 7
S64
S
E
H
F
T
K
D
S
F
S
K
R
L
E
D
Site 8
S66
H
F
T
K
D
S
F
S
K
R
L
E
D
Q
H
Site 9
T79
Q
H
R
L
L
K
P
T
A
V
P
S
I
F
H
Site 10
T88
V
P
S
I
F
H
L
T
E
K
K
R
G
A
G
Site 11
S106
R
T
R
R
K
D
A
S
K
A
T
G
G
V
R
Site 12
S116
T
G
G
V
R
G
H
S
S
A
A
T
S
R
G
Site 13
S117
G
G
V
R
G
H
S
S
A
A
T
S
R
G
A
Site 14
T120
R
G
H
S
S
A
A
T
S
R
G
A
A
G
W
Site 15
S121
G
H
S
S
A
A
T
S
R
G
A
A
G
W
S
Site 16
S128
S
R
G
A
A
G
W
S
P
S
S
S
G
N
P
Site 17
S130
G
A
A
G
W
S
P
S
S
S
G
N
P
M
A
Site 18
S131
A
A
G
W
S
P
S
S
S
G
N
P
M
A
K
Site 19
S132
A
G
W
S
P
S
S
S
G
N
P
M
A
K
P
Site 20
S141
N
P
M
A
K
P
E
S
R
R
L
K
Q
A
A
Site 21
T154
A
A
L
Q
G
E
A
T
P
R
A
A
Q
E
A
Site 22
S163
R
A
A
Q
E
A
A
S
Q
E
Q
A
Q
Q
A
Site 23
T174
A
Q
Q
A
L
E
R
T
P
G
D
G
L
A
T
Site 24
S193
S
Q
G
K
A
E
A
S
A
T
D
A
G
D
E
Site 25
T195
G
K
A
E
A
S
A
T
D
A
G
D
E
S
A
Site 26
S201
A
T
D
A
G
D
E
S
A
T
S
S
I
E
G
Site 27
S204
A
G
D
E
S
A
T
S
S
I
E
G
G
V
T
Site 28
S205
G
D
E
S
A
T
S
S
I
E
G
G
V
T
D
Site 29
T211
S
S
I
E
G
G
V
T
D
K
S
G
I
S
M
Site 30
S214
E
G
G
V
T
D
K
S
G
I
S
M
D
D
F
Site 31
T222
G
I
S
M
D
D
F
T
P
P
G
S
G
A
C
Site 32
S226
D
D
F
T
P
P
G
S
G
A
C
K
F
I
G
Site 33
S237
K
F
I
G
S
L
H
S
Y
S
F
S
S
K
H
Site 34
Y238
F
I
G
S
L
H
S
Y
S
F
S
S
K
H
T
Site 35
S239
I
G
S
L
H
S
Y
S
F
S
S
K
H
T
R
Site 36
S241
S
L
H
S
Y
S
F
S
S
K
H
T
R
E
R
Site 37
T245
Y
S
F
S
S
K
H
T
R
E
R
P
S
V
P
Site 38
S250
K
H
T
R
E
R
P
S
V
P
R
E
P
I
D
Site 39
S268
L
K
K
D
V
E
P
S
C
S
G
S
S
L
G
Site 40
S270
K
D
V
E
P
S
C
S
G
S
S
L
G
P
D
Site 41
S272
V
E
P
S
C
S
G
S
S
L
G
P
D
K
G
Site 42
S273
E
P
S
C
S
G
S
S
L
G
P
D
K
G
L
Site 43
S283
P
D
K
G
L
A
Q
S
P
P
S
S
S
L
T
Site 44
S286
G
L
A
Q
S
P
P
S
S
S
L
T
A
T
P
Site 45
S287
L
A
Q
S
P
P
S
S
S
L
T
A
T
P
Q
Site 46
S288
A
Q
S
P
P
S
S
S
L
T
A
T
P
Q
K
Site 47
T290
S
P
P
S
S
S
L
T
A
T
P
Q
K
P
S
Site 48
T292
P
S
S
S
L
T
A
T
P
Q
K
P
S
Q
S
Site 49
S297
T
A
T
P
Q
K
P
S
Q
S
P
S
A
P
P
Site 50
S299
T
P
Q
K
P
S
Q
S
P
S
A
P
P
A
D
Site 51
S301
Q
K
P
S
Q
S
P
S
A
P
P
A
D
V
T
Site 52
T308
S
A
P
P
A
D
V
T
P
K
P
A
T
E
A
Site 53
T313
D
V
T
P
K
P
A
T
E
A
V
Q
S
E
H
Site 54
S318
P
A
T
E
A
V
Q
S
E
H
S
D
A
S
P
Site 55
S321
E
A
V
Q
S
E
H
S
D
A
S
P
M
S
I
Site 56
S324
Q
S
E
H
S
D
A
S
P
M
S
I
N
E
V
Site 57
S327
H
S
D
A
S
P
M
S
I
N
E
V
I
L
S
Site 58
S347
K
L
I
D
S
L
H
S
Y
C
F
S
S
R
Q
Site 59
Y348
L
I
D
S
L
H
S
Y
C
F
S
S
R
Q
N
Site 60
S351
S
L
H
S
Y
C
F
S
S
R
Q
N
K
S
Q
Site 61
S352
L
H
S
Y
C
F
S
S
R
Q
N
K
S
Q
V
Site 62
S357
F
S
S
R
Q
N
K
S
Q
V
C
C
L
R
E
Site 63
S375
K
K
N
G
E
L
K
S
L
R
Q
R
V
S
R
Site 64
S381
K
S
L
R
Q
R
V
S
R
S
D
S
Q
V
R
Site 65
S383
L
R
Q
R
V
S
R
S
D
S
Q
V
R
K
L
Site 66
S385
Q
R
V
S
R
S
D
S
Q
V
R
K
L
Q
E
Site 67
S401
L
D
E
L
R
R
V
S
V
P
Y
P
S
S
L
Site 68
Y404
L
R
R
V
S
V
P
Y
P
S
S
L
L
S
P
Site 69
S406
R
V
S
V
P
Y
P
S
S
L
L
S
P
S
R
Site 70
S407
V
S
V
P
Y
P
S
S
L
L
S
P
S
R
E
Site 71
S410
P
Y
P
S
S
L
L
S
P
S
R
E
P
P
K
Site 72
S412
P
S
S
L
L
S
P
S
R
E
P
P
K
M
N
Site 73
S434
W
M
L
G
T
W
L
S
D
P
P
G
A
G
T
Site 74
Y442
D
P
P
G
A
G
T
Y
P
T
L
Q
P
F
Q
Site 75
T444
P
G
A
G
T
Y
P
T
L
Q
P
F
Q
Y
L
Site 76
Y450
P
T
L
Q
P
F
Q
Y
L
E
E
V
H
I
S
Site 77
S467
G
Q
P
M
L
N
F
S
F
N
S
F
H
P
D
Site 78
S470
M
L
N
F
S
F
N
S
F
H
P
D
T
R
K
Site 79
T475
F
N
S
F
H
P
D
T
R
K
P
M
H
R
E
Site 80
S529
S
H
S
I
A
R
I
S
F
A
K
E
P
H
V
Site 81
S547
T
R
K
F
R
L
N
S
E
G
K
L
E
Q
T
Site 82
T554
S
E
G
K
L
E
Q
T
V
S
M
A
T
T
T
Site 83
S556
G
K
L
E
Q
T
V
S
M
A
T
T
T
Q
P
Site 84
T560
Q
T
V
S
M
A
T
T
T
Q
P
M
T
Q
H
Site 85
Y572
T
Q
H
L
H
V
T
Y
K
K
V
T
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation