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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SORCS1
Full Name:
VPS10 domain-containing receptor SorCS1
Alias:
SORC1; SORCS; SORCS receptor 1; SorCS1; Sortilin-related VPS10 domain containing receptor 1; VPS10 domain receptor SorCS
Type:
Receptor, misc.
Mass (Da):
129635
Number AA:
1168
UniProt ID:
Q8WY21
International Prot ID:
IPI00103597
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008188
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
V
G
A
G
G
G
S
Q
A
R
L
S
A
L
Site 2
S36
P
G
V
C
G
G
G
S
C
C
P
S
P
H
P
Site 3
S40
G
G
G
S
C
C
P
S
P
H
P
S
S
A
P
Site 4
S44
C
C
P
S
P
H
P
S
S
A
P
R
S
A
S
Site 5
S45
C
P
S
P
H
P
S
S
A
P
R
S
A
S
T
Site 6
S49
H
P
S
S
A
P
R
S
A
S
T
P
R
G
F
Site 7
S51
S
S
A
P
R
S
A
S
T
P
R
G
F
S
H
Site 8
T52
S
A
P
R
S
A
S
T
P
R
G
F
S
H
Q
Site 9
S57
A
S
T
P
R
G
F
S
H
Q
G
R
P
G
R
Site 10
T68
R
P
G
R
A
P
A
T
P
L
P
L
V
V
R
Site 11
S88
A
P
G
D
R
A
L
S
L
E
R
A
R
G
T
Site 12
T95
S
L
E
R
A
R
G
T
G
A
S
M
A
V
A
Site 13
S98
R
A
R
G
T
G
A
S
M
A
V
A
A
R
S
Site 14
S105
S
M
A
V
A
A
R
S
G
R
R
R
R
S
G
Site 15
S111
R
S
G
R
R
R
R
S
G
A
D
Q
E
K
A
Site 16
S125
A
E
R
G
E
G
A
S
R
S
P
R
G
V
L
Site 17
S127
R
G
E
G
A
S
R
S
P
R
G
V
L
R
D
Site 18
T142
G
G
Q
Q
E
P
G
T
R
E
R
D
P
D
K
Site 19
T161
R
M
E
E
L
R
L
T
S
T
T
F
A
L
T
Site 20
T164
E
L
R
L
T
S
T
T
F
A
L
T
G
D
S
Site 21
S186
H
W
S
G
H
N
S
S
V
I
L
I
L
T
K
Site 22
Y197
I
L
T
K
L
Y
D
Y
N
L
G
S
I
T
E
Site 23
S201
L
Y
D
Y
N
L
G
S
I
T
E
S
S
L
W
Site 24
T203
D
Y
N
L
G
S
I
T
E
S
S
L
W
R
S
Site 25
S205
N
L
G
S
I
T
E
S
S
L
W
R
S
T
D
Site 26
S206
L
G
S
I
T
E
S
S
L
W
R
S
T
D
Y
Site 27
S210
T
E
S
S
L
W
R
S
T
D
Y
G
T
T
Y
Site 28
T211
E
S
S
L
W
R
S
T
D
Y
G
T
T
Y
E
Site 29
Y213
S
L
W
R
S
T
D
Y
G
T
T
Y
E
K
L
Site 30
Y217
S
T
D
Y
G
T
T
Y
E
K
L
N
D
K
V
Site 31
Y232
G
L
K
T
I
L
S
Y
L
Y
V
C
P
T
N
Site 32
Y234
K
T
I
L
S
Y
L
Y
V
C
P
T
N
K
R
Site 33
T247
K
R
K
I
M
L
L
T
D
P
E
I
E
S
S
Site 34
S254
T
D
P
E
I
E
S
S
L
L
I
S
S
D
E
Site 35
S258
I
E
S
S
L
L
I
S
S
D
E
G
A
T
Y
Site 36
S259
E
S
S
L
L
I
S
S
D
E
G
A
T
Y
Q
Site 37
Y265
S
S
D
E
G
A
T
Y
Q
K
Y
R
L
N
F
Site 38
Y268
E
G
A
T
Y
Q
K
Y
R
L
N
F
Y
I
Q
Site 39
Y273
Q
K
Y
R
L
N
F
Y
I
Q
S
L
L
F
H
Site 40
S291
E
D
W
I
L
A
Y
S
Q
D
Q
K
L
Y
S
Site 41
Y297
Y
S
Q
D
Q
K
L
Y
S
S
A
E
F
G
R
Site 42
S298
S
Q
D
Q
K
L
Y
S
S
A
E
F
G
R
R
Site 43
Y319
G
V
V
P
N
R
F
Y
W
S
V
M
G
S
N
Site 44
T338
L
V
H
L
E
A
R
T
V
D
G
H
S
H
Y
Site 45
Y345
T
V
D
G
H
S
H
Y
L
T
C
R
M
Q
N
Site 46
Y365
R
N
Q
P
F
P
G
Y
I
D
P
D
S
L
I
Site 47
S370
P
G
Y
I
D
P
D
S
L
I
V
Q
D
H
Y
Site 48
T383
H
Y
V
F
V
Q
L
T
S
G
G
R
P
H
Y
Site 49
Y390
T
S
G
G
R
P
H
Y
Y
V
S
Y
R
R
N
Site 50
Y391
S
G
G
R
P
H
Y
Y
V
S
Y
R
R
N
A
Site 51
Y394
R
P
H
Y
Y
V
S
Y
R
R
N
A
F
A
Q
Site 52
Y407
A
Q
M
K
L
P
K
Y
A
L
P
K
D
M
H
Site 53
S417
P
K
D
M
H
V
I
S
T
D
E
N
Q
V
F
Site 54
Y436
E
W
N
Q
N
D
T
Y
N
L
Y
I
S
D
T
Site 55
Y439
Q
N
D
T
Y
N
L
Y
I
S
D
T
R
G
V
Site 56
T449
D
T
R
G
V
Y
F
T
L
A
L
E
N
V
Q
Site 57
S457
L
A
L
E
N
V
Q
S
S
R
G
P
E
G
N
Site 58
T491
K
I
D
N
Q
V
K
T
F
I
T
Y
N
K
G
Site 59
T509
R
L
L
Q
A
P
D
T
D
L
R
G
D
P
V
Site 60
S532
L
H
L
H
L
K
V
S
E
N
P
Y
T
S
G
Site 61
Y536
L
K
V
S
E
N
P
Y
T
S
G
I
I
A
S
Site 62
T537
K
V
S
E
N
P
Y
T
S
G
I
I
A
S
K
Site 63
S543
Y
T
S
G
I
I
A
S
K
D
T
A
P
S
I
Site 64
S562
G
N
I
G
S
E
L
S
D
T
D
I
S
M
F
Site 65
S567
E
L
S
D
T
D
I
S
M
F
V
S
S
D
A
Site 66
S571
T
D
I
S
M
F
V
S
S
D
A
G
N
T
W
Site 67
S572
D
I
S
M
F
V
S
S
D
A
G
N
T
W
R
Site 68
S587
Q
I
F
E
E
E
H
S
V
L
Y
L
D
Q
G
Site 69
Y590
E
E
E
H
S
V
L
Y
L
D
Q
G
G
V
L
Site 70
S613
P
I
R
H
L
W
L
S
F
D
E
G
R
S
W
Site 71
S619
L
S
F
D
E
G
R
S
W
S
K
Y
S
F
T
Site 72
S621
F
D
E
G
R
S
W
S
K
Y
S
F
T
S
I
Site 73
Y623
E
G
R
S
W
S
K
Y
S
F
T
S
I
P
L
Site 74
S624
G
R
S
W
S
K
Y
S
F
T
S
I
P
L
F
Site 75
T626
S
W
S
K
Y
S
F
T
S
I
P
L
F
V
D
Site 76
Y665
W
Q
L
V
K
V
D
Y
K
S
I
F
D
R
R
Site 77
S667
L
V
K
V
D
Y
K
S
I
F
D
R
R
C
A
Site 78
Y678
R
R
C
A
E
E
D
Y
R
P
W
Q
L
H
S
Site 79
Y698
I
M
G
A
K
R
I
Y
K
K
R
K
S
E
R
Site 80
S703
R
I
Y
K
K
R
K
S
E
R
K
C
M
Q
G
Site 81
Y712
R
K
C
M
Q
G
K
Y
A
G
A
M
E
S
E
Site 82
S718
K
Y
A
G
A
M
E
S
E
P
C
V
C
T
E
Site 83
Y732
E
A
D
F
D
C
D
Y
G
Y
E
R
H
S
N
Site 84
Y734
D
F
D
C
D
Y
G
Y
E
R
H
S
N
G
Q
Site 85
S751
P
A
F
W
F
N
P
S
S
L
S
K
D
C
S
Site 86
S752
A
F
W
F
N
P
S
S
L
S
K
D
C
S
L
Site 87
S754
W
F
N
P
S
S
L
S
K
D
C
S
L
G
Q
Site 88
S758
S
S
L
S
K
D
C
S
L
G
Q
S
Y
L
N
Site 89
S762
K
D
C
S
L
G
Q
S
Y
L
N
S
T
G
Y
Site 90
Y763
D
C
S
L
G
Q
S
Y
L
N
S
T
G
Y
R
Site 91
S766
L
G
Q
S
Y
L
N
S
T
G
Y
R
K
V
V
Site 92
Y769
S
Y
L
N
S
T
G
Y
R
K
V
V
S
N
N
Site 93
S774
T
G
Y
R
K
V
V
S
N
N
C
T
D
G
V
Site 94
T778
K
V
V
S
N
N
C
T
D
G
V
R
E
Q
Y
Site 95
Y785
T
D
G
V
R
E
Q
Y
T
A
K
P
Q
K
C
Site 96
T786
D
G
V
R
E
Q
Y
T
A
K
P
Q
K
C
P
Site 97
T804
P
R
G
L
R
I
V
T
A
D
G
K
L
T
A
Site 98
Y859
E
D
G
I
K
H
V
Y
Q
N
V
G
I
F
R
Site 99
T910
K
N
K
E
V
N
A
T
A
V
L
W
P
S
Q
Site 100
Y923
S
Q
V
G
T
L
T
Y
V
W
W
Y
G
N
N
Site 101
T936
N
N
T
E
P
L
I
T
L
E
G
S
I
S
F
Site 102
S942
I
T
L
E
G
S
I
S
F
R
F
T
S
E
G
Site 103
T946
G
S
I
S
F
R
F
T
S
E
G
M
N
T
I
Site 104
S947
S
I
S
F
R
F
T
S
E
G
M
N
T
I
T
Site 105
T954
S
E
G
M
N
T
I
T
V
Q
V
S
A
G
N
Site 106
Y973
D
T
K
T
I
A
V
Y
E
E
F
R
S
L
R
Site 107
S978
A
V
Y
E
E
F
R
S
L
R
L
S
F
S
P
Site 108
S982
E
F
R
S
L
R
L
S
F
S
P
N
L
D
D
Site 109
S984
R
S
L
R
L
S
F
S
P
N
L
D
D
Y
N
Site 110
Y990
F
S
P
N
L
D
D
Y
N
P
D
I
P
E
W
Site 111
Y1039
A
E
L
F
V
L
P
Y
Q
D
P
A
G
E
N
Site 112
S1049
P
A
G
E
N
K
R
S
T
D
D
L
E
Q
I
Site 113
T1050
A
G
E
N
K
R
S
T
D
D
L
E
Q
I
S
Site 114
S1130
K
R
R
V
A
L
P
S
P
P
S
P
S
T
Q
Site 115
S1133
V
A
L
P
S
P
P
S
P
S
T
Q
P
G
D
Site 116
S1135
L
P
S
P
P
S
P
S
T
Q
P
G
D
S
S
Site 117
T1136
P
S
P
P
S
P
S
T
Q
P
G
D
S
S
L
Site 118
S1141
P
S
T
Q
P
G
D
S
S
L
R
L
Q
R
A
Site 119
S1142
S
T
Q
P
G
D
S
S
L
R
L
Q
R
A
R
Site 120
T1152
L
Q
R
A
R
H
A
T
P
P
S
T
P
K
R
Site 121
S1155
A
R
H
A
T
P
P
S
T
P
K
R
G
S
A
Site 122
T1156
R
H
A
T
P
P
S
T
P
K
R
G
S
A
G
Site 123
S1161
P
S
T
P
K
R
G
S
A
G
A
Q
Y
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation