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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOT11
Full Name:
Acyl-coenzyme A thioesterase 11
Alias:
ACO11; Acyl-CoA thioester hydrolase 11; Acyl-CoA thioesterase 11; Adipose-associated thioesterase; BFIT; BFIT1; BFIT2; Brown fat-inducible thioesterase; EC 3.1.2.-; KIAA0707; STARD14; StAR-related lipid transfer (START) domain containing 14; START domain containing 14; THEA; THEM1
Type:
EC 3.1.2.-; Hydrolase
Mass (Da):
68492
Number AA:
607
UniProt ID:
Q8WXI4
International Prot ID:
IPI00220903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016291
GO:0004091
PhosphoSite+
KinaseNET
Biological Process:
GO:0006631
GO:0007242
GO:0009409
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
H
L
R
R
G
L
A
S
V
F
S
N
R
T
S
Site 2
S18
R
G
L
A
S
V
F
S
N
R
T
S
R
K
S
Site 3
T21
A
S
V
F
S
N
R
T
S
R
K
S
A
L
R
Site 4
S22
S
V
F
S
N
R
T
S
R
K
S
A
L
R
A
Site 5
S25
S
N
R
T
S
R
K
S
A
L
R
A
G
N
D
Site 6
S33
A
L
R
A
G
N
D
S
A
M
A
D
G
E
G
Site 7
Y41
A
M
A
D
G
E
G
Y
R
N
P
T
E
V
Q
Site 8
T45
G
E
G
Y
R
N
P
T
E
V
Q
M
S
Q
L
Site 9
S50
N
P
T
E
V
Q
M
S
Q
L
V
L
P
C
H
Site 10
S65
T
N
Q
R
G
E
L
S
V
G
Q
L
L
K
W
Site 11
Y98
T
A
S
M
D
D
I
Y
F
E
H
T
I
S
V
Site 12
T156
F
V
A
R
R
E
I
T
K
V
K
L
K
Q
I
Site 13
T164
K
V
K
L
K
Q
I
T
P
R
T
E
E
E
K
Site 14
T167
L
K
Q
I
T
P
R
T
E
E
E
K
M
E
H
Site 15
Y187
R
R
R
M
R
L
V
Y
A
D
T
I
K
D
L
Site 16
S206
A
I
Q
G
D
L
E
S
R
D
C
S
R
M
V
Site 17
S210
D
L
E
S
R
D
C
S
R
M
V
P
A
E
K
Site 18
T218
R
M
V
P
A
E
K
T
R
V
E
S
V
E
L
Site 19
S222
A
E
K
T
R
V
E
S
V
E
L
V
L
P
P
Site 20
S276
M
F
H
F
R
G
P
S
Q
V
G
D
R
L
V
Site 21
T311
A
Y
R
Q
E
A
E
T
H
R
R
H
I
N
S
Site 22
Y349
P
G
D
G
E
R
R
Y
R
E
A
S
A
R
K
Site 23
S353
E
R
R
Y
R
E
A
S
A
R
K
K
I
R
L
Site 24
Y364
K
I
R
L
D
R
K
Y
I
V
S
C
K
Q
T
Site 25
S367
L
D
R
K
Y
I
V
S
C
K
Q
T
E
V
P
Site 26
S376
K
Q
T
E
V
P
L
S
V
P
W
D
P
S
N
Site 27
S382
L
S
V
P
W
D
P
S
N
Q
V
Y
L
S
Y
Site 28
Y386
W
D
P
S
N
Q
V
Y
L
S
Y
N
N
V
S
Site 29
S388
P
S
N
Q
V
Y
L
S
Y
N
N
V
S
S
L
Site 30
Y389
S
N
Q
V
Y
L
S
Y
N
N
V
S
S
L
K
Site 31
S407
A
K
D
N
W
V
L
S
S
E
I
S
Q
V
R
Site 32
Y416
E
I
S
Q
V
R
L
Y
T
L
E
D
D
K
F
Site 33
T417
I
S
Q
V
R
L
Y
T
L
E
D
D
K
F
L
Site 34
S444
A
Q
A
F
L
L
L
S
D
L
R
Q
R
P
E
Site 35
Y456
R
P
E
W
D
K
H
Y
R
S
V
E
L
V
Q
Site 36
Y472
V
D
E
D
D
A
I
Y
H
V
T
S
P
A
L
Site 37
S476
D
A
I
Y
H
V
T
S
P
A
L
G
G
H
T
Site 38
S493
Q
D
F
V
I
L
A
S
R
R
K
P
C
D
N
Site 39
Y504
P
C
D
N
G
D
P
Y
V
I
A
L
R
S
V
Site 40
T515
L
R
S
V
T
L
P
T
H
R
E
T
P
E
Y
Site 41
T519
T
L
P
T
H
R
E
T
P
E
Y
R
R
G
E
Site 42
Y522
T
H
R
E
T
P
E
Y
R
R
G
E
T
L
C
Site 43
T527
P
E
Y
R
R
G
E
T
L
C
S
G
F
C
L
Site 44
S562
V
S
A
S
G
F
Y
S
W
G
L
E
S
R
S
Site 45
S567
F
Y
S
W
G
L
E
S
R
S
K
G
R
R
S
Site 46
S569
S
W
G
L
E
S
R
S
K
G
R
R
S
D
G
Site 47
S574
S
R
S
K
G
R
R
S
D
G
W
N
G
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation