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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOCS4
Full Name:
Suppressor of cytokine signaling 4
Alias:
Suppressor of cytokine signaling 7
Type:
Mass (Da):
50623
Number AA:
440
UniProt ID:
Q8WXH5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
N
V
D
V
R
P
K
T
S
R
S
R
S
A
D
Site 2
S19
V
D
V
R
P
K
T
S
R
S
R
S
A
D
R
Site 3
S21
V
R
P
K
T
S
R
S
R
S
A
D
R
K
D
Site 4
S23
P
K
T
S
R
S
R
S
A
D
R
K
D
G
Y
Site 5
Y30
S
A
D
R
K
D
G
Y
V
W
S
G
K
K
L
Site 6
S33
R
K
D
G
Y
V
W
S
G
K
K
L
S
W
S
Site 7
S38
V
W
S
G
K
K
L
S
W
S
K
K
S
E
S
Site 8
S40
S
G
K
K
L
S
W
S
K
K
S
E
S
Y
S
Site 9
S43
K
L
S
W
S
K
K
S
E
S
Y
S
D
A
E
Site 10
S45
S
W
S
K
K
S
E
S
Y
S
D
A
E
T
V
Site 11
S47
S
K
K
S
E
S
Y
S
D
A
E
T
V
N
G
Site 12
T51
E
S
Y
S
D
A
E
T
V
N
G
I
E
K
T
Site 13
S61
G
I
E
K
T
E
V
S
L
R
N
Q
E
R
K
Site 14
S70
R
N
Q
E
R
K
H
S
C
S
S
I
E
L
D
Site 15
S72
Q
E
R
K
H
S
C
S
S
I
E
L
D
L
D
Site 16
S81
I
E
L
D
L
D
H
S
C
G
H
R
F
L
G
Site 17
S90
G
H
R
F
L
G
R
S
L
K
Q
K
L
Q
D
Site 18
S109
C
F
P
I
K
N
C
S
S
R
H
S
S
G
L
Site 19
S110
F
P
I
K
N
C
S
S
R
H
S
S
G
L
P
Site 20
S113
K
N
C
S
S
R
H
S
S
G
L
P
S
K
R
Site 21
S114
N
C
S
S
R
H
S
S
G
L
P
S
K
R
K
Site 22
S118
R
H
S
S
G
L
P
S
K
R
K
I
H
I
S
Site 23
S125
S
K
R
K
I
H
I
S
E
L
M
L
D
K
C
Site 24
T151
W
H
F
I
K
R
H
T
A
P
I
N
S
K
S
Site 25
S158
T
A
P
I
N
S
K
S
D
E
W
V
S
T
D
Site 26
T164
K
S
D
E
W
V
S
T
D
L
S
Q
T
E
L
Site 27
S167
E
W
V
S
T
D
L
S
Q
T
E
L
R
D
G
Site 28
S213
R
E
G
P
M
T
G
S
V
M
N
L
V
S
N
Site 29
S219
G
S
V
M
N
L
V
S
N
N
S
I
E
D
S
Site 30
S222
M
N
L
V
S
N
N
S
I
E
D
S
D
M
D
Site 31
S226
S
N
N
S
I
E
D
S
D
M
D
S
D
D
E
Site 32
S230
I
E
D
S
D
M
D
S
D
D
E
I
L
T
L
Site 33
T236
D
S
D
D
E
I
L
T
L
C
T
S
S
R
K
Site 34
S240
E
I
L
T
L
C
T
S
S
R
K
R
N
K
P
Site 35
T260
D
E
I
L
Q
L
E
T
P
P
K
Y
H
T
Q
Site 36
Y264
Q
L
E
T
P
P
K
Y
H
T
Q
I
D
Y
V
Site 37
T266
E
T
P
P
K
Y
H
T
Q
I
D
Y
V
H
C
Site 38
Y270
K
Y
H
T
Q
I
D
Y
V
H
C
L
V
P
D
Site 39
T307
L
E
G
K
P
E
G
T
F
L
L
R
D
S
A
Site 40
S313
G
T
F
L
L
R
D
S
A
Q
E
D
Y
L
F
Site 41
Y318
R
D
S
A
Q
E
D
Y
L
F
S
V
S
F
R
Site 42
S321
A
Q
E
D
Y
L
F
S
V
S
F
R
R
Y
S
Site 43
S323
E
D
Y
L
F
S
V
S
F
R
R
Y
S
R
S
Site 44
Y327
F
S
V
S
F
R
R
Y
S
R
S
L
H
A
R
Site 45
S328
S
V
S
F
R
R
Y
S
R
S
L
H
A
R
I
Site 46
S330
S
F
R
R
Y
S
R
S
L
H
A
R
I
E
Q
Site 47
T358
V
F
H
S
P
D
I
T
G
L
L
E
H
Y
K
Site 48
Y364
I
T
G
L
L
E
H
Y
K
D
P
S
A
C
M
Site 49
S414
D
A
L
P
I
P
S
S
M
K
L
Y
L
K
E
Site 50
Y418
I
P
S
S
M
K
L
Y
L
K
E
Y
H
Y
K
Site 51
Y422
M
K
L
Y
L
K
E
Y
H
Y
K
S
K
V
R
Site 52
Y424
L
Y
L
K
E
Y
H
Y
K
S
K
V
R
V
L
Site 53
S426
L
K
E
Y
H
Y
K
S
K
V
R
V
L
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation