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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STON2
Full Name:
Stonin-2
Alias:
Stoned B
Type:
Adaptor/scaffold
Mass (Da):
101165
Number AA:
905
UniProt ID:
Q8WXE9
International Prot ID:
IPI00103521
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030131
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0006886
GO:0030100
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
T
H
Q
S
E
W
V
S
F
N
E
E
P
P
F
Site 2
S28
E
P
P
F
P
A
H
S
Q
G
G
T
E
E
H
Site 3
T32
P
A
H
S
Q
G
G
T
E
E
H
L
P
G
L
Site 4
S40
E
E
H
L
P
G
L
S
S
S
P
D
Q
S
E
Site 5
S41
E
H
L
P
G
L
S
S
S
P
D
Q
S
E
S
Site 6
S42
H
L
P
G
L
S
S
S
P
D
Q
S
E
S
S
Site 7
S46
L
S
S
S
P
D
Q
S
E
S
S
S
G
E
N
Site 8
S48
S
S
P
D
Q
S
E
S
S
S
G
E
N
H
V
Site 9
S50
P
D
Q
S
E
S
S
S
G
E
N
H
V
V
D
Site 10
S60
N
H
V
V
D
G
G
S
Q
D
H
S
H
S
E
Site 11
S64
D
G
G
S
Q
D
H
S
H
S
E
Q
D
D
S
Site 12
S66
G
S
Q
D
H
S
H
S
E
Q
D
D
S
S
E
Site 13
S71
S
H
S
E
Q
D
D
S
S
E
K
M
G
L
I
Site 14
S72
H
S
E
Q
D
D
S
S
E
K
M
G
L
I
S
Site 15
S79
S
E
K
M
G
L
I
S
E
A
A
S
P
P
G
Site 16
S83
G
L
I
S
E
A
A
S
P
P
G
S
P
E
Q
Site 17
S87
E
A
A
S
P
P
G
S
P
E
Q
P
P
P
D
Site 18
S97
Q
P
P
P
D
L
A
S
A
I
S
N
W
V
Q
Site 19
S100
P
D
L
A
S
A
I
S
N
W
V
Q
F
E
D
Site 20
T109
W
V
Q
F
E
D
D
T
P
W
A
S
T
S
P
Site 21
S113
E
D
D
T
P
W
A
S
T
S
P
P
H
Q
E
Site 22
S115
D
T
P
W
A
S
T
S
P
P
H
Q
E
T
A
Site 23
T124
P
H
Q
E
T
A
E
T
A
L
P
L
T
M
P
Site 24
S140
W
T
C
P
S
F
D
S
L
G
R
C
P
L
T
Site 25
T147
S
L
G
R
C
P
L
T
S
E
S
S
W
T
T
Site 26
S148
L
G
R
C
P
L
T
S
E
S
S
W
T
T
H
Site 27
S150
R
C
P
L
T
S
E
S
S
W
T
T
H
S
E
Site 28
S151
C
P
L
T
S
E
S
S
W
T
T
H
S
E
D
Site 29
T153
L
T
S
E
S
S
W
T
T
H
S
E
D
T
S
Site 30
T154
T
S
E
S
S
W
T
T
H
S
E
D
T
S
S
Site 31
S156
E
S
S
W
T
T
H
S
E
D
T
S
S
P
S
Site 32
T159
W
T
T
H
S
E
D
T
S
S
P
S
F
G
C
Site 33
S160
T
T
H
S
E
D
T
S
S
P
S
F
G
C
S
Site 34
S161
T
H
S
E
D
T
S
S
P
S
F
G
C
S
Y
Site 35
S163
S
E
D
T
S
S
P
S
F
G
C
S
Y
T
D
Site 36
S167
S
S
P
S
F
G
C
S
Y
T
D
L
Q
L
I
Site 37
Y168
S
P
S
F
G
C
S
Y
T
D
L
Q
L
I
N
Site 38
S181
I
N
A
E
E
Q
T
S
G
Q
A
S
G
A
D
Site 39
S185
E
Q
T
S
G
Q
A
S
G
A
D
S
T
D
N
Site 40
S189
G
Q
A
S
G
A
D
S
T
D
N
S
S
S
L
Site 41
T190
Q
A
S
G
A
D
S
T
D
N
S
S
S
L
Q
Site 42
S193
G
A
D
S
T
D
N
S
S
S
L
Q
E
D
E
Site 43
S195
D
S
T
D
N
S
S
S
L
Q
E
D
E
E
V
Site 44
S208
E
V
E
M
E
A
I
S
W
Q
A
S
S
P
A
Site 45
S212
E
A
I
S
W
Q
A
S
S
P
A
M
N
G
H
Site 46
S213
A
I
S
W
Q
A
S
S
P
A
M
N
G
H
P
Site 47
T225
G
H
P
A
P
P
V
T
S
A
R
F
P
S
W
Site 48
S226
H
P
A
P
P
V
T
S
A
R
F
P
S
W
V
Site 49
S231
V
T
S
A
R
F
P
S
W
V
T
F
D
D
N
Site 50
T234
A
R
F
P
S
W
V
T
F
D
D
N
E
V
S
Site 51
S241
T
F
D
D
N
E
V
S
C
P
L
P
P
V
T
Site 52
T248
S
C
P
L
P
P
V
T
S
P
L
K
P
N
T
Site 53
S249
C
P
L
P
P
V
T
S
P
L
K
P
N
T
P
Site 54
T255
T
S
P
L
K
P
N
T
P
P
S
A
S
V
I
Site 55
S258
L
K
P
N
T
P
P
S
A
S
V
I
P
D
V
Site 56
S260
P
N
T
P
P
S
A
S
V
I
P
D
V
P
Y
Site 57
Y267
S
V
I
P
D
V
P
Y
N
S
M
G
S
F
K
Site 58
S269
I
P
D
V
P
Y
N
S
M
G
S
F
K
K
R
Site 59
S272
V
P
Y
N
S
M
G
S
F
K
K
R
D
R
P
Site 60
S281
K
K
R
D
R
P
K
S
T
L
M
N
F
S
K
Site 61
T282
K
R
D
R
P
K
S
T
L
M
N
F
S
K
V
Site 62
S296
V
Q
K
L
D
I
S
S
L
N
R
T
P
S
V
Site 63
T300
D
I
S
S
L
N
R
T
P
S
V
T
E
A
S
Site 64
S302
S
S
L
N
R
T
P
S
V
T
E
A
S
P
W
Site 65
T304
L
N
R
T
P
S
V
T
E
A
S
P
W
R
A
Site 66
S307
T
P
S
V
T
E
A
S
P
W
R
A
T
N
P
Site 67
T312
E
A
S
P
W
R
A
T
N
P
F
L
N
E
T
Site 68
T319
T
N
P
F
L
N
E
T
L
Q
D
V
Q
P
S
Site 69
S326
T
L
Q
D
V
Q
P
S
P
I
N
P
F
S
A
Site 70
S332
P
S
P
I
N
P
F
S
A
F
F
E
E
Q
E
Site 71
S342
F
E
E
Q
E
R
R
S
Q
N
S
S
I
S
S
Site 72
S345
Q
E
R
R
S
Q
N
S
S
I
S
S
T
T
G
Site 73
S346
E
R
R
S
Q
N
S
S
I
S
S
T
T
G
K
Site 74
S348
R
S
Q
N
S
S
I
S
S
T
T
G
K
S
Q
Site 75
S349
S
Q
N
S
S
I
S
S
T
T
G
K
S
Q
R
Site 76
T350
Q
N
S
S
I
S
S
T
T
G
K
S
Q
R
D
Site 77
S354
I
S
S
T
T
G
K
S
Q
R
D
S
L
I
V
Site 78
S358
T
G
K
S
Q
R
D
S
L
I
V
I
Y
Q
D
Site 79
S368
V
I
Y
Q
D
A
I
S
F
D
D
S
S
K
T
Site 80
S372
D
A
I
S
F
D
D
S
S
K
T
Q
S
H
S
Site 81
S373
A
I
S
F
D
D
S
S
K
T
Q
S
H
S
D
Site 82
T375
S
F
D
D
S
S
K
T
Q
S
H
S
D
A
V
Site 83
S377
D
D
S
S
K
T
Q
S
H
S
D
A
V
E
K
Site 84
S379
S
S
K
T
Q
S
H
S
D
A
V
E
K
L
K
Site 85
T400
P
D
H
F
G
S
A
T
L
P
D
D
D
P
V
Site 86
S419
L
D
A
H
P
P
G
S
A
R
S
Q
P
R
D
Site 87
S422
H
P
P
G
S
A
R
S
Q
P
R
D
G
W
P
Site 88
T454
G
P
I
F
V
K
L
T
D
T
G
Y
L
Q
L
Site 89
Y458
V
K
L
T
D
T
G
Y
L
Q
L
Y
Y
E
Q
Site 90
Y462
D
T
G
Y
L
Q
L
Y
Y
E
Q
G
L
E
K
Site 91
Y463
T
G
Y
L
Q
L
Y
Y
E
Q
G
L
E
K
P
Site 92
Y490
S
E
P
R
L
Q
N
Y
D
E
N
G
R
I
H
Site 93
S498
D
E
N
G
R
I
H
S
L
R
I
D
R
V
T
Site 94
T505
S
L
R
I
D
R
V
T
Y
K
E
K
K
K
Y
Site 95
Y506
L
R
I
D
R
V
T
Y
K
E
K
K
K
Y
Q
Site 96
Y512
T
Y
K
E
K
K
K
Y
Q
P
K
P
A
V
A
Site 97
T572
N
Y
L
E
E
E
I
T
V
D
V
R
D
E
F
Site 98
S580
V
D
V
R
D
E
F
S
G
I
V
S
K
G
D
Site 99
S584
D
E
F
S
G
I
V
S
K
G
D
N
Q
I
L
Site 100
T685
R
T
V
F
A
E
K
T
L
P
F
T
L
R
T
Site 101
T689
A
E
K
T
L
P
F
T
L
R
T
A
T
S
V
Site 102
S695
F
T
L
R
T
A
T
S
V
N
G
A
E
V
E
Site 103
S705
G
A
E
V
E
V
Q
S
W
L
R
M
S
T
G
Site 104
S710
V
Q
S
W
L
R
M
S
T
G
F
S
A
N
R
Site 105
T711
Q
S
W
L
R
M
S
T
G
F
S
A
N
R
D
Site 106
S714
L
R
M
S
T
G
F
S
A
N
R
D
P
L
T
Site 107
T721
S
A
N
R
D
P
L
T
Q
V
P
C
E
N
V
Site 108
Y732
C
E
N
V
M
I
R
Y
P
V
P
S
E
W
V
Site 109
S746
V
K
N
F
R
R
E
S
V
L
G
E
K
S
L
Site 110
S752
E
S
V
L
G
E
K
S
L
K
A
K
V
N
R
Site 111
S762
A
K
V
N
R
G
A
S
F
G
S
T
S
V
S
Site 112
S765
N
R
G
A
S
F
G
S
T
S
V
S
G
S
E
Site 113
T766
R
G
A
S
F
G
S
T
S
V
S
G
S
E
P
Site 114
S767
G
A
S
F
G
S
T
S
V
S
G
S
E
P
V
Site 115
S769
S
F
G
S
T
S
V
S
G
S
E
P
V
M
R
Site 116
S771
G
S
T
S
V
S
G
S
E
P
V
M
R
V
T
Site 117
T778
S
E
P
V
M
R
V
T
L
G
T
A
K
Y
E
Site 118
Y784
V
T
L
G
T
A
K
Y
E
H
A
F
N
S
I
Site 119
S803
N
R
L
P
D
K
N
S
A
S
G
H
P
H
C
Site 120
S805
L
P
D
K
N
S
A
S
G
H
P
H
C
F
F
Site 121
S819
F
C
H
L
E
L
G
S
D
R
E
V
P
S
R
Site 122
T840
V
E
F
S
M
P
T
T
S
A
S
K
A
S
V
Site 123
S841
E
F
S
M
P
T
T
S
A
S
K
A
S
V
R
Site 124
S843
S
M
P
T
T
S
A
S
K
A
S
V
R
S
I
Site 125
S846
T
T
S
A
S
K
A
S
V
R
S
I
S
V
E
Site 126
S851
K
A
S
V
R
S
I
S
V
E
D
K
T
D
V
Site 127
T856
S
I
S
V
E
D
K
T
D
V
R
K
W
V
N
Site 128
Y864
D
V
R
K
W
V
N
Y
S
A
H
Y
S
Y
Q
Site 129
S869
V
N
Y
S
A
H
Y
S
Y
Q
V
A
L
G
S
Site 130
Y870
N
Y
S
A
H
Y
S
Y
Q
V
A
L
G
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation