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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASKIN1
Full Name:
Caskin-1
Alias:
ANKS5A; CASK interacting protein 1; Cask-interacting protein 1; CSKI1; KIAA1306
Type:
Adaptor/scaffold
Mass (Da):
149814
Number AA:
1431
UniProt ID:
Q8WXD9
International Prot ID:
IPI00385480
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
V
K
A
E
D
V
G
T
A
Q
R
L
L
Q
R
Site 2
S36
G
K
A
K
L
L
G
S
T
K
K
I
N
V
N
Site 3
Y88
K
G
M
R
P
L
H
Y
A
A
W
Q
G
R
K
Site 4
S112
G
S
A
V
N
I
P
S
D
E
G
H
I
P
L
Site 5
T150
M
V
D
N
S
G
K
T
P
L
D
L
A
C
E
Site 6
T185
E
P
R
P
G
D
A
T
D
P
N
G
T
S
P
Site 7
S191
A
T
D
P
N
G
T
S
P
L
H
L
A
A
K
Site 8
T219
G
I
D
I
N
R
Q
T
K
S
G
T
A
L
H
Site 9
S221
D
I
N
R
Q
T
K
S
G
T
A
L
H
E
A
Site 10
T234
E
A
A
L
C
G
K
T
E
V
V
R
L
L
L
Site 11
T252
I
N
A
H
V
R
N
T
Y
S
Q
T
A
L
D
Site 12
Y253
N
A
H
V
R
N
T
Y
S
Q
T
A
L
D
I
Site 13
S254
A
H
V
R
N
T
Y
S
Q
T
A
L
D
I
V
Site 14
S267
I
V
H
Q
F
T
T
S
Q
A
S
R
E
I
K
Site 15
S281
K
Q
L
L
R
E
A
S
A
A
L
Q
V
R
A
Site 16
T289
A
A
L
Q
V
R
A
T
K
D
Y
C
N
N
Y
Site 17
Y292
Q
V
R
A
T
K
D
Y
C
N
N
Y
D
L
T
Site 18
Y296
T
K
D
Y
C
N
N
Y
D
L
T
S
L
N
V
Site 19
T299
Y
C
N
N
Y
D
L
T
S
L
N
V
K
A
G
Site 20
S300
C
N
N
Y
D
L
T
S
L
N
V
K
A
G
D
Site 21
T310
V
K
A
G
D
I
I
T
V
L
E
Q
H
P
D
Site 22
T329
G
C
I
H
D
N
R
T
G
N
D
R
V
G
Y
Site 23
Y336
T
G
N
D
R
V
G
Y
F
P
S
S
L
G
E
Site 24
S351
A
I
V
K
R
A
G
S
R
A
G
T
E
P
S
Site 25
T355
R
A
G
S
R
A
G
T
E
P
S
L
P
Q
G
Site 26
S358
S
R
A
G
T
E
P
S
L
P
Q
G
S
S
S
Site 27
S363
E
P
S
L
P
Q
G
S
S
S
S
G
P
S
A
Site 28
S364
P
S
L
P
Q
G
S
S
S
S
G
P
S
A
P
Site 29
S365
S
L
P
Q
G
S
S
S
S
G
P
S
A
P
P
Site 30
S366
L
P
Q
G
S
S
S
S
G
P
S
A
P
P
E
Site 31
S369
G
S
S
S
S
G
P
S
A
P
P
E
E
I
W
Site 32
S388
P
F
A
G
G
D
R
S
G
S
I
S
G
M
A
Site 33
S390
A
G
G
D
R
S
G
S
I
S
G
M
A
G
G
Site 34
S392
G
D
R
S
G
S
I
S
G
M
A
G
G
R
G
Site 35
S400
G
M
A
G
G
R
G
S
G
G
H
A
L
H
A
Site 36
T417
E
G
V
K
L
L
A
T
V
L
S
Q
K
S
V
Site 37
S420
K
L
L
A
T
V
L
S
Q
K
S
V
S
E
S
Site 38
S423
A
T
V
L
S
Q
K
S
V
S
E
S
G
P
G
Site 39
S425
V
L
S
Q
K
S
V
S
E
S
G
P
G
D
S
Site 40
S427
S
Q
K
S
V
S
E
S
G
P
G
D
S
P
A
Site 41
S432
S
E
S
G
P
G
D
S
P
A
K
P
P
E
G
Site 42
S446
G
S
A
G
V
A
R
S
Q
P
P
V
A
H
A
Site 43
Y457
V
A
H
A
G
Q
V
Y
G
E
Q
P
P
K
K
Site 44
S469
P
K
K
L
E
P
A
S
E
G
K
S
S
E
A
Site 45
S473
E
P
A
S
E
G
K
S
S
E
A
V
S
Q
W
Site 46
S474
P
A
S
E
G
K
S
S
E
A
V
S
Q
W
L
Site 47
S478
G
K
S
S
E
A
V
S
Q
W
L
T
A
F
Q
Site 48
Y498
P
N
F
I
S
A
G
Y
D
L
P
T
I
S
R
Site 49
T502
S
A
G
Y
D
L
P
T
I
S
R
M
T
P
E
Site 50
T512
R
M
T
P
E
D
L
T
A
I
G
V
T
K
P
Site 51
Y567
K
V
L
V
D
N
G
Y
E
N
I
D
F
I
T
Site 52
T587
D
L
Q
E
I
G
I
T
K
L
G
H
Q
K
K
Site 53
Y610
A
E
L
Q
K
A
E
Y
A
K
Y
E
G
G
P
Site 54
Y613
Q
K
A
E
Y
A
K
Y
E
G
G
P
L
R
R
Site 55
S625
L
R
R
K
A
P
Q
S
L
E
V
M
A
I
E
Site 56
S633
L
E
V
M
A
I
E
S
P
P
P
P
E
P
T
Site 57
T640
S
P
P
P
P
E
P
T
P
A
D
C
Q
S
P
Site 58
S646
P
T
P
A
D
C
Q
S
P
K
M
T
T
F
Q
Site 59
T650
D
C
Q
S
P
K
M
T
T
F
Q
D
S
E
L
Site 60
T651
C
Q
S
P
K
M
T
T
F
Q
D
S
E
L
S
Site 61
S658
T
F
Q
D
S
E
L
S
D
E
L
Q
A
A
M
Site 62
T674
G
P
A
E
V
G
P
T
T
E
K
P
S
S
H
Site 63
T675
P
A
E
V
G
P
T
T
E
K
P
S
S
H
L
Site 64
S680
P
T
T
E
K
P
S
S
H
L
P
P
T
P
R
Site 65
T685
P
S
S
H
L
P
P
T
P
R
A
T
T
R
Q
Site 66
T689
L
P
P
T
P
R
A
T
T
R
Q
D
S
S
L
Site 67
T690
P
P
T
P
R
A
T
T
R
Q
D
S
S
L
G
Site 68
S694
R
A
T
T
R
Q
D
S
S
L
G
G
R
A
R
Site 69
S695
A
T
T
R
Q
D
S
S
L
G
G
R
A
R
H
Site 70
S704
G
G
R
A
R
H
M
S
S
S
Q
E
L
L
G
Site 71
S705
G
R
A
R
H
M
S
S
S
Q
E
L
L
G
D
Site 72
S706
R
A
R
H
M
S
S
S
Q
E
L
L
G
D
G
Site 73
S718
G
D
G
P
P
G
P
S
S
P
M
S
R
S
Q
Site 74
S719
D
G
P
P
G
P
S
S
P
M
S
R
S
Q
E
Site 75
S722
P
G
P
S
S
P
M
S
R
S
Q
E
Y
L
L
Site 76
S724
P
S
S
P
M
S
R
S
Q
E
Y
L
L
D
E
Site 77
Y727
P
M
S
R
S
Q
E
Y
L
L
D
E
G
P
A
Site 78
T737
D
E
G
P
A
P
G
T
P
P
R
E
A
R
P
Site 79
S750
R
P
G
R
H
G
H
S
I
K
R
A
S
V
P
Site 80
S755
G
H
S
I
K
R
A
S
V
P
P
V
P
G
K
Site 81
T771
R
Q
V
L
P
P
G
T
S
H
F
T
P
P
Q
Site 82
S772
Q
V
L
P
P
G
T
S
H
F
T
P
P
Q
T
Site 83
T775
P
P
G
T
S
H
F
T
P
P
Q
T
P
T
K
Site 84
T779
S
H
F
T
P
P
Q
T
P
T
K
T
R
P
G
Site 85
T783
P
P
Q
T
P
T
K
T
R
P
G
S
P
Q
A
Site 86
S787
P
T
K
T
R
P
G
S
P
Q
A
L
G
G
P
Site 87
T801
P
H
G
P
A
P
A
T
A
K
V
K
P
T
P
Site 88
T807
A
T
A
K
V
K
P
T
P
Q
L
L
P
P
T
Site 89
T814
T
P
Q
L
L
P
P
T
E
R
P
M
S
P
R
Site 90
S819
P
P
T
E
R
P
M
S
P
R
S
L
P
Q
S
Site 91
S822
E
R
P
M
S
P
R
S
L
P
Q
S
P
T
H
Site 92
S826
S
P
R
S
L
P
Q
S
P
T
H
R
G
F
A
Site 93
T828
R
S
L
P
Q
S
P
T
H
R
G
F
A
Y
V
Site 94
Y834
P
T
H
R
G
F
A
Y
V
L
P
Q
P
V
E
Site 95
S882
R
P
K
K
R
A
H
S
L
N
R
Y
A
A
S
Site 96
Y886
R
A
H
S
L
N
R
Y
A
A
S
D
S
E
P
Site 97
S889
S
L
N
R
Y
A
A
S
D
S
E
P
E
R
D
Site 98
S891
N
R
Y
A
A
S
D
S
E
P
E
R
D
E
L
Site 99
Y907
V
P
A
A
A
G
P
Y
A
T
V
Q
R
R
V
Site 100
T909
A
A
A
G
P
Y
A
T
V
Q
R
R
V
G
R
Site 101
S917
V
Q
R
R
V
G
R
S
H
S
V
R
A
P
A
Site 102
S919
R
R
V
G
R
S
H
S
V
R
A
P
A
G
A
Site 103
S933
A
D
K
N
V
N
R
S
Q
S
F
A
V
R
P
Site 104
S935
K
N
V
N
R
S
Q
S
F
A
V
R
P
R
K
Site 105
S953
P
P
P
P
P
K
R
S
S
S
A
L
A
S
A
Site 106
S954
P
P
P
P
K
R
S
S
S
A
L
A
S
A
N
Site 107
S955
P
P
P
K
R
S
S
S
A
L
A
S
A
N
L
Site 108
S959
R
S
S
S
A
L
A
S
A
N
L
A
D
E
P
Site 109
S987
R
A
Q
C
R
R
A
S
D
L
A
G
S
V
D
Site 110
S992
R
A
S
D
L
A
G
S
V
D
T
G
S
A
G
Site 111
T1029
R
P
P
E
G
H
P
T
P
R
P
A
S
P
E
Site 112
S1034
H
P
T
P
R
P
A
S
P
E
P
G
R
V
A
Site 113
T1042
P
E
P
G
R
V
A
T
V
L
A
S
V
K
H
Site 114
S1046
R
V
A
T
V
L
A
S
V
K
H
K
E
A
I
Site 115
T1065
E
V
V
N
R
R
R
T
L
S
G
P
V
T
G
Site 116
S1067
V
N
R
R
R
T
L
S
G
P
V
T
G
L
L
Site 117
T1071
R
T
L
S
G
P
V
T
G
L
L
A
T
A
R
Site 118
T1076
P
V
T
G
L
L
A
T
A
R
R
G
P
G
E
Site 119
S1084
A
R
R
G
P
G
E
S
A
D
P
G
P
F
V
Site 120
T1095
G
P
F
V
E
D
G
T
G
R
Q
R
P
R
G
Site 121
S1104
R
Q
R
P
R
G
P
S
K
G
E
A
G
V
E
Site 122
T1123
A
K
V
E
A
S
A
T
L
K
R
R
I
R
A
Site 123
T1143
E
N
V
K
F
I
L
T
E
S
D
T
V
K
R
Site 124
S1145
V
K
F
I
L
T
E
S
D
T
V
K
R
R
P
Site 125
T1147
F
I
L
T
E
S
D
T
V
K
R
R
P
K
A
Site 126
S1168
P
E
P
P
P
P
L
S
V
Y
H
N
G
T
G
Site 127
Y1170
P
P
P
P
L
S
V
Y
H
N
G
T
G
T
V
Site 128
T1176
V
Y
H
N
G
T
G
T
V
R
R
R
P
A
S
Site 129
S1183
T
V
R
R
R
P
A
S
E
Q
A
G
P
P
E
Site 130
T1203
P
P
A
E
P
P
P
T
D
L
A
H
L
P
P
Site 131
S1227
K
P
A
K
P
P
V
S
P
K
P
V
L
T
Q
Site 132
T1233
V
S
P
K
P
V
L
T
Q
P
V
P
K
L
Q
Site 133
S1242
P
V
P
K
L
Q
G
S
P
T
P
T
S
K
K
Site 134
T1244
P
K
L
Q
G
S
P
T
P
T
S
K
K
V
P
Site 135
T1246
L
Q
G
S
P
T
P
T
S
K
K
V
P
L
P
Site 136
S1247
Q
G
S
P
T
P
T
S
K
K
V
P
L
P
G
Site 137
S1257
V
P
L
P
G
P
G
S
P
E
V
K
R
A
H
Site 138
T1266
E
V
K
R
A
H
G
T
P
P
P
V
S
P
K
Site 139
S1271
H
G
T
P
P
P
V
S
P
K
P
P
P
P
P
Site 140
T1279
P
K
P
P
P
P
P
T
A
P
K
P
V
K
A
Site 141
S1292
K
A
V
A
G
L
P
S
G
S
A
G
P
S
P
Site 142
S1298
P
S
G
S
A
G
P
S
P
A
P
S
P
A
R
Site 143
S1302
A
G
P
S
P
A
P
S
P
A
R
Q
P
P
A
Site 144
T1317
A
L
A
K
P
P
G
T
P
P
S
L
G
A
S
Site 145
S1320
K
P
P
G
T
P
P
S
L
G
A
S
P
A
K
Site 146
S1324
T
P
P
S
L
G
A
S
P
A
K
P
P
S
P
Site 147
S1330
A
S
P
A
K
P
P
S
P
G
A
P
A
L
H
Site 148
S1364
P
A
P
P
E
G
A
S
P
G
D
S
A
R
Q
Site 149
S1368
E
G
A
S
P
G
D
S
A
R
Q
K
L
E
E
Site 150
T1376
A
R
Q
K
L
E
E
T
S
A
C
L
A
A
A
Site 151
S1377
R
Q
K
L
E
E
T
S
A
C
L
A
A
A
L
Site 152
S1402
D
A
Q
G
P
R
D
S
A
A
E
K
S
T
G
Site 153
S1407
R
D
S
A
A
E
K
S
T
G
S
I
L
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation