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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RUFY2
Full Name:
RUN and FYVE domain-containing protein 2
Alias:
Rab4-interacting protein related; RABIP4R; RUN and FYVE domain containing 2
Type:
Nucleus protein
Mass (Da):
75055
Number AA:
655
UniProt ID:
Q8WXA3
International Prot ID:
IPI00760675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
C
L
G
L
G
G
S
R
G
R
H
G
N
A
Site 2
S34
P
A
R
V
L
R
H
S
G
R
G
L
E
V
P
Site 3
T48
P
R
R
P
G
A
R
T
G
P
A
T
K
D
P
Site 4
T52
G
A
R
T
G
P
A
T
K
D
P
T
A
V
E
Site 5
T84
S
A
L
S
F
G
R
T
L
D
S
D
Y
P
P
Site 6
S87
S
F
G
R
T
L
D
S
D
Y
P
P
L
Q
Q
Site 7
Y89
G
R
T
L
D
S
D
Y
P
P
L
Q
Q
F
F
Site 8
S112
H
G
L
K
V
R
K
S
F
L
S
Y
N
K
T
Site 9
S115
K
V
R
K
S
F
L
S
Y
N
K
T
I
W
G
Site 10
Y116
V
R
K
S
F
L
S
Y
N
K
T
I
W
G
P
Site 11
T119
S
F
L
S
Y
N
K
T
I
W
G
P
L
E
L
Site 12
Y131
L
E
L
V
E
K
L
Y
P
E
A
E
E
I
G
Site 13
S140
E
A
E
E
I
G
A
S
V
R
D
L
P
G
L
Site 14
T149
R
D
L
P
G
L
K
T
P
L
G
R
A
R
A
Site 15
Y170
M
Q
K
K
M
A
D
Y
L
R
C
L
I
I
Q
Site 16
Y185
R
D
L
L
S
E
F
Y
E
Y
H
A
L
M
M
Site 17
Y187
L
L
S
E
F
Y
E
Y
H
A
L
M
M
E
E
Site 18
S222
V
K
G
E
D
L
D
S
Q
V
G
V
I
D
F
Site 19
Y232
G
V
I
D
F
S
M
Y
L
K
N
E
E
D
I
Site 20
Y257
A
I
L
D
Q
K
N
Y
V
E
E
L
N
R
Q
Site 21
S267
E
L
N
R
Q
L
N
S
T
V
S
S
L
H
S
Site 22
T268
L
N
R
Q
L
N
S
T
V
S
S
L
H
S
R
Site 23
S270
R
Q
L
N
S
T
V
S
S
L
H
S
R
V
D
Site 24
S271
Q
L
N
S
T
V
S
S
L
H
S
R
V
D
S
Site 25
S274
S
T
V
S
S
L
H
S
R
V
D
S
L
E
K
Site 26
S278
S
L
H
S
R
V
D
S
L
E
K
S
N
T
K
Site 27
S282
R
V
D
S
L
E
K
S
N
T
K
L
I
E
E
Site 28
T284
D
S
L
E
K
S
N
T
K
L
I
E
E
L
A
Site 29
T318
N
K
L
I
L
M
K
T
Q
Q
H
L
E
V
T
Site 30
T325
T
Q
Q
H
L
E
V
T
K
V
D
V
E
T
E
Site 31
T331
V
T
K
V
D
V
E
T
E
L
Q
T
Y
K
H
Site 32
T335
D
V
E
T
E
L
Q
T
Y
K
H
S
R
Q
G
Site 33
Y336
V
E
T
E
L
Q
T
Y
K
H
S
R
Q
G
L
Site 34
Y347
R
Q
G
L
D
E
M
Y
N
E
A
R
R
Q
L
Site 35
S358
R
R
Q
L
R
D
E
S
Q
L
R
Q
D
V
E
Site 36
T395
D
I
H
E
K
Q
D
T
L
I
G
L
R
Q
Q
Site 37
Y414
K
A
I
N
I
E
M
Y
Q
K
L
Q
G
S
E
Site 38
T438
I
A
R
L
E
E
K
T
N
K
I
T
A
A
M
Site 39
Y469
A
E
D
E
D
E
K
Y
L
Q
E
C
L
S
K
Site 40
S475
K
Y
L
Q
E
C
L
S
K
S
D
S
L
Q
K
Site 41
S477
L
Q
E
C
L
S
K
S
D
S
L
Q
K
Q
I
Site 42
S479
E
C
L
S
K
S
D
S
L
Q
K
Q
I
S
Q
Site 43
S485
D
S
L
Q
K
Q
I
S
Q
K
E
K
Q
L
V
Site 44
T507
I
E
K
E
W
R
Q
T
L
Q
E
D
L
Q
K
Site 45
S520
Q
K
E
K
D
A
L
S
H
L
R
N
E
T
Q
Site 46
T526
L
S
H
L
R
N
E
T
Q
Q
I
I
S
L
K
Site 47
S565
Q
E
L
G
N
K
L
S
E
S
K
L
K
I
E
Site 48
S603
K
L
C
E
K
E
F
S
L
S
K
R
K
H
H
Site 49
S623
E
I
F
C
N
A
C
S
D
N
E
L
P
L
P
Site 50
S631
D
N
E
L
P
L
P
S
S
P
K
P
V
R
V
Site 51
S632
N
E
L
P
L
P
S
S
P
K
P
V
R
V
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation