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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP7
Full Name:
NACHT, LRR and PYD domains-containing protein 7
Alias:
Nucleotide-binding oligomerization domain protein 12;PYRIN-containing APAF1-like protein 3
Type:
Mass (Da):
111807
Number AA:
980
UniProt ID:
Q8WX94
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
T
S
P
Q
L
E
W
T
L
Q
T
L
L
E
Q
Site 2
S24
L
N
E
D
E
L
K
S
F
K
S
L
L
W
A
Site 3
T41
L
E
D
V
L
Q
K
T
P
W
S
E
V
E
E
Site 4
S44
V
L
Q
K
T
P
W
S
E
V
E
E
A
D
G
Site 5
T61
L
A
E
I
L
V
N
T
S
S
E
N
W
I
R
Site 6
S63
E
I
L
V
N
T
S
S
E
N
W
I
R
N
A
Site 7
T71
E
N
W
I
R
N
A
T
V
N
I
L
E
E
M
Site 8
T81
I
L
E
E
M
N
L
T
E
L
C
K
M
A
K
Site 9
S112
L
G
D
A
E
E
D
S
E
L
A
K
P
G
E
Site 10
S126
E
K
E
G
W
R
N
S
M
E
K
Q
S
L
V
Site 11
T165
I
P
F
L
N
P
R
T
P
R
K
L
T
P
Y
Site 12
T170
P
R
T
P
R
K
L
T
P
Y
T
V
V
L
H
Site 13
Y172
T
P
R
K
L
T
P
Y
T
V
V
L
H
G
P
Site 14
T173
P
R
K
L
T
P
Y
T
V
V
L
H
G
P
A
Site 15
T203
T
D
C
N
L
S
P
T
L
R
Y
A
F
Y
L
Site 16
Y209
P
T
L
R
Y
A
F
Y
L
S
C
K
E
L
S
Site 17
S211
L
R
Y
A
F
Y
L
S
C
K
E
L
S
R
M
Site 18
S216
Y
L
S
C
K
E
L
S
R
M
G
P
C
S
F
Site 19
S285
P
V
P
V
L
L
G
S
L
L
K
R
K
M
L
Site 20
T300
P
R
A
A
L
L
V
T
T
R
P
R
A
L
R
Site 21
Y318
L
L
A
Q
Q
P
I
Y
V
R
V
E
G
F
L
Site 22
Y332
L
E
E
D
R
R
A
Y
F
L
R
H
F
G
D
Site 23
S443
E
R
L
G
V
Q
E
S
D
L
R
L
F
L
D
Site 24
S460
I
L
R
Q
D
R
V
S
K
G
C
Y
S
F
I
Site 25
Y464
D
R
V
S
K
G
C
Y
S
F
I
H
L
S
F
Site 26
S465
R
V
S
K
G
C
Y
S
F
I
H
L
S
F
Q
Site 27
S505
G
D
V
Q
K
L
L
S
G
E
E
R
L
K
N
Site 28
T537
R
A
K
E
L
E
A
T
F
G
C
R
M
S
P
Site 29
S543
A
T
F
G
C
R
M
S
P
D
I
K
Q
E
L
Site 30
S564
L
H
A
N
K
P
L
S
V
T
D
L
K
E
V
Site 31
Y576
K
E
V
L
G
C
L
Y
E
S
Q
E
E
E
L
Site 32
S578
V
L
G
C
L
Y
E
S
Q
E
E
E
L
A
K
Site 33
T599
K
E
I
S
I
H
L
T
N
T
S
E
V
M
H
Site 34
Y647
I
E
F
E
R
C
T
Y
L
T
I
P
N
W
A
Site 35
S660
W
A
R
Q
D
L
R
S
L
R
L
W
T
D
F
Site 36
S669
R
L
W
T
D
F
C
S
L
F
S
S
N
S
N
Site 37
S672
T
D
F
C
S
L
F
S
S
N
S
N
L
K
F
Site 38
S685
K
F
L
E
V
K
Q
S
F
L
S
D
S
S
V
Site 39
S688
E
V
K
Q
S
F
L
S
D
S
S
V
R
I
L
Site 40
S690
K
Q
S
F
L
S
D
S
S
V
R
I
L
C
D
Site 41
S691
Q
S
F
L
S
D
S
S
V
R
I
L
C
D
H
Site 42
T703
C
D
H
V
T
R
S
T
C
H
L
Q
K
V
E
Site 43
T715
K
V
E
I
K
N
V
T
P
D
T
A
Y
R
D
Site 44
T718
I
K
N
V
T
P
D
T
A
Y
R
D
F
C
L
Site 45
Y720
N
V
T
P
D
T
A
Y
R
D
F
C
L
A
F
Site 46
T732
L
A
F
I
G
K
K
T
L
T
H
L
T
L
A
Site 47
T734
F
I
G
K
K
T
L
T
H
L
T
L
A
G
H
Site 48
T737
K
K
T
L
T
H
L
T
L
A
G
H
I
E
W
Site 49
Y765
N
H
K
C
N
L
Q
Y
L
R
L
G
G
H
C
Site 50
T774
R
L
G
G
H
C
A
T
P
E
Q
W
A
E
F
Site 51
Y783
E
Q
W
A
E
F
F
Y
V
L
K
A
N
Q
S
Site 52
S790
Y
V
L
K
A
N
Q
S
L
K
H
L
R
L
S
Site 53
S797
S
L
K
H
L
R
L
S
A
N
V
L
L
D
E
Site 54
Y810
D
E
G
A
M
L
L
Y
K
T
M
T
R
P
K
Site 55
T812
G
A
M
L
L
Y
K
T
M
T
R
P
K
H
F
Site 56
S824
K
H
F
L
Q
M
L
S
L
E
N
C
R
L
T
Site 57
T831
S
L
E
N
C
R
L
T
E
A
S
C
K
D
L
Site 58
T861
A
K
N
P
I
G
D
T
G
V
K
F
L
C
E
Site 59
S871
K
F
L
C
E
G
L
S
Y
P
D
C
K
L
Q
Site 60
Y872
F
L
C
E
G
L
S
Y
P
D
C
K
L
Q
T
Site 61
Y894
I
T
K
L
G
C
R
Y
L
S
E
A
L
Q
E
Site 62
S896
K
L
G
C
R
Y
L
S
E
A
L
Q
E
A
C
Site 63
S904
E
A
L
Q
E
A
C
S
L
T
N
L
D
L
S
Site 64
S911
S
L
T
N
L
D
L
S
I
N
Q
I
A
R
G
Site 65
T940
L
K
H
L
R
L
K
T
Y
E
T
N
L
E
I
Site 66
Y941
K
H
L
R
L
K
T
Y
E
T
N
L
E
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation