KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ABCA5
Full Name:
ATP-binding cassette sub-family A member 5
Alias:
ABC13; ATP-binding cassette A5; ATP-binding cassette, sub-family A (ABC1) member 5; ATP-binding cassette, sub-family A , member 5; EST90625
Type:
Transporter
Mass (Da):
186510
Number AA:
UniProt ID:
Q8WWZ7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005768
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
E
V
G
V
W
R
Q
T
R
T
L
L
L
K
N
Site 2
Y22
R
T
L
L
L
K
N
Y
L
I
K
C
R
T
K
Site 3
T28
N
Y
L
I
K
C
R
T
K
K
S
S
V
Q
E
Site 4
S31
I
K
C
R
T
K
K
S
S
V
Q
E
I
L
F
Site 5
S32
K
C
R
T
K
K
S
S
V
Q
E
I
L
F
P
Site 6
Y58
M
M
H
P
N
K
K
Y
E
E
V
P
N
I
E
Site 7
S96
S
S
I
M
Q
K
V
S
T
D
H
L
P
D
V
Site 8
T117
T
N
E
K
E
M
L
T
S
S
L
S
K
P
S
Site 9
S118
N
E
K
E
M
L
T
S
S
L
S
K
P
S
N
Site 10
S119
E
K
E
M
L
T
S
S
L
S
K
P
S
N
F
Site 11
S121
E
M
L
T
S
S
L
S
K
P
S
N
F
V
G
Site 12
S134
V
G
V
V
F
K
D
S
M
S
Y
E
L
R
F
Site 13
Y137
V
F
K
D
S
M
S
Y
E
L
R
F
F
P
D
Site 14
S149
F
P
D
M
I
P
V
S
S
I
Y
M
D
S
R
Site 15
Y152
M
I
P
V
S
S
I
Y
M
D
S
R
A
G
C
Site 16
S155
V
S
S
I
Y
M
D
S
R
A
G
C
S
K
S
Site 17
S162
S
R
A
G
C
S
K
S
C
E
A
A
Q
Y
W
Site 18
Y168
K
S
C
E
A
A
Q
Y
W
S
S
G
F
T
V
Site 19
T174
Q
Y
W
S
S
G
F
T
V
L
Q
A
S
I
D
Site 20
S192
I
Q
L
K
T
N
V
S
L
W
K
E
L
E
S
Site 21
T200
L
W
K
E
L
E
S
T
K
A
V
I
M
G
E
Site 22
S385
E
D
F
N
E
G
A
S
F
S
N
L
T
A
G
Site 23
S387
F
N
E
G
A
S
F
S
N
L
T
A
G
P
Y
Site 24
S430
G
E
F
G
L
R
R
S
S
L
Y
F
L
K
P
Site 25
S431
E
F
G
L
R
R
S
S
L
Y
F
L
K
P
S
Site 26
Y433
G
L
R
R
S
S
L
Y
F
L
K
P
S
Y
W
Site 27
S438
S
L
Y
F
L
K
P
S
Y
W
S
K
S
K
R
Site 28
Y439
L
Y
F
L
K
P
S
Y
W
S
K
S
K
R
N
Site 29
S443
K
P
S
Y
W
S
K
S
K
R
N
Y
E
E
L
Site 30
Y447
W
S
K
S
K
R
N
Y
E
E
L
S
E
G
N
Site 31
S460
G
N
V
N
G
N
I
S
F
S
E
I
I
E
P
Site 32
S469
S
E
I
I
E
P
V
S
S
E
F
V
G
K
E
Site 33
S470
E
I
I
E
P
V
S
S
E
F
V
G
K
E
A
Site 34
S481
G
K
E
A
I
R
I
S
G
I
Q
K
T
Y
R
Site 35
T486
R
I
S
G
I
Q
K
T
Y
R
K
K
G
E
N
Site 36
S501
V
E
A
L
R
N
L
S
F
D
I
Y
E
G
Q
Site 37
Y505
R
N
L
S
F
D
I
Y
E
G
Q
I
T
A
L
Site 38
T510
D
I
Y
E
G
Q
I
T
A
L
L
G
H
S
G
Site 39
T518
A
L
L
G
H
S
G
T
G
K
S
T
L
M
N
Site 40
S521
G
H
S
G
T
G
K
S
T
L
M
N
I
L
C
Site 41
T522
H
S
G
T
G
K
S
T
L
M
N
I
L
C
G
Site 42
Y541
S
D
G
F
A
S
I
Y
G
H
R
V
S
E
I
Site 43
S546
S
I
Y
G
H
R
V
S
E
I
D
E
M
F
E
Site 44
S624
G
G
Q
K
R
K
L
S
L
G
I
A
V
L
G
Site 45
T642
I
L
L
L
D
E
P
T
A
G
M
D
P
C
S
Site 46
S649
T
A
G
M
D
P
C
S
R
H
I
V
W
N
L
Site 47
S669
A
N
R
V
T
V
F
S
T
H
F
M
D
E
A
Site 48
S687
A
D
R
K
A
V
I
S
Q
G
M
L
K
C
V
Site 49
Y713
I
G
Y
R
L
S
M
Y
I
D
K
Y
C
A
T
Site 50
Y717
L
S
M
Y
I
D
K
Y
C
A
T
E
S
L
S
Site 51
S722
D
K
Y
C
A
T
E
S
L
S
S
L
V
K
Q
Site 52
S725
C
A
T
E
S
L
S
S
L
V
K
Q
H
I
P
Site 53
Y746
Q
N
D
Q
Q
L
V
Y
S
L
P
F
K
D
M
Site 54
S757
F
K
D
M
D
K
F
S
G
L
F
S
A
L
D
Site 55
S761
D
K
F
S
G
L
F
S
A
L
D
S
H
S
N
Site 56
Y799
A
E
I
D
Q
A
D
Y
S
V
F
T
Q
Q
P
Site 57
S800
E
I
D
Q
A
D
Y
S
V
F
T
Q
Q
P
L
Site 58
S813
P
L
E
E
E
M
D
S
K
S
F
D
E
M
E
Site 59
S815
E
E
E
M
D
S
K
S
F
D
E
M
E
Q
S
Site 60
S822
S
F
D
E
M
E
Q
S
L
L
I
L
S
E
T
Site 61
T854
I
A
K
F
H
F
F
T
L
K
R
E
S
K
S
Site 62
S859
F
F
T
L
K
R
E
S
K
S
V
R
S
V
L
Site 63
S861
T
L
K
R
E
S
K
S
V
R
S
V
L
L
L
Site 64
Y900
I
K
L
V
P
D
L
Y
F
L
K
P
G
D
K
Site 65
Y911
P
G
D
K
P
H
K
Y
K
T
S
L
L
L
Q
Site 66
S920
T
S
L
L
L
Q
N
S
A
D
S
D
I
S
D
Site 67
S923
L
L
Q
N
S
A
D
S
D
I
S
D
L
I
S
Site 68
S926
N
S
A
D
S
D
I
S
D
L
I
S
F
F
T
Site 69
Y947
T
M
I
N
D
S
D
Y
V
S
V
A
P
H
S
Site 70
S949
I
N
D
S
D
Y
V
S
V
A
P
H
S
A
A
Site 71
Y993
I
I
S
N
Y
Y
L
Y
H
L
N
V
T
E
T
Site 72
T1006
E
T
I
Q
I
W
S
T
P
F
F
Q
E
I
T
Site 73
T1200
N
V
R
K
N
V
D
T
Y
N
P
W
D
R
L
Site 74
Y1201
V
R
K
N
V
D
T
Y
N
P
W
D
R
L
S
Site 75
S1208
Y
N
P
W
D
R
L
S
V
A
V
I
S
P
Y
Site 76
Y1227
L
W
I
F
L
L
Q
Y
Y
E
K
K
Y
G
G
Site 77
Y1228
W
I
F
L
L
Q
Y
Y
E
K
K
Y
G
G
R
Site 78
Y1232
L
Q
Y
Y
E
K
K
Y
G
G
R
S
I
R
K
Site 79
S1236
E
K
K
Y
G
G
R
S
I
R
K
D
P
F
F
Site 80
S1247
D
P
F
F
R
N
L
S
T
K
S
K
N
R
K
Site 81
S1250
F
R
N
L
S
T
K
S
K
N
R
K
L
P
E
Site 82
S1293
E
K
P
S
I
M
V
S
N
L
H
K
E
Y
D
Site 83
Y1299
V
S
N
L
H
K
E
Y
D
D
K
K
D
F
L
Site 84
T1316
R
K
V
K
K
V
A
T
K
Y
I
S
F
C
V
Site 85
S1320
K
V
A
T
K
Y
I
S
F
C
V
K
K
G
E
Site 86
S1354
V
G
D
I
E
P
T
S
G
Q
V
F
L
G
D
Site 87
Y1362
G
Q
V
F
L
G
D
Y
S
S
E
T
S
E
D
Site 88
S1363
Q
V
F
L
G
D
Y
S
S
E
T
S
E
D
D
Site 89
S1364
V
F
L
G
D
Y
S
S
E
T
S
E
D
D
D
Site 90
S1367
G
D
Y
S
S
E
T
S
E
D
D
D
S
L
K
Site 91
Y1378
D
S
L
K
C
M
G
Y
C
P
Q
I
N
P
L
Site 92
T1389
I
N
P
L
W
P
D
T
T
L
Q
E
H
F
E
Site 93
T1390
N
P
L
W
P
D
T
T
L
Q
E
H
F
E
I
Site 94
Y1398
L
Q
E
H
F
E
I
Y
G
A
V
K
G
M
S
Site 95
S1407
A
V
K
G
M
S
A
S
D
M
K
E
V
I
S
Site 96
T1417
K
E
V
I
S
R
I
T
H
A
L
D
L
K
E
Site 97
T1429
L
K
E
H
L
Q
K
T
V
K
K
L
P
A
G
Site 98
S1460
I
T
L
L
D
E
P
S
T
G
M
D
P
K
A
Site 99
T1489
R
K
R
A
A
I
L
T
T
H
Y
M
E
E
A
Site 100
T1516
G
Q
L
R
C
I
G
T
V
Q
H
L
K
S
K
Site 101
S1522
G
T
V
Q
H
L
K
S
K
F
G
K
G
Y
F
Site 102
Y1528
K
S
K
F
G
K
G
Y
F
L
E
I
K
L
K
Site 103
Y1552
R
L
Q
R
E
I
Q
Y
I
F
P
N
A
S
R
Site 104
S1558
Q
Y
I
F
P
N
A
S
R
Q
E
S
F
S
S
Site 105
S1562
P
N
A
S
R
Q
E
S
F
S
S
I
L
A
Y
Site 106
S1564
A
S
R
Q
E
S
F
S
S
I
L
A
Y
K
I
Site 107
S1565
S
R
Q
E
S
F
S
S
I
L
A
Y
K
I
P
Site 108
Y1569
S
F
S
S
I
L
A
Y
K
I
P
K
E
D
V
Site 109
S1578
I
P
K
E
D
V
Q
S
L
S
Q
S
F
F
K
Site 110
S1580
K
E
D
V
Q
S
L
S
Q
S
F
F
K
L
E
Site 111
S1582
D
V
Q
S
L
S
Q
S
F
F
K
L
E
E
A
Site 112
S1599
A
F
A
I
E
E
Y
S
F
S
Q
A
T
L
E
Site 113
S1601
A
I
E
E
Y
S
F
S
Q
A
T
L
E
Q
V
Site 114
S1622
E
Q
E
E
E
D
N
S
C
G
T
L
N
S
T
Site 115
T1635
S
T
L
W
W
E
R
T
Q
E
D
R
V
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation