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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GAB3
Full Name:
GRB2-associated-binding protein 3
Alias:
DOS/Gab family member 3; Gab3 protein; Gab3 scaffolding protein; GRB2-associated binding protein 3
Type:
Adaptor/scaffold
Mass (Da):
65589
Number AA:
586
UniProt ID:
Q8WWW8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
C
T
G
W
L
V
K
S
P
P
E
R
K
L
Q
Site 2
Y24
P
E
R
K
L
Q
R
Y
A
W
R
K
R
W
F
Site 3
S39
V
L
R
R
G
R
M
S
G
N
P
D
V
L
E
Site 4
Y47
G
N
P
D
V
L
E
Y
Y
R
N
K
H
S
S
Site 5
Y48
N
P
D
V
L
E
Y
Y
R
N
K
H
S
S
K
Site 6
S54
Y
Y
R
N
K
H
S
S
K
P
I
R
V
I
D
Site 7
Y96
K
T
T
S
R
T
F
Y
L
V
A
K
T
E
Q
Site 8
S127
H
L
E
D
G
A
D
S
M
E
S
L
S
Y
T
Site 9
S130
D
G
A
D
S
M
E
S
L
S
Y
T
P
S
S
Site 10
S132
A
D
S
M
E
S
L
S
Y
T
P
S
S
L
Q
Site 11
Y133
D
S
M
E
S
L
S
Y
T
P
S
S
L
Q
P
Site 12
T134
S
M
E
S
L
S
Y
T
P
S
S
L
Q
P
S
Site 13
S136
E
S
L
S
Y
T
P
S
S
L
Q
P
S
S
A
Site 14
S137
S
L
S
Y
T
P
S
S
L
Q
P
S
S
A
S
Site 15
S141
T
P
S
S
L
Q
P
S
S
A
S
S
L
L
T
Site 16
S142
P
S
S
L
Q
P
S
S
A
S
S
L
L
T
A
Site 17
T148
S
S
A
S
S
L
L
T
A
H
A
A
S
S
S
Site 18
S155
T
A
H
A
A
S
S
S
L
P
R
D
D
P
N
Site 19
T163
L
P
R
D
D
P
N
T
N
A
V
A
T
E
E
Site 20
S173
V
A
T
E
E
T
R
S
E
S
E
L
L
F
L
Site 21
S175
T
E
E
T
R
S
E
S
E
L
L
F
L
P
D
Site 22
Y183
E
L
L
F
L
P
D
Y
L
V
L
S
N
C
E
Site 23
T191
L
V
L
S
N
C
E
T
G
R
L
H
H
T
S
Site 24
T197
E
T
G
R
L
H
H
T
S
L
P
T
R
C
D
Site 25
S198
T
G
R
L
H
H
T
S
L
P
T
R
C
D
S
Site 26
T201
L
H
H
T
S
L
P
T
R
C
D
S
W
S
N
Site 27
S205
S
L
P
T
R
C
D
S
W
S
N
S
D
R
S
Site 28
S207
P
T
R
C
D
S
W
S
N
S
D
R
S
L
E
Site 29
S209
R
C
D
S
W
S
N
S
D
R
S
L
E
Q
A
Site 30
S212
S
W
S
N
S
D
R
S
L
E
Q
A
S
F
D
Site 31
S217
D
R
S
L
E
Q
A
S
F
D
D
V
F
V
D
Site 32
S231
D
C
L
Q
P
L
P
S
S
H
L
V
H
P
S
Site 33
S238
S
S
H
L
V
H
P
S
C
H
G
S
G
A
Q
Site 34
S242
V
H
P
S
C
H
G
S
G
A
Q
E
V
P
S
Site 35
S249
S
G
A
Q
E
V
P
S
S
R
P
Q
A
A
L
Site 36
S250
G
A
Q
E
V
P
S
S
R
P
Q
A
A
L
I
Site 37
S271
G
P
P
R
D
H
L
S
S
S
P
L
L
E
S
Site 38
S272
P
P
R
D
H
L
S
S
S
P
L
L
E
S
S
Site 39
S273
P
R
D
H
L
S
S
S
P
L
L
E
S
S
L
Site 40
S278
S
S
S
P
L
L
E
S
S
L
S
S
T
I
Q
Site 41
S281
P
L
L
E
S
S
L
S
S
T
I
Q
V
D
K
Site 42
S282
L
L
E
S
S
L
S
S
T
I
Q
V
D
K
N
Site 43
T283
L
E
S
S
L
S
S
T
I
Q
V
D
K
N
Q
Site 44
S292
Q
V
D
K
N
Q
G
S
L
P
C
G
A
K
E
Site 45
S304
A
K
E
L
D
I
M
S
N
T
P
P
P
R
P
Site 46
T306
E
L
D
I
M
S
N
T
P
P
P
R
P
P
K
Site 47
S315
P
P
R
P
P
K
P
S
H
L
S
E
R
R
Q
Site 48
S318
P
P
K
P
S
H
L
S
E
R
R
Q
E
E
W
Site 49
S326
E
R
R
Q
E
E
W
S
T
H
S
G
S
K
K
Site 50
T327
R
R
Q
E
E
W
S
T
H
S
G
S
K
K
P
Site 51
S329
Q
E
E
W
S
T
H
S
G
S
K
K
P
E
C
Site 52
S344
T
L
V
P
R
R
I
S
L
S
G
L
D
N
M
Site 53
S346
V
P
R
R
I
S
L
S
G
L
D
N
M
R
T
Site 54
T353
S
G
L
D
N
M
R
T
W
K
A
D
V
E
G
Site 55
S362
K
A
D
V
E
G
Q
S
L
R
H
R
D
K
R
Site 56
S371
R
H
R
D
K
R
L
S
L
N
L
P
C
R
F
Site 57
S379
L
N
L
P
C
R
F
S
P
M
Y
P
T
A
S
Site 58
Y382
P
C
R
F
S
P
M
Y
P
T
A
S
A
S
I
Site 59
T384
R
F
S
P
M
Y
P
T
A
S
A
S
I
E
D
Site 60
S386
S
P
M
Y
P
T
A
S
A
S
I
E
D
S
Y
Site 61
S388
M
Y
P
T
A
S
A
S
I
E
D
S
Y
V
P
Site 62
S392
A
S
A
S
I
E
D
S
Y
V
P
M
S
P
Q
Site 63
Y393
S
A
S
I
E
D
S
Y
V
P
M
S
P
Q
A
Site 64
S397
E
D
S
Y
V
P
M
S
P
Q
A
G
A
S
G
Site 65
S403
M
S
P
Q
A
G
A
S
G
L
G
P
H
C
S
Site 66
S410
S
G
L
G
P
H
C
S
P
D
D
Y
I
P
M
Site 67
Y414
P
H
C
S
P
D
D
Y
I
P
M
N
S
G
S
Site 68
S419
D
D
Y
I
P
M
N
S
G
S
I
S
S
P
L
Site 69
S421
Y
I
P
M
N
S
G
S
I
S
S
P
L
P
E
Site 70
S423
P
M
N
S
G
S
I
S
S
P
L
P
E
L
P
Site 71
S424
M
N
S
G
S
I
S
S
P
L
P
E
L
P
A
Site 72
S448
D
L
K
P
Q
R
K
S
R
P
P
P
L
D
L
Site 73
S459
P
L
D
L
R
N
L
S
I
I
R
E
H
A
S
Site 74
S466
S
I
I
R
E
H
A
S
L
T
R
T
R
T
V
Site 75
T470
E
H
A
S
L
T
R
T
R
T
V
P
C
S
R
Site 76
T472
A
S
L
T
R
T
R
T
V
P
C
S
R
T
S
Site 77
S476
R
T
R
T
V
P
C
S
R
T
S
F
L
S
P
Site 78
T478
R
T
V
P
C
S
R
T
S
F
L
S
P
E
R
Site 79
S479
T
V
P
C
S
R
T
S
F
L
S
P
E
R
N
Site 80
S482
C
S
R
T
S
F
L
S
P
E
R
N
G
I
N
Site 81
S490
P
E
R
N
G
I
N
S
A
R
F
F
A
N
P
Site 82
S499
R
F
F
A
N
P
V
S
R
E
D
E
E
S
Y
Site 83
S505
V
S
R
E
D
E
E
S
Y
I
E
M
E
E
H
Site 84
Y506
S
R
E
D
E
E
S
Y
I
E
M
E
E
H
R
Site 85
T514
I
E
M
E
E
H
R
T
A
S
S
L
S
S
G
Site 86
S516
M
E
E
H
R
T
A
S
S
L
S
S
G
A
L
Site 87
S517
E
E
H
R
T
A
S
S
L
S
S
G
A
L
T
Site 88
S519
H
R
T
A
S
S
L
S
S
G
A
L
T
W
T
Site 89
S520
R
T
A
S
S
L
S
S
G
A
L
T
W
T
K
Site 90
T524
S
L
S
S
G
A
L
T
W
T
K
K
F
S
L
Site 91
T526
S
S
G
A
L
T
W
T
K
K
F
S
L
D
Y
Site 92
Y533
T
K
K
F
S
L
D
Y
L
A
L
D
F
N
S
Site 93
S540
Y
L
A
L
D
F
N
S
A
S
P
A
P
M
Q
Site 94
S542
A
L
D
F
N
S
A
S
P
A
P
M
Q
Q
K
Site 95
S553
M
Q
Q
K
L
L
L
S
E
E
Q
R
V
D
Y
Site 96
Y560
S
E
E
Q
R
V
D
Y
V
Q
V
D
E
Q
K
Site 97
S573
Q
K
T
Q
A
L
Q
S
T
K
Q
E
W
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation