KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PHIP
Full Name:
PH-interacting protein
Alias:
DCAF14; DDB1 and CUL4 associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; Ndrp; Pleckstriny domain interacting protein; WDR11
Type:
Adapter/scaffold protein
Mass (Da):
206647
Number AA:
1821
UniProt ID:
Q8WWQ0
International Prot ID:
IPI00291916
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005102
GO:0005158
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0007166
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
C
E
R
K
G
L
S
E
L
R
S
E
L
Y
Site 2
Y16
S
E
L
R
S
E
L
Y
F
L
I
A
R
F
L
Site 3
T49
K
E
L
L
P
R
R
T
D
W
T
G
K
E
H
Site 4
T52
L
P
R
R
T
D
W
T
G
K
E
H
P
R
T
Site 5
T59
T
G
K
E
H
P
R
T
Y
Q
N
L
V
K
Y
Site 6
Y60
G
K
E
H
P
R
T
Y
Q
N
L
V
K
Y
Y
Site 7
Y66
T
Y
Q
N
L
V
K
Y
Y
R
H
L
A
P
D
Site 8
S93
L
E
Q
E
I
P
Q
S
V
P
G
V
Q
T
L
Site 9
S107
L
L
G
A
G
R
Q
S
L
L
R
T
N
K
S
Site 10
T111
G
R
Q
S
L
L
R
T
N
K
S
C
K
H
V
Site 11
S114
S
L
L
R
T
N
K
S
C
K
H
V
V
W
K
Site 12
S123
K
H
V
V
W
K
G
S
A
L
A
A
L
H
C
Site 13
S136
H
C
G
R
P
P
E
S
P
V
N
Y
G
S
P
Site 14
Y140
P
P
E
S
P
V
N
Y
G
S
P
P
S
I
A
Site 15
S142
E
S
P
V
N
Y
G
S
P
P
S
I
A
D
T
Site 16
S145
V
N
Y
G
S
P
P
S
I
A
D
T
L
F
S
Site 17
T149
S
P
P
S
I
A
D
T
L
F
S
R
K
L
N
Site 18
S152
S
I
A
D
T
L
F
S
R
K
L
N
G
K
Y
Site 19
Y170
R
L
V
P
T
A
V
Y
Q
H
M
K
M
H
K
Site 20
T190
L
S
S
V
Y
C
V
T
F
D
R
T
G
R
R
Site 21
T194
Y
C
V
T
F
D
R
T
G
R
R
I
F
T
G
Site 22
T200
R
T
G
R
R
I
F
T
G
S
D
D
C
L
V
Site 23
S202
G
R
R
I
F
T
G
S
D
D
C
L
V
K
I
Site 24
T220
D
D
G
R
L
L
A
T
L
R
G
H
A
A
E
Site 25
S229
R
G
H
A
A
E
I
S
D
M
A
V
N
Y
E
Site 26
Y235
I
S
D
M
A
V
N
Y
E
N
T
M
I
A
A
Site 27
T271
Q
G
H
S
A
S
I
T
S
L
Q
F
S
P
L
Site 28
S276
S
I
T
S
L
Q
F
S
P
L
C
S
G
S
K
Site 29
S280
L
Q
F
S
P
L
C
S
G
S
K
R
Y
L
S
Site 30
S282
F
S
P
L
C
S
G
S
K
R
Y
L
S
S
T
Site 31
Y285
L
C
S
G
S
K
R
Y
L
S
S
T
G
A
D
Site 32
S287
S
G
S
K
R
Y
L
S
S
T
G
A
D
G
T
Site 33
S288
G
S
K
R
Y
L
S
S
T
G
A
D
G
T
I
Site 34
T289
S
K
R
Y
L
S
S
T
G
A
D
G
T
I
C
Site 35
T315
N
P
R
P
A
K
F
T
E
R
P
R
P
G
V
Site 36
Y348
T
D
H
I
I
R
V
Y
F
F
G
S
G
Q
P
Site 37
S359
S
G
Q
P
E
K
I
S
E
L
E
F
H
T
D
Site 38
S370
F
H
T
D
K
V
D
S
I
Q
F
S
N
T
S
Site 39
S374
K
V
D
S
I
Q
F
S
N
T
S
N
R
F
V
Site 40
T376
D
S
I
Q
F
S
N
T
S
N
R
F
V
S
G
Site 41
S377
S
I
Q
F
S
N
T
S
N
R
F
V
S
G
S
Site 42
S382
N
T
S
N
R
F
V
S
G
S
R
D
G
T
A
Site 43
S384
S
N
R
F
V
S
G
S
R
D
G
T
A
R
I
Site 44
T388
V
S
G
S
R
D
G
T
A
R
I
W
Q
F
K
Site 45
S401
F
K
R
R
E
W
K
S
I
L
L
D
M
A
T
Site 46
T423
Q
G
I
E
D
K
I
T
K
M
K
V
T
M
V
Site 47
T438
A
W
D
R
H
D
N
T
V
I
T
A
V
N
N
Site 48
T441
R
H
D
N
T
V
I
T
A
V
N
N
M
T
L
Site 49
T447
I
T
A
V
N
N
M
T
L
K
V
W
N
S
Y
Site 50
Y454
T
L
K
V
W
N
S
Y
T
G
Q
L
I
H
V
Site 51
S484
F
D
P
R
V
L
F
S
A
G
H
D
G
N
V
Site 52
Y505
R
G
V
K
I
R
S
Y
F
N
M
I
E
G
Q
Site 53
S547
I
F
G
F
G
S
S
S
K
Y
D
K
I
A
D
Site 54
Y549
G
F
G
S
S
S
K
Y
D
K
I
A
D
Q
M
Site 55
Y562
Q
M
F
F
H
S
D
Y
R
P
L
I
R
D
A
Site 56
Y602
G
N
P
H
P
S
R
Y
Q
R
L
V
P
G
R
Site 57
S626
P
Q
M
G
V
T
S
S
G
L
N
Q
V
L
S
Site 58
S633
S
G
L
N
Q
V
L
S
Q
Q
A
N
Q
E
I
Site 59
S641
Q
Q
A
N
Q
E
I
S
P
L
D
S
M
I
Q
Site 60
S645
Q
E
I
S
P
L
D
S
M
I
Q
R
L
Q
Q
Site 61
S659
Q
E
Q
D
L
R
R
S
G
E
A
G
I
S
N
Site 62
S665
R
S
G
E
A
G
I
S
N
T
S
R
L
S
R
Site 63
T667
G
E
A
G
I
S
N
T
S
R
L
S
R
G
S
Site 64
S668
E
A
G
I
S
N
T
S
R
L
S
R
G
S
I
Site 65
S671
I
S
N
T
S
R
L
S
R
G
S
I
S
S
T
Site 66
S674
T
S
R
L
S
R
G
S
I
S
S
T
S
E
V
Site 67
S676
R
L
S
R
G
S
I
S
S
T
S
E
V
H
S
Site 68
S677
L
S
R
G
S
I
S
S
T
S
E
V
H
S
P
Site 69
T678
S
R
G
S
I
S
S
T
S
E
V
H
S
P
P
Site 70
S679
R
G
S
I
S
S
T
S
E
V
H
S
P
P
N
Site 71
S683
S
S
T
S
E
V
H
S
P
P
N
V
G
L
R
Site 72
S692
P
N
V
G
L
R
R
S
G
Q
I
E
G
V
R
Site 73
S703
E
G
V
R
Q
M
H
S
N
A
P
R
S
E
I
Site 74
S708
M
H
S
N
A
P
R
S
E
I
A
T
E
R
D
Site 75
T712
A
P
R
S
E
I
A
T
E
R
D
L
V
A
W
Site 76
S720
E
R
D
L
V
A
W
S
R
R
V
V
V
P
E
Site 77
T741
S
R
Q
E
E
W
R
T
A
K
G
E
E
E
I
Site 78
T750
K
G
E
E
E
I
K
T
Y
R
S
E
E
K
R
Site 79
Y751
G
E
E
E
I
K
T
Y
R
S
E
E
K
R
K
Site 80
T761
E
E
K
R
K
H
L
T
V
P
K
E
N
K
I
Site 81
T770
P
K
E
N
K
I
P
T
V
S
K
N
H
A
H
Site 82
S786
H
F
L
D
L
G
E
S
K
K
Q
Q
T
N
Q
Site 83
S800
Q
H
N
Y
R
T
R
S
A
L
E
E
T
P
R
Site 84
T805
T
R
S
A
L
E
E
T
P
R
P
S
E
E
I
Site 85
S809
L
E
E
T
P
R
P
S
E
E
I
E
N
G
S
Site 86
S817
E
E
I
E
N
G
S
S
S
S
D
E
G
E
V
Site 87
S832
V
A
V
S
G
G
T
S
E
E
E
E
R
A
W
Site 88
S841
E
E
E
R
A
W
H
S
D
G
S
S
S
D
Y
Site 89
S844
R
A
W
H
S
D
G
S
S
S
D
Y
S
S
D
Site 90
S845
A
W
H
S
D
G
S
S
S
D
Y
S
S
D
Y
Site 91
S846
W
H
S
D
G
S
S
S
D
Y
S
S
D
Y
S
Site 92
Y848
S
D
G
S
S
S
D
Y
S
S
D
Y
S
D
W
Site 93
S849
D
G
S
S
S
D
Y
S
S
D
Y
S
D
W
T
Site 94
S850
G
S
S
S
D
Y
S
S
D
Y
S
D
W
T
A
Site 95
Y852
S
S
D
Y
S
S
D
Y
S
D
W
T
A
D
A
Site 96
S853
S
D
Y
S
S
D
Y
S
D
W
T
A
D
A
G
Site 97
T856
S
S
D
Y
S
D
W
T
A
D
A
G
I
N
L
Site 98
T874
K
K
V
P
K
N
K
T
K
K
A
E
S
S
S
Site 99
S879
N
K
T
K
K
A
E
S
S
S
D
E
E
E
E
Site 100
S880
K
T
K
K
A
E
S
S
S
D
E
E
E
E
S
Site 101
S881
T
K
K
A
E
S
S
S
D
E
E
E
E
S
E
Site 102
S887
S
S
D
E
E
E
E
S
E
K
Q
K
Q
K
Q
Site 103
S911
E
E
K
D
G
P
I
S
P
K
K
K
K
P
K
Site 104
T936
E
L
T
E
N
G
L
T
L
E
E
W
L
P
S
Site 105
T947
W
L
P
S
T
W
I
T
D
T
I
P
R
R
C
Site 106
T949
P
S
T
W
I
T
D
T
I
P
R
R
C
P
F
Site 107
Y965
P
Q
M
G
D
E
V
Y
Y
F
R
Q
G
H
E
Site 108
Y966
Q
M
G
D
E
V
Y
Y
F
R
Q
G
H
E
A
Site 109
Y974
F
R
Q
G
H
E
A
Y
V
E
M
A
R
K
N
Site 110
Y984
M
A
R
K
N
K
I
Y
S
I
N
P
K
K
Q
Site 111
T1030
L
A
F
L
D
P
D
T
G
K
L
T
G
G
S
Site 112
T1034
D
P
D
T
G
K
L
T
G
G
S
F
T
M
K
Site 113
S1037
T
G
K
L
T
G
G
S
F
T
M
K
Y
H
D
Site 114
Y1042
G
G
S
F
T
M
K
Y
H
D
M
P
D
V
I
Site 115
Y1063
Q
Q
F
D
D
A
K
Y
R
R
W
N
I
G
D
Site 116
Y1095
Q
E
P
L
Q
L
E
Y
P
D
S
L
F
Q
C
Site 117
S1116
N
G
D
T
E
K
M
S
P
W
D
M
E
L
I
Site 118
S1136
F
P
E
E
L
G
T
S
V
P
L
T
D
G
E
Site 119
T1140
L
G
T
S
V
P
L
T
D
G
E
C
R
S
L
Site 120
S1146
L
T
D
G
E
C
R
S
L
I
Y
K
P
L
D
Site 121
Y1218
Q
R
L
E
N
R
F
Y
R
R
V
S
S
L
M
Site 122
S1222
N
R
F
Y
R
R
V
S
S
L
M
W
E
V
R
Site 123
S1223
R
F
Y
R
R
V
S
S
L
M
W
E
V
R
Y
Site 124
Y1230
S
L
M
W
E
V
R
Y
I
E
H
N
T
R
T
Site 125
T1237
Y
I
E
H
N
T
R
T
F
N
E
P
G
S
P
Site 126
S1243
R
T
F
N
E
P
G
S
P
I
V
K
S
A
K
Site 127
Y1266
F
I
K
D
Q
T
C
Y
N
I
I
P
L
Y
N
Site 128
Y1272
C
Y
N
I
I
P
L
Y
N
S
M
K
K
K
V
Site 129
S1274
N
I
I
P
L
Y
N
S
M
K
K
K
V
L
S
Site 130
S1281
S
M
K
K
K
V
L
S
D
S
E
D
E
E
K
Site 131
S1283
K
K
K
V
L
S
D
S
E
D
E
E
K
D
A
Site 132
T1295
K
D
A
D
V
P
G
T
S
T
R
K
R
K
D
Site 133
S1296
D
A
D
V
P
G
T
S
T
R
K
R
K
D
H
Site 134
T1297
A
D
V
P
G
T
S
T
R
K
R
K
D
H
Q
Site 135
S1315
R
L
R
N
R
A
Q
S
Y
D
I
Q
A
W
K
Site 136
Y1316
L
R
N
R
A
Q
S
Y
D
I
Q
A
W
K
K
Site 137
Y1350
Q
P
V
D
L
L
E
Y
P
D
Y
R
D
I
I
Site 138
Y1353
D
L
L
E
Y
P
D
Y
R
D
I
I
D
T
P
Site 139
T1359
D
Y
R
D
I
I
D
T
P
M
D
F
A
T
V
Site 140
T1365
D
T
P
M
D
F
A
T
V
R
E
T
L
E
A
Site 141
T1369
D
F
A
T
V
R
E
T
L
E
A
G
N
Y
E
Site 142
Y1375
E
T
L
E
A
G
N
Y
E
S
P
M
E
L
C
Site 143
S1377
L
E
A
G
N
Y
E
S
P
M
E
L
C
K
D
Site 144
S1390
K
D
V
R
L
I
F
S
N
S
K
A
Y
T
P
Site 145
S1392
V
R
L
I
F
S
N
S
K
A
Y
T
P
S
K
Site 146
T1396
F
S
N
S
K
A
Y
T
P
S
K
R
S
R
I
Site 147
S1398
N
S
K
A
Y
T
P
S
K
R
S
R
I
Y
S
Site 148
S1401
A
Y
T
P
S
K
R
S
R
I
Y
S
M
S
L
Site 149
Y1404
P
S
K
R
S
R
I
Y
S
M
S
L
R
L
S
Site 150
S1405
S
K
R
S
R
I
Y
S
M
S
L
R
L
S
A
Site 151
S1407
R
S
R
I
Y
S
M
S
L
R
L
S
A
F
F
Site 152
S1419
A
F
F
E
E
H
I
S
S
V
L
S
D
Y
K
Site 153
S1420
F
F
E
E
H
I
S
S
V
L
S
D
Y
K
S
Site 154
S1423
E
H
I
S
S
V
L
S
D
Y
K
S
A
L
R
Site 155
Y1425
I
S
S
V
L
S
D
Y
K
S
A
L
R
F
H
Site 156
S1427
S
V
L
S
D
Y
K
S
A
L
R
F
H
K
R
Site 157
T1436
L
R
F
H
K
R
N
T
I
T
K
R
R
K
K
Site 158
T1438
F
H
K
R
N
T
I
T
K
R
R
K
K
R
N
Site 159
S1447
R
R
K
K
R
N
R
S
S
S
V
S
S
S
A
Site 160
S1448
R
K
K
R
N
R
S
S
S
V
S
S
S
A
A
Site 161
S1449
K
K
R
N
R
S
S
S
V
S
S
S
A
A
S
Site 162
S1451
R
N
R
S
S
S
V
S
S
S
A
A
S
S
P
Site 163
S1452
N
R
S
S
S
V
S
S
S
A
A
S
S
P
E
Site 164
S1453
R
S
S
S
V
S
S
S
A
A
S
S
P
E
R
Site 165
S1456
S
V
S
S
S
A
A
S
S
P
E
R
K
K
R
Site 166
S1457
V
S
S
S
A
A
S
S
P
E
R
K
K
R
I
Site 167
S1471
I
L
K
P
Q
L
K
S
E
S
S
T
S
A
F
Site 168
S1473
K
P
Q
L
K
S
E
S
S
T
S
A
F
S
T
Site 169
S1474
P
Q
L
K
S
E
S
S
T
S
A
F
S
T
P
Site 170
T1475
Q
L
K
S
E
S
S
T
S
A
F
S
T
P
T
Site 171
S1476
L
K
S
E
S
S
T
S
A
F
S
T
P
T
R
Site 172
S1479
E
S
S
T
S
A
F
S
T
P
T
R
S
I
P
Site 173
T1480
S
S
T
S
A
F
S
T
P
T
R
S
I
P
P
Site 174
S1484
A
F
S
T
P
T
R
S
I
P
P
R
H
N
A
Site 175
T1498
A
A
Q
I
N
G
K
T
E
S
S
S
V
V
R
Site 176
S1500
Q
I
N
G
K
T
E
S
S
S
V
V
R
T
R
Site 177
S1501
I
N
G
K
T
E
S
S
S
V
V
R
T
R
S
Site 178
S1502
N
G
K
T
E
S
S
S
V
V
R
T
R
S
N
Site 179
T1506
E
S
S
S
V
V
R
T
R
S
N
R
V
V
V
Site 180
S1508
S
S
V
V
R
T
R
S
N
R
V
V
V
D
P
Site 181
S1522
P
V
V
T
E
Q
P
S
T
S
S
A
A
K
T
Site 182
T1523
V
V
T
E
Q
P
S
T
S
S
A
A
K
T
F
Site 183
S1524
V
T
E
Q
P
S
T
S
S
A
A
K
T
F
I
Site 184
S1525
T
E
Q
P
S
T
S
S
A
A
K
T
F
I
T
Site 185
T1529
S
T
S
S
A
A
K
T
F
I
T
K
A
N
A
Site 186
S1548
G
K
T
I
L
E
N
S
V
K
H
S
K
A
L
Site 187
S1552
L
E
N
S
V
K
H
S
K
A
L
N
T
L
S
Site 188
T1557
K
H
S
K
A
L
N
T
L
S
S
P
G
Q
S
Site 189
S1559
S
K
A
L
N
T
L
S
S
P
G
Q
S
S
F
Site 190
S1560
K
A
L
N
T
L
S
S
P
G
Q
S
S
F
S
Site 191
S1564
T
L
S
S
P
G
Q
S
S
F
S
H
G
T
R
Site 192
S1565
L
S
S
P
G
Q
S
S
F
S
H
G
T
R
N
Site 193
S1567
S
P
G
Q
S
S
F
S
H
G
T
R
N
N
S
Site 194
S1574
S
H
G
T
R
N
N
S
A
K
E
N
M
E
K
Site 195
S1591
P
V
K
R
K
M
K
S
S
V
L
P
K
A
S
Site 196
S1592
V
K
R
K
M
K
S
S
V
L
P
K
A
S
T
Site 197
S1598
S
S
V
L
P
K
A
S
T
L
S
K
S
S
A
Site 198
S1601
L
P
K
A
S
T
L
S
K
S
S
A
V
I
E
Site 199
S1603
K
A
S
T
L
S
K
S
S
A
V
I
E
Q
G
Site 200
T1621
N
N
A
L
V
P
G
T
I
Q
V
N
G
H
G
Site 201
S1632
N
G
H
G
G
Q
P
S
K
L
V
K
R
G
P
Site 202
S1651
K
V
E
V
N
T
N
S
G
E
I
I
H
K
K
Site 203
Y1668
R
K
P
K
K
L
Q
Y
A
K
P
E
D
L
E
Site 204
S1689
I
R
D
E
V
L
P
S
S
T
C
N
F
L
S
Site 205
S1690
R
D
E
V
L
P
S
S
T
C
N
F
L
S
E
Site 206
S1696
S
S
T
C
N
F
L
S
E
T
N
N
V
K
E
Site 207
S1734
A
D
L
L
V
P
A
S
V
K
V
L
R
R
S
Site 208
S1741
S
V
K
V
L
R
R
S
N
R
K
K
I
D
D
Site 209
S1762
E
F
E
E
L
K
G
S
E
P
H
M
R
T
R
Site 210
T1775
T
R
N
Q
G
R
R
T
A
F
Y
N
E
D
D
Site 211
Y1778
Q
G
R
R
T
A
F
Y
N
E
D
D
S
E
E
Site 212
S1783
A
F
Y
N
E
D
D
S
E
E
E
Q
R
Q
L
Site 213
T1795
R
Q
L
L
F
E
D
T
S
L
T
F
G
T
S
Site 214
S1796
Q
L
L
F
E
D
T
S
L
T
F
G
T
S
S
Site 215
T1798
L
F
E
D
T
S
L
T
F
G
T
S
S
R
G
Site 216
S1802
T
S
L
T
F
G
T
S
S
R
G
R
V
R
K
Site 217
S1803
S
L
T
F
G
T
S
S
R
G
R
V
R
K
L
Site 218
T1811
R
G
R
V
R
K
L
T
E
K
A
K
A
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation