KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SPIRE2
Full Name:
Protein spire homolog 2
Alias:
Spir-2
Type:
Cytoskeleton protein
Mass (Da):
79598
Number AA:
714
UniProt ID:
Q8WWL2
International Prot ID:
IPI00162208
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0051234
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
R
P
E
P
W
E
L
S
L
E
E
V
L
K
A
Site 2
Y31
L
E
E
V
L
K
A
Y
E
Q
P
L
N
E
E
Site 3
S54
G
C
R
G
L
R
G
S
P
G
R
R
L
R
D
Site 4
T62
P
G
R
R
L
R
D
T
G
D
L
L
L
R
G
Site 5
S72
L
L
L
R
G
D
G
S
V
G
A
R
E
P
E
Site 6
S116
L
D
W
G
L
D
E
S
E
E
R
E
L
S
P
Site 7
S122
E
S
E
E
R
E
L
S
P
Q
L
E
R
L
I
Site 8
S137
D
L
M
A
N
N
D
S
E
D
S
G
C
G
A
Site 9
S140
A
N
N
D
S
E
D
S
G
C
G
A
A
D
E
Site 10
Y149
C
G
A
A
D
E
G
Y
G
G
P
E
E
E
E
Site 11
S164
E
A
E
G
V
P
R
S
V
R
T
F
A
Q
A
Site 12
T167
G
V
P
R
S
V
R
T
F
A
Q
A
M
R
L
Site 13
T180
R
L
C
A
A
R
L
T
D
P
R
G
A
Q
A
Site 14
Y189
P
R
G
A
Q
A
H
Y
Q
A
V
C
R
A
L
Site 15
T229
E
D
E
P
H
L
E
T
P
R
A
E
L
D
S
Site 16
S236
T
P
R
A
E
L
D
S
L
G
H
T
D
W
A
Site 17
T240
E
L
D
S
L
G
H
T
D
W
A
R
L
W
V
Site 18
Y291
Q
D
I
R
A
R
N
Y
K
L
R
K
V
M
V
Site 19
S328
R
P
P
L
K
Q
V
S
E
R
R
L
R
P
L
Site 20
S341
P
L
P
P
K
Q
R
S
L
H
E
K
I
L
E
Site 21
S371
W
A
A
R
G
F
G
S
L
P
C
I
L
N
A
Site 22
S380
P
C
I
L
N
A
C
S
G
D
A
K
S
T
S
Site 23
S385
W
A
A
R
G
F
G
S
L
P
C
I
L
N
A
Site 24
S387
S
G
D
A
K
S
T
S
C
I
N
L
S
V
T
Site 25
T422
A
E
M
E
E
M
N
T
S
E
E
E
E
S
P
Site 26
S423
E
M
E
E
M
N
T
S
E
E
E
E
S
P
C
Site 27
S428
N
T
S
E
E
E
E
S
P
C
G
E
V
T
L
Site 28
T434
E
S
P
C
G
E
V
T
L
K
R
D
R
S
F
Site 29
S440
V
T
L
K
R
D
R
S
F
S
E
H
D
L
A
Site 30
S442
L
K
R
D
R
S
F
S
E
H
D
L
A
Q
L
Site 31
S451
H
D
L
A
Q
L
R
S
E
V
A
S
G
L
Q
Site 32
S455
Q
L
R
S
E
V
A
S
G
L
Q
S
A
T
H
Site 33
S459
E
V
A
S
G
L
Q
S
A
T
H
P
P
G
G
Site 34
T461
A
S
G
L
Q
S
A
T
H
P
P
G
G
T
E
Site 35
T467
A
T
H
P
P
G
G
T
E
P
P
R
P
R
A
Site 36
S476
P
P
R
P
R
A
G
S
A
H
V
W
R
P
G
Site 37
S484
A
H
V
W
R
P
G
S
R
D
Q
G
T
C
P
Site 38
T489
P
G
S
R
D
Q
G
T
C
P
A
S
V
S
D
Site 39
S493
D
Q
G
T
C
P
A
S
V
S
D
P
S
H
P
Site 40
S495
G
T
C
P
A
S
V
S
D
P
S
H
P
L
L
Site 41
S498
P
A
S
V
S
D
P
S
H
P
L
L
S
N
R
Site 42
S503
D
P
S
H
P
L
L
S
N
R
G
S
S
G
D
Site 43
S507
P
L
L
S
N
R
G
S
S
G
D
R
P
E
A
Site 44
S508
L
L
S
N
R
G
S
S
G
D
R
P
E
A
S
Site 45
S515
S
G
D
R
P
E
A
S
M
T
P
D
A
K
H
Site 46
T517
D
R
P
E
A
S
M
T
P
D
A
K
H
L
W
Site 47
S528
K
H
L
W
L
E
F
S
H
P
V
E
S
L
A
Site 48
S533
E
F
S
H
P
V
E
S
L
A
L
T
V
E
E
Site 49
S565
Q
N
K
E
L
F
S
S
L
K
K
G
K
I
C
Site 50
Y616
K
F
G
H
I
P
V
Y
T
L
G
F
E
S
P
Site 51
T617
F
G
H
I
P
V
Y
T
L
G
F
E
S
P
Q
Site 52
S622
V
Y
T
L
G
F
E
S
P
Q
R
V
S
A
A
Site 53
S627
F
E
S
P
Q
R
V
S
A
A
K
T
A
P
I
Site 54
T631
Q
R
V
S
A
A
K
T
A
P
I
Q
R
R
D
Site 55
S642
Q
R
R
D
I
F
Q
S
L
Q
G
P
Q
W
Q
Site 56
S650
L
Q
G
P
Q
W
Q
S
V
E
E
A
F
P
H
Site 57
S686
V
V
R
S
S
R
K
S
V
D
V
L
N
T
T
Site 58
T693
S
V
D
V
L
N
T
T
P
R
R
S
R
Q
T
Site 59
S697
L
N
T
T
P
R
R
S
R
Q
T
Q
S
L
Y
Site 60
T700
T
P
R
R
S
R
Q
T
Q
S
L
Y
I
P
N
Site 61
S702
R
R
S
R
Q
T
Q
S
L
Y
I
P
N
T
R
Site 62
Y704
S
R
Q
T
Q
S
L
Y
I
P
N
T
R
T
L
Site 63
T708
Q
S
L
Y
I
P
N
T
R
T
L
D
F
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation