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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRUB1
Full Name:
Probable tRNA pseudouridine synthase 1
Alias:
EC 5.4.99.-; TruB pseudouridine (psi) synthase 1
Type:
RNA processing, Isomerase
Mass (Da):
37253
Number AA:
349
UniProt ID:
Q8WWH5
International Prot ID:
IPI00103341
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0009982
GO:0016853
PhosphoSite+
KinaseNET
Biological Process:
GO:0001522
GO:0008033
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
E
A
A
V
V
S
S
P
S
L
K
T
D
T
Site 2
S13
A
A
V
V
S
S
P
S
L
K
T
D
T
S
P
Site 3
T18
S
P
S
L
K
T
D
T
S
P
V
L
E
T
A
Site 4
S19
P
S
L
K
T
D
T
S
P
V
L
E
T
A
G
Site 5
T24
D
T
S
P
V
L
E
T
A
G
T
V
A
A
M
Site 6
S52
A
A
A
A
R
T
G
S
E
A
R
V
S
K
A
Site 7
S57
T
G
S
E
A
R
V
S
K
A
A
L
A
T
K
Site 8
S82
H
K
P
K
G
P
T
S
A
E
L
L
N
R
L
Site 9
S101
L
A
E
A
G
M
P
S
P
E
W
T
K
R
K
Site 10
T105
G
M
P
S
P
E
W
T
K
R
K
K
Q
T
L
Site 11
S134
V
L
V
V
G
I
G
S
G
T
K
M
L
T
S
Site 12
T140
G
S
G
T
K
M
L
T
S
M
L
S
G
S
K
Site 13
S141
S
G
T
K
M
L
T
S
M
L
S
G
S
K
R
Site 14
S144
K
M
L
T
S
M
L
S
G
S
K
R
Y
T
A
Site 15
S146
L
T
S
M
L
S
G
S
K
R
Y
T
A
I
G
Site 16
Y149
M
L
S
G
S
K
R
Y
T
A
I
G
E
L
G
Site 17
T150
L
S
G
S
K
R
Y
T
A
I
G
E
L
G
K
Site 18
T161
E
L
G
K
A
T
D
T
L
D
S
T
G
R
V
Site 19
S164
K
A
T
D
T
L
D
S
T
G
R
V
T
E
E
Site 20
T165
A
T
D
T
L
D
S
T
G
R
V
T
E
E
K
Site 21
T169
L
D
S
T
G
R
V
T
E
E
K
P
Y
D
K
Site 22
Y174
R
V
T
E
E
K
P
Y
D
K
I
T
Q
E
D
Site 23
T178
E
K
P
Y
D
K
I
T
Q
E
D
I
E
G
I
Site 24
Y200
I
M
Q
V
P
P
L
Y
S
A
L
K
K
D
G
Site 25
S201
M
Q
V
P
P
L
Y
S
A
L
K
K
D
G
Q
Site 26
S211
K
K
D
G
Q
R
L
S
T
L
M
K
R
G
E
Site 27
T212
K
D
G
Q
R
L
S
T
L
M
K
R
G
E
V
Site 28
T229
A
K
P
A
R
P
V
T
V
Y
S
I
S
L
Q
Site 29
S234
P
V
T
V
Y
S
I
S
L
Q
K
F
Q
P
P
Site 30
T244
K
F
Q
P
P
F
F
T
L
D
V
E
C
G
G
Site 31
S267
S
D
I
G
K
E
L
S
S
C
A
N
V
L
E
Site 32
T278
N
V
L
E
L
T
R
T
K
Q
G
P
F
T
L
Site 33
T284
R
T
K
Q
G
P
F
T
L
E
E
H
A
L
P
Site 34
T296
A
L
P
E
D
K
W
T
I
D
D
I
A
Q
S
Site 35
S303
T
I
D
D
I
A
Q
S
L
E
H
C
S
S
L
Site 36
S309
Q
S
L
E
H
C
S
S
L
F
P
A
E
L
A
Site 37
S320
A
E
L
A
L
K
K
S
K
P
E
S
N
E
Q
Site 38
S324
L
K
K
S
K
P
E
S
N
E
Q
V
L
S
C
Site 39
S330
E
S
N
E
Q
V
L
S
C
E
Y
I
T
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation