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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCFD1
Full Name:
Sec1 family domain-containing protein 1
Alias:
C14orf163; KIAA0917; RA410; sec1 family domain containing 1; SLY1; Sly1p; STXBP1L2; syntaxin-binding protein 1-like 2; vesicle transport-related protein
Type:
Vesicle protein
Mass (Da):
72380
Number AA:
642
UniProt ID:
Q8WVM8
International Prot ID:
IPI00165261
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005798
GO:0005801
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0051535
PhosphoSite+
KinaseNET
Biological Process:
GO:0006892
GO:0015031
GO:0060628
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
T
A
A
A
A
A
S
I
R
E
R
Q
T
V
Site 2
T20
A
S
I
R
E
R
Q
T
V
A
L
K
R
M
L
Site 3
S57
R
F
G
Q
D
I
I
S
P
L
L
S
V
K
E
Site 4
S78
T
L
H
L
L
L
H
S
D
R
D
P
I
P
D
Site 5
Y111
Q
D
L
R
N
Q
L
Y
E
S
Y
Y
L
N
F
Site 6
S113
L
R
N
Q
L
Y
E
S
Y
Y
L
N
F
I
S
Site 7
Y114
R
N
Q
L
Y
E
S
Y
Y
L
N
F
I
S
A
Site 8
Y115
N
Q
L
Y
E
S
Y
Y
L
N
F
I
S
A
I
Site 9
S120
S
Y
Y
L
N
F
I
S
A
I
S
R
S
K
L
Site 10
S172
N
Q
N
K
E
L
V
S
Y
R
A
I
N
R
P
Site 11
Y173
Q
N
K
E
L
V
S
Y
R
A
I
N
R
P
D
Site 12
T182
A
I
N
R
P
D
I
T
D
T
E
M
E
T
V
Site 13
T184
N
R
P
D
I
T
D
T
E
M
E
T
V
M
D
Site 14
S239
N
L
R
D
A
R
N
S
L
F
T
G
D
T
L
Site 15
T242
D
A
R
N
S
L
F
T
G
D
T
L
G
A
G
Site 16
T245
N
S
L
F
T
G
D
T
L
G
A
G
Q
F
S
Site 17
T269
D
R
N
I
D
L
A
T
P
L
H
H
T
W
T
Site 18
S297
N
R
V
N
L
E
E
S
S
G
V
E
N
S
P
Site 19
S298
R
V
N
L
E
E
S
S
G
V
E
N
S
P
A
Site 20
S303
E
S
S
G
V
E
N
S
P
A
G
A
R
P
K
Site 21
S316
P
K
R
K
N
K
K
S
Y
D
L
T
P
V
D
Site 22
T320
N
K
K
S
Y
D
L
T
P
V
D
K
F
W
Q
Site 23
S332
F
W
Q
K
H
K
G
S
P
F
P
E
V
A
E
Site 24
S340
P
F
P
E
V
A
E
S
V
Q
Q
E
L
E
S
Site 25
S347
S
V
Q
Q
E
L
E
S
Y
R
A
Q
E
D
E
Site 26
Y348
V
Q
Q
E
L
E
S
Y
R
A
Q
E
D
E
V
Site 27
S360
D
E
V
K
R
L
K
S
I
M
G
L
E
G
E
Site 28
S373
G
E
D
E
G
A
I
S
M
L
S
D
N
T
A
Site 29
T383
S
D
N
T
A
K
L
T
S
A
V
S
S
L
P
Site 30
S384
D
N
T
A
K
L
T
S
A
V
S
S
L
P
E
Site 31
S387
A
K
L
T
S
A
V
S
S
L
P
E
L
L
E
Site 32
S388
K
L
T
S
A
V
S
S
L
P
E
L
L
E
K
Site 33
Y421
K
A
R
K
L
D
V
Y
F
E
Y
E
E
K
I
Site 34
Y424
K
L
D
V
Y
F
E
Y
E
E
K
I
M
S
K
Site 35
S430
E
Y
E
E
K
I
M
S
K
T
T
L
D
K
S
Site 36
T432
E
E
K
I
M
S
K
T
T
L
D
K
S
L
L
Site 37
T433
E
K
I
M
S
K
T
T
L
D
K
S
L
L
D
Site 38
S437
S
K
T
T
L
D
K
S
L
L
D
I
I
S
D
Site 39
S443
K
S
L
L
D
I
I
S
D
P
D
A
G
T
P
Site 40
T449
I
S
D
P
D
A
G
T
P
E
D
K
M
R
L
Site 41
S469
I
S
T
Q
Q
A
P
S
E
A
D
L
E
Q
Y
Site 42
S504
K
A
F
T
K
M
A
S
A
P
A
S
Y
G
S
Site 43
S508
K
M
A
S
A
P
A
S
Y
G
S
T
T
T
K
Site 44
S511
S
A
P
A
S
Y
G
S
T
T
T
K
P
M
G
Site 45
T512
A
P
A
S
Y
G
S
T
T
T
K
P
M
G
L
Site 46
S521
T
K
P
M
G
L
L
S
R
V
M
N
T
G
S
Site 47
S528
S
R
V
M
N
T
G
S
Q
F
V
M
E
G
V
Site 48
S559
D
N
L
M
E
M
K
S
N
P
E
T
D
D
Y
Site 49
T563
E
M
K
S
N
P
E
T
D
D
Y
R
Y
F
D
Site 50
Y566
S
N
P
E
T
D
D
Y
R
Y
F
D
P
K
M
Site 51
Y568
P
E
T
D
D
Y
R
Y
F
D
P
K
M
L
R
Site 52
S579
K
M
L
R
G
N
D
S
S
V
P
R
N
K
N
Site 53
S580
M
L
R
G
N
D
S
S
V
P
R
N
K
N
P
Site 54
Y604
G
G
G
N
Y
I
E
Y
Q
N
L
V
D
Y
I
Site 55
Y610
E
Y
Q
N
L
V
D
Y
I
K
G
K
Q
G
K
Site 56
Y621
K
Q
G
K
H
I
L
Y
G
C
S
E
L
F
N
Site 57
S637
T
Q
F
I
K
Q
L
S
Q
L
G
Q
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation