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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHTF18
Full Name:
Chromosome transmission fidelity protein 18 homolog
Alias:
C16orf41; C321D2.4; CHL12; CTF18
Type:
DNA replication
Mass (Da):
107383
Number AA:
975
UniProt ID:
Q8WVB6
International Prot ID:
IPI00414657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0017111
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
L
A
E
L
E
G
A
S
T
P
S
P
S
G
V
Site 2
T34
A
E
L
E
G
A
S
T
P
S
P
S
G
V
P
Site 3
T44
P
S
G
V
P
L
F
T
A
G
R
P
P
R
T
Site 4
T51
T
A
G
R
P
P
R
T
F
E
E
A
L
A
R
Site 5
S63
L
A
R
G
D
A
A
S
S
P
A
P
A
A
S
Site 6
S64
A
R
G
D
A
A
S
S
P
A
P
A
A
S
V
Site 7
S70
S
S
P
A
P
A
A
S
V
G
S
S
Q
G
G
Site 8
S73
A
P
A
A
S
V
G
S
S
Q
G
G
A
R
K
Site 9
S74
P
A
A
S
V
G
S
S
Q
G
G
A
R
K
R
Site 10
S92
A
D
L
Q
P
A
G
S
L
P
H
A
P
R
I
Site 11
S114
V
K
R
L
N
F
R
S
E
E
M
E
E
P
P
Site 12
S125
E
E
P
P
P
P
D
S
S
P
T
D
I
T
P
Site 13
S126
E
P
P
P
P
D
S
S
P
T
D
I
T
P
P
Site 14
T131
D
S
S
P
T
D
I
T
P
P
P
S
P
E
D
Site 15
S135
T
D
I
T
P
P
P
S
P
E
D
L
A
E
L
Site 16
T157
A
A
A
D
V
G
L
T
R
A
S
P
A
A
R
Site 17
S160
D
V
G
L
T
R
A
S
P
A
A
R
N
P
V
Site 18
Y177
R
P
P
I
L
E
D
Y
V
H
V
T
S
T
E
Site 19
Y189
S
T
E
G
V
R
A
Y
L
V
L
R
A
D
P
Site 20
S225
L
L
G
V
S
L
A
S
L
K
K
Q
V
D
G
Site 21
T248
E
A
Q
K
L
S
D
T
L
H
S
L
R
S
G
Site 22
S251
K
L
S
D
T
L
H
S
L
R
S
G
E
E
E
Site 23
S254
D
T
L
H
S
L
R
S
G
E
E
E
A
A
Q
Site 24
T271
G
A
P
E
E
E
P
T
D
G
Q
D
A
S
S
Site 25
S277
P
T
D
G
Q
D
A
S
S
H
C
L
W
V
D
Site 26
Y291
D
E
F
A
P
R
H
Y
T
E
L
L
S
D
D
Site 27
T292
E
F
A
P
R
H
Y
T
E
L
L
S
D
D
F
Site 28
S296
R
H
Y
T
E
L
L
S
D
D
F
T
N
R
C
Site 29
T300
E
L
L
S
D
D
F
T
N
R
C
L
L
K
W
Site 30
S322
V
F
G
H
E
R
P
S
R
K
P
R
P
S
V
Site 31
S328
P
S
R
K
P
R
P
S
V
E
P
A
R
V
S
Site 32
S335
S
V
E
P
A
R
V
S
K
E
A
T
A
P
G
Site 33
T339
A
R
V
S
K
E
A
T
A
P
G
K
W
K
S
Site 34
S346
T
A
P
G
K
W
K
S
H
E
Q
V
L
E
E
Site 35
S362
L
E
A
G
L
D
P
S
Q
R
P
K
Q
K
V
Site 36
T381
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
Site 37
T382
P
P
G
L
G
K
T
T
L
A
H
V
I
A
R
Site 38
S401
S
V
V
E
M
N
A
S
D
D
R
S
P
E
V
Site 39
S405
M
N
A
S
D
D
R
S
P
E
V
F
R
T
R
Site 40
T411
R
S
P
E
V
F
R
T
R
I
E
A
A
T
Q
Site 41
T417
R
T
R
I
E
A
A
T
Q
M
E
S
V
L
G
Site 42
S421
E
A
A
T
Q
M
E
S
V
L
G
A
G
G
K
Site 43
S497
C
N
D
Q
F
A
P
S
L
R
Q
L
K
Q
Q
Site 44
S526
V
Q
R
L
Q
E
V
S
L
R
Q
G
M
R
A
Site 45
Y560
I
N
T
L
Q
F
L
Y
S
R
G
Q
R
E
L
Site 46
S561
N
T
L
Q
F
L
Y
S
R
G
Q
R
E
L
S
Site 47
S568
S
R
G
Q
R
E
L
S
V
R
D
V
Q
A
T
Site 48
T575
S
V
R
D
V
Q
A
T
R
V
G
L
K
D
Q
Site 49
S588
D
Q
R
R
G
L
F
S
V
W
Q
E
V
F
Q
Site 50
S624
L
G
D
G
D
A
G
S
L
T
S
A
S
Q
R
Site 51
T626
D
G
D
A
G
S
L
T
S
A
S
Q
R
F
Y
Site 52
S627
G
D
A
G
S
L
T
S
A
S
Q
R
F
Y
R
Site 53
S629
A
G
S
L
T
S
A
S
Q
R
F
Y
R
V
L
Site 54
Y633
T
S
A
S
Q
R
F
Y
R
V
L
H
A
A
A
Site 55
S641
R
V
L
H
A
A
A
S
A
G
E
H
E
K
V
Site 56
S689
L
A
G
A
A
H
H
S
Q
S
F
Q
L
L
R
Site 57
S691
G
A
A
H
H
S
Q
S
F
Q
L
L
R
Y
P
Site 58
T718
S
S
H
T
P
R
I
T
F
P
S
S
Q
Q
E
Site 59
S721
T
P
R
I
T
F
P
S
S
Q
Q
E
A
Q
N
Site 60
S722
P
R
I
T
F
P
S
S
Q
Q
E
A
Q
N
R
Site 61
S731
Q
E
A
Q
N
R
M
S
Q
M
R
N
L
I
Q
Site 62
S742
N
L
I
Q
T
L
V
S
G
I
A
P
A
T
R
Site 63
T748
V
S
G
I
A
P
A
T
R
S
R
A
T
P
Q
Site 64
S750
G
I
A
P
A
T
R
S
R
A
T
P
Q
A
L
Site 65
T753
P
A
T
R
S
R
A
T
P
Q
A
L
L
L
D
Site 66
S777
A
P
K
L
R
P
V
S
T
Q
L
Y
S
T
R
Site 67
T778
P
K
L
R
P
V
S
T
Q
L
Y
S
T
R
E
Site 68
Y781
R
P
V
S
T
Q
L
Y
S
T
R
E
K
Q
Q
Site 69
S782
P
V
S
T
Q
L
Y
S
T
R
E
K
Q
Q
L
Site 70
S791
R
E
K
Q
Q
L
A
S
L
V
G
T
M
L
A
Site 71
S800
V
G
T
M
L
A
Y
S
L
T
Y
R
Q
E
R
Site 72
T802
T
M
L
A
Y
S
L
T
Y
R
Q
E
R
T
P
Site 73
T808
L
T
Y
R
Q
E
R
T
P
D
G
Q
Y
I
Y
Site 74
Y813
E
R
T
P
D
G
Q
Y
I
Y
R
L
E
P
N
Site 75
T837
L
P
A
R
K
P
L
T
Y
Q
T
K
Q
L
I
Site 76
Y838
P
A
R
K
P
L
T
Y
Q
T
K
Q
L
I
A
Site 77
S859
K
M
R
R
A
E
A
S
A
R
V
E
N
S
P
Site 78
S865
A
S
A
R
V
E
N
S
P
Q
V
D
G
S
P
Site 79
S871
N
S
P
Q
V
D
G
S
P
P
G
L
E
G
L
Site 80
T933
A
V
P
S
A
G
D
T
A
P
E
Q
D
S
V
Site 81
S939
D
T
A
P
E
Q
D
S
V
E
R
R
M
G
T
Site 82
T946
S
V
E
R
R
M
G
T
A
V
G
R
S
E
V
Site 83
Y970
N
A
V
R
R
S
L
Y
I
R
D
L
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation