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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Alix
Full Name:
Programmed cell death 6-interacting protein
Alias:
AIP1; ALG-2 interacting protein 1; ALG-2 interacting protein X; Alix/AIP1; Hp95; PDC6I; PDCD6-interacting protein; PDCD6IP; Programmed cell death 6 interacting protein
Type:
Apoptosis; Adaptor/scaffold
Mass (Da):
96023
Number AA:
868
UniProt ID:
Q8WUM4
International Prot ID:
IPI00246058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0048306
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007049
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
V
K
F
I
Q
Q
T
Y
P
S
G
G
E
E
Q
Site 2
Y39
G
G
E
E
Q
A
Q
Y
C
R
A
A
E
E
L
Site 3
S47
C
R
A
A
E
E
L
S
K
L
R
R
A
A
V
Site 4
Y72
L
E
T
L
L
R
Y
Y
D
Q
I
C
S
I
E
Site 5
S85
I
E
P
K
F
P
F
S
E
N
Q
I
C
L
T
Site 6
S103
K
D
A
F
D
K
G
S
L
F
G
G
S
V
K
Site 7
S169
H
I
K
E
T
V
L
S
A
L
S
R
E
P
T
Site 8
T176
S
A
L
S
R
E
P
T
V
D
I
S
P
D
T
Site 9
S180
R
E
P
T
V
D
I
S
P
D
T
V
G
T
L
Site 10
T186
I
S
P
D
T
V
G
T
L
S
L
I
M
L
A
Site 11
Y223
L
A
N
Q
A
A
D
Y
F
G
D
A
F
K
Q
Site 12
T236
K
Q
C
Q
Y
K
D
T
L
P
K
E
V
F
P
Site 13
T286
H
A
A
E
L
I
K
T
V
A
S
R
Y
D
E
Site 14
Y294
V
A
S
R
Y
D
E
Y
V
N
V
K
D
F
S
Site 15
Y319
K
K
D
N
D
F
I
Y
H
D
R
V
P
D
L
Site 16
S366
V
P
V
S
V
Q
Q
S
L
A
A
Y
N
Q
R
Site 17
Y370
V
Q
Q
S
L
A
A
Y
N
Q
R
K
A
D
L
Site 18
S409
P
A
A
I
E
D
V
S
G
D
T
V
P
Q
S
Site 19
S416
S
G
D
T
V
P
Q
S
I
L
T
K
S
R
S
Site 20
T419
T
V
P
Q
S
I
L
T
K
S
R
S
V
I
E
Site 21
S421
P
Q
S
I
L
T
K
S
R
S
V
I
E
Q
G
Site 22
S423
S
I
L
T
K
S
R
S
V
I
E
Q
G
G
I
Site 23
S454
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
Site 24
T464
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
Site 25
T479
F
K
E
R
W
Q
R
T
P
S
N
E
L
Y
K
Site 26
S481
E
R
W
Q
R
T
P
S
N
E
L
Y
K
P
L
Site 27
Y485
R
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
Site 28
T493
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
Site 29
T497
A
E
G
T
N
F
R
T
V
L
D
K
A
V
Q
Site 30
Y513
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
Site 31
T519
C
Y
Q
S
H
R
D
T
I
V
L
L
C
K
P
Site 32
T542
P
S
A
N
P
A
K
T
M
Q
G
S
E
V
V
Site 33
S557
N
V
L
K
S
L
L
S
N
L
D
E
V
K
K
Site 34
S575
G
L
E
N
D
L
K
S
V
N
F
D
M
T
S
Site 35
T681
T
K
F
Y
N
E
L
T
E
I
L
V
R
F
Q
Site 36
T700
D
I
V
F
A
R
K
T
E
R
D
E
L
L
K
Site 37
S712
L
L
K
D
L
Q
Q
S
I
A
R
E
P
S
A
Site 38
S718
Q
S
I
A
R
E
P
S
A
P
S
I
P
T
P
Site 39
T724
P
S
A
P
S
I
P
T
P
A
Y
Q
S
S
P
Site 40
Y727
P
S
I
P
T
P
A
Y
Q
S
S
P
A
G
G
Site 41
S729
I
P
T
P
A
Y
Q
S
S
P
A
G
G
H
A
Site 42
S730
P
T
P
A
Y
Q
S
S
P
A
G
G
H
A
P
Site 43
T738
P
A
G
G
H
A
P
T
P
P
T
P
A
P
R
Site 44
T741
G
H
A
P
T
P
P
T
P
A
P
R
T
M
P
Site 45
T746
P
P
T
P
A
P
R
T
M
P
P
T
K
P
Q
Site 46
T750
A
P
R
T
M
P
P
T
K
P
Q
P
P
A
R
Site 47
S770
L
P
A
N
R
A
P
S
A
T
A
P
S
P
V
Site 48
T772
A
N
R
A
P
S
A
T
A
P
S
P
V
G
A
Site 49
T781
P
S
P
V
G
A
G
T
A
A
P
A
P
S
Q
Site 50
S787
G
T
A
A
P
A
P
S
Q
T
P
G
S
A
P
Site 51
T789
A
A
P
A
P
S
Q
T
P
G
S
A
P
P
P
Site 52
S792
A
P
S
Q
T
P
G
S
A
P
P
P
Q
A
Q
Site 53
Y803
P
Q
A
Q
G
P
P
Y
P
T
Y
P
G
Y
P
Site 54
T805
A
Q
G
P
P
Y
P
T
Y
P
G
Y
P
G
Y
Site 55
Y806
Q
G
P
P
Y
P
T
Y
P
G
Y
P
G
Y
C
Site 56
Y809
P
Y
P
T
Y
P
G
Y
P
G
Y
C
Q
M
P
Site 57
Y829
N
P
Y
A
Y
G
Q
Y
N
M
P
Y
P
P
V
Site 58
Y833
Y
G
Q
Y
N
M
P
Y
P
P
V
Y
H
Q
S
Site 59
Y837
N
M
P
Y
P
P
V
Y
H
Q
S
P
G
Q
A
Site 60
S840
Y
P
P
V
Y
H
Q
S
P
G
Q
A
P
Y
P
Site 61
Y846
Q
S
P
G
Q
A
P
Y
P
G
P
Q
Q
P
S
Site 62
S853
Y
P
G
P
Q
Q
P
S
Y
P
F
P
Q
P
P
Site 63
Y854
P
G
P
Q
Q
P
S
Y
P
F
P
Q
P
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation