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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF3C2
Full Name:
General transcription factor 3C polypeptide 2
Alias:
General transcription factor IIIC, polypeptide 2 (beta subunit, 110kD); General transcription factor IIIC, polypeptide 2, beta 110kDa; KIAA0011; TF3C2; TF3C-beta; TFIIIC 110 kDa; TFIIIC110; TFIIIC-BETA; Transcription factor IIIC subunit beta; Transcription factor IIIC-beta
Type:
Transcription initiation complex
Mass (Da):
100680
Number AA:
911
UniProt ID:
Q8WUA4
International Prot ID:
IPI00412837
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000127
GO:0005634
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003677
GO:0003709
PhosphoSite+
KinaseNET
Biological Process:
GO:0042791
GO:0042797
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
A
G
P
V
G
N
M
T
V
V
D
S
P
G
Q
Site 2
S25
G
N
M
T
V
V
D
S
P
G
Q
E
V
L
N
Site 3
T38
L
N
Q
L
D
V
K
T
S
S
E
M
T
S
A
Site 4
S39
N
Q
L
D
V
K
T
S
S
E
M
T
S
A
E
Site 5
S40
Q
L
D
V
K
T
S
S
E
M
T
S
A
E
A
Site 6
S44
K
T
S
S
E
M
T
S
A
E
A
S
V
E
M
Site 7
S48
E
M
T
S
A
E
A
S
V
E
M
S
L
P
T
Site 8
T55
S
V
E
M
S
L
P
T
P
L
P
G
F
E
D
Site 9
S63
P
L
P
G
F
E
D
S
P
D
Q
R
R
L
P
Site 10
S75
R
L
P
P
E
Q
E
S
L
S
R
L
E
Q
P
Site 11
S77
P
P
E
Q
E
S
L
S
R
L
E
Q
P
D
L
Site 12
S85
R
L
E
Q
P
D
L
S
S
E
M
S
K
V
S
Site 13
S86
L
E
Q
P
D
L
S
S
E
M
S
K
V
S
K
Site 14
S89
P
D
L
S
S
E
M
S
K
V
S
K
P
R
A
Site 15
S92
S
S
E
M
S
K
V
S
K
P
R
A
S
K
P
Site 16
S97
K
V
S
K
P
R
A
S
K
P
G
R
K
R
G
Site 17
S121
P
Q
Q
P
N
P
P
S
A
P
L
V
P
G
L
Site 18
S132
V
P
G
L
L
D
Q
S
N
P
L
S
T
P
M
Site 19
S136
L
D
Q
S
N
P
L
S
T
P
M
P
K
K
R
Site 20
T137
D
Q
S
N
P
L
S
T
P
M
P
K
K
R
G
Site 21
S147
P
K
K
R
G
R
K
S
K
A
E
L
L
L
L
Site 22
S157
E
L
L
L
L
K
L
S
K
D
L
D
R
P
E
Site 23
S165
K
D
L
D
R
P
E
S
Q
S
P
K
R
P
P
Site 24
S167
L
D
R
P
E
S
Q
S
P
K
R
P
P
E
D
Site 25
T177
R
P
P
E
D
F
E
T
P
S
G
E
R
P
R
Site 26
S220
P
E
G
P
K
V
S
S
P
T
K
P
K
K
I
Site 27
T222
G
P
K
V
S
S
P
T
K
P
K
K
I
R
Q
Site 28
S260
E
A
E
D
V
E
E
S
E
G
P
S
E
S
S
Site 29
S264
V
E
E
S
E
G
P
S
E
S
S
S
E
P
E
Site 30
S267
S
E
G
P
S
E
S
S
S
E
P
E
P
V
V
Site 31
S268
E
G
P
S
E
S
S
S
E
P
E
P
V
V
P
Site 32
S277
P
E
P
V
V
P
R
S
T
P
R
G
S
T
S
Site 33
T278
E
P
V
V
P
R
S
T
P
R
G
S
T
S
G
Site 34
S282
P
R
S
T
P
R
G
S
T
S
G
K
Q
K
P
Site 35
T283
R
S
T
P
R
G
S
T
S
G
K
Q
K
P
H
Site 36
S284
S
T
P
R
G
S
T
S
G
K
Q
K
P
H
C
Site 37
Y348
S
E
L
E
A
A
P
Y
L
P
Q
E
E
K
S
Site 38
S355
Y
L
P
Q
E
E
K
S
P
L
F
S
V
Q
R
Site 39
S359
E
E
K
S
P
L
F
S
V
Q
R
E
G
L
P
Site 40
T370
E
G
L
P
E
D
G
T
L
Y
R
I
N
R
F
Site 41
Y372
L
P
E
D
G
T
L
Y
R
I
N
R
F
S
S
Site 42
S378
L
Y
R
I
N
R
F
S
S
I
T
A
H
P
E
Site 43
S379
Y
R
I
N
R
F
S
S
I
T
A
H
P
E
R
Site 44
T381
I
N
R
F
S
S
I
T
A
H
P
E
R
W
D
Site 45
S390
H
P
E
R
W
D
V
S
F
F
T
G
G
P
L
Site 46
S419
S
Q
Y
V
A
L
F
S
S
P
D
M
N
E
T
Site 47
S420
Q
Y
V
A
L
F
S
S
P
D
M
N
E
T
H
Site 48
T426
S
S
P
D
M
N
E
T
H
P
L
S
Q
L
H
Site 49
S430
M
N
E
T
H
P
L
S
Q
L
H
S
G
P
G
Site 50
S434
H
P
L
S
Q
L
H
S
G
P
G
L
L
Q
L
Site 51
T446
L
Q
L
W
G
L
G
T
L
Q
Q
E
S
C
P
Site 52
S451
L
G
T
L
Q
Q
E
S
C
P
G
N
R
A
H
Site 53
Y461
G
N
R
A
H
F
V
Y
G
I
A
C
D
N
G
Site 54
T486
G
A
W
E
L
P
G
T
P
R
K
A
P
L
L
Site 55
T549
Q
V
G
S
M
Q
A
T
D
P
S
E
C
G
Q
Site 56
S552
S
M
Q
A
T
D
P
S
E
C
G
Q
C
L
S
Site 57
S589
F
W
N
L
P
T
N
S
P
L
Q
R
I
R
L
Site 58
S597
P
L
Q
R
I
R
L
S
D
G
S
L
K
L
Y
Site 59
S600
R
I
R
L
S
D
G
S
L
K
L
Y
P
F
Q
Site 60
S634
H
F
L
V
S
A
G
S
D
R
K
I
K
F
W
Site 61
Y647
F
W
D
L
R
R
P
Y
E
P
I
N
S
I
K
Site 62
S652
R
P
Y
E
P
I
N
S
I
K
R
F
L
S
T
Site 63
Y678
T
V
A
Q
D
N
C
Y
A
S
Y
G
L
C
G
Site 64
Y699
G
Y
L
G
F
K
A
Y
F
T
A
P
R
K
G
Site 65
T701
L
G
F
K
A
Y
F
T
A
P
R
K
G
T
V
Site 66
T707
F
T
A
P
R
K
G
T
V
W
S
L
S
G
S
Site 67
S710
P
R
K
G
T
V
W
S
L
S
G
S
D
W
L
Site 68
S712
K
G
T
V
W
S
L
S
G
S
D
W
L
G
T
Site 69
Y755
V
E
R
R
F
P
I
Y
K
A
D
L
I
P
Y
Site 70
S765
D
L
I
P
Y
Q
D
S
P
E
G
P
D
H
S
Site 71
S772
S
P
E
G
P
D
H
S
S
A
S
S
G
V
P
Site 72
S773
P
E
G
P
D
H
S
S
A
S
S
G
V
P
N
Site 73
S776
P
D
H
S
S
A
S
S
G
V
P
N
P
P
K
Site 74
Y787
N
P
P
K
A
R
T
Y
T
E
T
V
N
H
H
Site 75
T788
P
P
K
A
R
T
Y
T
E
T
V
N
H
H
Y
Site 76
T790
K
A
R
T
Y
T
E
T
V
N
H
H
Y
L
L
Site 77
T801
H
Y
L
L
F
Q
D
T
D
L
G
S
F
H
D
Site 78
S805
F
Q
D
T
D
L
G
S
F
H
D
L
L
R
R
Site 79
S843
A
I
H
K
V
R
F
S
P
N
L
D
S
Y
G
Site 80
S848
R
F
S
P
N
L
D
S
Y
G
W
L
V
S
G
Site 81
Y849
F
S
P
N
L
D
S
Y
G
W
L
V
S
G
G
Site 82
S854
D
S
Y
G
W
L
V
S
G
G
Q
S
G
L
V
Site 83
S871
H
F
V
R
G
L
A
S
P
L
G
H
R
M
Q
Site 84
S892
F
N
A
M
F
Q
P
S
S
P
T
R
R
P
G
Site 85
S893
N
A
M
F
Q
P
S
S
P
T
R
R
P
G
F
Site 86
T895
M
F
Q
P
S
S
P
T
R
R
P
G
F
S
P
Site 87
S901
P
T
R
R
P
G
F
S
P
T
S
H
R
L
L
Site 88
T903
R
R
P
G
F
S
P
T
S
H
R
L
L
P
T
Site 89
S904
R
P
G
F
S
P
T
S
H
R
L
L
P
T
P
Site 90
T910
T
S
H
R
L
L
P
T
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation