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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP8B4
Full Name:
Probable phospholipid-transporting ATPase IM
Alias:
AT8B4; ATPase class I type 8B member 4; ATPase, class I, type 8B, member 4; ATPIM; KIAA1939
Type:
Hydrolase; Transporter; EC 3.6.3.1
Mass (Da):
135870
Number AA:
UniProt ID:
Q8TF62
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015914
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
V
K
A
N
D
R
E
Y
N
E
K
F
Q
Y
A
Site 2
Y28
E
Y
N
E
K
F
Q
Y
A
D
N
R
I
H
T
Site 3
T35
Y
A
D
N
R
I
H
T
S
K
Y
N
I
L
T
Site 4
Y38
N
R
I
H
T
S
K
Y
N
I
L
T
F
L
P
Site 5
T97
M
T
A
V
K
D
A
T
D
D
Y
F
R
H
K
Site 6
Y100
V
K
D
A
T
D
D
Y
F
R
H
K
S
D
N
Site 7
S114
N
Q
V
N
N
R
Q
S
E
V
L
I
N
S
K
Site 8
Y161
S
E
P
H
G
L
C
Y
V
E
T
A
E
L
D
Site 9
S190
S
E
L
G
A
D
I
S
R
L
A
G
F
D
G
Site 10
S216
D
K
F
M
G
I
L
S
W
K
D
S
K
H
S
Site 11
S220
G
I
L
S
W
K
D
S
K
H
S
L
N
N
E
Site 12
S223
S
W
K
D
S
K
H
S
L
N
N
E
K
I
I
Site 13
T253
V
I
F
A
G
P
D
T
K
L
M
Q
N
S
G
Site 14
S268
K
T
K
F
K
R
T
S
I
D
R
L
M
N
T
Site 15
S300
I
G
N
S
I
W
E
S
Q
T
G
D
Q
F
R
Site 16
S318
F
W
N
E
G
E
K
S
S
V
F
S
G
F
L
Site 17
S319
W
N
E
G
E
K
S
S
V
F
S
G
F
L
T
Site 18
S322
G
E
K
S
S
V
F
S
G
F
L
T
F
W
S
Site 19
Y355
V
I
R
L
G
H
S
Y
F
I
N
W
D
R
K
Site 20
Y364
I
N
W
D
R
K
M
Y
Y
S
R
K
A
I
P
Site 21
Y365
N
W
D
R
K
M
Y
Y
S
R
K
A
I
P
A
Site 22
T378
P
A
V
A
R
T
T
T
L
N
E
E
L
G
Q
Site 23
S391
G
Q
I
E
Y
I
F
S
D
K
T
G
T
L
T
Site 24
T394
E
Y
I
F
S
D
K
T
G
T
L
T
Q
N
I
Site 25
T398
S
D
K
T
G
T
L
T
Q
N
I
M
T
F
K
Site 26
T403
T
L
T
Q
N
I
M
T
F
K
R
C
S
I
N
Site 27
Y414
C
S
I
N
G
R
I
Y
G
E
V
H
D
D
L
Site 28
T425
H
D
D
L
D
Q
K
T
E
I
T
Q
E
K
E
Site 29
S437
E
K
E
P
V
D
F
S
V
K
S
Q
A
D
R
Site 30
S440
P
V
D
F
S
V
K
S
Q
A
D
R
E
F
Q
Site 31
T476
R
L
L
A
L
C
H
T
V
M
S
E
E
N
S
Site 32
S479
A
L
C
H
T
V
M
S
E
E
N
S
A
G
E
Site 33
S483
T
V
M
S
E
E
N
S
A
G
E
L
I
Y
Q
Site 34
Y489
N
S
A
G
E
L
I
Y
Q
V
Q
S
P
D
E
Site 35
S493
E
L
I
Y
Q
V
Q
S
P
D
E
G
A
L
V
Site 36
S512
N
F
G
F
I
F
K
S
R
T
P
E
T
I
T
Site 37
T514
G
F
I
F
K
S
R
T
P
E
T
I
T
I
E
Site 38
T540
A
F
L
D
F
N
N
T
R
K
R
M
S
V
I
Site 39
S545
N
N
T
R
K
R
M
S
V
I
V
R
N
P
E
Site 40
Y558
P
E
G
Q
I
K
L
Y
S
K
G
A
D
T
I
Site 41
S579
P
S
N
E
V
L
L
S
L
T
S
D
H
L
S
Site 42
S586
S
L
T
S
D
H
L
S
E
F
A
G
E
G
L
Site 43
Y607
Y
R
D
L
D
D
K
Y
F
K
E
W
H
K
M
Site 44
Y633
D
E
R
I
A
G
L
Y
E
E
I
E
R
D
L
Site 45
S744
K
Q
Q
L
E
L
D
S
I
V
E
E
T
I
T
Site 46
Y754
E
E
T
I
T
G
D
Y
A
L
I
I
N
G
H
Site 47
Y805
V
V
E
L
V
K
K
Y
R
N
A
V
T
L
A
Site 48
S821
G
D
G
A
N
D
V
S
M
I
K
S
A
H
I
Site 49
Y846
Q
A
V
L
A
S
D
Y
S
F
A
Q
F
R
Y
Site 50
S930
G
I
F
D
Q
D
V
S
D
Q
N
S
V
D
C
Site 51
S934
Q
D
V
S
D
Q
N
S
V
D
C
P
Q
L
Y
Site 52
Y941
S
V
D
C
P
Q
L
Y
K
P
G
Q
L
N
L
Site 53
Y991
D
G
Q
H
I
A
D
Y
Q
S
F
A
V
T
M
Site 54
T1063
G
N
A
R
H
S
L
T
Q
K
C
I
W
L
V
Site 55
Y1093
R
F
L
K
V
D
L
Y
P
T
L
S
D
Q
I
Site 56
T1095
L
K
V
D
L
Y
P
T
L
S
D
Q
I
R
R
Site 57
S1097
V
D
L
Y
P
T
L
S
D
Q
I
R
R
W
Q
Site 58
S1114
Q
K
K
A
R
P
P
S
S
R
R
P
R
T
R
Site 59
S1115
K
K
A
R
P
P
S
S
R
R
P
R
T
R
R
Site 60
T1120
P
S
S
R
R
P
R
T
R
R
S
S
S
R
R
Site 61
S1123
R
R
P
R
T
R
R
S
S
S
R
R
S
G
Y
Site 62
S1124
R
P
R
T
R
R
S
S
S
R
R
S
G
Y
A
Site 63
S1125
P
R
T
R
R
S
S
S
R
R
S
G
Y
A
F
Site 64
S1128
R
R
S
S
S
R
R
S
G
Y
A
F
A
H
Q
Site 65
Y1130
S
S
S
R
R
S
G
Y
A
F
A
H
Q
E
G
Site 66
S1144
G
Y
G
E
L
I
T
S
G
K
N
M
R
A
K
Site 67
S1157
A
K
N
P
P
P
T
S
G
L
E
K
T
H
Y
Site 68
T1162
P
T
S
G
L
E
K
T
H
Y
N
S
T
S
W
Site 69
Y1164
S
G
L
E
K
T
H
Y
N
S
T
S
W
I
E
Site 70
T1177
I
E
N
L
C
K
K
T
T
D
T
V
S
S
F
Site 71
T1178
E
N
L
C
K
K
T
T
D
T
V
S
S
F
S
Site 72
T1180
L
C
K
K
T
T
D
T
V
S
S
F
S
Q
D
Site 73
S1183
K
T
T
D
T
V
S
S
F
S
Q
D
K
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation