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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP4R1
Full Name:
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Alias:
MEG1; PP4(Rmeg); PP4R1; Protein phosphatase 4, regulatory subunit 1
Type:
Mass (Da):
106986
Number AA:
950
UniProt ID:
Q8TF05
International Prot ID:
IPI00411730
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0030362
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
D
G
F
G
V
D
D
Y
S
S
E
S
D
V
I
Site 2
S24
G
F
G
V
D
D
Y
S
S
E
S
D
V
I
I
Site 3
S27
V
D
D
Y
S
S
E
S
D
V
I
I
I
P
S
Site 4
S40
P
S
A
L
D
F
V
S
Q
D
E
M
L
T
P
Site 5
T46
V
S
Q
D
E
M
L
T
P
L
G
R
L
D
K
Site 6
Y54
P
L
G
R
L
D
K
Y
A
A
S
E
N
I
F
Site 7
S57
R
L
D
K
Y
A
A
S
E
N
I
F
N
R
Q
Site 8
S69
N
R
Q
M
V
A
R
S
L
L
D
T
L
R
E
Site 9
T73
V
A
R
S
L
L
D
T
L
R
E
V
C
D
D
Site 10
S92
I
A
V
L
E
R
I
S
R
L
A
D
D
S
E
Site 11
S98
I
S
R
L
A
D
D
S
E
P
T
V
R
A
E
Site 12
T101
L
A
D
D
S
E
P
T
V
R
A
E
L
M
E
Site 13
S123
F
C
Q
E
N
R
P
S
I
P
Y
A
F
S
K
Site 14
Y126
E
N
R
P
S
I
P
Y
A
F
S
K
F
L
L
Site 15
T150
Q
N
N
Q
V
R
K
T
S
Q
A
A
L
L
A
Site 16
S151
N
N
Q
V
R
K
T
S
Q
A
A
L
L
A
L
Site 17
T181
C
P
V
L
I
E
L
T
A
P
D
S
N
D
D
Site 18
S185
I
E
L
T
A
P
D
S
N
D
D
V
K
T
E
Site 19
T191
D
S
N
D
D
V
K
T
E
A
V
A
I
M
C
Site 20
T209
P
M
V
G
K
D
I
T
E
R
L
I
L
P
R
Site 21
S320
Q
S
L
G
P
F
I
S
T
F
A
N
P
S
S
Site 22
T321
S
L
G
P
F
I
S
T
F
A
N
P
S
S
S
Site 23
S326
I
S
T
F
A
N
P
S
S
S
G
Q
Y
F
K
Site 24
S327
S
T
F
A
N
P
S
S
S
G
Q
Y
F
K
E
Site 25
S328
T
F
A
N
P
S
S
S
G
Q
Y
F
K
E
E
Site 26
Y331
N
P
S
S
S
G
Q
Y
F
K
E
E
S
K
S
Site 27
S336
G
Q
Y
F
K
E
E
S
K
S
S
E
E
M
S
Site 28
S338
Y
F
K
E
E
S
K
S
S
E
E
M
S
V
E
Site 29
S339
F
K
E
E
S
K
S
S
E
E
M
S
V
E
N
Site 30
S343
S
K
S
S
E
E
M
S
V
E
N
K
N
R
T
Site 31
T366
V
Q
V
R
P
E
D
T
P
S
D
L
S
V
S
Site 32
S368
V
R
P
E
D
T
P
S
D
L
S
V
S
N
S
Site 33
S371
E
D
T
P
S
D
L
S
V
S
N
S
S
V
I
Site 34
S373
T
P
S
D
L
S
V
S
N
S
S
V
I
L
E
Site 35
S375
S
D
L
S
V
S
N
S
S
V
I
L
E
N
T
Site 36
S399
G
K
P
L
G
E
I
S
V
P
L
D
S
S
L
Site 37
T409
L
D
S
S
L
L
C
T
L
S
S
E
S
H
Q
Site 38
S411
S
S
L
L
C
T
L
S
S
E
S
H
Q
E
A
Site 39
S412
S
L
L
C
T
L
S
S
E
S
H
Q
E
A
A
Site 40
S432
K
K
P
G
N
Y
K
S
M
L
R
P
E
V
G
Site 41
T440
M
L
R
P
E
V
G
T
T
S
Q
D
S
A
L
Site 42
T441
L
R
P
E
V
G
T
T
S
Q
D
S
A
L
L
Site 43
S442
R
P
E
V
G
T
T
S
Q
D
S
A
L
L
D
Site 44
Y453
A
L
L
D
Q
E
L
Y
N
S
F
H
F
W
R
Site 45
T461
N
S
F
H
F
W
R
T
P
L
P
E
I
D
L
Site 46
S481
Q
N
S
G
G
K
P
S
P
E
G
P
E
E
E
Site 47
S489
P
E
G
P
E
E
E
S
E
G
P
V
P
S
S
Site 48
S495
E
S
E
G
P
V
P
S
S
P
N
I
T
M
A
Site 49
S496
S
E
G
P
V
P
S
S
P
N
I
T
M
A
T
Site 50
T500
V
P
S
S
P
N
I
T
M
A
T
R
K
E
L
Site 51
S537
L
S
A
A
L
R
A
S
S
L
D
A
H
E
E
Site 52
S538
S
A
A
L
R
A
S
S
L
D
A
H
E
E
T
Site 53
S547
D
A
H
E
E
T
I
S
I
E
K
R
S
D
L
Site 54
S573
C
K
I
N
Q
E
D
S
V
P
L
I
S
D
A
Site 55
S578
E
D
S
V
P
L
I
S
D
A
V
E
N
M
D
Site 56
T587
A
V
E
N
M
D
S
T
L
H
Y
I
H
S
D
Site 57
Y590
N
M
D
S
T
L
H
Y
I
H
S
D
S
D
L
Site 58
S593
S
T
L
H
Y
I
H
S
D
S
D
L
S
N
N
Site 59
S595
L
H
Y
I
H
S
D
S
D
L
S
N
N
S
S
Site 60
S598
I
H
S
D
S
D
L
S
N
N
S
S
F
S
P
Site 61
S602
S
D
L
S
N
N
S
S
F
S
P
D
E
E
R
Site 62
S604
L
S
N
N
S
S
F
S
P
D
E
E
R
R
T
Site 63
T611
S
P
D
E
E
R
R
T
K
V
Q
D
V
V
P
Site 64
Y625
P
Q
A
L
L
D
Q
Y
L
S
M
T
D
P
S
Site 65
S627
A
L
L
D
Q
Y
L
S
M
T
D
P
S
R
A
Site 66
T636
T
D
P
S
R
A
Q
T
V
D
T
E
I
A
K
Site 67
T639
S
R
A
Q
T
V
D
T
E
I
A
K
H
C
A
Site 68
T655
S
L
P
G
V
A
L
T
L
G
R
Q
N
W
H
Site 69
T667
N
W
H
C
L
R
E
T
Y
E
T
L
A
S
D
Site 70
Y668
W
H
C
L
R
E
T
Y
E
T
L
A
S
D
M
Site 71
S673
E
T
Y
E
T
L
A
S
D
M
Q
W
K
V
R
Site 72
T682
M
Q
W
K
V
R
R
T
L
A
F
S
I
H
E
Site 73
Y740
H
I
D
K
R
R
E
Y
L
Y
Q
L
Q
E
F
Site 74
Y742
D
K
R
R
E
Y
L
Y
Q
L
Q
E
F
L
V
Site 75
T750
Q
L
Q
E
F
L
V
T
D
N
S
R
N
W
R
Site 76
Y779
L
Y
S
P
R
D
V
Y
D
Y
L
R
P
I
A
Site 77
Y781
S
P
R
D
V
Y
D
Y
L
R
P
I
A
L
N
Site 78
S796
L
C
A
D
K
V
S
S
V
R
W
I
S
Y
K
Site 79
T816
V
K
K
L
H
A
A
T
P
P
T
F
G
V
D
Site 80
T892
L
A
K
T
L
R
Q
T
L
L
E
K
D
Y
F
Site 81
S902
E
K
D
Y
F
L
A
S
A
S
C
H
Q
E
A
Site 82
S923
A
L
Q
M
D
R
D
S
D
V
K
Y
F
A
S
Site 83
Y927
D
R
D
S
D
V
K
Y
F
A
S
I
H
P
A
Site 84
S930
S
D
V
K
Y
F
A
S
I
H
P
A
S
T
K
Site 85
S935
F
A
S
I
H
P
A
S
T
K
I
S
E
D
A
Site 86
S939
H
P
A
S
T
K
I
S
E
D
A
M
S
T
A
Site 87
S944
K
I
S
E
D
A
M
S
T
A
S
S
T
Y
_
Site 88
S947
E
D
A
M
S
T
A
S
S
T
Y
_
_
_
_
Site 89
S948
D
A
M
S
T
A
S
S
T
Y
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation