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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOK4
Full Name:
Docking protein 4
Alias:
Downstream of tyrosine kinase 4; FLJ10488
Type:
Adaptor/scaffold; Cell development/differentiation
Mass (Da):
37028
Number AA:
326
UniProt ID:
Q8TEW6
International Prot ID:
IPI00550728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
S
D
I
V
K
Q
G
Y
V
K
M
K
S
R
K
Site 2
S18
Q
G
Y
V
K
M
K
S
R
K
L
G
I
Y
R
Site 3
Y24
K
S
R
K
L
G
I
Y
R
R
C
W
L
V
F
Site 4
S34
C
W
L
V
F
R
K
S
S
S
K
G
P
Q
R
Site 5
S35
W
L
V
F
R
K
S
S
S
K
G
P
Q
R
L
Site 6
S36
L
V
F
R
K
S
S
S
K
G
P
Q
R
L
E
Site 7
Y45
G
P
Q
R
L
E
K
Y
P
D
E
K
S
V
C
Site 8
S50
E
K
Y
P
D
E
K
S
V
C
L
R
G
C
P
Site 9
T75
V
T
R
L
P
K
E
T
K
R
Q
A
V
A
I
Site 10
T91
F
T
D
D
S
A
R
T
F
T
C
D
S
E
L
Site 11
T93
D
D
S
A
R
T
F
T
C
D
S
E
L
E
A
Site 12
S96
A
R
T
F
T
C
D
S
E
L
E
A
E
E
W
Site 13
Y104
E
L
E
A
E
E
W
Y
K
T
L
S
V
E
C
Site 14
T106
E
A
E
E
W
Y
K
T
L
S
V
E
C
L
G
Site 15
S108
E
E
W
Y
K
T
L
S
V
E
C
L
G
S
R
Site 16
S120
G
S
R
L
N
D
I
S
L
G
E
P
D
L
L
Site 17
T136
P
G
V
Q
C
E
Q
T
D
R
F
N
V
F
L
Site 18
Y152
P
C
P
N
L
D
V
Y
G
E
C
K
L
Q
I
Site 19
Y165
Q
I
T
H
E
N
I
Y
L
W
D
I
H
N
P
Site 20
S178
N
P
R
V
K
L
V
S
W
P
L
C
S
L
R
Site 21
S183
L
V
S
W
P
L
C
S
L
R
R
Y
G
R
D
Site 22
Y187
P
L
C
S
L
R
R
Y
G
R
D
A
T
R
F
Site 23
T192
R
R
Y
G
R
D
A
T
R
F
T
F
E
A
G
Site 24
T195
G
R
D
A
T
R
F
T
F
E
A
G
R
M
C
Site 25
T210
D
A
G
E
G
L
Y
T
F
Q
T
Q
E
G
E
Site 26
T213
E
G
L
Y
T
F
Q
T
Q
E
G
E
Q
I
Y
Site 27
Y220
T
Q
E
G
E
Q
I
Y
Q
R
V
H
S
A
T
Site 28
S225
Q
I
Y
Q
R
V
H
S
A
T
L
A
I
A
E
Site 29
T227
Y
Q
R
V
H
S
A
T
L
A
I
A
E
Q
H
Site 30
T252
V
R
L
L
N
K
G
T
E
H
Y
S
Y
P
C
Site 31
Y255
L
N
K
G
T
E
H
Y
S
Y
P
C
T
P
T
Site 32
S256
N
K
G
T
E
H
Y
S
Y
P
C
T
P
T
T
Site 33
Y257
K
G
T
E
H
Y
S
Y
P
C
T
P
T
T
M
Site 34
T260
E
H
Y
S
Y
P
C
T
P
T
T
M
L
P
R
Site 35
T263
S
Y
P
C
T
P
T
T
M
L
P
R
S
A
Y
Site 36
Y270
T
M
L
P
R
S
A
Y
W
H
H
I
T
G
S
Site 37
S285
Q
N
I
A
E
A
S
S
Y
A
G
E
G
Y
G
Site 38
Y286
N
I
A
E
A
S
S
Y
A
G
E
G
Y
G
A
Site 39
S298
Y
G
A
A
Q
A
S
S
E
T
D
L
L
N
R
Site 40
S314
I
L
L
K
P
K
P
S
Q
G
D
S
S
E
A
Site 41
S318
P
K
P
S
Q
G
D
S
S
E
A
K
T
P
S
Site 42
S319
K
P
S
Q
G
D
S
S
E
A
K
T
P
S
Q
Site 43
T323
G
D
S
S
E
A
K
T
P
S
Q
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation