KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SMCR8
Full Name:
Smith-Magenis syndrome chromosomal region candidate gene 8 protein
Alias:
FLJ34716; Smith-Magenis syndrome chromosome region candidate gene 8 protein; Smith-Magenis syndrome chromosome region, candidate 8
Type:
Unknown function
Mass (Da):
105022
Number AA:
937
UniProt ID:
Q8TEV9
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
E
E
Y
E
E
E
P
Y
N
E
P
A
L
P
E
Site 2
Y30
E
P
A
L
P
E
E
Y
S
V
P
L
F
P
F
Site 3
S46
S
Q
G
A
N
P
W
S
K
L
S
G
A
K
F
Site 4
S49
A
N
P
W
S
K
L
S
G
A
K
F
S
R
D
Site 5
S61
S
R
D
F
I
L
I
S
E
F
S
E
Q
V
G
Site 6
T74
V
G
P
Q
P
L
L
T
I
P
N
D
T
K
V
Site 7
T84
N
D
T
K
V
F
G
T
F
D
L
N
Y
F
S
Site 8
S102
M
S
V
D
Y
Q
A
S
F
V
G
H
P
P
G
Site 9
S110
F
V
G
H
P
P
G
S
A
Y
P
K
L
N
F
Site 10
Y112
G
H
P
P
G
S
A
Y
P
K
L
N
F
V
E
Site 11
S121
K
L
N
F
V
E
D
S
K
V
V
L
G
D
S
Site 12
S128
S
K
V
V
L
G
D
S
K
E
G
A
F
A
Y
Site 13
Y135
S
K
E
G
A
F
A
Y
V
H
H
L
T
L
Y
Site 14
Y142
Y
V
H
H
L
T
L
Y
D
L
E
A
R
G
F
Site 15
Y157
V
R
P
F
C
M
A
Y
I
S
A
D
Q
H
K
Site 16
S173
M
Q
Q
F
Q
E
L
S
A
E
F
S
R
A
S
Site 17
S177
Q
E
L
S
A
E
F
S
R
A
S
E
C
L
K
Site 18
S180
S
A
E
F
S
R
A
S
E
C
L
K
T
G
N
Site 19
T185
R
A
S
E
C
L
K
T
G
N
R
K
A
F
A
Site 20
Y204
K
K
L
K
D
L
D
Y
T
R
T
V
L
H
T
Site 21
T205
K
L
K
D
L
D
Y
T
R
T
V
L
H
T
E
Site 22
T207
K
D
L
D
Y
T
R
T
V
L
H
T
E
T
E
Site 23
T211
Y
T
R
T
V
L
H
T
E
T
E
I
Q
K
K
Site 24
S226
A
N
D
K
G
F
Y
S
S
Q
A
I
E
K
A
Site 25
S227
N
D
K
G
F
Y
S
S
Q
A
I
E
K
A
N
Site 26
S238
E
K
A
N
E
L
A
S
V
E
K
S
I
I
E
Site 27
S242
E
L
A
S
V
E
K
S
I
I
E
H
Q
D
L
Site 28
S255
D
L
L
K
Q
I
R
S
Y
P
H
R
K
L
K
Site 29
Y256
L
L
K
Q
I
R
S
Y
P
H
R
K
L
K
G
Site 30
S279
E
H
I
Q
D
Q
A
S
Q
A
S
T
T
S
N
Site 31
T283
D
Q
A
S
Q
A
S
T
T
S
N
P
D
E
S
Site 32
S285
A
S
Q
A
S
T
T
S
N
P
D
E
S
A
D
Site 33
T293
N
P
D
E
S
A
D
T
D
L
Y
T
C
R
P
Site 34
Y296
E
S
A
D
T
D
L
Y
T
C
R
P
A
Y
T
Site 35
T297
S
A
D
T
D
L
Y
T
C
R
P
A
Y
T
P
Site 36
Y302
L
Y
T
C
R
P
A
Y
T
P
K
L
I
K
A
Site 37
T303
Y
T
C
R
P
A
Y
T
P
K
L
I
K
A
K
Site 38
S311
P
K
L
I
K
A
K
S
T
K
C
F
D
K
K
Site 39
T321
C
F
D
K
K
L
K
T
L
E
E
L
C
D
T
Site 40
T328
T
L
E
E
L
C
D
T
E
Y
F
T
Q
T
L
Site 41
Y330
E
E
L
C
D
T
E
Y
F
T
Q
T
L
A
Q
Site 42
T334
D
T
E
Y
F
T
Q
T
L
A
Q
L
S
H
I
Site 43
S388
R
M
V
E
K
Q
E
S
I
P
S
K
P
S
Q
Site 44
S391
E
K
Q
E
S
I
P
S
K
P
S
Q
D
R
P
Site 45
S394
E
S
I
P
S
K
P
S
Q
D
R
P
P
S
S
Site 46
S400
P
S
Q
D
R
P
P
S
S
S
L
E
E
C
P
Site 47
S401
S
Q
D
R
P
P
S
S
S
L
E
E
C
P
I
Site 48
S402
Q
D
R
P
P
S
S
S
L
E
E
C
P
I
P
Site 49
S414
P
I
P
K
V
L
I
S
V
G
S
Y
K
S
S
Site 50
S417
K
V
L
I
S
V
G
S
Y
K
S
S
V
E
S
Site 51
Y418
V
L
I
S
V
G
S
Y
K
S
S
V
E
S
V
Site 52
S421
S
V
G
S
Y
K
S
S
V
E
S
V
L
I
K
Site 53
S424
S
Y
K
S
S
V
E
S
V
L
I
K
M
E
Q
Site 54
Y438
Q
E
L
G
D
E
E
Y
K
E
V
E
V
T
E
Site 55
T444
E
Y
K
E
V
E
V
T
E
L
S
S
F
D
P
Site 56
S447
E
V
E
V
T
E
L
S
S
F
D
P
Q
E
N
Site 57
S448
V
E
V
T
E
L
S
S
F
D
P
Q
E
N
L
Site 58
Y457
D
P
Q
E
N
L
D
Y
L
D
M
D
M
K
G
Site 59
S465
L
D
M
D
M
K
G
S
I
S
S
G
E
S
I
Site 60
S467
M
D
M
K
G
S
I
S
S
G
E
S
I
E
V
Site 61
S468
D
M
K
G
S
I
S
S
G
E
S
I
E
V
L
Site 62
S471
G
S
I
S
S
G
E
S
I
E
V
L
G
T
E
Site 63
T477
E
S
I
E
V
L
G
T
E
K
S
T
S
V
L
Site 64
S480
E
V
L
G
T
E
K
S
T
S
V
L
S
K
S
Site 65
S482
L
G
T
E
K
S
T
S
V
L
S
K
S
D
S
Site 66
S485
E
K
S
T
S
V
L
S
K
S
D
S
Q
A
S
Site 67
S487
S
T
S
V
L
S
K
S
D
S
Q
A
S
L
T
Site 68
S489
S
V
L
S
K
S
D
S
Q
A
S
L
T
V
P
Site 69
S492
S
K
S
D
S
Q
A
S
L
T
V
P
L
S
P
Site 70
T494
S
D
S
Q
A
S
L
T
V
P
L
S
P
Q
V
Site 71
S498
A
S
L
T
V
P
L
S
P
Q
V
V
R
S
K
Site 72
S504
L
S
P
Q
V
V
R
S
K
A
V
S
H
R
T
Site 73
S508
V
V
R
S
K
A
V
S
H
R
T
I
S
E
D
Site 74
S513
A
V
S
H
R
T
I
S
E
D
S
I
E
V
L
Site 75
S516
H
R
T
I
S
E
D
S
I
E
V
L
S
T
C
Site 76
S521
E
D
S
I
E
V
L
S
T
C
P
S
E
A
L
Site 77
S525
E
V
L
S
T
C
P
S
E
A
L
I
P
D
D
Site 78
S536
I
P
D
D
F
K
A
S
Y
P
S
A
I
N
E
Site 79
Y537
P
D
D
F
K
A
S
Y
P
S
A
I
N
E
E
Site 80
S546
S
A
I
N
E
E
E
S
Y
P
D
G
N
E
G
Site 81
Y547
A
I
N
E
E
E
S
Y
P
D
G
N
E
G
A
Site 82
S560
G
A
I
R
F
Q
A
S
I
S
P
P
E
L
G
Site 83
S562
I
R
F
Q
A
S
I
S
P
P
E
L
G
E
T
Site 84
T569
S
P
P
E
L
G
E
T
E
E
G
S
I
E
N
Site 85
S573
L
G
E
T
E
E
G
S
I
E
N
T
P
S
Q
Site 86
T577
E
E
G
S
I
E
N
T
P
S
Q
I
D
S
S
Site 87
S579
G
S
I
E
N
T
P
S
Q
I
D
S
S
C
C
Site 88
S583
N
T
P
S
Q
I
D
S
S
C
C
I
G
K
E
Site 89
S584
T
P
S
Q
I
D
S
S
C
C
I
G
K
E
S
Site 90
S599
D
G
Q
L
V
L
P
S
T
P
A
H
T
H
S
Site 91
T600
G
Q
L
V
L
P
S
T
P
A
H
T
H
S
D
Site 92
S606
S
T
P
A
H
T
H
S
D
E
D
G
V
V
S
Site 93
S614
D
E
D
G
V
V
S
S
P
P
Q
R
H
R
Q
Site 94
S631
Q
G
F
R
V
D
F
S
V
E
N
A
N
P
S
Site 95
S638
S
V
E
N
A
N
P
S
S
R
D
N
S
C
E
Site 96
S639
V
E
N
A
N
P
S
S
R
D
N
S
C
E
G
Site 97
S643
N
P
S
S
R
D
N
S
C
E
G
F
P
A
Y
Site 98
Y650
S
C
E
G
F
P
A
Y
E
L
D
P
S
H
L
Site 99
S655
P
A
Y
E
L
D
P
S
H
L
L
A
S
R
D
Site 100
S660
D
P
S
H
L
L
A
S
R
D
I
S
K
T
S
Site 101
S664
L
L
A
S
R
D
I
S
K
T
S
L
D
N
Y
Site 102
T666
A
S
R
D
I
S
K
T
S
L
D
N
Y
S
D
Site 103
S667
S
R
D
I
S
K
T
S
L
D
N
Y
S
D
T
Site 104
Y671
S
K
T
S
L
D
N
Y
S
D
T
T
S
Y
V
Site 105
S672
K
T
S
L
D
N
Y
S
D
T
T
S
Y
V
S
Site 106
T674
S
L
D
N
Y
S
D
T
T
S
Y
V
S
S
V
Site 107
T675
L
D
N
Y
S
D
T
T
S
Y
V
S
S
V
A
Site 108
S676
D
N
Y
S
D
T
T
S
Y
V
S
S
V
A
S
Site 109
Y677
N
Y
S
D
T
T
S
Y
V
S
S
V
A
S
T
Site 110
S679
S
D
T
T
S
Y
V
S
S
V
A
S
T
S
S
Site 111
S680
D
T
T
S
Y
V
S
S
V
A
S
T
S
S
D
Site 112
S683
S
Y
V
S
S
V
A
S
T
S
S
D
R
I
P
Site 113
T684
Y
V
S
S
V
A
S
T
S
S
D
R
I
P
S
Site 114
S685
V
S
S
V
A
S
T
S
S
D
R
I
P
S
A
Site 115
S686
S
S
V
A
S
T
S
S
D
R
I
P
S
A
Y
Site 116
S691
T
S
S
D
R
I
P
S
A
Y
P
A
G
L
S
Site 117
Y693
S
D
R
I
P
S
A
Y
P
A
G
L
S
S
D
Site 118
S699
A
Y
P
A
G
L
S
S
D
R
H
K
K
R
A
Site 119
Y760
F
V
P
S
Y
G
C
Y
A
K
P
V
K
H
W
Site 120
S790
I
G
L
Q
R
V
A
S
P
A
G
A
G
T
L
Site 121
T796
A
S
P
A
G
A
G
T
L
H
A
L
S
R
Y
Site 122
S801
A
G
T
L
H
A
L
S
R
Y
S
R
Y
T
S
Site 123
Y803
T
L
H
A
L
S
R
Y
S
R
Y
T
S
I
L
Site 124
S804
L
H
A
L
S
R
Y
S
R
Y
T
S
I
L
D
Site 125
T807
L
S
R
Y
S
R
Y
T
S
I
L
D
L
D
N
Site 126
S808
S
R
Y
S
R
Y
T
S
I
L
D
L
D
N
K
Site 127
T816
I
L
D
L
D
N
K
T
L
R
C
P
L
Y
R
Site 128
Y822
K
T
L
R
C
P
L
Y
R
G
T
L
V
P
R
Site 129
T825
R
C
P
L
Y
R
G
T
L
V
P
R
L
A
D
Site 130
T835
P
R
L
A
D
H
R
T
Q
I
K
R
G
S
T
Site 131
S841
R
T
Q
I
K
R
G
S
T
Y
Y
L
H
V
Q
Site 132
T842
T
Q
I
K
R
G
S
T
Y
Y
L
H
V
Q
S
Site 133
Y843
Q
I
K
R
G
S
T
Y
Y
L
H
V
Q
S
M
Site 134
Y844
I
K
R
G
S
T
Y
Y
L
H
V
Q
S
M
L
Site 135
S882
E
T
E
E
L
V
A
S
R
Q
M
S
F
L
K
Site 136
Y913
A
E
L
L
K
L
H
Y
M
Q
E
S
P
G
T
Site 137
S917
K
L
H
Y
M
Q
E
S
P
G
T
S
H
P
M
Site 138
T920
Y
M
Q
E
S
P
G
T
S
H
P
M
L
R
F
Site 139
S921
M
Q
E
S
P
G
T
S
H
P
M
L
R
F
D
Site 140
Y929
H
P
M
L
R
F
D
Y
V
P
S
F
L
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation