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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOLO
Full Name:
Rho guanine nucleotide exchange factor 40
Alias:
FLJ00128; Protein SOLO: Protein SOLO: Protein SOLO: Protein SOLO
Type:
Unknown function
Mass (Da):
164646
Number AA:
1519
UniProt ID:
Q8TER5
International Prot ID:
IPI00398991
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
F
Q
V
V
E
R
T
Y
R
E
D
A
L
R
Y
Site 2
T48
R
E
D
A
L
R
Y
T
L
D
F
L
V
P
A
Site 3
T159
G
I
N
K
D
R
P
T
G
R
L
S
T
C
L
Site 4
S163
D
R
P
T
G
R
L
S
T
C
L
L
S
A
P
Site 5
T164
R
P
T
G
R
L
S
T
C
L
L
S
A
P
S
Site 6
S168
R
L
S
T
C
L
L
S
A
P
S
G
I
Q
R
Site 7
S199
L
M
V
G
H
Q
P
S
T
L
P
P
E
L
P
Site 8
T200
M
V
G
H
Q
P
S
T
L
P
P
E
L
P
S
Site 9
S207
T
L
P
P
E
L
P
S
G
P
P
G
L
P
S
Site 10
S214
S
G
P
P
G
L
P
S
P
P
L
P
E
E
A
Site 11
T224
L
P
E
E
A
L
G
T
R
S
P
G
D
G
H
Site 12
S226
E
E
A
L
G
T
R
S
P
G
D
G
H
N
A
Site 13
Y242
V
E
G
P
E
G
E
Y
V
E
L
L
E
V
T
Site 14
S255
V
T
L
P
V
R
G
S
P
T
D
A
E
G
S
Site 15
T257
L
P
V
R
G
S
P
T
D
A
E
G
S
P
G
Site 16
S262
S
P
T
D
A
E
G
S
P
G
L
S
R
V
R
Site 17
S266
A
E
G
S
P
G
L
S
R
V
R
T
V
P
T
Site 18
T270
P
G
L
S
R
V
R
T
V
P
T
R
K
G
A
Site 19
S310
A
R
P
P
G
E
G
S
S
T
G
A
S
P
E
Site 20
S311
R
P
P
G
E
G
S
S
T
G
A
S
P
E
S
Site 21
T312
P
P
G
E
G
S
S
T
G
A
S
P
E
S
P
Site 22
S315
E
G
S
S
T
G
A
S
P
E
S
P
P
G
A
Site 23
S318
S
T
G
A
S
P
E
S
P
P
G
A
E
A
V
Site 24
S345
A
E
A
V
G
E
A
S
G
S
C
P
L
R
P
Site 25
S347
A
V
G
E
A
S
G
S
C
P
L
R
P
G
E
Site 26
T371
G
A
E
G
P
P
G
T
P
R
R
T
G
K
G
Site 27
T375
P
P
G
T
P
R
R
T
G
K
G
N
R
R
K
Site 28
S392
A
A
G
R
G
A
L
S
R
G
G
D
S
A
P
Site 29
S397
A
L
S
R
G
G
D
S
A
P
L
S
P
G
D
Site 30
S401
G
G
D
S
A
P
L
S
P
G
D
K
E
D
A
Site 31
S409
P
G
D
K
E
D
A
S
H
Q
E
A
L
G
N
Site 32
S419
E
A
L
G
N
L
P
S
P
S
E
H
K
L
P
Site 33
S421
L
G
N
L
P
S
P
S
E
H
K
L
P
E
C
Site 34
Y435
C
H
L
V
K
E
E
Y
E
G
S
G
K
P
E
Site 35
S438
V
K
E
E
Y
E
G
S
G
K
P
E
S
E
P
Site 36
S443
E
G
S
G
K
P
E
S
E
P
K
E
L
K
T
Site 37
S459
G
E
K
E
P
Q
L
S
E
A
C
G
P
T
E
Site 38
S493
T
G
P
E
G
P
L
S
D
T
P
T
P
P
L
Site 39
T495
P
E
G
P
L
S
D
T
P
T
P
P
L
E
T
Site 40
T497
G
P
L
S
D
T
P
T
P
P
L
E
T
V
Q
Site 41
S519
P
E
E
A
L
A
V
S
V
S
D
H
P
D
V
Site 42
T551
Q
S
G
R
A
L
L
T
I
T
P
P
C
P
P
Site 43
T553
G
R
A
L
L
T
I
T
P
P
C
P
P
E
E
Site 44
S564
P
P
E
E
P
P
P
S
R
D
T
L
N
T
T
Site 45
T567
E
P
P
P
S
R
D
T
L
N
T
T
L
H
Y
Site 46
T570
P
S
R
D
T
L
N
T
T
L
H
Y
L
H
S
Site 47
T571
S
R
D
T
L
N
T
T
L
H
Y
L
H
S
L
Site 48
S577
T
T
L
H
Y
L
H
S
L
L
R
P
D
L
Q
Site 49
S609
P
A
L
I
P
A
L
S
Q
L
Q
D
S
G
D
Site 50
S614
A
L
S
Q
L
Q
D
S
G
D
P
P
L
V
Q
Site 51
S669
L
G
G
H
R
D
P
S
P
S
H
W
V
E
I
Site 52
T729
V
L
A
D
P
R
L
T
A
L
Q
R
D
G
G
Site 53
S744
A
I
L
M
R
L
R
S
T
P
S
S
K
L
E
Site 54
T745
I
L
M
R
L
R
S
T
P
S
S
K
L
E
G
Site 55
S747
M
R
L
R
S
T
P
S
S
K
L
E
G
Q
G
Site 56
S748
R
L
R
S
T
P
S
S
K
L
E
G
Q
G
P
Site 57
Y759
G
Q
G
P
A
T
L
Y
Q
E
V
D
E
A
I
Site 58
S773
I
H
Q
L
V
R
L
S
N
L
H
V
Q
Q
Q
Site 59
S797
Q
Q
V
L
Q
W
L
S
G
P
G
E
E
Q
L
Site 60
S806
P
G
E
E
Q
L
A
S
F
A
M
P
G
D
T
Site 61
T813
S
F
A
M
P
G
D
T
L
S
A
L
Q
E
T
Site 62
S815
A
M
P
G
D
T
L
S
A
L
Q
E
T
E
L
Site 63
S828
E
L
R
F
R
A
F
S
A
E
V
Q
E
R
L
Site 64
T849
L
A
L
E
E
N
A
T
S
Q
K
V
L
D
I
Site 65
S850
A
L
E
E
N
A
T
S
Q
K
V
L
D
I
F
Site 66
S915
L
R
R
A
P
E
P
S
A
G
T
F
Q
E
M
Site 67
S931
A
L
A
L
D
L
G
S
P
A
A
L
R
E
W
Site 68
S961
Q
H
L
G
E
E
A
S
P
R
G
Y
R
R
R
Site 69
Y965
E
E
A
S
P
R
G
Y
R
R
R
R
A
D
G
Site 70
S974
R
R
R
A
D
G
A
S
S
G
G
A
Q
W
G
Site 71
S975
R
R
A
D
G
A
S
S
G
G
A
Q
W
G
P
Site 72
S984
G
A
Q
W
G
P
R
S
P
S
P
S
L
S
S
Site 73
S986
Q
W
G
P
R
S
P
S
P
S
L
S
S
L
L
Site 74
S988
Q
H
L
G
E
E
A
S
P
R
G
Y
R
R
R
Site 75
S990
R
S
P
S
P
S
L
S
S
L
L
L
P
S
S
Site 76
S991
S
P
S
P
S
L
S
S
L
L
L
P
S
S
P
Site 77
S996
L
S
S
L
L
L
P
S
S
P
G
P
R
P
A
Site 78
S997
S
S
L
L
L
P
S
S
P
G
P
R
P
A
P
Site 79
S1005
P
G
P
R
P
A
P
S
H
C
S
L
A
P
C
Site 80
S1008
R
P
A
P
S
H
C
S
L
A
P
C
G
E
D
Site 81
Y1016
L
A
P
C
G
E
D
Y
E
E
E
G
P
E
L
Site 82
T1045
R
G
L
E
V
T
S
T
E
V
V
D
R
T
C
Site 83
T1051
S
T
E
V
V
D
R
T
C
S
P
R
E
H
V
Site 84
S1053
E
V
V
D
R
T
C
S
P
R
E
H
V
L
L
Site 85
T1074
D
G
P
W
G
V
G
T
P
R
M
E
R
K
R
Site 86
S1082
P
R
M
E
R
K
R
S
I
S
A
Q
Q
R
L
Site 87
S1084
M
E
R
K
R
S
I
S
A
Q
Q
R
L
V
S
Site 88
S1091
S
A
Q
Q
R
L
V
S
E
L
I
A
C
E
Q
Site 89
S1105
Q
D
Y
V
A
T
L
S
E
P
V
P
P
P
G
Site 90
T1116
P
P
P
G
P
E
L
T
P
E
L
R
G
T
W
Site 91
S1128
G
T
W
A
A
A
L
S
A
R
E
R
L
R
S
Site 92
S1135
S
A
R
E
R
L
R
S
F
H
R
T
H
F
L
Site 93
T1139
R
L
R
S
F
H
R
T
H
F
L
R
E
L
Q
Site 94
S1167
L
R
H
G
D
Q
F
S
L
Y
A
Q
Y
V
K
Site 95
Y1169
H
G
D
Q
F
S
L
Y
A
Q
Y
V
K
H
R
Site 96
Y1172
Q
F
S
L
Y
A
Q
Y
V
K
H
R
H
K
L
Site 97
S1187
E
N
G
L
A
A
L
S
P
S
S
K
G
S
M
Site 98
S1189
G
L
A
A
L
S
P
S
S
K
G
S
M
E
A
Site 99
S1190
L
A
A
L
S
P
S
S
K
G
S
M
E
A
G
Site 100
S1193
L
S
P
S
S
K
G
S
M
E
A
G
P
Y
L
Site 101
Y1199
G
S
M
E
A
G
P
Y
L
P
R
A
L
Q
Q
Site 102
Y1214
P
L
E
Q
L
T
R
Y
G
R
L
L
E
E
L
Site 103
S1231
E
A
G
P
E
L
S
S
E
C
R
A
L
G
A
Site 104
T1279
L
L
H
R
D
P
F
T
V
I
C
G
R
K
K
Site 105
Y1315
G
G
S
E
M
F
V
Y
K
Q
A
F
K
T
A
Site 106
T1321
V
Y
K
Q
A
F
K
T
A
D
M
G
L
T
E
Site 107
Y1350
R
R
R
A
R
E
A
Y
T
L
Q
A
T
S
P
Site 108
S1356
A
Y
T
L
Q
A
T
S
P
E
I
K
L
K
W
Site 109
T1412
R
T
L
S
A
L
L
T
G
R
A
A
R
T
R
Site 110
S1421
R
A
A
R
T
R
A
S
V
A
V
S
S
F
E
Site 111
S1425
T
R
A
S
V
A
V
S
S
F
E
H
A
G
P
Site 112
S1426
R
A
S
V
A
V
S
S
F
E
H
A
G
P
S
Site 113
S1433
S
F
E
H
A
G
P
S
L
P
G
L
S
P
G
Site 114
S1461
D
L
D
V
K
Q
I
S
L
A
P
E
T
L
D
Site 115
T1466
Q
I
S
L
A
P
E
T
L
D
S
S
G
D
V
Site 116
S1469
L
A
P
E
T
L
D
S
S
G
D
V
S
P
G
Site 117
S1470
A
P
E
T
L
D
S
S
G
D
V
S
P
G
P
Site 118
S1474
L
D
S
S
G
D
V
S
P
G
P
R
N
S
P
Site 119
S1480
V
S
P
G
P
R
N
S
P
S
L
Q
P
P
H
Site 120
S1482
P
G
P
R
N
S
P
S
L
Q
P
P
H
P
G
Site 121
S1490
L
Q
P
P
H
P
G
S
S
T
P
T
L
A
S
Site 122
S1491
Q
P
P
H
P
G
S
S
T
P
T
L
A
S
R
Site 123
T1492
P
P
H
P
G
S
S
T
P
T
L
A
S
R
G
Site 124
T1494
H
P
G
S
S
T
P
T
L
A
S
R
G
I
L
Site 125
S1504
S
R
G
I
L
G
L
S
R
Q
S
H
A
R
A
Site 126
S1507
I
L
G
L
S
R
Q
S
H
A
R
A
L
S
D
Site 127
S1513
Q
S
H
A
R
A
L
S
D
P
T
T
P
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation