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Updated November 2019
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Protein Info
Short Name:
CEP192
Full Name:
Centrosomal protein of 192 kDa
Alias:
Cep192
Type:
Mass (Da):
213146
Number AA:
1941
UniProt ID:
Q8TEP8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005815
GO:0043226
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
T
S
D
L
V
P
S
F
G
Y
F
I
R
S
Site 2
Y12
D
L
V
P
S
F
G
Y
F
I
R
S
P
E
K
Site 3
S16
S
F
G
Y
F
I
R
S
P
E
K
R
E
P
I
Site 4
S29
P
I
A
L
I
R
K
S
D
V
S
R
G
N
L
Site 5
S32
L
I
R
K
S
D
V
S
R
G
N
L
E
K
E
Site 6
Y48
A
H
L
N
H
D
L
Y
S
G
D
L
N
E
Q
Site 7
S56
S
G
D
L
N
E
Q
S
Q
A
Q
L
S
E
G
Site 8
S61
E
Q
S
Q
A
Q
L
S
E
G
S
I
T
L
Q
Site 9
T66
Q
L
S
E
G
S
I
T
L
Q
V
E
A
V
E
Site 10
S74
L
Q
V
E
A
V
E
S
T
S
Q
V
D
E
N
Site 11
T84
Q
V
D
E
N
D
V
T
L
T
A
D
K
G
K
Site 12
T95
D
K
G
K
T
E
D
T
F
F
M
S
N
K
P
Site 13
S112
Y
K
D
K
L
P
D
S
G
D
S
M
L
R
I
Site 14
S115
K
L
P
D
S
G
D
S
M
L
R
I
S
T
I
Site 15
S130
A
S
A
I
A
E
A
S
V
N
T
D
P
S
Q
Site 16
S136
A
S
V
N
T
D
P
S
Q
L
A
A
M
I
K
Site 17
T153
S
N
K
T
R
D
K
T
F
Q
E
D
E
K
Q
Site 18
Y163
E
D
E
K
Q
K
D
Y
S
H
V
R
H
F
L
Site 19
S164
D
E
K
Q
K
D
Y
S
H
V
R
H
F
L
P
Site 20
S177
L
P
N
D
L
E
K
S
N
G
S
N
A
L
D
Site 21
Y188
N
A
L
D
M
E
K
Y
L
K
K
T
E
V
S
Site 22
Y197
K
K
T
E
V
S
R
Y
E
S
A
L
E
N
F
Site 23
S199
T
E
V
S
R
Y
E
S
A
L
E
N
F
S
R
Site 24
S205
E
S
A
L
E
N
F
S
R
A
S
M
S
D
T
Site 25
S208
L
E
N
F
S
R
A
S
M
S
D
T
W
D
L
Site 26
S210
N
F
S
R
A
S
M
S
D
T
W
D
L
S
L
Site 27
T212
S
R
A
S
M
S
D
T
W
D
L
S
L
P
K
Site 28
S216
M
S
D
T
W
D
L
S
L
P
K
E
Q
T
T
Site 29
S232
D
I
H
P
V
D
L
S
A
T
S
V
S
V
R
Site 30
S235
P
V
D
L
S
A
T
S
V
S
V
R
A
P
E
Site 31
S237
D
L
S
A
T
S
V
S
V
R
A
P
E
E
N
Site 32
Y250
E
N
T
A
A
I
V
Y
V
E
N
G
E
S
E
Site 33
S256
V
Y
V
E
N
G
E
S
E
N
Q
E
S
F
R
Site 34
S261
G
E
S
E
N
Q
E
S
F
R
T
I
N
S
S
Site 35
T264
E
N
Q
E
S
F
R
T
I
N
S
S
N
S
V
Site 36
S267
E
S
F
R
T
I
N
S
S
N
S
V
T
N
R
Site 37
S268
S
F
R
T
I
N
S
S
N
S
V
T
N
R
E
Site 38
S270
R
T
I
N
S
S
N
S
V
T
N
R
E
N
N
Site 39
T272
I
N
S
S
N
S
V
T
N
R
E
N
N
S
A
Site 40
S303
G
N
D
E
K
A
T
S
I
S
T
P
S
D
S
Site 41
S305
D
E
K
A
T
S
I
S
T
P
S
D
S
Y
S
Site 42
T306
E
K
A
T
S
I
S
T
P
S
D
S
Y
S
S
Site 43
S308
A
T
S
I
S
T
P
S
D
S
Y
S
S
V
R
Site 44
S310
S
I
S
T
P
S
D
S
Y
S
S
V
R
N
P
Site 45
Y311
I
S
T
P
S
D
S
Y
S
S
V
R
N
P
R
Site 46
S312
S
T
P
S
D
S
Y
S
S
V
R
N
P
R
I
Site 47
S313
T
P
S
D
S
Y
S
S
V
R
N
P
R
I
T
Site 48
T320
S
V
R
N
P
R
I
T
S
L
C
L
L
K
D
Site 49
S345
Q
R
Q
N
E
C
V
S
E
I
S
N
S
E
K
Site 50
S350
C
V
S
E
I
S
N
S
E
K
H
V
T
F
E
Site 51
T355
S
N
S
E
K
H
V
T
F
E
N
H
R
I
V
Site 52
S363
F
E
N
H
R
I
V
S
P
K
N
S
D
L
K
Site 53
S367
R
I
V
S
P
K
N
S
D
L
K
N
T
S
P
Site 54
S373
N
S
D
L
K
N
T
S
P
E
H
G
G
R
G
Site 55
S381
P
E
H
G
G
R
G
S
E
D
E
Q
E
S
F
Site 56
S387
G
S
E
D
E
Q
E
S
F
R
P
S
T
S
P
Site 57
S391
E
Q
E
S
F
R
P
S
T
S
P
L
S
H
S
Site 58
T392
Q
E
S
F
R
P
S
T
S
P
L
S
H
S
S
Site 59
S393
E
S
F
R
P
S
T
S
P
L
S
H
S
S
P
Site 60
S396
R
P
S
T
S
P
L
S
H
S
S
P
S
E
I
Site 61
S398
S
T
S
P
L
S
H
S
S
P
S
E
I
S
G
Site 62
S399
T
S
P
L
S
H
S
S
P
S
E
I
S
G
T
Site 63
S401
P
L
S
H
S
S
P
S
E
I
S
G
T
S
S
Site 64
S404
H
S
S
P
S
E
I
S
G
T
S
S
S
G
C
Site 65
T406
S
P
S
E
I
S
G
T
S
S
S
G
C
A
L
Site 66
S408
S
E
I
S
G
T
S
S
S
G
C
A
L
E
S
Site 67
S409
E
I
S
G
T
S
S
S
G
C
A
L
E
S
F
Site 68
S415
S
S
G
C
A
L
E
S
F
G
S
A
A
Q
Q
Site 69
S432
P
P
C
E
Q
E
L
S
P
L
V
C
S
P
A
Site 70
T445
P
A
G
V
S
R
L
T
Y
V
S
E
P
E
S
Site 71
Y446
A
G
V
S
R
L
T
Y
V
S
E
P
E
S
S
Site 72
S448
V
S
R
L
T
Y
V
S
E
P
E
S
S
Y
P
Site 73
S452
T
Y
V
S
E
P
E
S
S
Y
P
T
T
A
T
Site 74
S453
Y
V
S
E
P
E
S
S
Y
P
T
T
A
T
D
Site 75
T457
P
E
S
S
Y
P
T
T
A
T
D
D
A
L
E
Site 76
S468
D
A
L
E
D
R
K
S
D
I
T
S
E
L
S
Site 77
T471
E
D
R
K
S
D
I
T
S
E
L
S
T
T
I
Site 78
S472
D
R
K
S
D
I
T
S
E
L
S
T
T
I
I
Site 79
S475
S
D
I
T
S
E
L
S
T
T
I
I
Q
G
S
Site 80
T476
D
I
T
S
E
L
S
T
T
I
I
Q
G
S
P
Site 81
S482
S
T
T
I
I
Q
G
S
P
A
A
L
E
E
R
Site 82
S509
N
R
G
K
G
T
L
S
S
I
I
Q
N
N
S
Site 83
S510
R
G
K
G
T
L
S
S
I
I
Q
N
N
S
D
Site 84
S516
S
S
I
I
Q
N
N
S
D
T
R
K
A
T
E
Site 85
T522
N
S
D
T
R
K
A
T
E
T
T
S
L
S
S
Site 86
T524
D
T
R
K
A
T
E
T
T
S
L
S
S
K
P
Site 87
S526
R
K
A
T
E
T
T
S
L
S
S
K
P
E
Y
Site 88
S528
A
T
E
T
T
S
L
S
S
K
P
E
Y
V
K
Site 89
Y533
S
L
S
S
K
P
E
Y
V
K
P
D
F
R
W
Site 90
S541
V
K
P
D
F
R
W
S
K
D
P
S
S
K
S
Site 91
S545
F
R
W
S
K
D
P
S
S
K
S
G
N
L
L
Site 92
S546
R
W
S
K
D
P
S
S
K
S
G
N
L
L
E
Site 93
S548
S
K
D
P
S
S
K
S
G
N
L
L
E
T
S
Site 94
S555
S
G
N
L
L
E
T
S
E
V
G
W
T
S
N
Site 95
T560
E
T
S
E
V
G
W
T
S
N
P
E
E
L
D
Site 96
S561
T
S
E
V
G
W
T
S
N
P
E
E
L
D
P
Site 97
S585
G
L
S
C
Q
V
G
S
A
T
S
H
P
V
S
Site 98
T587
S
C
Q
V
G
S
A
T
S
H
P
V
S
C
Q
Site 99
S588
C
Q
V
G
S
A
T
S
H
P
V
S
C
Q
E
Site 100
S592
S
A
T
S
H
P
V
S
C
Q
E
P
I
D
E
Site 101
S604
I
D
E
D
Q
R
I
S
P
K
D
K
S
T
A
Site 102
S609
R
I
S
P
K
D
K
S
T
A
G
R
E
F
S
Site 103
T610
I
S
P
K
D
K
S
T
A
G
R
E
F
S
G
Site 104
S616
S
T
A
G
R
E
F
S
G
Q
V
S
H
Q
T
Site 105
S620
R
E
F
S
G
Q
V
S
H
Q
T
T
S
E
N
Site 106
T630
T
T
S
E
N
Q
C
T
P
I
P
S
S
T
V
Site 107
S634
N
Q
C
T
P
I
P
S
S
T
V
H
S
S
V
Site 108
S635
Q
C
T
P
I
P
S
S
T
V
H
S
S
V
A
Site 109
T636
C
T
P
I
P
S
S
T
V
H
S
S
V
A
D
Site 110
S639
I
P
S
S
T
V
H
S
S
V
A
D
M
Q
N
Site 111
S640
P
S
S
T
V
H
S
S
V
A
D
M
Q
N
M
Site 112
Y669
A
A
P
F
A
Q
R
Y
L
G
T
L
P
S
T
Site 113
T672
F
A
Q
R
Y
L
G
T
L
P
S
T
G
S
T
Site 114
S675
R
Y
L
G
T
L
P
S
T
G
S
T
T
L
P
Site 115
T676
Y
L
G
T
L
P
S
T
G
S
T
T
L
P
Q
Site 116
S678
G
T
L
P
S
T
G
S
T
T
L
P
Q
C
H
Site 117
T679
T
L
P
S
T
G
S
T
T
L
P
Q
C
H
A
Site 118
S724
C
L
G
S
N
I
G
S
G
W
M
G
T
S
S
Site 119
S730
G
S
G
W
M
G
T
S
S
L
C
N
P
Y
S
Site 120
S731
S
G
W
M
G
T
S
S
L
C
N
P
Y
S
N
Site 121
S737
S
S
L
C
N
P
Y
S
N
T
L
N
Q
N
L
Site 122
T739
L
C
N
P
Y
S
N
T
L
N
Q
N
L
L
S
Site 123
S746
T
L
N
Q
N
L
L
S
T
T
K
P
F
P
V
Site 124
T747
L
N
Q
N
L
L
S
T
T
K
P
F
P
V
P
Site 125
S767
C
G
I
E
P
W
D
S
G
V
T
S
G
L
G
Site 126
S771
P
W
D
S
G
V
T
S
G
L
G
S
V
R
V
Site 127
S827
N
G
E
K
V
D
L
S
T
Y
R
C
L
V
F
Site 128
T828
G
E
K
V
D
L
S
T
Y
R
C
L
V
F
K
Site 129
Y829
E
K
V
D
L
S
T
Y
R
C
L
V
F
K
N
Site 130
S868
R
C
T
F
S
V
A
S
W
P
C
S
T
D
A
Site 131
Y916
L
D
F
G
D
L
T
Y
G
G
W
K
A
L
P
Site 132
T951
A
V
A
W
R
C
F
T
F
S
K
E
S
V
R
Site 133
S953
A
W
R
C
F
T
F
S
K
E
S
V
R
A
P
Site 134
S986
V
N
H
M
M
P
A
S
Y
D
G
Q
D
P
E
Site 135
S1003
M
I
W
V
L
F
H
S
P
K
K
Q
I
S
S
Site 136
S1009
H
S
P
K
K
Q
I
S
S
S
D
I
L
D
S
Site 137
S1011
P
K
K
Q
I
S
S
S
D
I
L
D
S
A
E
Site 138
S1016
S
S
S
D
I
L
D
S
A
E
E
F
S
A
K
Site 139
S1030
K
V
D
I
E
V
D
S
P
N
P
T
P
V
L
Site 140
T1034
E
V
D
S
P
N
P
T
P
V
L
R
S
V
S
Site 141
S1068
H
F
L
A
K
V
A
S
S
R
K
Q
H
L
P
Site 142
Y1085
N
A
G
N
I
E
V
Y
L
D
I
K
V
P
E
Site 143
S1098
P
E
Q
G
S
H
F
S
V
D
P
K
N
L
L
Site 144
S1117
E
E
H
E
V
I
V
S
F
T
P
K
D
P
E
Site 145
T1119
H
E
V
I
V
S
F
T
P
K
D
P
E
A
C
Site 146
Y1142
V
Q
P
F
G
P
Q
Y
E
V
V
L
K
G
E
Site 147
S1152
V
L
K
G
E
V
I
S
S
G
S
K
P
L
S
Site 148
S1153
L
K
G
E
V
I
S
S
G
S
K
P
L
S
P
Site 149
S1155
G
E
V
I
S
S
G
S
K
P
L
S
P
G
P
Site 150
S1159
S
S
G
S
K
P
L
S
P
G
P
C
L
D
I
Site 151
S1197
K
L
A
L
R
N
N
S
A
S
T
T
Q
H
L
Site 152
S1199
A
L
R
N
N
S
A
S
T
T
Q
H
L
R
L
Site 153
T1201
R
N
N
S
A
S
T
T
Q
H
L
R
L
L
I
Site 154
T1221
D
C
F
Q
L
Q
N
T
F
G
S
E
Q
R
L
Site 155
T1229
F
G
S
E
Q
R
L
T
S
N
C
E
I
R
I
Site 156
S1230
G
S
E
Q
R
L
T
S
N
C
E
I
R
I
H
Site 157
S1269
I
K
Q
L
G
N
R
S
Q
P
G
I
K
F
T
Site 158
T1276
S
Q
P
G
I
K
F
T
I
P
L
S
G
Y
G
Site 159
S1280
I
K
F
T
I
P
L
S
G
Y
G
G
T
S
N
Site 160
S1299
G
V
K
K
L
S
D
S
Y
M
V
T
V
N
G
Site 161
S1318
K
E
S
K
I
V
F
S
V
R
N
T
G
S
R
Site 162
S1337
K
A
V
G
F
K
D
S
Q
K
K
V
L
L
D
Site 163
S1372
V
T
L
I
Y
N
P
S
D
R
G
I
N
N
K
Site 164
T1380
D
R
G
I
N
N
K
T
A
T
E
L
S
T
V
Site 165
S1385
N
K
T
A
T
E
L
S
T
V
Y
L
F
G
G
Site 166
T1386
K
T
A
T
E
L
S
T
V
Y
L
F
G
G
D
Site 167
S1396
L
F
G
G
D
E
I
S
R
Q
Q
Y
R
R
A
Site 168
Y1400
D
E
I
S
R
Q
Q
Y
R
R
A
L
L
H
K
Site 169
T1437
F
Q
D
E
L
L
V
T
E
V
Y
D
L
P
Q
Site 170
Y1440
E
L
L
V
T
E
V
Y
D
L
P
Q
R
P
N
Site 171
S1472
G
E
F
R
D
C
I
S
S
R
E
F
L
Q
P
Site 172
S1473
E
F
R
D
C
I
S
S
R
E
F
L
Q
P
S
Site 173
S1480
S
R
E
F
L
Q
P
S
S
K
A
S
L
E
S
Site 174
S1481
R
E
F
L
Q
P
S
S
K
A
S
L
E
S
T
Site 175
S1484
L
Q
P
S
S
K
A
S
L
E
S
T
S
D
L
Site 176
S1487
S
S
K
A
S
L
E
S
T
S
D
L
G
A
S
Site 177
T1488
S
K
A
S
L
E
S
T
S
D
L
G
A
S
G
Site 178
S1489
K
A
S
L
E
S
T
S
D
L
G
A
S
G
K
Site 179
S1494
S
T
S
D
L
G
A
S
G
K
H
G
G
N
V
Site 180
S1502
G
K
H
G
G
N
V
S
L
D
V
L
P
V
K
Site 181
S1514
P
V
K
G
P
Q
G
S
P
L
L
S
R
A
A
Site 182
S1518
P
Q
G
S
P
L
L
S
R
A
A
R
P
P
L
Site 183
S1530
P
P
L
D
Q
L
A
S
E
E
P
W
T
V
L
Site 184
T1554
S
P
C
D
M
A
K
T
G
R
F
Q
I
V
N
Site 185
S1563
R
F
Q
I
V
N
N
S
V
R
L
L
R
F
E
Site 186
S1598
S
K
L
Q
I
L
V
S
P
N
S
S
L
S
T
Site 187
S1601
Q
I
L
V
S
P
N
S
S
L
S
T
K
Q
S
Site 188
S1602
I
L
V
S
P
N
S
S
L
S
T
K
Q
S
M
Site 189
S1604
V
S
P
N
S
S
L
S
T
K
Q
S
M
F
P
Site 190
T1605
S
P
N
S
S
L
S
T
K
Q
S
M
F
P
W
Site 191
S1608
S
S
L
S
T
K
Q
S
M
F
P
W
S
G
L
Site 192
T1637
V
Q
I
R
E
D
L
T
Q
V
E
L
L
T
R
Site 193
S1654
S
K
P
F
G
I
L
S
P
V
S
E
P
S
V
Site 194
S1660
L
S
P
V
S
E
P
S
V
S
H
L
V
K
P
Site 195
S1662
P
V
S
E
P
S
V
S
H
L
V
K
P
M
T
Site 196
T1669
S
H
L
V
K
P
M
T
K
P
P
S
T
K
V
Site 197
S1673
K
P
M
T
K
P
P
S
T
K
V
E
I
R
N
Site 198
T1674
P
M
T
K
P
P
S
T
K
V
E
I
R
N
K
Site 199
S1682
K
V
E
I
R
N
K
S
I
T
F
P
T
T
E
Site 200
T1684
E
I
R
N
K
S
I
T
F
P
T
T
E
P
G
Site 201
T1688
K
S
I
T
F
P
T
T
E
P
G
E
T
S
E
Site 202
T1693
P
T
T
E
P
G
E
T
S
E
S
C
L
E
L
Site 203
S1696
E
P
G
E
T
S
E
S
C
L
E
L
E
N
H
Site 204
T1705
L
E
L
E
N
H
G
T
T
D
V
K
W
H
L
Site 205
S1713
T
D
V
K
W
H
L
S
S
L
A
P
P
Y
V
Site 206
S1714
D
V
K
W
H
L
S
S
L
A
P
P
Y
V
K
Site 207
Y1719
L
S
S
L
A
P
P
Y
V
K
G
V
D
E
S
Site 208
T1733
S
G
D
V
F
R
A
T
Y
A
A
F
R
C
S
Site 209
Y1734
G
D
V
F
R
A
T
Y
A
A
F
R
C
S
P
Site 210
S1748
P
I
S
G
L
L
E
S
H
G
I
Q
K
V
S
Site 211
S1755
S
H
G
I
Q
K
V
S
I
T
F
L
P
R
G
Site 212
T1757
G
I
Q
K
V
S
I
T
F
L
P
R
G
R
G
Site 213
Y1766
L
P
R
G
R
G
D
Y
A
Q
F
W
D
V
E
Site 214
T1785
K
E
P
H
M
K
H
T
L
R
F
Q
L
S
G
Site 215
S1791
H
T
L
R
F
Q
L
S
G
Q
S
I
E
A
E
Site 216
S1807
E
P
E
N
A
C
L
S
T
D
S
L
I
K
I
Site 217
S1826
K
P
R
R
Q
A
V
S
E
A
S
A
R
I
P
Site 218
T1839
I
P
E
Q
L
D
V
T
A
R
G
V
Y
A
P
Site 219
Y1844
D
V
T
A
R
G
V
Y
A
P
E
D
V
Y
R
Site 220
Y1850
V
Y
A
P
E
D
V
Y
R
F
R
P
T
S
V
Site 221
T1855
D
V
Y
R
F
R
P
T
S
V
G
E
S
R
T
Site 222
S1856
V
Y
R
F
R
P
T
S
V
G
E
S
R
T
L
Site 223
S1860
R
P
T
S
V
G
E
S
R
T
L
K
V
N
L
Site 224
T1862
T
S
V
G
E
S
R
T
L
K
V
N
L
R
N
Site 225
S1871
K
V
N
L
R
N
N
S
F
I
T
H
S
L
K
Site 226
S1876
N
N
S
F
I
T
H
S
L
K
F
L
S
P
R
Site 227
S1881
T
H
S
L
K
F
L
S
P
R
E
P
F
Y
V
Site 228
Y1887
L
S
P
R
E
P
F
Y
V
K
H
S
K
Y
S
Site 229
Y1893
F
Y
V
K
H
S
K
Y
S
L
R
A
Q
H
Y
Site 230
S1911
P
V
Q
F
K
P
K
S
A
G
K
F
E
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation