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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFAP1L1
Full Name:
Actin filament-associated protein 1-like 1
Alias:
Actin filament associated protein 1-like 1; AF1L1; FLJ00258; FLJ36748
Type:
Cytoskeleton associated protein
Mass (Da):
86432
Number AA:
768
UniProt ID:
Q8TED9
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
L
S
L
L
D
H
E
Y
L
S
D
T
T
L
E
Site 2
S27
L
L
D
H
E
Y
L
S
D
T
T
L
E
K
K
Site 3
S39
E
K
K
M
A
V
A
S
I
L
Q
S
L
Q
P
Site 4
Y54
L
P
A
K
E
V
S
Y
L
Y
V
N
T
A
D
Site 5
Y56
A
K
E
V
S
Y
L
Y
V
N
T
A
D
L
H
Site 6
S64
V
N
T
A
D
L
H
S
G
P
S
F
V
E
S
Site 7
S67
A
D
L
H
S
G
P
S
F
V
E
S
L
F
E
Site 8
S71
S
G
P
S
F
V
E
S
L
F
E
E
F
D
C
Site 9
S81
E
E
F
D
C
D
L
S
D
L
R
D
M
P
E
Site 10
S94
P
E
D
D
G
E
P
S
K
G
A
S
P
E
L
Site 11
S98
G
E
P
S
K
G
A
S
P
E
L
A
K
S
P
Site 12
S104
A
S
P
E
L
A
K
S
P
R
L
R
N
A
A
Site 13
Y126
N
K
P
P
P
E
D
Y
Y
E
E
A
L
P
L
Site 14
Y127
K
P
P
P
E
D
Y
Y
E
E
A
L
P
L
G
Site 15
S138
L
P
L
G
P
G
K
S
P
E
Y
I
S
S
H
Site 16
Y141
G
P
G
K
S
P
E
Y
I
S
S
H
N
G
C
Site 17
S143
G
K
S
P
E
Y
I
S
S
H
N
G
C
S
P
Site 18
S144
K
S
P
E
Y
I
S
S
H
N
G
C
S
P
S
Site 19
S149
I
S
S
H
N
G
C
S
P
S
H
S
I
V
D
Site 20
S151
S
H
N
G
C
S
P
S
H
S
I
V
D
G
Y
Site 21
S153
N
G
C
S
P
S
H
S
I
V
D
G
Y
Y
E
Site 22
Y158
S
H
S
I
V
D
G
Y
Y
E
D
A
D
S
S
Site 23
Y159
H
S
I
V
D
G
Y
Y
E
D
A
D
S
S
Y
Site 24
S164
G
Y
Y
E
D
A
D
S
S
Y
P
A
T
R
V
Site 25
S165
Y
Y
E
D
A
D
S
S
Y
P
A
T
R
V
N
Site 26
Y166
Y
E
D
A
D
S
S
Y
P
A
T
R
V
N
G
Site 27
T169
A
D
S
S
Y
P
A
T
R
V
N
G
E
L
K
Site 28
S177
R
V
N
G
E
L
K
S
S
Y
N
D
S
D
A
Site 29
S178
V
N
G
E
L
K
S
S
Y
N
D
S
D
A
M
Site 30
Y179
N
G
E
L
K
S
S
Y
N
D
S
D
A
M
S
Site 31
S182
L
K
S
S
Y
N
D
S
D
A
M
S
S
S
Y
Site 32
S186
Y
N
D
S
D
A
M
S
S
S
Y
E
S
Y
D
Site 33
S187
N
D
S
D
A
M
S
S
S
Y
E
S
Y
D
E
Site 34
S188
D
S
D
A
M
S
S
S
Y
E
S
Y
D
E
E
Site 35
S191
A
M
S
S
S
Y
E
S
Y
D
E
E
E
E
E
Site 36
Y192
M
S
S
S
Y
E
S
Y
D
E
E
E
E
E
G
Site 37
S201
E
E
E
E
E
G
K
S
P
Q
P
R
H
Q
W
Site 38
S210
Q
P
R
H
Q
W
P
S
E
E
A
S
M
H
L
Site 39
T241
G
Q
W
A
K
Q
L
T
V
I
R
E
D
Q
L
Site 40
Y251
R
E
D
Q
L
L
C
Y
K
S
S
K
D
R
Q
Site 41
S253
D
Q
L
L
C
Y
K
S
S
K
D
R
Q
P
H
Site 42
S254
Q
L
L
C
Y
K
S
S
K
D
R
Q
P
H
L
Site 43
Y272
L
D
T
C
S
I
I
Y
V
P
K
D
S
R
H
Site 44
T287
K
R
H
E
L
R
F
T
Q
G
A
T
E
V
L
Site 45
S315
L
K
V
I
R
E
V
S
K
P
V
G
G
A
E
Site 46
S329
E
G
V
E
V
P
R
S
P
V
L
L
C
K
L
Site 47
S343
L
D
L
D
K
R
L
S
Q
E
K
Q
T
S
D
Site 48
T348
R
L
S
Q
E
K
Q
T
S
D
S
D
S
V
G
Site 49
S349
L
S
Q
E
K
Q
T
S
D
S
D
S
V
G
V
Site 50
S351
Q
E
K
Q
T
S
D
S
D
S
V
G
V
G
D
Site 51
S353
K
Q
T
S
D
S
D
S
V
G
V
G
D
N
C
Site 52
S361
V
G
V
G
D
N
C
S
T
L
G
R
R
E
T
Site 53
T362
G
V
G
D
N
C
S
T
L
G
R
R
E
T
C
Site 54
T368
S
T
L
G
R
R
E
T
C
D
H
G
K
G
K
Site 55
S377
D
H
G
K
G
K
K
S
S
L
A
E
L
K
G
Site 56
S378
H
G
K
G
K
K
S
S
L
A
E
L
K
G
S
Site 57
S385
S
L
A
E
L
K
G
S
M
S
R
A
A
G
R
Site 58
S387
A
E
L
K
G
S
M
S
R
A
A
G
R
K
I
Site 59
T395
R
A
A
G
R
K
I
T
R
I
I
G
F
S
K
Site 60
S401
I
T
R
I
I
G
F
S
K
K
K
T
L
A
D
Site 61
T405
I
G
F
S
K
K
K
T
L
A
D
D
L
Q
T
Site 62
T412
T
L
A
D
D
L
Q
T
S
S
T
E
E
E
V
Site 63
S413
L
A
D
D
L
Q
T
S
S
T
E
E
E
V
P
Site 64
S414
A
D
D
L
Q
T
S
S
T
E
E
E
V
P
C
Site 65
T415
D
D
L
Q
T
S
S
T
E
E
E
V
P
C
C
Site 66
Y424
E
E
V
P
C
C
G
Y
L
N
V
L
V
N
Q
Site 67
Y446
R
L
K
C
N
T
L
Y
F
H
K
D
H
M
D
Site 68
T456
K
D
H
M
D
L
R
T
H
V
N
A
I
A
L
Site 69
T516
V
E
M
G
S
R
V
T
P
E
A
L
H
Y
D
Site 70
Y522
V
T
P
E
A
L
H
Y
D
Y
V
D
V
E
T
Site 71
Y524
P
E
A
L
H
Y
D
Y
V
D
V
E
T
L
T
Site 72
Y543
A
G
R
N
S
F
L
Y
A
R
S
C
Q
N
Q
Site 73
Y557
Q
W
P
E
P
R
V
Y
D
D
V
P
Y
E
K
Site 74
Y562
R
V
Y
D
D
V
P
Y
E
K
M
Q
D
E
E
Site 75
T574
D
E
E
P
E
R
P
T
G
A
Q
V
K
R
H
Site 76
S583
A
Q
V
K
R
H
A
S
S
C
S
E
K
S
H
Site 77
S584
Q
V
K
R
H
A
S
S
C
S
E
K
S
H
R
Site 78
S586
K
R
H
A
S
S
C
S
E
K
S
H
R
V
D
Site 79
S589
A
S
S
C
S
E
K
S
H
R
V
D
P
Q
V
Site 80
S603
V
K
V
K
R
H
A
S
S
A
N
Q
Y
K
Y
Site 81
Y610
S
S
A
N
Q
Y
K
Y
G
K
N
R
A
E
E
Site 82
Y622
A
E
E
D
A
R
R
Y
L
V
E
K
E
K
L
Site 83
T638
K
E
K
E
T
I
R
T
E
L
I
A
L
R
Q
Site 84
S657
L
K
E
A
I
R
S
S
P
G
A
K
L
K
A
Site 85
S700
V
K
E
R
L
Q
Q
S
L
A
G
G
P
A
L
Site 86
S710
G
G
P
A
L
G
L
S
V
S
S
K
P
K
S
Site 87
S712
P
A
L
G
L
S
V
S
S
K
P
K
S
G
E
Site 88
S713
A
L
G
L
S
V
S
S
K
P
K
S
G
E
T
Site 89
S717
S
V
S
S
K
P
K
S
G
E
T
A
N
K
P
Site 90
T720
S
K
P
K
S
G
E
T
A
N
K
P
Q
N
S
Site 91
S727
T
A
N
K
P
Q
N
S
V
P
E
Q
P
L
P
Site 92
S739
P
L
P
V
N
C
V
S
E
L
R
K
R
S
P
Site 93
S745
V
S
E
L
R
K
R
S
P
S
I
V
A
S
N
Site 94
S747
E
L
R
K
R
S
P
S
I
V
A
S
N
Q
G
Site 95
S751
R
S
P
S
I
V
A
S
N
Q
G
R
V
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation