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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRHL3
Full Name:
Grainyhead-like protein 3 homolog
Alias:
Sister of mammalian grainyhead;Transcription factor CP2-like 4
Type:
Mass (Da):
70345
Number AA:
626
UniProt ID:
Q8TE85
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
N
E
L
D
F
R
S
V
R
L
L
K
N
D
Site 2
Y25
V
N
L
Q
K
F
S
Y
T
S
E
D
E
A
W
Site 3
T34
S
E
D
E
A
W
K
T
Y
L
E
N
P
L
T
Site 4
S56
R
V
N
G
D
D
D
S
V
A
A
L
S
F
L
Site 5
Y66
A
L
S
F
L
Y
D
Y
Y
M
G
P
K
E
K
Site 6
Y67
L
S
F
L
Y
D
Y
Y
M
G
P
K
E
K
R
Site 7
S77
P
K
E
K
R
I
L
S
S
S
T
G
G
R
N
Site 8
S79
E
K
R
I
L
S
S
S
T
G
G
R
N
D
Q
Site 9
Y90
R
N
D
Q
G
K
R
Y
Y
H
G
M
E
Y
E
Site 10
Y91
N
D
Q
G
K
R
Y
Y
H
G
M
E
Y
E
T
Site 11
Y96
R
Y
Y
H
G
M
E
Y
E
T
D
L
T
P
L
Site 12
T101
M
E
Y
E
T
D
L
T
P
L
E
S
P
T
H
Site 13
S105
T
D
L
T
P
L
E
S
P
T
H
L
M
K
F
Site 14
T114
T
H
L
M
K
F
L
T
E
N
V
S
G
T
P
Site 15
S118
K
F
L
T
E
N
V
S
G
T
P
E
Y
P
D
Site 16
T120
L
T
E
N
V
S
G
T
P
E
Y
P
D
L
L
Site 17
Y123
N
V
S
G
T
P
E
Y
P
D
L
L
K
K
N
Site 18
S134
L
K
K
N
N
L
M
S
L
E
G
A
L
P
T
Site 19
S159
P
S
K
L
E
A
G
S
V
D
S
Y
L
L
P
Site 20
Y163
E
A
G
S
V
D
S
Y
L
L
P
T
T
D
M
Site 21
T168
D
S
Y
L
L
P
T
T
D
M
Y
D
N
G
S
Site 22
Y171
L
L
P
T
T
D
M
Y
D
N
G
S
L
N
S
Site 23
S175
T
D
M
Y
D
N
G
S
L
N
S
L
F
E
S
Site 24
S178
Y
D
N
G
S
L
N
S
L
F
E
S
I
H
G
Site 25
S182
S
L
N
S
L
F
E
S
I
H
G
V
P
P
T
Site 26
T189
S
I
H
G
V
P
P
T
Q
R
W
Q
P
D
S
Site 27
S196
T
Q
R
W
Q
P
D
S
T
F
K
D
D
P
Q
Site 28
T197
Q
R
W
Q
P
D
S
T
F
K
D
D
P
Q
E
Site 29
T214
L
F
P
D
I
L
K
T
S
P
E
P
P
C
P
Site 30
S215
F
P
D
I
L
K
T
S
P
E
P
P
C
P
E
Site 31
Y224
E
P
P
C
P
E
D
Y
P
S
L
K
S
D
F
Site 32
S226
P
C
P
E
D
Y
P
S
L
K
S
D
F
E
Y
Site 33
S229
E
D
Y
P
S
L
K
S
D
F
E
Y
T
L
G
Site 34
Y233
S
L
K
S
D
F
E
Y
T
L
G
S
P
K
A
Site 35
S237
D
F
E
Y
T
L
G
S
P
K
A
I
H
I
K
Site 36
S245
P
K
A
I
H
I
K
S
G
E
S
P
M
A
Y
Site 37
S248
I
H
I
K
S
G
E
S
P
M
A
Y
L
N
K
Site 38
Y252
S
G
E
S
P
M
A
Y
L
N
K
G
Q
F
Y
Site 39
Y259
Y
L
N
K
G
Q
F
Y
P
V
T
L
R
T
P
Site 40
T262
K
G
Q
F
Y
P
V
T
L
R
T
P
A
G
G
Site 41
S275
G
G
K
G
L
A
L
S
S
N
K
V
K
S
V
Site 42
T309
H
W
H
S
R
Q
P
T
A
K
Q
R
V
I
D
Site 43
T326
D
C
K
E
N
F
N
T
V
E
H
I
E
E
V
Site 44
S358
F
I
G
V
N
C
L
S
T
D
F
S
S
Q
K
Site 45
T359
I
G
V
N
C
L
S
T
D
F
S
S
Q
K
G
Site 46
S362
N
C
L
S
T
D
F
S
S
Q
K
G
V
K
G
Site 47
S363
C
L
S
T
D
F
S
S
Q
K
G
V
K
G
V
Site 48
T378
P
L
N
L
Q
I
D
T
Y
D
C
G
L
G
T
Site 49
Y379
L
N
L
Q
I
D
T
Y
D
C
G
L
G
T
E
Site 50
T385
T
Y
D
C
G
L
G
T
E
R
L
V
H
R
A
Site 51
S425
R
K
V
K
C
P
D
S
S
N
S
G
V
K
G
Site 52
S426
K
V
K
C
P
D
S
S
N
S
G
V
K
G
C
Site 53
S428
K
C
P
D
S
S
N
S
G
V
K
G
C
L
L
Site 54
S436
G
V
K
G
C
L
L
S
G
F
R
G
N
E
T
Site 55
T443
S
G
F
R
G
N
E
T
T
Y
L
R
P
E
T
Site 56
T444
G
F
R
G
N
E
T
T
Y
L
R
P
E
T
D
Site 57
Y445
F
R
G
N
E
T
T
Y
L
R
P
E
T
D
L
Site 58
T450
T
T
Y
L
R
P
E
T
D
L
E
T
P
P
V
Site 59
T454
R
P
E
T
D
L
E
T
P
P
V
L
F
I
P
Site 60
S466
F
I
P
N
V
H
F
S
S
L
Q
R
S
G
G
Site 61
S467
I
P
N
V
H
F
S
S
L
Q
R
S
G
G
A
Site 62
S471
H
F
S
S
L
Q
R
S
G
G
A
A
P
S
A
Site 63
S477
R
S
G
G
A
A
P
S
A
G
P
S
S
S
N
Site 64
S481
A
A
P
S
A
G
P
S
S
S
N
R
L
P
L
Site 65
S482
A
P
S
A
G
P
S
S
S
N
R
L
P
L
K
Site 66
S483
P
S
A
G
P
S
S
S
N
R
L
P
L
K
R
Site 67
T491
N
R
L
P
L
K
R
T
C
S
P
F
T
E
E
Site 68
S493
L
P
L
K
R
T
C
S
P
F
T
E
E
F
E
Site 69
T496
K
R
T
C
S
P
F
T
E
E
F
E
P
L
P
Site 70
S504
E
E
F
E
P
L
P
S
K
Q
A
K
E
G
D
Site 71
Y518
D
L
Q
R
V
L
L
Y
V
R
R
E
T
E
E
Site 72
T523
L
L
Y
V
R
R
E
T
E
E
V
F
D
A
L
Site 73
T534
F
D
A
L
M
L
K
T
P
D
L
K
G
L
R
Site 74
S545
K
G
L
R
N
A
I
S
E
K
Y
G
F
P
E
Site 75
Y548
R
N
A
I
S
E
K
Y
G
F
P
E
E
N
I
Site 76
Y556
G
F
P
E
E
N
I
Y
K
V
Y
K
K
C
K
Site 77
T567
K
K
C
K
R
G
E
T
S
L
L
H
P
R
L
Site 78
S568
K
C
K
R
G
E
T
S
L
L
H
P
R
L
S
Site 79
S575
S
L
L
H
P
R
L
S
R
H
P
P
P
D
C
Site 80
S586
P
P
D
C
L
E
C
S
H
P
V
T
Q
V
R
Site 81
T590
L
E
C
S
H
P
V
T
Q
V
R
N
M
G
F
Site 82
S609
W
R
Q
R
D
L
D
S
N
P
S
P
T
T
V
Site 83
S612
R
D
L
D
S
N
P
S
P
T
T
V
N
S
L
Site 84
T614
L
D
S
N
P
S
P
T
T
V
N
S
L
H
F
Site 85
T615
D
S
N
P
S
P
T
T
V
N
S
L
H
F
T
Site 86
S618
P
S
P
T
T
V
N
S
L
H
F
T
V
N
S
Site 87
S625
S
L
H
F
T
V
N
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation