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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Sh3tc1
Full Name:
SH3 domain and tetratricopeptide repeats-containing protein 1
Alias:
Flj20356; Flj32999; Flj36243; Flj46394; Sh3 domain and tetratricopeptide repeats 1
Type:
Mass (Da):
146927
Number AA:
1336
UniProt ID:
Q8TE82
International Prot ID:
IPI00152665
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
E
N
L
P
A
V
T
T
E
E
P
T
P
M
G
Site 2
T13
A
V
T
T
E
E
P
T
P
M
G
R
G
P
V
Site 3
S23
G
R
G
P
V
G
P
S
G
G
G
S
T
R
D
Site 4
S27
V
G
P
S
G
G
G
S
T
R
D
Q
V
R
T
Site 5
T34
S
T
R
D
Q
V
R
T
V
V
M
R
P
S
V
Site 6
S40
R
T
V
V
M
R
P
S
V
S
W
E
K
A
G
Site 7
S42
V
V
M
R
P
S
V
S
W
E
K
A
G
P
E
Site 8
Y80
P
P
C
Q
M
G
V
Y
P
T
D
L
T
L
Q
Site 9
S95
L
L
A
V
R
R
K
S
R
L
R
D
P
G
L
Site 10
T105
R
D
P
G
L
Q
Q
T
L
R
G
Q
L
R
L
Site 11
S117
L
R
L
L
E
N
D
S
R
E
M
A
R
V
L
Site 12
S133
E
L
S
A
R
L
L
S
I
H
S
D
Q
D
R
Site 13
T144
D
Q
D
R
I
V
V
T
F
K
T
F
E
E
I
Site 14
Y157
E
I
W
K
F
S
T
Y
H
A
L
G
F
T
H
Site 15
T187
L
P
S
E
E
E
E
T
A
I
Q
V
H
V
D
Site 16
T201
D
E
N
A
L
R
L
T
H
E
S
L
L
I
Q
Site 17
S204
A
L
R
L
T
H
E
S
L
L
I
Q
E
G
P
Site 18
T225
D
H
H
V
R
V
M
T
G
P
R
D
A
G
N
Site 19
S241
P
Q
A
L
R
Q
A
S
G
A
P
Q
G
E
A
Site 20
T252
Q
G
E
A
A
P
E
T
D
S
S
P
P
S
P
Site 21
S254
E
A
A
P
E
T
D
S
S
P
P
S
P
S
V
Site 22
S255
A
A
P
E
T
D
S
S
P
P
S
P
S
V
S
Site 23
S258
E
T
D
S
S
P
P
S
P
S
V
S
S
E
E
Site 24
S260
D
S
S
P
P
S
P
S
V
S
S
E
E
V
A
Site 25
S262
S
P
P
S
P
S
V
S
S
E
E
V
A
V
A
Site 26
T325
G
S
G
P
E
E
M
T
F
R
G
G
D
L
I
Site 27
S374
G
P
V
S
E
L
E
S
A
I
F
L
N
E
E
Site 28
S384
F
L
N
E
E
E
K
S
F
F
S
E
G
C
F
Site 29
S392
F
F
S
E
G
C
F
S
E
E
D
A
R
Q
L
Site 30
S404
R
Q
L
L
R
R
M
S
G
T
D
V
C
S
V
Site 31
Y412
G
T
D
V
C
S
V
Y
S
L
D
S
V
E
E
Site 32
S413
T
D
V
C
S
V
Y
S
L
D
S
V
E
E
A
Site 33
S416
C
S
V
Y
S
L
D
S
V
E
E
A
E
T
E
Site 34
T422
D
S
V
E
E
A
E
T
E
Q
P
Q
E
K
E
Site 35
S436
E
I
P
P
P
C
L
S
P
E
P
Q
E
T
L
Site 36
T442
L
S
P
E
P
Q
E
T
L
Q
K
V
K
N
V
Site 37
S465
G
C
P
Q
E
P
A
S
W
G
L
C
A
A
S
Site 38
S472
S
W
G
L
C
A
A
S
S
D
V
S
L
Q
D
Site 39
S473
W
G
L
C
A
A
S
S
D
V
S
L
Q
D
P
Site 40
S476
C
A
A
S
S
D
V
S
L
Q
D
P
E
E
P
Site 41
S484
L
Q
D
P
E
E
P
S
F
C
L
E
A
E
D
Site 42
S514
N
A
P
G
Y
K
A
S
F
R
G
L
Y
D
V
Site 43
S532
W
L
S
S
V
F
R
S
F
S
D
E
E
E
L
Site 44
S534
S
S
V
F
R
S
F
S
D
E
E
E
L
T
G
Site 45
T540
F
S
D
E
E
E
L
T
G
R
L
A
Q
A
R
Site 46
S571
F
L
L
G
R
L
C
S
R
R
L
K
L
S
Q
Site 47
S577
C
S
R
R
L
K
L
S
Q
A
R
V
Y
F
E
Site 48
Y582
K
L
S
Q
A
R
V
Y
F
E
E
A
L
G
A
Site 49
S609
A
V
Y
A
N
L
A
S
I
Y
R
K
Q
K
N
Site 50
S640
G
T
P
D
H
I
C
S
T
E
A
E
G
E
L
Site 51
S740
A
S
L
R
T
R
G
S
L
A
G
S
L
R
S
Site 52
S760
Q
N
A
P
Q
P
H
S
L
P
A
Q
T
S
H
Site 53
Y768
L
P
A
Q
T
S
H
Y
L
R
Q
A
L
A
S
Site 54
S775
Y
L
R
Q
A
L
A
S
L
T
P
G
T
G
Q
Site 55
T777
R
Q
A
L
A
S
L
T
P
G
T
G
Q
A
L
Site 56
Y789
Q
A
L
R
G
P
L
Y
T
S
L
A
Q
L
Y
Site 57
S791
L
R
G
P
L
Y
T
S
L
A
Q
L
Y
S
H
Site 58
Y796
Y
T
S
L
A
Q
L
Y
S
H
H
G
C
H
G
Site 59
S797
T
S
L
A
Q
L
Y
S
H
H
G
C
H
G
P
Site 60
S885
R
T
R
Q
A
A
E
S
Y
Y
R
A
L
R
V
Site 61
Y968
P
A
Q
Q
G
K
G
Y
Y
E
W
A
L
L
V
Site 62
S984
V
E
M
G
H
V
E
S
Q
L
R
A
V
Q
R
Site 63
Y996
V
Q
R
L
C
H
F
Y
S
A
V
M
P
S
E
Site 64
S997
Q
R
L
C
H
F
Y
S
A
V
M
P
S
E
A
Site 65
Y1037
L
E
T
I
S
Q
L
Y
L
S
L
G
T
E
R
Site 66
S1039
T
I
S
Q
L
Y
L
S
L
G
T
E
R
A
Y
Site 67
Y1046
S
L
G
T
E
R
A
Y
K
S
A
L
D
Y
T
Site 68
S1048
G
T
E
R
A
Y
K
S
A
L
D
Y
T
K
R
Site 69
Y1052
A
Y
K
S
A
L
D
Y
T
K
R
S
L
G
I
Site 70
T1053
Y
K
S
A
L
D
Y
T
K
R
S
L
G
I
F
Site 71
Y1081
L
Q
A
G
K
I
Y
Y
I
L
R
Q
S
E
L
Site 72
S1132
W
E
R
E
K
A
V
S
F
Y
R
D
R
A
L
Site 73
Y1195
R
L
N
E
R
V
A
Y
H
R
L
A
A
L
Q
Site 74
S1224
K
A
L
S
L
C
N
S
P
L
E
F
D
E
E
Site 75
T1232
P
L
E
F
D
E
E
T
L
Y
Y
V
K
V
Y
Site 76
Y1234
E
F
D
E
E
T
L
Y
Y
V
K
V
Y
L
V
Site 77
Y1248
V
L
G
D
I
I
F
Y
D
L
K
D
P
F
D
Site 78
Y1280
K
K
A
Q
L
K
I
Y
T
R
L
A
T
I
Y
Site 79
Y1287
Y
T
R
L
A
T
I
Y
H
N
F
L
L
D
R
Site 80
S1297
F
L
L
D
R
E
K
S
L
F
F
Y
Q
K
A
Site 81
Y1301
R
E
K
S
L
F
F
Y
Q
K
A
R
T
F
A
Site 82
T1306
F
F
Y
Q
K
A
R
T
F
A
T
E
L
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation