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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNAH5
Full Name:
Dynein heavy chain 5, axonemal
Alias:
Axonemal beta dynein heavy chain 5; CILD3; Ciliary dynein heavy chain 5; DNAHC5; DYH5; Dynein heavy chain; Dynein heavy chain 5; Dynein, axonemal, heavy chain 5; Dynein, axonemal, heavy polypeptide 5; HL1; KTGNR; PCD
Type:
Microtubule, Axonemal dynein complex protein
Mass (Da):
529021
Number AA:
4624
UniProt ID:
Q8TE73
International Prot ID:
IPI00152653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
R
Q
L
W
K
H
S
V
T
R
V
L
T
Q
Site 2
T19
H
S
V
T
R
V
L
T
Q
R
L
K
G
E
K
Site 3
T53
S
C
L
D
L
N
K
T
E
V
E
D
A
I
L
Site 4
Y83
G
L
R
H
L
M
F
Y
Y
Q
D
V
E
E
A
Site 5
Y84
L
R
H
L
M
F
Y
Y
Q
D
V
E
E
A
E
Site 6
T92
Q
D
V
E
E
A
E
T
G
Q
L
G
S
L
G
Site 7
S105
L
G
G
V
N
L
V
S
G
K
I
K
K
P
K
Site 8
S136
F
F
I
R
T
D
P
S
K
A
I
T
P
D
N
Site 9
T140
T
D
P
S
K
A
I
T
P
D
N
I
H
Q
E
Site 10
S163
A
D
G
G
L
L
N
S
V
R
R
L
L
S
D
Site 11
S180
I
P
A
L
R
A
T
S
H
G
W
G
E
L
E
Site 12
S201
N
I
R
Q
E
F
L
S
S
L
E
G
F
V
N
Site 13
S211
E
G
F
V
N
V
L
S
G
A
Q
E
S
L
K
Site 14
Y240
T
L
K
E
P
T
D
Y
L
T
L
A
N
N
P
Site 15
T242
K
E
P
T
D
Y
L
T
L
A
N
N
P
E
T
Site 16
S295
E
H
W
K
K
R
L
S
K
F
N
Y
L
L
E
Site 17
Y299
K
R
L
S
K
F
N
Y
L
L
E
Q
L
K
S
Site 18
T326
A
K
S
K
L
L
K
T
W
R
E
M
D
I
R
Site 19
T335
R
E
M
D
I
R
I
T
D
A
T
N
E
A
K
Site 20
T338
D
I
R
I
T
D
A
T
N
E
A
K
D
N
V
Site 21
Y347
E
A
K
D
N
V
K
Y
L
Y
T
L
E
K
C
Site 22
Y349
K
D
N
V
K
Y
L
Y
T
L
E
K
C
C
D
Site 23
Y359
E
K
C
C
D
P
L
Y
S
S
D
P
L
S
M
Site 24
S360
K
C
C
D
P
L
Y
S
S
D
P
L
S
M
M
Site 25
S361
C
C
D
P
L
Y
S
S
D
P
L
S
M
M
D
Site 26
Y386
M
I
Y
S
I
S
H
Y
Y
N
T
S
E
K
I
Site 27
S395
N
T
S
E
K
I
T
S
L
F
V
K
V
T
N
Site 28
S434
V
V
E
E
K
I
L
S
A
I
K
L
K
Q
E
Site 29
Y442
A
I
K
L
K
Q
E
Y
Q
L
C
F
H
K
T
Site 30
T475
Y
I
F
G
K
F
E
T
F
H
R
R
L
A
K
Site 31
T492
D
I
F
T
T
L
K
T
Y
S
V
L
Q
D
S
Site 32
S499
T
Y
S
V
L
Q
D
S
T
I
E
G
L
E
D
Site 33
T509
E
G
L
E
D
M
A
T
K
Y
Q
G
I
V
A
Site 34
Y537
K
M
D
F
D
Q
D
Y
E
E
F
C
K
Q
T
Site 35
T558
L
R
K
F
M
D
V
T
F
A
K
I
Q
N
T
Site 36
Y589
N
L
G
I
D
D
K
Y
Q
L
I
L
E
N
Y
Site 37
Y596
Y
Q
L
I
L
E
N
Y
G
A
D
I
D
M
I
Site 38
T608
D
M
I
S
K
L
Y
T
K
Q
K
Y
D
P
P
Site 39
Y612
K
L
Y
T
K
Q
K
Y
D
P
P
L
A
R
N
Site 40
Y663
A
K
P
I
I
R
S
Y
N
R
M
A
K
V
L
Site 41
Y745
L
F
Q
K
R
D
R
Y
K
R
N
F
S
N
M
Site 42
Y759
M
K
M
M
L
A
E
Y
Q
R
V
K
S
K
I
Site 43
S764
A
E
Y
Q
R
V
K
S
K
I
P
A
A
I
E
Site 44
Y802
T
S
L
N
I
E
A
Y
L
E
N
T
F
A
K
Site 45
T806
I
E
A
Y
L
E
N
T
F
A
K
I
K
D
L
Site 46
T838
I
L
E
E
M
S
S
T
P
L
C
Q
L
P
Q
Site 47
T850
L
P
Q
E
E
P
L
T
C
E
E
F
L
Q
M
Site 48
S894
L
L
D
V
E
V
L
S
E
E
E
S
E
K
I
Site 49
S898
E
V
L
S
E
E
E
S
E
K
I
S
N
E
N
Site 50
S902
E
E
E
S
E
K
I
S
N
E
N
S
V
N
Y
Site 51
S906
E
K
I
S
N
E
N
S
V
N
Y
K
N
E
S
Site 52
Y909
S
N
E
N
S
V
N
Y
K
N
E
S
S
A
K
Site 53
S914
V
N
Y
K
N
E
S
S
A
K
R
E
E
G
N
Site 54
T924
R
E
E
G
N
F
D
T
L
T
S
S
I
N
A
Site 55
T926
E
G
N
F
D
T
L
T
S
S
I
N
A
R
A
Site 56
S928
N
F
D
T
L
T
S
S
I
N
A
R
A
N
A
Site 57
T939
R
A
N
A
L
L
L
T
T
V
T
R
K
K
K
Site 58
T940
A
N
A
L
L
L
T
T
V
T
R
K
K
K
E
Site 59
T977
L
L
K
V
T
R
N
T
L
E
A
I
R
K
R
Site 60
S987
A
I
R
K
R
I
H
S
S
H
T
I
N
F
R
Site 61
S996
H
T
I
N
F
R
D
S
N
S
A
S
N
M
K
Site 62
S998
I
N
F
R
D
S
N
S
A
S
N
M
K
Q
N
Site 63
S1000
F
R
D
S
N
S
A
S
N
M
K
Q
N
S
L
Site 64
S1006
A
S
N
M
K
Q
N
S
L
P
I
F
R
A
S
Site 65
S1052
P
K
G
V
R
Q
W
S
S
E
L
L
S
K
K
Site 66
S1053
K
G
V
R
Q
W
S
S
E
L
L
S
K
K
K
Site 67
S1057
Q
W
S
S
E
L
L
S
K
K
K
I
Q
E
R
Site 68
S1071
R
K
M
A
A
L
Q
S
N
E
D
S
D
S
D
Site 69
S1075
A
L
Q
S
N
E
D
S
D
S
D
V
E
M
G
Site 70
S1077
Q
S
N
E
D
S
D
S
D
V
E
M
G
E
N
Site 71
T1089
G
E
N
E
L
Q
D
T
L
E
I
A
S
V
N
Site 72
Y1107
P
V
Q
T
K
N
Y
Y
K
N
V
S
E
N
K
Site 73
T1125
K
L
V
S
V
L
S
T
I
I
N
S
T
K
K
Site 74
S1129
V
L
S
T
I
I
N
S
T
K
K
E
V
I
T
Site 75
T1158
G
K
E
E
A
I
K
T
F
I
T
Q
S
P
L
Site 76
S1171
P
L
L
S
E
F
E
S
Q
I
L
Y
F
Q
N
Site 77
Y1175
E
F
E
S
Q
I
L
Y
F
Q
N
L
E
Q
E
Site 78
Y1225
G
R
H
C
N
K
K
Y
R
S
E
M
E
N
I
Site 79
S1269
E
I
R
E
E
Q
I
S
I
D
F
Q
V
G
P
Site 80
Y1281
V
G
P
I
E
E
S
Y
A
L
L
N
R
Y
G
Site 81
T1301
E
E
I
D
K
V
D
T
L
H
Y
A
W
E
K
Site 82
S1322
E
V
Q
N
K
L
V
S
L
Q
P
S
F
K
K
Site 83
S1326
K
L
V
S
L
Q
P
S
F
K
K
E
L
I
S
Site 84
Y1346
L
Q
D
C
H
Q
F
Y
L
D
Y
D
L
N
G
Site 85
Y1349
C
H
Q
F
Y
L
D
Y
D
L
N
G
P
M
A
Site 86
S1365
G
L
K
P
Q
E
A
S
D
R
L
I
M
F
Q
Site 87
Y1379
Q
N
Q
F
D
N
I
Y
R
K
Y
I
T
Y
T
Site 88
Y1382
F
D
N
I
Y
R
K
Y
I
T
Y
T
G
G
E
Site 89
Y1385
I
Y
R
K
Y
I
T
Y
T
G
G
E
E
L
F
Site 90
T1397
E
L
F
G
L
P
A
T
Q
Y
P
Q
L
L
E
Site 91
Y1399
F
G
L
P
A
T
Q
Y
P
Q
L
L
E
I
K
Site 92
S1421
K
I
Y
T
L
Y
N
S
V
I
E
T
V
N
S
Site 93
T1425
L
Y
N
S
V
I
E
T
V
N
S
Y
Y
D
I
Site 94
S1477
K
K
I
I
D
D
F
S
E
C
C
P
L
L
E
Site 95
S1488
P
L
L
E
Y
M
A
S
K
A
M
M
E
R
H
Site 96
T1500
E
R
H
W
E
R
I
T
T
L
T
G
H
S
L
Site 97
T1501
R
H
W
E
R
I
T
T
L
T
G
H
S
L
D
Site 98
T1503
W
E
R
I
T
T
L
T
G
H
S
L
D
V
G
Site 99
S1513
S
L
D
V
G
N
E
S
F
K
L
R
N
I
M
Site 100
S1537
E
I
E
D
I
C
I
S
A
V
K
E
R
D
I
Site 101
T1561
E
W
D
N
K
T
F
T
F
G
S
F
K
T
R
Site 102
S1564
N
K
T
F
T
F
G
S
F
K
T
R
G
E
L
Site 103
S1577
E
L
L
L
R
G
D
S
T
S
E
I
I
A
N
Site 104
S1579
L
L
R
G
D
S
T
S
E
I
I
A
N
M
E
Site 105
S1594
D
S
L
M
L
L
G
S
L
L
S
N
R
Y
N
Site 106
Y1600
G
S
L
L
S
N
R
Y
N
M
P
F
K
A
Q
Site 107
Y1614
Q
I
Q
K
W
V
Q
Y
L
S
N
S
T
D
I
Site 108
S1656
P
K
E
A
K
R
F
S
N
I
D
K
S
W
V
Site 109
T1684
Q
C
C
V
G
D
E
T
L
G
Q
L
L
P
H
Site 110
S1702
Q
L
E
I
C
Q
K
S
L
T
G
Y
L
E
K
Site 111
Y1706
C
Q
K
S
L
T
G
Y
L
E
K
K
R
L
C
Site 112
S1733
L
E
I
L
G
Q
A
S
D
S
H
T
I
Q
A
Site 113
S1735
I
L
G
Q
A
S
D
S
H
T
I
Q
A
H
L
Site 114
T1737
G
Q
A
S
D
S
H
T
I
Q
A
H
L
L
N
Site 115
Y1759
V
K
F
H
E
K
I
Y
D
R
I
L
S
I
S
Site 116
S1764
K
I
Y
D
R
I
L
S
I
S
S
Q
E
G
E
Site 117
S1766
Y
D
R
I
L
S
I
S
S
Q
E
G
E
T
I
Site 118
S1767
D
R
I
L
S
I
S
S
Q
E
G
E
T
I
E
Site 119
S1791
N
V
E
V
W
L
N
S
L
L
E
E
S
Q
S
Site 120
S1796
L
N
S
L
L
E
E
S
Q
S
S
L
H
L
V
Site 121
S1798
S
L
L
E
E
S
Q
S
S
L
H
L
V
I
R
Site 122
S1799
L
L
E
E
S
Q
S
S
L
H
L
V
I
R
Q
Site 123
T1819
Q
E
T
G
F
Q
L
T
E
F
L
S
S
F
P
Site 124
S1842
Q
M
I
W
T
R
D
S
E
E
A
L
R
N
A
Site 125
T1859
D
K
K
I
M
Q
K
T
N
Q
A
F
L
E
L
Site 126
T1874
L
N
T
L
I
D
V
T
T
R
D
L
S
S
T
Site 127
T1875
N
T
L
I
D
V
T
T
R
D
L
S
S
T
E
Site 128
S1879
D
V
T
T
R
D
L
S
S
T
E
R
V
K
Y
Site 129
S1880
V
T
T
R
D
L
S
S
T
E
R
V
K
Y
E
Site 130
T1881
T
T
R
D
L
S
S
T
E
R
V
K
Y
E
T
Site 131
Y1886
S
S
T
E
R
V
K
Y
E
T
L
I
T
I
H
Site 132
T1888
T
E
R
V
K
Y
E
T
L
I
T
I
H
V
H
Site 133
Y1923
W
L
K
Q
C
R
F
Y
F
N
E
D
S
D
K
Site 134
T1956
C
T
D
R
L
V
I
T
P
L
T
D
R
C
Y
Site 135
S2027
K
G
L
A
Q
S
G
S
W
G
C
F
D
E
F
Site 136
T2054
Q
Q
I
S
I
I
L
T
C
K
K
E
H
K
K
Site 137
S2062
C
K
K
E
H
K
K
S
F
I
F
T
D
G
D
Site 138
T2066
H
K
K
S
F
I
F
T
D
G
D
N
V
T
M
Site 139
T2072
F
T
D
G
D
N
V
T
M
N
P
E
F
G
L
Site 140
Y2087
F
L
T
M
N
P
G
Y
A
G
R
Q
E
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D
P
T
D
S
I
I
A
L
G
K
R
Site 293
T4070
G
K
R
L
K
I
E
T
R
Y
V
S
M
G
Q
Site 294
Y4072
R
L
K
I
E
T
R
Y
V
S
M
G
Q
G
Q
Site 295
S4074
K
I
E
T
R
Y
V
S
M
G
Q
G
Q
E
V
Site 296
T4164
L
R
A
G
L
K
R
T
Y
S
G
V
S
Q
D
Site 297
Y4165
R
A
G
L
K
R
T
Y
S
G
V
S
Q
D
L
Site 298
S4166
A
G
L
K
R
T
Y
S
G
V
S
Q
D
L
L
Site 299
S4176
S
Q
D
L
L
D
V
S
S
G
S
Q
W
K
P
Site 300
S4177
Q
D
L
L
D
V
S
S
G
S
Q
W
K
P
M
Site 301
S4179
L
L
D
V
S
S
G
S
Q
W
K
P
M
L
Y
Site 302
S4193
Y
A
V
A
F
L
H
S
T
V
Q
E
R
R
K
Site 303
T4194
A
V
A
F
L
H
S
T
V
Q
E
R
R
K
F
Site 304
Y4244
V
S
W
T
T
I
R
Y
M
I
G
E
I
Q
Y
Site 305
Y4251
Y
M
I
G
E
I
Q
Y
G
G
R
V
T
D
D
Site 306
T4256
I
Q
Y
G
G
R
V
T
D
D
Y
D
K
R
L
Site 307
Y4259
G
G
R
V
T
D
D
Y
D
K
R
L
L
N
T
Site 308
T4266
Y
D
K
R
L
L
N
T
F
A
K
V
W
F
S
Site 309
Y4284
F
G
P
D
F
S
F
Y
Q
G
Y
N
I
P
K
Site 310
Y4287
D
F
S
F
Y
Q
G
Y
N
I
P
K
C
S
T
Site 311
Y4298
K
C
S
T
V
D
N
Y
L
Q
Y
I
Q
S
L
Site 312
Y4301
T
V
D
N
Y
L
Q
Y
I
Q
S
L
P
A
Y
Site 313
S4304
N
Y
L
Q
Y
I
Q
S
L
P
A
Y
D
S
P
Site 314
Y4308
Y
I
Q
S
L
P
A
Y
D
S
P
E
V
F
G
Site 315
S4310
Q
S
L
P
A
Y
D
S
P
E
V
F
G
L
H
Site 316
T4323
L
H
P
N
A
D
I
T
Y
Q
S
K
L
A
K
Site 317
Y4324
H
P
N
A
D
I
T
Y
Q
S
K
L
A
K
D
Site 318
T4344
L
G
I
Q
P
K
D
T
S
G
G
G
D
E
T
Site 319
Y4371
L
E
K
L
P
P
D
Y
V
P
F
E
V
K
E
Site 320
S4405
D
R
M
Q
R
V
L
S
L
V
R
S
T
L
T
Site 321
S4448
P
A
W
W
K
K
A
S
W
I
S
S
T
L
G
Site 322
T4459
S
T
L
G
F
W
F
T
E
L
I
E
R
N
S
Site 323
S4466
T
E
L
I
E
R
N
S
Q
F
T
S
W
V
F
Site 324
S4470
E
R
N
S
Q
F
T
S
W
V
F
N
G
R
P
Site 325
T4493
F
N
P
Q
G
F
L
T
A
M
R
Q
E
I
T
Site 326
S4526
K
W
M
K
D
D
I
S
A
P
P
T
E
G
V
Site 327
T4530
D
D
I
S
A
P
P
T
E
G
V
Y
V
Y
G
Site 328
S4555
R
N
M
K
L
I
E
S
K
P
K
V
L
F
E
Site 329
T4575
R
I
Y
A
E
N
N
T
L
R
D
P
R
F
Y
Site 330
Y4582
T
L
R
D
P
R
F
Y
S
C
P
I
Y
K
K
Site 331
S4583
L
R
D
P
R
F
Y
S
C
P
I
Y
K
K
P
Site 332
Y4587
R
F
Y
S
C
P
I
Y
K
K
P
V
R
T
D
Site 333
T4608
V
D
L
R
T
A
Q
T
P
E
H
W
V
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation