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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS18
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 18
Alias:
Type:
Mass (Da):
135167
Number AA:
1221
UniProt ID:
Q8TE60
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S51
A
A
L
A
S
D
S
S
S
G
A
S
G
L
N
Site 2
S52
A
L
A
S
D
S
S
S
G
A
S
G
L
N
D
Site 3
S55
S
D
S
S
S
G
A
S
G
L
N
D
D
Y
V
Site 4
T65
N
D
D
Y
V
F
V
T
P
V
E
V
D
S
A
Site 5
S71
V
T
P
V
E
V
D
S
A
G
S
Y
I
S
H
Site 6
Y75
E
V
D
S
A
G
S
Y
I
S
H
D
I
L
H
Site 7
S77
D
S
A
G
S
Y
I
S
H
D
I
L
H
N
G
Site 8
S96
S
A
Q
N
A
R
S
S
L
H
Y
R
F
S
A
Site 9
Y99
N
A
R
S
S
L
H
Y
R
F
S
A
F
G
Q
Site 10
S102
S
S
L
H
Y
R
F
S
A
F
G
Q
E
L
H
Site 11
T135
G
K
D
G
A
S
E
T
Q
K
P
E
V
Q
Q
Site 12
Y145
P
E
V
Q
Q
C
F
Y
Q
G
F
I
R
N
D
Site 13
S153
Q
G
F
I
R
N
D
S
S
S
S
V
A
V
S
Site 14
S154
G
F
I
R
N
D
S
S
S
S
V
A
V
S
T
Site 15
S155
F
I
R
N
D
S
S
S
S
V
A
V
S
T
C
Site 16
S156
I
R
N
D
S
S
S
S
V
A
V
S
T
C
A
Site 17
S192
L
A
Q
E
H
N
H
S
S
P
A
G
H
H
P
Site 18
S193
A
Q
E
H
N
H
S
S
P
A
G
H
H
P
H
Site 19
Y203
G
H
H
P
H
V
L
Y
K
R
T
A
E
E
K
Site 20
Y217
K
I
Q
R
Y
R
G
Y
P
G
S
G
R
N
Y
Site 21
S220
R
Y
R
G
Y
P
G
S
G
R
N
Y
P
G
Y
Site 22
Y224
Y
P
G
S
G
R
N
Y
P
G
Y
S
P
S
H
Site 23
Y227
S
G
R
N
Y
P
G
Y
S
P
S
H
I
P
H
Site 24
S228
G
R
N
Y
P
G
Y
S
P
S
H
I
P
H
A
Site 25
S230
N
Y
P
G
Y
S
P
S
H
I
P
H
A
S
Q
Site 26
S236
P
S
H
I
P
H
A
S
Q
S
R
E
T
E
Y
Site 27
S238
H
I
P
H
A
S
Q
S
R
E
T
E
Y
H
H
Site 28
T241
H
A
S
Q
S
R
E
T
E
Y
H
H
R
R
L
Site 29
Y243
S
Q
S
R
E
T
E
Y
H
H
R
R
L
Q
K
Site 30
Y260
F
C
G
R
R
K
K
Y
A
P
K
P
P
T
E
Site 31
T266
K
Y
A
P
K
P
P
T
E
D
T
Y
L
R
F
Site 32
T269
P
K
P
P
T
E
D
T
Y
L
R
F
D
E
Y
Site 33
Y270
K
P
P
T
E
D
T
Y
L
R
F
D
E
Y
G
Site 34
Y276
T
Y
L
R
F
D
E
Y
G
S
S
G
R
P
R
Site 35
S279
R
F
D
E
Y
G
S
S
G
R
P
R
R
S
A
Site 36
S285
S
S
G
R
P
R
R
S
A
G
K
S
Q
K
G
Site 37
S289
P
R
R
S
A
G
K
S
Q
K
G
L
N
V
E
Site 38
T333
S
G
L
F
K
D
G
T
I
G
S
D
I
N
V
Site 39
T404
W
K
N
E
P
C
D
T
L
G
F
A
P
I
S
Site 40
Y417
I
S
G
M
C
S
K
Y
R
S
C
T
I
N
E
Site 41
T421
C
S
K
Y
R
S
C
T
I
N
E
D
T
G
L
Site 42
S462
K
A
E
G
N
I
M
S
P
T
L
T
G
N
N
Site 43
T464
E
G
N
I
M
S
P
T
L
T
G
N
N
G
V
Site 44
T466
N
I
M
S
P
T
L
T
G
N
N
G
V
F
S
Site 45
S473
T
G
N
N
G
V
F
S
W
S
S
C
S
R
Q
Site 46
S476
N
G
V
F
S
W
S
S
C
S
R
Q
Y
L
K
Site 47
Y481
W
S
S
C
S
R
Q
Y
L
K
K
F
L
S
T
Site 48
S487
Q
Y
L
K
K
F
L
S
T
P
Q
A
G
C
L
Site 49
Y504
E
P
K
Q
A
G
Q
Y
K
Y
P
D
K
L
P
Site 50
Y506
K
Q
A
G
Q
Y
K
Y
P
D
K
L
P
G
Q
Site 51
Y515
D
K
L
P
G
Q
I
Y
D
A
D
T
Q
C
K
Site 52
T555
R
V
G
H
R
C
E
T
K
F
M
P
A
A
E
Site 53
T604
K
W
S
E
C
S
R
T
C
G
G
G
V
K
F
Site 54
Y623
C
N
N
P
K
P
Q
Y
G
G
I
F
C
P
G
Site 55
Y635
C
P
G
S
S
R
I
Y
Q
L
C
N
I
N
P
Site 56
Y658
R
A
Q
Q
C
A
E
Y
N
S
K
P
F
R
G
Site 57
Y685
E
E
D
R
C
K
L
Y
C
K
A
E
N
F
E
Site 58
T705
S
G
K
V
K
D
G
T
P
C
S
P
N
K
N
Site 59
S708
V
K
D
G
T
P
C
S
P
N
K
N
D
V
C
Site 60
S731
G
C
D
H
E
L
G
S
K
A
V
S
D
A
C
Site 61
Y755
C
K
F
Y
K
G
L
Y
L
N
Q
H
K
A
N
Site 62
Y764
N
Q
H
K
A
N
E
Y
Y
P
V
V
L
I
P
Site 63
Y765
Q
H
K
A
N
E
Y
Y
P
V
V
L
I
P
A
Site 64
S785
E
I
Q
E
L
Q
V
S
S
S
Y
L
A
V
R
Site 65
S787
Q
E
L
Q
V
S
S
S
Y
L
A
V
R
S
L
Site 66
Y788
E
L
Q
V
S
S
S
Y
L
A
V
R
S
L
S
Site 67
S793
S
S
Y
L
A
V
R
S
L
S
Q
K
Y
Y
L
Site 68
S795
Y
L
A
V
R
S
L
S
Q
K
Y
Y
L
T
G
Site 69
Y798
V
R
S
L
S
Q
K
Y
Y
L
T
G
G
W
S
Site 70
Y799
R
S
L
S
Q
K
Y
Y
L
T
G
G
W
S
I
Site 71
T818
E
F
P
F
A
G
T
T
F
E
Y
Q
R
S
F
Site 72
Y821
F
A
G
T
T
F
E
Y
Q
R
S
F
N
R
P
Site 73
S824
T
T
F
E
Y
Q
R
S
F
N
R
P
E
R
L
Site 74
Y832
F
N
R
P
E
R
L
Y
A
P
G
P
T
N
E
Site 75
Y858
N
P
G
I
A
W
K
Y
A
L
P
K
V
M
N
Site 76
T867
L
P
K
V
M
N
G
T
P
P
A
T
K
R
P
Site 77
T871
M
N
G
T
P
P
A
T
K
R
P
A
Y
T
W
Site 78
Y876
P
A
T
K
R
P
A
Y
T
W
S
I
V
Q
S
Site 79
S879
K
R
P
A
Y
T
W
S
I
V
Q
S
E
C
S
Site 80
S883
Y
T
W
S
I
V
Q
S
E
C
S
V
S
C
G
Site 81
S888
V
Q
S
E
C
S
V
S
C
G
G
G
Y
I
N
Site 82
Y893
S
V
S
C
G
G
G
Y
I
N
V
K
A
I
C
Site 83
T906
I
C
L
R
D
Q
N
T
Q
V
N
S
S
F
C
Site 84
S911
Q
N
T
Q
V
N
S
S
F
C
S
A
K
T
K
Site 85
S914
Q
V
N
S
S
F
C
S
A
K
T
K
P
V
T
Site 86
T917
S
S
F
C
S
A
K
T
K
P
V
T
E
P
K
Site 87
T921
S
A
K
T
K
P
V
T
E
P
K
I
C
N
A
Site 88
S944
P
G
E
W
S
T
C
S
K
A
C
A
G
G
Q
Site 89
S973
K
E
E
A
V
L
H
S
L
C
P
V
S
T
P
Site 90
T1006
P
W
S
Q
C
S
K
T
C
G
R
G
V
R
K
Site 91
S1021
R
E
L
L
C
K
G
S
A
A
E
T
L
P
E
Site 92
T1025
C
K
G
S
A
A
E
T
L
P
E
S
Q
C
T
Site 93
S1029
A
A
E
T
L
P
E
S
Q
C
T
S
L
P
R
Site 94
T1032
T
L
P
E
S
Q
C
T
S
L
P
R
P
E
L
Site 95
S1033
L
P
E
S
Q
C
T
S
L
P
R
P
E
L
Q
Site 96
S1052
L
G
R
C
P
K
N
S
R
L
Q
W
V
A
S
Site 97
S1059
S
R
L
Q
W
V
A
S
S
W
S
E
C
S
A
Site 98
S1060
R
L
Q
W
V
A
S
S
W
S
E
C
S
A
T
Site 99
T1067
S
W
S
E
C
S
A
T
C
G
L
G
V
R
K
Site 100
S1080
R
K
R
E
M
K
C
S
E
K
G
F
Q
G
K
Site 101
T1090
G
F
Q
G
K
L
I
T
F
P
E
R
R
C
R
Site 102
T1109
P
N
L
D
L
E
E
T
C
N
R
R
A
C
P
Site 103
S1147
G
G
G
V
Q
T
R
S
V
H
C
V
Q
Q
G
Site 104
S1157
C
V
Q
Q
G
R
P
S
S
S
C
L
L
H
Q
Site 105
S1158
V
Q
Q
G
R
P
S
S
S
C
L
L
H
Q
K
Site 106
Y1209
G
V
C
N
H
K
F
Y
G
K
Q
C
C
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation