KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ADAMTS19
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 19
Alias:
ADAM metallopeptidase with thrombospondin type 1 motif, 19; ATS19; EC 3.4.24.-
Type:
Protease; EC 3.4.24.-; Extracellular matrix
Mass (Da):
134062
Number AA:
1207
UniProt ID:
Q8TE59
International Prot ID:
IPI00152639
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S57
P
A
G
G
S
G
G
S
A
D
P
G
W
V
R
Site 2
S71
R
G
V
G
G
G
G
S
A
R
A
Q
A
A
G
Site 3
S79
A
R
A
Q
A
A
G
S
S
R
E
V
R
S
V
Site 4
S85
G
S
S
R
E
V
R
S
V
A
P
V
P
L
E
Site 5
S101
P
V
E
G
R
S
E
S
R
L
R
P
P
P
P
Site 6
S109
R
L
R
P
P
P
P
S
E
G
E
E
D
E
E
Site 7
S119
E
E
D
E
E
L
E
S
Q
E
L
P
R
G
S
Site 8
S126
S
Q
E
L
P
R
G
S
S
G
A
A
A
L
S
Site 9
S127
Q
E
L
P
R
G
S
S
G
A
A
A
L
S
P
Site 10
S139
L
S
P
G
A
P
A
S
W
Q
P
P
P
P
P
Site 11
S151
P
P
P
Q
P
P
P
S
P
P
P
A
Q
H
A
Site 12
Y177
P
A
F
S
R
D
L
Y
L
L
L
R
R
D
G
Site 13
S208
P
G
P
T
G
A
A
S
A
P
Q
P
P
A
P
Site 14
Y222
P
P
D
A
G
C
F
Y
T
G
A
V
L
R
H
Site 15
T223
P
D
A
G
C
F
Y
T
G
A
V
L
R
H
P
Site 16
S235
R
H
P
G
S
L
A
S
F
S
T
C
G
G
G
Site 17
Y273
T
G
H
P
H
R
V
Y
R
Q
K
R
S
M
E
Site 18
S278
R
V
Y
R
Q
K
R
S
M
E
E
K
V
T
E
Site 19
T284
R
S
M
E
E
K
V
T
E
K
S
A
L
H
S
Site 20
S287
E
E
K
V
T
E
K
S
A
L
H
S
H
Y
C
Site 21
S291
T
E
K
S
A
L
H
S
H
Y
C
G
I
I
S
Site 22
Y293
K
S
A
L
H
S
H
Y
C
G
I
I
S
D
K
Site 23
S298
S
H
Y
C
G
I
I
S
D
K
G
R
P
R
S
Site 24
S305
S
D
K
G
R
P
R
S
R
K
I
A
E
S
G
Site 25
S311
R
S
R
K
I
A
E
S
G
R
G
K
R
Y
S
Site 26
S318
S
G
R
G
K
R
Y
S
Y
K
L
P
Q
E
Y
Site 27
Y319
G
R
G
K
R
Y
S
Y
K
L
P
Q
E
Y
N
Site 28
T329
P
Q
E
Y
N
I
E
T
V
V
V
A
D
P
A
Site 29
Y388
H
E
T
P
P
E
L
Y
I
G
H
H
G
E
K
Site 30
T450
H
K
D
E
P
C
D
T
V
G
I
A
Y
L
S
Site 31
S520
G
Q
N
L
G
D
V
S
W
S
R
C
S
K
E
Site 32
S525
D
V
S
W
S
R
C
S
K
E
D
L
E
R
F
Site 33
S538
R
F
L
R
S
K
A
S
N
C
L
L
Q
T
N
Site 34
T544
A
S
N
C
L
L
Q
T
N
P
Q
S
V
N
S
Site 35
Y563
S
K
L
P
G
M
T
Y
T
A
D
E
Q
C
Q
Site 36
T603
E
G
E
K
E
C
R
T
K
L
D
P
P
M
D
Site 37
T612
L
D
P
P
M
D
G
T
D
C
D
L
G
K
W
Site 38
S627
C
K
A
G
E
C
T
S
R
T
S
A
P
E
H
Site 39
T629
A
G
E
C
T
S
R
T
S
A
P
E
H
L
A
Site 40
S630
G
E
C
T
S
R
T
S
A
P
E
H
L
A
G
Site 41
S640
E
H
L
A
G
E
W
S
L
W
S
P
C
S
R
Site 42
S643
A
G
E
W
S
L
W
S
P
C
S
R
T
C
S
Site 43
T648
L
W
S
P
C
S
R
T
C
S
A
G
I
S
S
Site 44
S650
S
P
C
S
R
T
C
S
A
G
I
S
S
R
E
Site 45
S654
R
T
C
S
A
G
I
S
S
R
E
R
K
C
P
Site 46
S655
T
C
S
A
G
I
S
S
R
E
R
K
C
P
G
Site 47
S665
R
K
C
P
G
L
D
S
E
A
R
D
C
N
G
Site 48
Y677
C
N
G
P
R
K
Q
Y
R
I
C
E
N
P
P
Site 49
Y700
R
D
W
Q
C
Q
A
Y
S
V
R
T
S
S
P
Site 50
S701
D
W
Q
C
Q
A
Y
S
V
R
T
S
S
P
K
Site 51
S705
Q
A
Y
S
V
R
T
S
S
P
K
H
I
L
Q
Site 52
S706
A
Y
S
V
R
T
S
S
P
K
H
I
L
Q
W
Site 53
S728
K
P
C
A
L
F
C
S
P
V
G
K
E
Q
P
Site 54
T746
S
E
K
V
M
D
G
T
S
C
G
Y
Q
G
L
Site 55
S747
E
K
V
M
D
G
T
S
C
G
Y
Q
G
L
D
Site 56
S772
G
C
D
G
L
L
G
S
L
A
R
E
D
H
C
Site 57
S841
A
G
K
Q
S
I
N
S
D
W
K
I
E
H
S
Site 58
S848
S
D
W
K
I
E
H
S
G
A
F
N
L
A
G
Site 59
Y860
L
A
G
T
T
V
H
Y
V
R
R
G
L
W
E
Site 60
S870
R
G
L
W
E
K
I
S
A
K
G
P
T
T
A
Site 61
Y891
L
L
F
Q
D
Q
N
Y
G
L
H
Y
E
Y
T
Site 62
Y895
D
Q
N
Y
G
L
H
Y
E
Y
T
I
P
S
D
Site 63
Y897
N
Y
G
L
H
Y
E
Y
T
I
P
S
D
P
L
Site 64
T898
Y
G
L
H
Y
E
Y
T
I
P
S
D
P
L
P
Site 65
S910
P
L
P
E
N
Q
S
S
K
A
P
E
P
L
F
Site 66
T938
C
G
G
G
E
R
K
T
T
V
S
C
T
K
I
Site 67
T939
G
G
G
E
R
K
T
T
V
S
C
T
K
I
M
Site 68
S941
G
E
R
K
T
T
V
S
C
T
K
I
M
S
K
Site 69
S951
K
I
M
S
K
N
I
S
I
V
D
N
E
K
C
Site 70
Y960
V
D
N
E
K
C
K
Y
L
T
K
P
E
P
Q
Site 71
T978
C
N
E
Q
P
C
Q
T
R
W
M
M
T
E
W
Site 72
T1004
Q
S
R
Q
V
A
C
T
Q
Q
L
S
N
G
T
Site 73
S1027
C
I
G
P
K
P
A
S
A
Q
R
C
E
G
Q
Site 74
T1060
G
K
G
I
R
H
R
T
V
R
C
T
N
P
R
Site 75
T1064
R
H
R
T
V
R
C
T
N
P
R
K
K
C
V
Site 76
S1073
P
R
K
K
C
V
L
S
T
R
P
R
E
A
E
Site 77
Y1085
E
A
E
D
C
E
D
Y
S
K
C
Y
V
W
R
Site 78
S1129
H
G
N
E
C
F
S
S
E
K
P
A
A
Y
R
Site 79
Y1172
L
G
D
Q
W
P
V
Y
C
R
V
I
R
E
K
Site 80
Y1199
C
E
T
C
R
D
F
Y
A
Q
K
L
Q
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation