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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS15
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 15
Alias:
ADAM metallopeptidase with thrombospondin type 1 motif, 15; ATS15; EC 3.4.24.-
Type:
Protease; EC 3.4.24.-; Extracellular matrix
Mass (Da):
103287
Number AA:
950
UniProt ID:
Q8TE58
International Prot ID:
IPI00152637
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
A
G
R
T
A
G
G
S
E
P
E
R
E
V
V
Site 2
Y40
P
D
I
N
G
R
R
Y
Y
W
R
G
P
E
D
Site 3
Y41
D
I
N
G
R
R
Y
Y
W
R
G
P
E
D
S
Site 4
S48
Y
W
R
G
P
E
D
S
G
D
Q
G
L
I
F
Site 5
Y65
T
A
F
Q
E
D
F
Y
L
H
L
T
P
D
A
Site 6
T69
E
D
F
Y
L
H
L
T
P
D
A
Q
F
L
A
Site 7
T92
G
V
P
L
Q
G
L
T
G
G
S
S
D
L
R
Site 8
S96
Q
G
L
T
G
G
S
S
D
L
R
R
C
F
Y
Site 9
Y103
S
D
L
R
R
C
F
Y
S
G
D
V
N
A
E
Site 10
S104
D
L
R
R
C
F
Y
S
G
D
V
N
A
E
P
Site 11
Y134
F
G
Y
R
G
A
E
Y
V
I
S
P
L
P
N
Site 12
S137
R
G
A
E
Y
V
I
S
P
L
P
N
A
S
A
Site 13
S151
A
P
A
A
Q
R
N
S
Q
G
A
H
L
L
Q
Site 14
S167
R
G
V
P
G
G
P
S
G
D
P
T
S
R
C
Site 15
T171
G
G
P
S
G
D
P
T
S
R
C
G
V
A
S
Site 16
S172
G
P
S
G
D
P
T
S
R
C
G
V
A
S
G
Site 17
Y191
I
L
R
A
L
D
P
Y
K
P
R
R
A
G
F
Site 18
S201
R
R
A
G
F
G
E
S
R
S
R
R
R
S
G
Site 19
S203
A
G
F
G
E
S
R
S
R
R
R
S
G
R
A
Site 20
S207
E
S
R
S
R
R
R
S
G
R
A
K
R
F
V
Site 21
S215
G
R
A
K
R
F
V
S
I
P
R
Y
V
E
T
Site 22
Y253
L
A
T
A
A
R
L
Y
R
H
P
S
I
L
N
Site 23
S257
A
R
L
Y
R
H
P
S
I
L
N
P
I
N
I
Site 24
S277
L
L
L
R
D
R
D
S
G
P
K
V
T
G
N
Site 25
Y309
V
S
D
K
H
P
E
Y
W
D
T
A
I
L
F
Site 26
T337
L
G
M
A
D
V
G
T
M
C
D
P
K
R
S
Site 27
S346
C
D
P
K
R
S
C
S
V
I
E
D
D
G
L
Site 28
S355
I
E
D
D
G
L
P
S
A
F
T
T
A
H
E
Site 29
T358
D
G
L
P
S
A
F
T
T
A
H
E
L
G
H
Site 30
S391
L
R
A
N
H
M
M
S
P
T
L
I
Q
I
D
Site 31
S428
D
C
L
L
D
Q
P
S
K
P
I
S
L
P
E
Site 32
S432
D
Q
P
S
K
P
I
S
L
P
E
D
L
P
G
Site 33
S441
P
E
D
L
P
G
A
S
Y
T
L
S
Q
Q
C
Site 34
T443
D
L
P
G
A
S
Y
T
L
S
Q
Q
C
E
L
Site 35
S445
P
G
A
S
Y
T
L
S
Q
Q
C
E
L
A
F
Site 36
Y461
V
G
S
K
P
C
P
Y
M
Q
Y
C
T
K
L
Site 37
T491
H
F
P
W
A
D
G
T
S
C
G
E
G
K
L
Site 38
T544
Q
L
A
R
R
Q
C
T
N
P
T
P
A
N
G
Site 39
T547
R
R
Q
C
T
N
P
T
P
A
N
G
G
K
Y
Site 40
Y554
T
P
A
N
G
G
K
Y
C
E
G
V
R
V
K
Site 41
Y562
C
E
G
V
R
V
K
Y
R
S
C
N
L
E
P
Site 42
S564
G
V
R
V
K
Y
R
S
C
N
L
E
P
C
P
Site 43
S572
C
N
L
E
P
C
P
S
S
A
S
G
K
S
F
Site 44
S573
N
L
E
P
C
P
S
S
A
S
G
K
S
F
R
Site 45
S575
E
P
C
P
S
S
A
S
G
K
S
F
R
E
E
Site 46
S578
P
S
S
A
S
G
K
S
F
R
E
E
Q
C
E
Site 47
S593
A
F
N
G
Y
N
H
S
T
N
R
L
T
L
A
Site 48
T598
N
H
S
T
N
R
L
T
L
A
V
A
W
V
P
Site 49
Y607
A
V
A
W
V
P
K
Y
S
G
V
S
P
R
D
Site 50
S611
V
P
K
Y
S
G
V
S
P
R
D
K
C
K
L
Site 51
Y627
C
R
A
N
G
T
G
Y
F
Y
V
L
A
P
K
Site 52
Y629
A
N
G
T
G
Y
F
Y
V
L
A
P
K
V
V
Site 53
T639
A
P
K
V
V
D
G
T
L
C
S
P
D
S
T
Site 54
T646
T
L
C
S
P
D
S
T
S
V
C
V
Q
G
K
Site 55
S665
G
C
D
G
N
L
G
S
K
K
R
F
D
K
C
Site 56
S681
V
C
G
G
D
N
K
S
C
K
K
V
T
G
L
Site 57
Y696
F
T
K
P
M
H
G
Y
N
F
V
V
A
I
P
Site 58
Y716
I
D
I
R
Q
R
G
Y
K
G
L
I
G
D
D
Site 59
Y725
G
L
I
G
D
D
N
Y
L
A
L
K
N
S
Q
Site 60
S731
N
Y
L
A
L
K
N
S
Q
G
K
Y
L
L
N
Site 61
Y735
L
K
N
S
Q
G
K
Y
L
L
N
G
H
F
V
Site 62
S755
R
D
L
V
V
K
G
S
L
L
R
Y
S
G
T
Site 63
S760
K
G
S
L
L
R
Y
S
G
T
G
T
A
V
E
Site 64
T764
L
R
Y
S
G
T
G
T
A
V
E
S
L
Q
A
Site 65
S768
G
T
G
T
A
V
E
S
L
Q
A
S
R
P
I
Site 66
T790
V
L
S
V
G
K
M
T
P
P
R
V
R
Y
S
Site 67
Y796
M
T
P
P
R
V
R
Y
S
F
Y
L
P
K
E
Site 68
S797
T
P
P
R
V
R
Y
S
F
Y
L
P
K
E
P
Site 69
Y799
P
R
V
R
Y
S
F
Y
L
P
K
E
P
R
E
Site 70
S809
K
E
P
R
E
D
K
S
S
H
P
K
D
P
R
Site 71
S810
E
P
R
E
D
K
S
S
H
P
K
D
P
R
G
Site 72
S819
P
K
D
P
R
G
P
S
V
L
H
N
S
V
L
Site 73
S824
G
P
S
V
L
H
N
S
V
L
S
L
S
N
Q
Site 74
S827
V
L
H
N
S
V
L
S
L
S
N
Q
V
E
Q
Site 75
S829
H
N
S
V
L
S
L
S
N
Q
V
E
Q
P
D
Site 76
S847
P
A
R
W
V
A
G
S
W
G
P
C
S
A
S
Site 77
S854
S
W
G
P
C
S
A
S
C
G
S
G
L
Q
K
Site 78
S869
R
A
V
D
C
R
G
S
A
G
Q
R
T
V
P
Site 79
T874
R
G
S
A
G
Q
R
T
V
P
A
C
D
A
A
Site 80
T896
A
C
G
E
P
C
P
T
W
E
L
S
A
W
S
Site 81
S903
T
W
E
L
S
A
W
S
P
C
S
K
S
C
G
Site 82
S906
L
S
A
W
S
P
C
S
K
S
C
G
R
G
F
Site 83
S908
A
W
S
P
C
S
K
S
C
G
R
G
F
Q
R
Site 84
S917
G
R
G
F
Q
R
R
S
L
K
C
V
G
H
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation