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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS16
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 16
Alias:
Type:
Mass (Da):
136203
Number AA:
1224
UniProt ID:
Q8TE57
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
P
A
A
A
A
P
G
S
P
S
V
P
R
P
P
Site 2
S41
A
A
A
P
G
S
P
S
V
P
R
P
P
P
P
Site 3
Y60
G
W
M
E
K
G
E
Y
D
L
V
S
A
Y
E
Site 4
S64
K
G
E
Y
D
L
V
S
A
Y
E
V
D
H
R
Site 5
Y66
E
Y
D
L
V
S
A
Y
E
V
D
H
R
G
D
Site 6
Y74
E
V
D
H
R
G
D
Y
V
S
H
E
I
M
H
Site 7
S92
R
R
R
A
V
A
V
S
E
V
E
S
L
H
L
Site 8
T114
D
F
H
M
D
L
R
T
S
S
S
L
V
A
P
Site 9
S115
F
H
M
D
L
R
T
S
S
S
L
V
A
P
G
Site 10
S116
H
M
D
L
R
T
S
S
S
L
V
A
P
G
F
Site 11
T133
Q
T
L
G
K
T
G
T
K
S
V
Q
T
L
P
Site 12
S135
L
G
K
T
G
T
K
S
V
Q
T
L
P
P
E
Site 13
T138
T
G
T
K
S
V
Q
T
L
P
P
E
D
F
C
Site 14
Y147
P
P
E
D
F
C
F
Y
Q
G
S
L
R
S
H
Site 15
S150
D
F
C
F
Y
Q
G
S
L
R
S
H
R
N
S
Site 16
S153
F
Y
Q
G
S
L
R
S
H
R
N
S
S
V
A
Site 17
S157
S
L
R
S
H
R
N
S
S
V
A
L
S
T
C
Site 18
S158
L
R
S
H
R
N
S
S
V
A
L
S
T
C
Q
Site 19
S162
R
N
S
S
V
A
L
S
T
C
Q
G
L
S
G
Site 20
Y178
I
R
T
E
E
A
D
Y
F
L
R
P
L
P
S
Site 21
S185
Y
F
L
R
P
L
P
S
H
L
S
W
K
L
G
Site 22
S188
R
P
L
P
S
H
L
S
W
K
L
G
R
A
A
Site 23
S198
L
G
R
A
A
Q
G
S
S
P
S
H
V
L
Y
Site 24
S199
G
R
A
A
Q
G
S
S
P
S
H
V
L
Y
K
Site 25
Y205
S
S
P
S
H
V
L
Y
K
R
S
T
E
P
H
Site 26
S208
S
H
V
L
Y
K
R
S
T
E
P
H
A
P
G
Site 27
T209
H
V
L
Y
K
R
S
T
E
P
H
A
P
G
A
Site 28
S217
E
P
H
A
P
G
A
S
E
V
L
V
T
S
R
Site 29
S223
A
S
E
V
L
V
T
S
R
T
W
E
L
A
H
Site 30
S236
A
H
Q
P
L
H
S
S
D
L
R
L
G
L
P
Site 31
Y255
F
C
G
R
R
K
K
Y
M
P
Q
P
P
K
E
Site 32
Y271
L
F
I
L
P
D
E
Y
K
S
C
L
R
H
K
Site 33
S273
I
L
P
D
E
Y
K
S
C
L
R
H
K
R
S
Site 34
S280
S
C
L
R
H
K
R
S
L
L
R
S
H
R
N
Site 35
S284
H
K
R
S
L
L
R
S
H
R
N
E
E
L
N
Site 36
T313
H
G
H
E
N
I
T
T
Y
V
L
T
I
L
N
Site 37
S355
E
Q
P
G
L
V
I
S
H
H
A
D
H
T
L
Site 38
T361
I
S
H
H
A
D
H
T
L
S
S
F
C
Q
W
Site 39
T401
W
K
N
E
P
C
D
T
L
G
F
A
P
I
S
Site 40
Y414
I
S
G
M
C
S
K
Y
R
S
C
T
I
N
E
Site 41
T418
C
S
K
Y
R
S
C
T
I
N
E
D
T
G
L
Site 42
S453
E
G
N
M
C
K
K
S
E
G
N
I
M
S
P
Site 43
S459
K
S
E
G
N
I
M
S
P
T
L
A
G
R
N
Site 44
T461
E
G
N
I
M
S
P
T
L
A
G
R
N
G
V
Site 45
S470
A
G
R
N
G
V
F
S
W
S
P
C
S
R
Q
Site 46
S472
R
N
G
V
F
S
W
S
P
C
S
R
Q
Y
L
Site 47
Y478
W
S
P
C
S
R
Q
Y
L
H
K
F
L
S
T
Site 48
Y501
Q
P
K
P
V
K
E
Y
K
Y
P
E
K
L
P
Site 49
Y503
K
P
V
K
E
Y
K
Y
P
E
K
L
P
G
E
Site 50
Y512
E
K
L
P
G
E
L
Y
D
A
N
T
Q
C
K
Site 51
Y577
R
G
G
Q
C
V
K
Y
G
D
E
G
P
K
P
Site 52
T601
S
W
S
P
C
S
R
T
C
G
G
G
V
S
H
Site 53
S607
R
T
C
G
G
G
V
S
H
R
S
R
L
C
T
Site 54
S610
G
G
G
V
S
H
R
S
R
L
C
T
N
P
K
Site 55
T614
S
H
R
S
R
L
C
T
N
P
K
P
S
H
G
Site 56
S628
G
G
K
F
C
E
G
S
T
R
T
L
K
L
C
Site 57
S637
R
T
L
K
L
C
N
S
Q
K
C
P
R
D
S
Site 58
S644
S
Q
K
C
P
R
D
S
V
D
F
R
A
A
Q
Site 59
Y665
R
R
F
R
G
R
H
Y
K
W
K
P
Y
T
Q
Site 60
Y670
R
H
Y
K
W
K
P
Y
T
Q
V
E
D
Q
D
Site 61
Y682
D
Q
D
L
C
K
L
Y
C
I
A
E
G
F
D
Site 62
S693
E
G
F
D
F
F
F
S
L
S
N
K
V
K
D
Site 63
S695
F
D
F
F
F
S
L
S
N
K
V
K
D
G
T
Site 64
T702
S
N
K
V
K
D
G
T
P
C
S
E
D
S
R
Site 65
S705
V
K
D
G
T
P
C
S
E
D
S
R
N
V
C
Site 66
S708
G
T
P
C
S
E
D
S
R
N
V
C
I
D
G
Site 67
S773
T
I
P
S
G
A
R
S
I
R
I
Y
E
M
N
Site 68
Y777
G
A
R
S
I
R
I
Y
E
M
N
V
S
T
S
Site 69
S782
R
I
Y
E
M
N
V
S
T
S
Y
I
S
V
R
Site 70
S784
Y
E
M
N
V
S
T
S
Y
I
S
V
R
N
A
Site 71
Y785
E
M
N
V
S
T
S
Y
I
S
V
R
N
A
L
Site 72
S787
N
V
S
T
S
Y
I
S
V
R
N
A
L
R
R
Site 73
Y795
V
R
N
A
L
R
R
Y
Y
L
N
G
H
W
T
Site 74
Y796
R
N
A
L
R
R
Y
Y
L
N
G
H
W
T
V
Site 75
Y809
T
V
D
W
P
G
R
Y
K
F
S
G
T
T
F
Site 76
T815
R
Y
K
F
S
G
T
T
F
D
Y
R
R
S
Y
Site 77
Y818
F
S
G
T
T
F
D
Y
R
R
S
Y
N
E
P
Site 78
S821
T
T
F
D
Y
R
R
S
Y
N
E
P
E
N
L
Site 79
Y822
T
F
D
Y
R
R
S
Y
N
E
P
E
N
L
I
Site 80
Y855
N
P
G
V
A
W
E
Y
S
M
P
R
L
G
T
Site 81
S856
P
G
V
A
W
E
Y
S
M
P
R
L
G
T
E
Site 82
T862
Y
S
M
P
R
L
G
T
E
K
Q
P
P
A
Q
Site 83
Y872
Q
P
P
A
Q
P
S
Y
T
W
A
I
V
R
S
Site 84
S884
V
R
S
E
C
S
V
S
C
G
G
G
Q
M
T
Site 85
T891
S
C
G
G
G
Q
M
T
V
R
E
G
C
Y
R
Site 86
T917
N
P
K
T
R
P
V
T
G
L
V
P
C
K
V
Site 87
S930
K
V
S
A
C
P
P
S
W
S
V
G
N
W
S
Site 88
S949
T
C
G
G
G
A
Q
S
R
P
V
Q
C
T
R
Site 89
T955
Q
S
R
P
V
Q
C
T
R
R
V
H
Y
D
S
Site 90
Y960
Q
C
T
R
R
V
H
Y
D
S
E
P
V
P
A
Site 91
S962
T
R
R
V
H
Y
D
S
E
P
V
P
A
S
L
Site 92
S968
D
S
E
P
V
P
A
S
L
C
P
Q
P
A
P
Site 93
S976
L
C
P
Q
P
A
P
S
S
R
Q
A
C
N
S
Site 94
S977
C
P
Q
P
A
P
S
S
R
Q
A
C
N
S
Q
Site 95
S983
S
S
R
Q
A
C
N
S
Q
S
C
P
P
A
W
Site 96
S985
R
Q
A
C
N
S
Q
S
C
P
P
A
W
S
A
Site 97
S1015
K
R
A
V
A
C
K
S
T
N
P
S
A
R
A
Site 98
S1019
A
C
K
S
T
N
P
S
A
R
A
Q
L
L
P
Site 99
T1031
L
L
P
D
A
V
C
T
S
E
P
K
P
R
M
Site 100
S1032
L
P
D
A
V
C
T
S
E
P
K
P
R
M
H
Site 101
T1066
A
W
S
Q
C
S
V
T
C
E
R
G
T
Q
K
Site 102
T1071
S
V
T
C
E
R
G
T
Q
K
R
F
L
K
C
Site 103
Y1082
F
L
K
C
A
E
K
Y
V
S
G
K
Y
R
E
Site 104
Y1087
E
K
Y
V
S
G
K
Y
R
E
L
A
S
K
K
Site 105
S1092
G
K
Y
R
E
L
A
S
K
K
C
S
H
L
P
Site 106
S1096
E
L
A
S
K
K
C
S
H
L
P
K
P
S
L
Site 107
S1129
A
A
G
P
S
R
G
S
W
F
A
S
P
W
S
Site 108
S1133
S
R
G
S
W
F
A
S
P
W
S
Q
C
T
A
Site 109
T1139
A
S
P
W
S
Q
C
T
A
S
C
G
G
G
V
Site 110
S1161
L
A
G
G
R
P
A
S
G
C
L
L
H
Q
K
Site 111
S1170
C
L
L
H
Q
K
P
S
A
S
L
A
C
N
T
Site 112
S1172
L
H
Q
K
P
S
A
S
L
A
C
N
T
H
F
Site 113
Y1211
G
M
C
S
H
K
F
Y
G
K
Q
C
C
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation