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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMC2
Full Name:
Transmembrane channel-like protein 2
Alias:
Transmembrane cochlear-expressed protein 2
Type:
Mass (Da):
102582
Number AA:
906
UniProt ID:
Q8TDI7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
H
Q
V
K
G
L
K
Site 2
S22
G
V
K
G
R
V
K
S
G
S
P
H
T
G
D
Site 3
S24
K
G
R
V
K
S
G
S
P
H
T
G
D
R
L
Site 4
T27
V
K
S
G
S
P
H
T
G
D
R
L
G
R
R
Site 5
S35
G
D
R
L
G
R
R
S
S
S
K
R
A
L
K
Site 6
S36
D
R
L
G
R
R
S
S
S
K
R
A
L
K
A
Site 7
S37
R
L
G
R
R
S
S
S
K
R
A
L
K
A
E
Site 8
T46
R
A
L
K
A
E
G
T
P
G
R
R
G
A
Q
Site 9
S55
G
R
R
G
A
Q
R
S
Q
K
E
R
A
G
G
Site 10
S63
Q
K
E
R
A
G
G
S
P
S
P
G
S
P
R
Site 11
S65
E
R
A
G
G
S
P
S
P
G
S
P
R
R
K
Site 12
S68
G
G
S
P
S
P
G
S
P
R
R
K
Q
T
G
Site 13
T74
G
S
P
R
R
K
Q
T
G
R
R
R
H
R
E
Site 14
T94
E
R
G
E
A
E
R
T
C
E
G
R
R
K
R
Site 15
S106
R
K
R
D
E
R
A
S
F
Q
E
R
T
A
A
Site 16
S127
I
P
R
K
E
E
K
S
K
R
Q
K
K
P
R
Site 17
S135
K
R
Q
K
K
P
R
S
S
S
L
A
S
S
A
Site 18
S136
R
Q
K
K
P
R
S
S
S
L
A
S
S
A
S
Site 19
S137
Q
K
K
P
R
S
S
S
L
A
S
S
A
S
G
Site 20
S140
P
R
S
S
S
L
A
S
S
A
S
G
G
E
S
Site 21
S141
R
S
S
S
L
A
S
S
A
S
G
G
E
S
L
Site 22
S143
S
S
L
A
S
S
A
S
G
G
E
S
L
S
E
Site 23
S147
S
S
A
S
G
G
E
S
L
S
E
E
E
L
A
Site 24
S149
A
S
G
G
E
S
L
S
E
E
E
L
A
Q
I
Site 25
T169
E
K
K
K
L
I
A
T
M
R
S
K
P
W
P
Site 26
Y194
A
Q
E
F
V
E
K
Y
E
G
A
L
G
K
G
Site 27
Y207
K
G
K
G
K
Q
L
Y
A
Y
K
M
L
M
A
Site 28
Y209
K
G
K
Q
L
Y
A
Y
K
M
L
M
A
K
K
Site 29
S243
M
K
I
K
D
I
E
S
H
F
G
S
S
V
A
Site 30
Y285
E
V
L
M
G
M
P
Y
G
S
I
P
R
K
T
Site 31
S287
L
M
G
M
P
Y
G
S
I
P
R
K
T
V
P
Site 32
T292
Y
G
S
I
P
R
K
T
V
P
R
A
E
E
E
Site 33
S305
E
E
K
A
M
D
F
S
V
L
W
D
F
E
G
Site 34
Y316
D
F
E
G
Y
I
K
Y
S
A
L
F
Y
G
Y
Site 35
Y321
I
K
Y
S
A
L
F
Y
G
Y
Y
N
N
Q
R
Site 36
Y324
S
A
L
F
Y
G
Y
Y
N
N
Q
R
T
I
G
Site 37
Y335
R
T
I
G
W
L
R
Y
R
L
P
M
A
Y
F
Site 38
S362
I
V
I
R
S
M
A
S
N
T
Q
G
S
T
G
Site 39
S373
G
S
T
G
E
G
E
S
D
N
F
T
F
S
F
Site 40
T377
E
G
E
S
D
N
F
T
F
S
F
K
M
F
T
Site 41
S379
E
S
D
N
F
T
F
S
F
K
M
F
T
S
W
Site 42
Y388
K
M
F
T
S
W
D
Y
L
I
G
N
S
E
T
Site 43
Y400
S
E
T
A
D
N
K
Y
A
S
I
T
T
S
F
Site 44
S402
T
A
D
N
K
Y
A
S
I
T
T
S
F
K
E
Site 45
S406
K
Y
A
S
I
T
T
S
F
K
E
S
I
V
D
Site 46
S410
I
T
T
S
F
K
E
S
I
V
D
E
Q
E
S
Site 47
S417
S
I
V
D
E
Q
E
S
N
K
E
E
N
I
H
Site 48
Y467
K
M
Q
N
V
S
W
Y
E
R
N
E
V
E
I
Site 49
T489
F
C
P
P
L
F
E
T
I
A
A
L
E
N
Y
Site 50
Y496
T
I
A
A
L
E
N
Y
H
P
R
T
G
L
K
Site 51
T537
L
K
L
A
N
E
E
T
I
K
N
I
T
H
W
Site 52
S558
N
S
S
G
W
N
E
S
V
P
R
P
P
L
H
Site 53
S573
P
A
D
V
P
R
G
S
C
W
E
T
A
V
G
Site 54
T597
D
M
L
V
T
Y
I
T
I
L
L
G
D
F
L
Site 55
S626
D
L
E
A
G
F
P
S
Y
A
E
F
D
I
S
Site 56
Y627
L
E
A
G
F
P
S
Y
A
E
F
D
I
S
G
Site 57
Y733
F
S
G
K
N
R
M
Y
D
V
L
Q
E
T
I
Site 58
S779
I
Y
Y
L
N
S
V
S
K
S
L
S
R
A
N
Site 59
S781
Y
L
N
S
V
S
K
S
L
S
R
A
N
A
Q
Site 60
S783
N
S
V
S
K
S
L
S
R
A
N
A
Q
L
R
Site 61
S802
V
L
R
E
V
E
K
S
H
K
S
V
K
G
K
Site 62
S805
E
V
E
K
S
H
K
S
V
K
G
K
A
T
A
Site 63
T811
K
S
V
K
G
K
A
T
A
R
D
S
E
D
T
Site 64
S815
G
K
A
T
A
R
D
S
E
D
T
P
K
S
S
Site 65
T818
T
A
R
D
S
E
D
T
P
K
S
S
S
K
N
Site 66
S821
D
S
E
D
T
P
K
S
S
S
K
N
A
T
Q
Site 67
T827
K
S
S
S
K
N
A
T
Q
L
Q
L
T
K
E
Site 68
T836
L
Q
L
T
K
E
E
T
T
P
P
S
A
S
Q
Site 69
T837
Q
L
T
K
E
E
T
T
P
P
S
A
S
Q
S
Site 70
S840
K
E
E
T
T
P
P
S
A
S
Q
S
Q
A
M
Site 71
S842
E
T
T
P
P
S
A
S
Q
S
Q
A
M
D
K
Site 72
S844
T
P
P
S
A
S
Q
S
Q
A
M
D
K
K
A
Site 73
T856
K
K
A
Q
G
P
G
T
S
N
S
A
S
R
T
Site 74
S857
K
A
Q
G
P
G
T
S
N
S
A
S
R
T
T
Site 75
S859
Q
G
P
G
T
S
N
S
A
S
R
T
T
L
P
Site 76
S861
P
G
T
S
N
S
A
S
R
T
T
L
P
A
S
Site 77
T863
T
S
N
S
A
S
R
T
T
L
P
A
S
G
H
Site 78
T864
S
N
S
A
S
R
T
T
L
P
A
S
G
H
L
Site 79
S868
S
R
T
T
L
P
A
S
G
H
L
P
I
S
R
Site 80
S874
A
S
G
H
L
P
I
S
R
P
P
G
I
G
P
Site 81
S883
P
P
G
I
G
P
D
S
G
H
A
P
S
Q
T
Site 82
S888
P
D
S
G
H
A
P
S
Q
T
H
P
W
R
S
Site 83
T890
S
G
H
A
P
S
Q
T
H
P
W
R
S
A
S
Site 84
S895
S
Q
T
H
P
W
R
S
A
S
G
K
S
A
Q
Site 85
S897
T
H
P
W
R
S
A
S
G
K
S
A
Q
R
P
Site 86
S900
W
R
S
A
S
G
K
S
A
Q
R
P
P
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation