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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEL308
Full Name:
Helicase POLQ-like
Alias:
Hel308; helicase, POLQ-like
Type:
EC 3.6.1.-; Helicase
Mass (Da):
124180
Number AA:
UniProt ID:
Q8TDG4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
S
R
I
R
R
R
V
S
L
P
K
R
N
R
P
Site 2
S21
L
P
K
R
N
R
P
S
L
G
C
I
F
G
A
Site 3
T55
A
E
N
R
R
R
K
T
A
G
V
L
P
V
E
Site 4
T82
L
V
L
G
G
G
D
T
N
P
D
L
L
R
H
Site 5
T92
D
L
L
R
H
M
P
T
D
R
G
V
G
D
Q
Site 6
S103
V
G
D
Q
P
N
D
S
E
V
D
M
F
G
D
Site 7
Y111
E
V
D
M
F
G
D
Y
D
S
F
T
E
N
S
Site 8
T115
F
G
D
Y
D
S
F
T
E
N
S
F
I
A
Q
Site 9
S118
Y
D
S
F
T
E
N
S
F
I
A
Q
V
D
D
Site 10
Y130
V
D
D
L
E
Q
K
Y
M
Q
L
P
E
H
K
Site 11
T145
K
H
A
T
D
F
A
T
E
N
L
C
S
E
S
Site 12
S150
F
A
T
E
N
L
C
S
E
S
I
K
N
K
L
Site 13
S152
T
E
N
L
C
S
E
S
I
K
N
K
L
S
I
Site 14
S158
E
S
I
K
N
K
L
S
I
T
T
I
G
N
L
Site 15
T174
E
L
Q
T
D
K
H
T
E
N
Q
S
G
Y
E
Site 16
T184
Q
S
G
Y
E
G
V
T
I
E
P
G
A
D
L
Site 17
Y193
E
P
G
A
D
L
L
Y
D
V
P
S
S
Q
A
Site 18
S197
D
L
L
Y
D
V
P
S
S
Q
A
I
Y
F
E
Site 19
S198
L
L
Y
D
V
P
S
S
Q
A
I
Y
F
E
N
Site 20
Y202
V
P
S
S
Q
A
I
Y
F
E
N
L
Q
N
S
Site 21
S209
Y
F
E
N
L
Q
N
S
S
N
D
L
G
D
H
Site 22
S217
S
N
D
L
G
D
H
S
M
K
E
R
D
W
K
Site 23
S225
M
K
E
R
D
W
K
S
S
S
H
N
T
V
N
Site 24
S226
K
E
R
D
W
K
S
S
S
H
N
T
V
N
E
Site 25
S227
E
R
D
W
K
S
S
S
H
N
T
V
N
E
E
Site 26
T230
W
K
S
S
S
H
N
T
V
N
E
E
L
P
H
Site 27
S250
P
Q
Q
N
D
E
S
S
S
K
V
R
T
S
S
Site 28
S251
Q
Q
N
D
E
S
S
S
K
V
R
T
S
S
D
Site 29
T255
E
S
S
S
K
V
R
T
S
S
D
M
N
R
R
Site 30
S256
S
S
S
K
V
R
T
S
S
D
M
N
R
R
K
Site 31
S257
S
S
K
V
R
T
S
S
D
M
N
R
R
K
S
Site 32
S264
S
D
M
N
R
R
K
S
I
K
D
H
L
K
N
Site 33
T281
T
G
N
A
K
A
Q
T
P
I
F
S
R
S
K
Site 34
S285
K
A
Q
T
P
I
F
S
R
S
K
Q
L
K
D
Site 35
T293
R
S
K
Q
L
K
D
T
L
L
S
E
E
I
N
Site 36
T305
E
I
N
V
A
K
K
T
I
E
S
S
S
N
D
Site 37
S309
A
K
K
T
I
E
S
S
S
N
D
L
G
P
F
Site 38
S310
K
K
T
I
E
S
S
S
N
D
L
G
P
F
Y
Site 39
Y317
S
N
D
L
G
P
F
Y
S
L
P
S
K
V
R
Site 40
S318
N
D
L
G
P
F
Y
S
L
P
S
K
V
R
D
Site 41
S321
G
P
F
Y
S
L
P
S
K
V
R
D
L
Y
A
Site 42
Y327
P
S
K
V
R
D
L
Y
A
Q
F
K
G
I
E
Site 43
Y337
F
K
G
I
E
K
L
Y
E
W
Q
H
T
C
L
Site 44
T342
K
L
Y
E
W
Q
H
T
C
L
T
L
N
S
V
Site 45
T345
E
W
Q
H
T
C
L
T
L
N
S
V
Q
E
R
Site 46
Y357
Q
E
R
K
N
L
I
Y
S
L
P
T
S
G
G
Site 47
S358
E
R
K
N
L
I
Y
S
L
P
T
S
G
G
K
Site 48
Y415
L
G
F
F
V
E
E
Y
A
G
S
K
G
R
F
Site 49
S418
F
V
E
E
Y
A
G
S
K
G
R
F
P
P
T
Site 50
T425
S
K
G
R
F
P
P
T
K
R
R
E
K
K
S
Site 51
S432
T
K
R
R
E
K
K
S
L
Y
I
A
T
I
E
Site 52
Y434
R
R
E
K
K
S
L
Y
I
A
T
I
E
K
G
Site 53
S447
K
G
H
S
L
V
N
S
L
I
E
T
G
R
I
Site 54
T476
G
E
G
S
R
G
A
T
L
E
M
T
L
A
K
Site 55
T480
R
G
A
T
L
E
M
T
L
A
K
I
L
Y
T
Site 56
Y486
M
T
L
A
K
I
L
Y
T
S
K
T
T
Q
I
Site 57
Y515
K
F
L
Q
A
E
Y
Y
T
S
Q
F
R
P
V
Site 58
S517
L
Q
A
E
Y
Y
T
S
Q
F
R
P
V
E
L
Site 59
Y527
R
P
V
E
L
K
E
Y
L
K
I
N
D
T
I
Site 60
T533
E
Y
L
K
I
N
D
T
I
Y
E
V
D
S
K
Site 61
Y535
L
K
I
N
D
T
I
Y
E
V
D
S
K
A
E
Site 62
T546
S
K
A
E
N
G
M
T
F
S
R
L
L
N
Y
Site 63
Y555
S
R
L
L
N
Y
K
Y
S
D
T
L
K
K
M
Site 64
S556
R
L
L
N
Y
K
Y
S
D
T
L
K
K
M
D
Site 65
T558
L
N
Y
K
Y
S
D
T
L
K
K
M
D
P
D
Site 66
S602
E
M
I
C
K
F
L
S
K
E
Y
L
K
H
K
Site 67
S649
Y
H
H
S
G
L
T
S
D
E
R
K
L
L
E
Site 68
Y701
E
F
L
K
R
N
Q
Y
K
Q
M
I
G
R
A
Site 69
Y774
A
T
N
L
D
D
I
Y
H
F
M
N
G
T
F
Site 70
S794
K
V
L
L
K
E
K
S
L
W
E
I
T
V
E
Site 71
T799
E
K
S
L
W
E
I
T
V
E
S
L
R
Y
L
Site 72
S802
L
W
E
I
T
V
E
S
L
R
Y
L
T
E
K
Site 73
Y805
I
T
V
E
S
L
R
Y
L
T
E
K
G
L
L
Site 74
T807
V
E
S
L
R
Y
L
T
E
K
G
L
L
Q
K
Site 75
T816
K
G
L
L
Q
K
D
T
I
Y
K
S
E
E
E
Site 76
Y818
L
L
Q
K
D
T
I
Y
K
S
E
E
E
V
Q
Site 77
S820
Q
K
D
T
I
Y
K
S
E
E
E
V
Q
Y
N
Site 78
Y826
K
S
E
E
E
V
Q
Y
N
F
H
I
T
K
L
Site 79
T841
G
R
A
S
F
K
G
T
I
D
L
A
Y
C
D
Site 80
Y846
K
G
T
I
D
L
A
Y
C
D
I
L
Y
R
D
Site 81
S894
M
I
Y
F
R
Q
F
S
Q
L
S
P
A
E
Q
Site 82
S897
F
R
Q
F
S
Q
L
S
P
A
E
Q
N
V
A
Site 83
S919
S
F
I
G
K
K
A
S
G
Q
A
I
G
K
K
Site 84
Y942
L
Y
L
S
F
V
L
Y
T
L
L
K
E
T
N
Site 85
Y963
K
F
N
M
P
R
G
Y
I
Q
N
L
L
T
G
Site 86
Y1028
E
G
R
A
K
Q
L
Y
S
A
G
Y
K
S
L
Site 87
S1029
G
R
A
K
Q
L
Y
S
A
G
Y
K
S
L
M
Site 88
S1054
V
R
T
I
D
H
L
S
R
R
Q
A
K
Q
I
Site 89
S1096
D
F
P
G
A
V
A
S
S
T
D
K
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation