KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRPM4
Full Name:
Transient receptor potential cation channel subfamily M member 4
Alias:
Calcium-activated non-selective cation channel 1; FLJ20041; Long transient receptor potential channel 4; Melastatin-4; Transient receptor potential cation channel, subfamily M, member 4; TRPM4B
Type:
Mass (Da):
134301
Number AA:
1214
UniProt ID:
Q8TD43
International Prot ID:
IPI00294933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
V
P
E
K
E
Q
S
W
I
P
K
I
F
K
Site 2
T19
P
K
I
F
K
K
K
T
C
T
T
F
I
V
D
Site 3
T22
F
K
K
K
T
C
T
T
F
I
V
D
S
T
D
Site 4
T42
C
Q
C
G
R
P
R
T
A
H
P
A
V
A
M
Site 5
S63
A
V
V
T
V
W
D
S
D
A
H
T
T
E
K
Site 6
T67
V
W
D
S
D
A
H
T
T
E
K
P
T
D
A
Site 7
Y75
T
E
K
P
T
D
A
Y
G
E
L
D
F
T
G
Site 8
T81
A
Y
G
E
L
D
F
T
G
A
G
R
K
H
S
Site 9
S88
T
G
A
G
R
K
H
S
N
F
L
R
L
S
D
Site 10
S94
H
S
N
F
L
R
L
S
D
R
T
D
P
A
A
Site 11
T97
F
L
R
L
S
D
R
T
D
P
A
A
V
Y
S
Site 12
S104
T
D
P
A
A
V
Y
S
L
V
T
R
T
W
G
Site 13
T132
S
G
G
P
V
L
Q
T
W
L
Q
D
L
L
R
Site 14
T199
G
V
V
R
N
R
D
T
L
I
N
P
K
G
S
Site 15
S206
T
L
I
N
P
K
G
S
F
P
A
R
Y
R
W
Site 16
Y211
K
G
S
F
P
A
R
Y
R
W
R
G
D
P
E
Site 17
S255
R
F
R
L
R
L
E
S
Y
I
S
Q
Q
K
T
Site 18
Y256
F
R
L
R
L
E
S
Y
I
S
Q
Q
K
T
G
Site 19
S258
L
R
L
E
S
Y
I
S
Q
Q
K
T
G
V
G
Site 20
T262
S
Y
I
S
Q
Q
K
T
G
V
G
G
T
G
I
Site 21
T286
D
G
D
E
K
M
L
T
R
I
E
N
A
T
Q
Site 22
T292
L
T
R
I
E
N
A
T
Q
A
Q
L
P
C
L
Site 23
T318
L
A
E
T
L
E
D
T
L
A
P
G
S
G
G
Site 24
S323
E
D
T
L
A
P
G
S
G
G
A
R
Q
G
E
Site 25
T356
A
Q
V
E
R
I
M
T
R
K
E
L
L
T
V
Site 26
T362
M
T
R
K
E
L
L
T
V
Y
S
S
E
D
G
Site 27
Y364
R
K
E
L
L
T
V
Y
S
S
E
D
G
S
E
Site 28
S365
K
E
L
L
T
V
Y
S
S
E
D
G
S
E
E
Site 29
S366
E
L
L
T
V
Y
S
S
E
D
G
S
E
E
F
Site 30
S370
V
Y
S
S
E
D
G
S
E
E
F
E
T
I
V
Site 31
S391
A
C
G
S
S
E
A
S
A
Y
L
D
E
L
R
Site 32
Y393
G
S
S
E
A
S
A
Y
L
D
E
L
R
L
A
Site 33
S422
R
G
D
I
Q
W
R
S
F
H
L
E
A
S
L
Site 34
Y464
P
M
R
L
A
Q
L
Y
S
A
A
P
S
N
S
Site 35
S465
M
R
L
A
Q
L
Y
S
A
A
P
S
N
S
L
Site 36
S469
Q
L
Y
S
A
A
P
S
N
S
L
I
R
N
L
Site 37
S471
Y
S
A
A
P
S
N
S
L
I
R
N
L
L
D
Site 38
S481
R
N
L
L
D
Q
A
S
H
S
A
G
T
K
A
Site 39
Y519
G
K
M
C
A
P
R
Y
P
S
G
G
A
W
D
Site 40
S536
P
G
Q
G
F
G
E
S
M
Y
L
L
S
D
K
Site 41
Y538
Q
G
F
G
E
S
M
Y
L
L
S
D
K
A
T
Site 42
S541
G
E
S
M
Y
L
L
S
D
K
A
T
S
P
L
Site 43
T545
Y
L
L
S
D
K
A
T
S
P
L
S
L
D
A
Site 44
S546
L
L
S
D
K
A
T
S
P
L
S
L
D
A
G
Site 45
S549
D
K
A
T
S
P
L
S
L
D
A
G
L
G
Q
Site 46
Y577
N
R
A
Q
M
A
M
Y
F
W
E
M
G
S
N
Site 47
Y631
V
D
L
F
G
E
C
Y
R
S
S
E
V
R
A
Site 48
S633
L
F
G
E
C
Y
R
S
S
E
V
R
A
A
R
Site 49
S634
F
G
E
C
Y
R
S
S
E
V
R
A
A
R
L
Site 50
T709
L
I
Y
T
R
L
I
T
F
R
K
S
E
E
E
Site 51
S713
R
L
I
T
F
R
K
S
E
E
E
P
T
R
E
Site 52
T718
R
K
S
E
E
E
P
T
R
E
E
L
E
F
D
Site 53
S728
E
L
E
F
D
M
D
S
V
I
N
G
E
G
P
Site 54
T738
N
G
E
G
P
V
G
T
A
D
P
A
E
K
T
Site 55
T745
T
A
D
P
A
E
K
T
P
L
G
V
P
R
Q
Site 56
S753
P
L
G
V
P
R
Q
S
G
R
P
G
C
C
G
Site 57
S834
E
E
L
R
Q
G
L
S
G
G
G
G
S
L
A
Site 58
S839
G
L
S
G
G
G
G
S
L
A
S
G
G
P
G
Site 59
S842
G
G
G
G
S
L
A
S
G
G
P
G
P
G
H
Site 60
S851
G
P
G
P
G
H
A
S
L
S
Q
R
L
R
L
Site 61
S853
G
P
G
H
A
S
L
S
Q
R
L
R
L
Y
L
Site 62
Y859
L
S
Q
R
L
R
L
Y
L
A
D
S
W
N
Q
Site 63
S957
G
L
L
R
P
R
D
S
D
F
P
S
I
L
R
Site 64
S961
P
R
D
S
D
F
P
S
I
L
R
R
V
F
Y
Site 65
Y971
R
R
V
F
Y
R
P
Y
L
Q
I
F
G
Q
I
Site 66
S991
D
V
A
L
M
E
H
S
N
C
S
S
E
P
G
Site 67
Y1057
V
Q
G
N
S
D
L
Y
W
K
A
Q
R
Y
R
Site 68
S1098
Q
L
C
R
R
P
R
S
P
Q
P
S
S
P
A
Site 69
S1102
R
P
R
S
P
Q
P
S
S
P
A
L
E
H
F
Site 70
S1103
P
R
S
P
Q
P
S
S
P
A
L
E
H
F
R
Site 71
Y1112
A
L
E
H
F
R
V
Y
L
S
K
E
A
E
R
Site 72
S1126
R
K
L
L
T
W
E
S
V
H
K
E
N
F
L
Site 73
S1143
R
A
R
D
K
R
E
S
D
S
E
R
L
K
R
Site 74
S1145
R
D
K
R
E
S
D
S
E
R
L
K
R
T
S
Site 75
S1152
S
E
R
L
K
R
T
S
Q
K
V
D
L
A
L
Site 76
Y1168
Q
L
G
H
I
R
E
Y
E
Q
R
L
K
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation