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Updated November 2019
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Protein Info
Short Name:
CHD6
Full Name:
Chromodomain-helicase-DNA-binding protein 6
Alias:
ATP-dependent helicase CHD6; CHD5; Chromodomain helicase DNA binding protein 6; DJ620E11.1; FLJ22369; KIAA1335; Radiation; RIGB
Type:
EC 3.6.1.-; DNA binding protein; Helicase
Mass (Da):
305412
Number AA:
2715
UniProt ID:
Q8TD26
International Prot ID:
IPI00220289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0006338
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
K
K
E
K
Q
L
S
N
L
K
V
L
N
H
Site 2
S21
N
L
K
V
L
N
H
S
P
M
S
D
A
S
V
Site 3
S24
V
L
N
H
S
P
M
S
D
A
S
V
N
F
D
Site 4
S27
H
S
P
M
S
D
A
S
V
N
F
D
Y
K
S
Site 5
Y32
D
A
S
V
N
F
D
Y
K
S
P
S
P
F
D
Site 6
S34
S
V
N
F
D
Y
K
S
P
S
P
F
D
C
S
Site 7
S36
N
F
D
Y
K
S
P
S
P
F
D
C
S
T
D
Site 8
S41
S
P
S
P
F
D
C
S
T
D
Q
E
E
K
I
Site 9
T42
P
S
P
F
D
C
S
T
D
Q
E
E
K
I
E
Site 10
S53
E
K
I
E
D
V
A
S
H
C
L
P
Q
K
D
Site 11
Y62
C
L
P
Q
K
D
L
Y
T
A
E
E
E
A
A
Site 12
T70
T
A
E
E
E
A
A
T
L
F
P
R
K
M
T
Site 13
T77
T
L
F
P
R
K
M
T
S
H
N
G
M
E
D
Site 14
S78
L
F
P
R
K
M
T
S
H
N
G
M
E
D
S
Site 15
S85
S
H
N
G
M
E
D
S
G
G
G
G
T
G
V
Site 16
S111
Q
E
G
A
A
K
G
S
K
D
R
E
P
K
P
Site 17
S161
A
R
K
P
R
E
A
S
G
T
K
E
A
K
E
Site 18
T163
K
P
R
E
A
S
G
T
K
E
A
K
E
K
R
Site 19
S171
K
E
A
K
E
K
R
S
C
T
D
S
A
A
R
Site 20
T173
A
K
E
K
R
S
C
T
D
S
A
A
R
T
K
Site 21
S175
E
K
R
S
C
T
D
S
A
A
R
T
K
S
R
Site 22
T179
C
T
D
S
A
A
R
T
K
S
R
K
A
S
K
Site 23
S181
D
S
A
A
R
T
K
S
R
K
A
S
K
E
Q
Site 24
S185
R
T
K
S
R
K
A
S
K
E
Q
G
P
T
P
Site 25
T191
A
S
K
E
Q
G
P
T
P
V
E
K
K
K
K
Site 26
S203
K
K
K
G
K
R
K
S
E
T
T
V
E
S
L
Site 27
T205
K
G
K
R
K
S
E
T
T
V
E
S
L
E
L
Site 28
T206
G
K
R
K
S
E
T
T
V
E
S
L
E
L
D
Site 29
S209
K
S
E
T
T
V
E
S
L
E
L
D
Q
G
L
Site 30
T217
L
E
L
D
Q
G
L
T
N
P
S
L
R
S
P
Site 31
S220
D
Q
G
L
T
N
P
S
L
R
S
P
E
E
S
Site 32
S223
L
T
N
P
S
L
R
S
P
E
E
S
T
E
S
Site 33
S227
S
L
R
S
P
E
E
S
T
E
S
T
D
S
Q
Site 34
S230
S
P
E
E
S
T
E
S
T
D
S
Q
K
R
R
Site 35
T231
P
E
E
S
T
E
S
T
D
S
Q
K
R
R
S
Site 36
S233
E
S
T
E
S
T
D
S
Q
K
R
R
S
G
R
Site 37
S238
T
D
S
Q
K
R
R
S
G
R
Q
V
K
R
R
Site 38
Y247
R
Q
V
K
R
R
K
Y
N
E
D
L
D
F
K
Site 39
S275
A
G
R
T
S
A
L
S
A
S
T
L
A
W
Q
Site 40
T302
E
K
I
L
A
S
K
T
V
Q
E
V
H
P
G
Site 41
Y319
P
F
D
L
E
L
F
Y
V
K
Y
R
N
F
S
Site 42
Y322
L
E
L
F
Y
V
K
Y
R
N
F
S
Y
L
H
Site 43
Y374
E
D
L
F
N
P
D
Y
V
E
V
D
R
I
L
Site 44
T386
R
I
L
E
V
A
H
T
K
D
A
E
T
G
E
Site 45
T391
A
H
T
K
D
A
E
T
G
E
E
V
T
H
Y
Site 46
Y398
T
G
E
E
V
T
H
Y
L
V
K
W
C
S
L
Site 47
S410
C
S
L
P
Y
E
E
S
T
W
E
L
E
E
D
Site 48
S428
A
K
V
K
E
F
E
S
L
Q
V
L
P
E
I
Site 49
S443
K
H
V
E
R
P
A
S
D
S
W
Q
K
L
E
Site 50
S445
V
E
R
P
A
S
D
S
W
Q
K
L
E
K
S
Site 51
S452
S
W
Q
K
L
E
K
S
R
E
Y
K
N
S
N
Site 52
Y455
K
L
E
K
S
R
E
Y
K
N
S
N
Q
L
R
Site 53
S458
K
S
R
E
Y
K
N
S
N
Q
L
R
E
Y
Q
Site 54
Y464
N
S
N
Q
L
R
E
Y
Q
L
E
G
M
N
W
Site 55
Y539
T
E
M
N
A
I
V
Y
H
G
S
Q
I
S
R
Site 56
Y552
S
R
Q
M
I
Q
Q
Y
E
M
V
Y
R
D
A
Site 57
S565
D
A
Q
G
N
P
L
S
G
V
F
K
F
H
V
Site 58
T626
L
E
H
K
V
L
L
T
G
T
P
L
Q
N
S
Site 59
T628
H
K
V
L
L
T
G
T
P
L
Q
N
S
V
E
Site 60
S633
T
G
T
P
L
Q
N
S
V
E
E
L
F
S
L
Site 61
S647
L
L
N
F
L
E
P
S
Q
F
P
S
E
T
A
Site 62
S651
L
E
P
S
Q
F
P
S
E
T
A
F
L
E
E
Site 63
T664
E
E
F
G
D
L
K
T
E
E
Q
V
K
K
L
Site 64
T704
T
I
I
E
V
E
L
T
N
I
Q
K
K
Y
Y
Site 65
Y710
L
T
N
I
Q
K
K
Y
Y
R
A
I
L
E
K
Site 66
S720
A
I
L
E
K
N
F
S
F
L
T
K
G
A
N
Site 67
Y749
R
K
C
C
N
H
P
Y
L
I
N
G
A
E
E
Site 68
T765
I
L
E
D
F
R
K
T
H
S
P
D
A
P
D
Site 69
S767
E
D
F
R
K
T
H
S
P
D
A
P
D
F
Q
Site 70
Y818
C
L
D
I
L
E
D
Y
L
I
Q
R
R
Y
T
Site 71
Y824
D
Y
L
I
Q
R
R
Y
T
Y
E
R
I
D
G
Site 72
T825
Y
L
I
Q
R
R
Y
T
Y
E
R
I
D
G
R
Site 73
Y826
L
I
Q
R
R
Y
T
Y
E
R
I
D
G
R
V
Site 74
S850
D
R
F
C
K
P
D
S
D
R
F
V
F
L
L
Site 75
T909
V
K
V
Y
R
L
I
T
R
N
S
Y
E
R
E
Site 76
S912
Y
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
Site 77
Y913
R
L
I
T
R
N
S
Y
E
R
E
M
F
D
K
Site 78
S922
R
E
M
F
D
K
A
S
L
K
L
G
L
D
K
Site 79
S972
M
D
E
E
D
E
G
S
K
F
C
E
E
D
I
Site 80
T987
D
Q
I
L
Q
R
R
T
H
T
I
T
I
Q
S
Site 81
T989
I
L
Q
R
R
T
H
T
I
T
I
Q
S
E
G
Site 82
T991
Q
R
R
T
H
T
I
T
I
Q
S
E
G
K
G
Site 83
T1000
Q
S
E
G
K
G
S
T
F
A
K
A
S
F
V
Site 84
S1005
G
S
T
F
A
K
A
S
F
V
A
S
G
N
R
Site 85
S1009
A
K
A
S
F
V
A
S
G
N
R
T
D
I
S
Site 86
T1013
F
V
A
S
G
N
R
T
D
I
S
L
D
D
P
Site 87
S1016
S
G
N
R
T
D
I
S
L
D
D
P
N
F
W
Site 88
T1054
R
P
R
V
R
K
Q
T
K
H
Y
N
S
F
E
Site 89
S1059
K
Q
T
K
H
Y
N
S
F
E
E
D
E
L
M
Site 90
S1069
E
D
E
L
M
E
F
S
E
L
D
S
D
S
D
Site 91
S1073
M
E
F
S
E
L
D
S
D
S
D
E
R
P
T
Site 92
S1075
F
S
E
L
D
S
D
S
D
E
R
P
T
R
S
Site 93
T1080
S
D
S
D
E
R
P
T
R
S
R
R
L
N
D
Site 94
S1082
S
D
E
R
P
T
R
S
R
R
L
N
D
K
A
Site 95
Y1092
L
N
D
K
A
R
R
Y
L
R
A
E
C
F
R
Site 96
S1153
K
G
D
E
K
I
K
S
F
I
W
E
L
I
T
Site 97
T1160
S
F
I
W
E
L
I
T
P
T
K
D
G
Q
A
Site 98
T1169
T
K
D
G
Q
A
Q
T
L
Q
N
H
S
G
L
Site 99
S1174
A
Q
T
L
Q
N
H
S
G
L
S
A
P
V
P
Site 100
S1177
L
Q
N
H
S
G
L
S
A
P
V
P
R
G
R
Site 101
T1189
R
G
R
K
G
K
K
T
K
N
Q
L
L
I
P
Site 102
Y1218
V
V
L
H
D
D
G
Y
K
K
H
L
K
Q
H
Site 103
S1255
A
E
K
A
F
E
G
S
P
A
R
E
L
D
V
Site 104
S1284
W
D
A
E
A
D
K
S
L
L
I
G
V
F
K
Site 105
Y1294
I
G
V
F
K
H
G
Y
E
R
Y
N
A
M
R
Site 106
S1319
V
G
M
P
D
E
K
S
L
S
A
E
Q
G
V
Site 107
S1321
M
P
D
E
K
S
L
S
A
E
Q
G
V
T
D
Site 108
T1327
L
S
A
E
Q
G
V
T
D
G
T
S
D
I
P
Site 109
S1331
Q
G
V
T
D
G
T
S
D
I
P
E
R
G
N
Site 110
T1339
D
I
P
E
R
G
N
T
D
K
E
D
N
A
E
Site 111
T1356
V
D
G
L
Q
K
Q
T
E
S
S
S
D
G
G
Site 112
S1358
G
L
Q
K
Q
T
E
S
S
S
D
G
G
D
G
Site 113
S1360
Q
K
Q
T
E
S
S
S
D
G
G
D
G
V
F
Site 114
S1368
D
G
G
D
G
V
F
S
E
K
K
D
D
S
R
Site 115
S1374
F
S
E
K
K
D
D
S
R
A
A
Q
D
G
S
Site 116
S1381
S
R
A
A
Q
D
G
S
D
P
D
K
S
P
W
Site 117
S1386
D
G
S
D
P
D
K
S
P
W
P
V
S
S
A
Site 118
S1391
D
K
S
P
W
P
V
S
S
A
L
T
A
R
L
Site 119
S1392
K
S
P
W
P
V
S
S
A
L
T
A
R
L
R
Site 120
T1403
A
R
L
R
R
L
V
T
V
Y
Q
R
C
N
R
Site 121
Y1405
L
R
R
L
V
T
V
Y
Q
R
C
N
R
K
E
Site 122
Y1426
L
G
P
G
N
Q
G
Y
W
V
Q
E
E
M
F
Site 123
T1436
Q
E
E
M
F
R
R
T
S
E
M
D
L
I
N
Site 124
S1437
E
E
M
F
R
R
T
S
E
M
D
L
I
N
K
Site 125
T1451
K
E
A
Q
K
R
W
T
R
R
E
Q
A
D
F
Site 126
Y1459
R
R
E
Q
A
D
F
Y
R
T
V
S
S
F
G
Site 127
T1461
E
Q
A
D
F
Y
R
T
V
S
S
F
G
V
V
Site 128
S1464
D
F
Y
R
T
V
S
S
F
G
V
V
Y
D
Q
Site 129
S1485
W
T
Q
F
R
I
I
S
R
L
D
K
K
S
D
Site 130
S1491
I
S
R
L
D
K
K
S
D
E
S
L
E
Q
Y
Site 131
S1494
L
D
K
K
S
D
E
S
L
E
Q
Y
F
Y
S
Site 132
Y1498
S
D
E
S
L
E
Q
Y
F
Y
S
F
V
A
M
Site 133
Y1500
E
S
L
E
Q
Y
F
Y
S
F
V
A
M
C
R
Site 134
T1514
R
N
V
C
R
L
P
T
W
K
D
G
G
P
P
Site 135
T1523
K
D
G
G
P
P
D
T
T
I
Y
V
E
P
I
Site 136
T1524
D
G
G
P
P
D
T
T
I
Y
V
E
P
I
T
Site 137
Y1526
G
P
P
D
T
T
I
Y
V
E
P
I
T
E
E
Site 138
Y1540
E
R
A
A
R
T
L
Y
R
I
E
L
L
R
K
Site 139
Y1599
G
L
N
R
T
D
C
Y
I
M
N
D
P
Q
L
Site 140
S1607
I
M
N
D
P
Q
L
S
F
L
D
A
Y
R
N
Site 141
Y1612
Q
L
S
F
L
D
A
Y
R
N
Y
A
Q
H
K
Site 142
Y1615
F
L
D
A
Y
R
N
Y
A
Q
H
K
R
S
G
Site 143
T1623
A
Q
H
K
R
S
G
T
Q
A
P
G
N
L
C
Site 144
Y1633
P
G
N
L
C
C
L
Y
Q
T
N
S
K
L
Y
Site 145
Y1640
Y
Q
T
N
S
K
L
Y
E
S
L
T
Y
S
Q
Site 146
S1642
T
N
S
K
L
Y
E
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L
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Y
S
Q
M
S
Site 147
T1644
S
K
L
Y
E
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L
T
Y
S
Q
M
S
R
T
Site 148
Y1645
K
L
Y
E
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L
T
Y
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Q
M
S
R
T
S
Site 149
S1646
L
Y
E
S
L
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Y
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Site 150
S1649
S
L
T
Y
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L
E
Site 151
S1652
Y
S
Q
M
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S
E
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L
E
N
E
P
Site 152
S1654
Q
M
S
R
T
S
E
S
L
E
N
E
P
E
N
Site 153
S1667
E
N
L
V
R
V
E
S
R
D
D
H
L
S
L
Site 154
S1673
E
S
R
D
D
H
L
S
L
P
D
V
T
C
E
Site 155
T1678
H
L
S
L
P
D
V
T
C
E
N
F
I
S
K
Site 156
S1691
S
K
V
Q
D
V
I
S
I
N
H
D
E
S
L
Site 157
S1697
I
S
I
N
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L
L
P
E
S
L
E
Site 158
S1702
D
E
S
L
L
P
E
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L
E
S
M
M
Y
G
Site 159
S1705
L
L
P
E
S
L
E
S
M
M
Y
G
K
K
V
Site 160
Y1708
E
S
L
E
S
M
M
Y
G
K
K
V
L
S
Q
Site 161
S1714
M
Y
G
K
K
V
L
S
Q
E
P
S
S
F
Q
Site 162
S1718
K
V
L
S
Q
E
P
S
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F
Q
E
S
P
S
Site 163
S1719
V
L
S
Q
E
P
S
S
F
Q
E
S
P
S
T
Site 164
S1723
E
P
S
S
F
Q
E
S
P
S
T
N
T
E
S
Site 165
S1725
S
S
F
Q
E
S
P
S
T
N
T
E
S
R
K
Site 166
T1726
S
F
Q
E
S
P
S
T
N
T
E
S
R
K
D
Site 167
T1736
E
S
R
K
D
V
I
T
I
S
I
S
K
D
G
Site 168
S1738
R
K
D
V
I
T
I
S
I
S
K
D
G
N
C
Site 169
S1747
S
K
D
G
N
C
Q
S
G
G
P
E
A
E
I
Site 170
S1756
G
P
E
A
E
I
A
S
G
P
T
F
M
G
S
Site 171
S1783
N
G
K
H
L
L
M
S
I
S
K
E
G
E
L
Site 172
S1793
K
E
G
E
L
C
C
S
E
A
G
Q
R
P
E
Site 173
S1812
L
E
A
K
C
L
A
S
P
S
L
N
P
G
N
Site 174
S1814
A
K
C
L
A
S
P
S
L
N
P
G
N
E
S
Site 175
S1830
F
V
D
M
C
S
L
S
V
C
D
S
K
R
N
Site 176
S1834
C
S
L
S
V
C
D
S
K
R
N
L
S
S
D
Site 177
S1839
C
D
S
K
R
N
L
S
S
D
Q
Q
L
I
D
Site 178
S1840
D
S
K
R
N
L
S
S
D
Q
Q
L
I
D
L
Site 179
S1860
L
E
S
K
L
I
L
S
Q
N
H
S
D
E
E
Site 180
S1864
L
I
L
S
Q
N
H
S
D
E
E
E
E
E
E
Site 181
T1894
R
P
E
V
L
H
L
T
E
P
T
T
N
I
S
Site 182
T1912
N
Q
G
F
Q
D
E
T
K
K
G
S
L
E
V
Site 183
T1923
S
L
E
V
A
N
Q
T
P
G
L
Q
R
A
F
Site 184
T1972
P
D
L
F
K
S
K
T
N
T
I
A
M
E
G
Site 185
T1974
L
F
K
S
K
T
N
T
I
A
M
E
G
E
P
Site 186
T1982
I
A
M
E
G
E
P
T
A
I
P
S
Q
P
F
Site 187
S1986
G
E
P
T
A
I
P
S
Q
P
F
K
V
K
H
Site 188
T2012
E
G
Q
N
V
F
P
T
Y
P
L
E
G
S
E
Site 189
Y2013
G
Q
N
V
F
P
T
Y
P
L
E
G
S
E
L
Site 190
S2018
P
T
Y
P
L
E
G
S
E
L
K
S
E
D
M
Site 191
S2022
L
E
G
S
E
L
K
S
E
D
M
D
F
E
N
Site 192
Y2033
D
F
E
N
K
D
D
Y
D
R
D
G
N
C
H
Site 193
S2041
D
R
D
G
N
C
H
S
Q
D
Y
P
G
K
Y
Site 194
Y2044
G
N
C
H
S
Q
D
Y
P
G
K
Y
S
E
E
Site 195
Y2048
S
Q
D
Y
P
G
K
Y
S
E
E
E
S
K
S
Site 196
S2049
Q
D
Y
P
G
K
Y
S
E
E
E
S
K
S
S
Site 197
S2053
G
K
Y
S
E
E
E
S
K
S
S
T
S
G
I
Site 198
S2055
Y
S
E
E
E
S
K
S
S
T
S
G
I
T
G
Site 199
S2056
S
E
E
E
S
K
S
S
T
S
G
I
T
G
D
Site 200
T2057
E
E
E
S
K
S
S
T
S
G
I
T
G
D
I
Site 201
T2075
L
Q
E
A
R
A
P
T
I
A
Q
L
L
Q
E
Site 202
T2084
A
Q
L
L
Q
E
K
T
L
Y
S
F
S
E
W
Site 203
Y2086
L
L
Q
E
K
T
L
Y
S
F
S
E
W
P
K
Site 204
S2087
L
Q
E
K
T
L
Y
S
F
S
E
W
P
K
D
Site 205
S2089
E
K
T
L
Y
S
F
S
E
W
P
K
D
R
V
Site 206
S2116
L
K
G
K
W
P
S
S
Q
Q
Y
E
P
S
G
Site 207
Y2119
K
W
P
S
S
Q
Q
Y
E
P
S
G
T
L
P
Site 208
S2122
S
S
Q
Q
Y
E
P
S
G
T
L
P
T
P
V
Site 209
T2124
Q
Q
Y
E
P
S
G
T
L
P
T
P
V
L
T
Site 210
T2127
E
P
S
G
T
L
P
T
P
V
L
T
S
S
A
Site 211
S2132
L
P
T
P
V
L
T
S
S
A
G
S
R
T
S
Site 212
S2133
P
T
P
V
L
T
S
S
A
G
S
R
T
S
L
Site 213
S2136
V
L
T
S
S
A
G
S
R
T
S
L
S
E
P
Site 214
S2139
S
S
A
G
S
R
T
S
L
S
E
P
E
A
A
Site 215
S2141
A
G
S
R
T
S
L
S
E
P
E
A
A
E
H
Site 216
S2149
E
P
E
A
A
E
H
S
F
S
N
G
A
A
L
Site 217
S2151
E
A
A
E
H
S
F
S
N
G
A
A
L
A
A
Site 218
T2171
S
F
L
A
P
V
F
T
K
D
E
Q
K
H
R
Site 219
Y2181
E
Q
K
H
R
R
P
Y
E
F
E
V
E
R
D
Site 220
S2220
G
E
S
A
M
D
L
S
C
S
S
E
G
S
P
Site 221
S2222
S
A
M
D
L
S
C
S
S
E
G
S
P
G
A
Site 222
S2223
A
M
D
L
S
C
S
S
E
G
S
P
G
A
T
Site 223
S2226
L
S
C
S
S
E
G
S
P
G
A
T
S
P
F
Site 224
T2230
S
E
G
S
P
G
A
T
S
P
F
P
V
S
A
Site 225
S2231
E
G
S
P
G
A
T
S
P
F
P
V
S
A
S
Site 226
S2236
A
T
S
P
F
P
V
S
A
S
T
P
K
I
G
Site 227
S2276
T
G
Q
I
V
N
G
S
L
R
R
D
D
A
A
Site 228
T2284
L
R
R
D
D
A
A
T
R
R
R
R
G
R
R
Site 229
S2325
D
P
G
Q
A
T
L
S
T
T
H
P
E
G
P
Site 230
T2326
P
G
Q
A
T
L
S
T
T
H
P
E
G
P
G
Site 231
T2336
P
E
G
P
G
P
A
T
S
A
P
E
P
A
T
Site 232
S2337
E
G
P
G
P
A
T
S
A
P
E
P
A
T
A
Site 233
T2343
T
S
A
P
E
P
A
T
A
A
S
S
Q
A
E
Site 234
S2347
E
P
A
T
A
A
S
S
Q
A
E
K
S
I
P
Site 235
S2352
A
S
S
Q
A
E
K
S
I
P
S
K
S
L
L
Site 236
S2357
E
K
S
I
P
S
K
S
L
L
D
W
L
R
Q
Site 237
Y2368
W
L
R
Q
Q
A
D
Y
S
L
E
V
P
G
F
Site 238
S2369
L
R
Q
Q
A
D
Y
S
L
E
V
P
G
F
G
Site 239
S2380
P
G
F
G
A
N
F
S
D
K
P
K
Q
R
R
Site 240
S2399
E
P
G
K
L
D
V
S
S
L
S
G
E
E
R
Site 241
S2400
P
G
K
L
D
V
S
S
L
S
G
E
E
R
V
Site 242
S2402
K
L
D
V
S
S
L
S
G
E
E
R
V
P
A
Site 243
T2437
A
E
P
I
L
R
D
T
G
P
R
R
R
G
R
Site 244
S2448
R
R
G
R
R
P
R
S
E
L
L
K
A
P
S
Site 245
S2455
S
E
L
L
K
A
P
S
I
V
A
D
S
P
S
Site 246
S2513
P
T
G
E
E
V
K
S
T
L
S
M
L
P
M
Site 247
T2514
T
G
E
E
V
K
S
T
L
S
M
L
P
M
M
Site 248
S2553
C
T
S
T
A
P
A
S
L
S
S
T
T
K
S
Site 249
S2555
S
T
A
P
A
S
L
S
S
T
T
K
S
G
T
Site 250
S2556
T
A
P
A
S
L
S
S
T
T
K
S
G
T
A
Site 251
T2557
A
P
A
S
L
S
S
T
T
K
S
G
T
A
V
Site 252
S2560
S
L
S
S
T
T
K
S
G
T
A
V
T
E
K
Site 253
T2568
G
T
A
V
T
E
K
T
A
E
D
K
P
S
S
Site 254
S2574
K
T
A
E
D
K
P
S
S
H
D
V
K
T
D
Site 255
S2575
T
A
E
D
K
P
S
S
H
D
V
K
T
D
T
Site 256
T2580
P
S
S
H
D
V
K
T
D
T
L
A
E
D
K
Site 257
T2582
S
H
D
V
K
T
D
T
L
A
E
D
K
P
G
Site 258
S2594
K
P
G
P
G
P
F
S
D
Q
S
E
P
A
I
Site 259
S2597
P
G
P
F
S
D
Q
S
E
P
A
I
T
T
S
Site 260
T2602
D
Q
S
E
P
A
I
T
T
S
S
P
V
A
F
Site 261
S2604
S
E
P
A
I
T
T
S
S
P
V
A
F
N
P
Site 262
S2645
A
M
Q
Q
A
R
H
S
E
I
V
G
L
E
S
Site 263
S2652
S
E
I
V
G
L
E
S
Q
K
R
K
K
K
K
Site 264
T2660
Q
K
R
K
K
K
K
T
K
G
D
N
P
N
S
Site 265
S2667
T
K
G
D
N
P
N
S
H
P
E
P
A
P
S
Site 266
S2674
S
H
P
E
P
A
P
S
C
E
R
E
P
S
G
Site 267
S2680
P
S
C
E
R
E
P
S
G
D
E
N
C
A
E
Site 268
S2710
G
E
G
A
L
K
D
S
N
N
D
T
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation