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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
URG4
Full Name:
Up-regulator of cell proliferation
Alias:
Up-regulated gene 4
Type:
Cytoplasm, Nucleus protein
Mass (Da):
104987
Number AA:
931
UniProt ID:
Q8TCY9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
L
L
G
K
G
H
S
D
L
G
E
V
A
P
Site 2
S28
V
A
P
E
I
K
A
S
E
R
R
T
A
V
A
Site 3
Y53
G
D
D
C
E
F
R
Y
G
D
G
T
N
E
A
Site 4
T57
E
F
R
Y
G
D
G
T
N
E
A
Q
D
N
D
Site 5
T67
A
Q
D
N
D
F
P
T
V
E
R
S
R
L
Q
Site 6
S78
S
R
L
Q
E
M
L
S
L
L
G
L
E
T
Y
Site 7
S91
T
Y
Q
V
Q
K
L
S
L
Q
D
S
L
Q
I
Site 8
S95
Q
K
L
S
L
Q
D
S
L
Q
I
S
F
D
S
Site 9
S99
L
Q
D
S
L
Q
I
S
F
D
S
M
K
N
W
Site 10
S102
S
L
Q
I
S
F
D
S
M
K
N
W
A
P
Q
Site 11
T132
L
N
A
D
A
R
N
T
T
M
V
L
D
V
L
Site 12
T133
N
A
D
A
R
N
T
T
M
V
L
D
V
L
P
Site 13
Y157
Q
M
E
E
E
I
I
Y
W
D
P
A
D
D
L
Site 14
Y169
D
D
L
A
A
D
I
Y
S
F
S
E
L
P
T
Site 15
S170
D
L
A
A
D
I
Y
S
F
S
E
L
P
T
P
Site 16
S172
A
A
D
I
Y
S
F
S
E
L
P
T
P
D
T
Site 17
T176
Y
S
F
S
E
L
P
T
P
D
T
P
V
N
P
Site 18
T179
S
E
L
P
T
P
D
T
P
V
N
P
L
D
L
Site 19
S220
L
P
L
V
L
P
D
S
E
N
H
Y
H
T
F
Site 20
Y224
L
P
D
S
E
N
H
Y
H
T
F
L
L
W
A
Site 21
S249
Q
P
P
R
G
M
G
S
F
R
E
D
S
V
V
Site 22
S254
M
G
S
F
R
E
D
S
V
V
L
S
R
A
P
Site 23
S271
A
F
V
R
M
D
V
S
S
N
S
K
S
Q
L
Site 24
S272
F
V
R
M
D
V
S
S
N
S
K
S
Q
L
L
Site 25
S274
R
M
D
V
S
S
N
S
K
S
Q
L
L
N
A
Site 26
S276
D
V
S
S
N
S
K
S
Q
L
L
N
A
V
L
Site 27
S284
Q
L
L
N
A
V
L
S
P
G
H
R
Q
W
D
Site 28
S308
G
T
N
A
R
E
I
S
D
G
L
V
E
I
S
Site 29
S315
S
D
G
L
V
E
I
S
W
F
F
P
S
G
R
Site 30
S320
E
I
S
W
F
F
P
S
G
R
E
D
L
D
I
Site 31
T362
S
S
A
V
F
I
L
T
D
N
I
S
K
K
E
Site 32
S366
F
I
L
T
D
N
I
S
K
K
E
Y
K
L
L
Site 33
Y370
D
N
I
S
K
K
E
Y
K
L
L
Y
S
M
K
Site 34
Y374
K
K
E
Y
K
L
L
Y
S
M
K
E
S
T
T
Site 35
S375
K
E
Y
K
L
L
Y
S
M
K
E
S
T
T
K
Site 36
Y383
M
K
E
S
T
T
K
Y
Y
F
I
L
S
P
Y
Site 37
Y384
K
E
S
T
T
K
Y
Y
F
I
L
S
P
Y
R
Site 38
S388
T
K
Y
Y
F
I
L
S
P
Y
R
G
K
R
N
Site 39
Y390
Y
Y
F
I
L
S
P
Y
R
G
K
R
N
T
N
Site 40
T396
P
Y
R
G
K
R
N
T
N
L
R
F
L
N
K
Site 41
S420
S
H
V
L
V
K
V
S
S
T
D
S
D
S
F
Site 42
S424
V
K
V
S
S
T
D
S
D
S
F
V
K
R
I
Site 43
S426
V
S
S
T
D
S
D
S
F
V
K
R
I
R
A
Site 44
S447
R
A
P
C
R
R
V
S
V
E
D
M
A
H
A
Site 45
T480
K
D
R
M
E
R
I
T
R
K
I
K
D
S
D
Site 46
S486
I
T
R
K
I
K
D
S
D
A
Y
R
R
D
E
Site 47
Y489
K
I
K
D
S
D
A
Y
R
R
D
E
L
R
L
Site 48
S546
Q
N
G
H
D
P
S
S
G
V
Q
E
F
I
S
Site 49
S557
E
F
I
S
G
I
S
S
P
S
L
S
E
K
Q
Site 50
S559
I
S
G
I
S
S
P
S
L
S
E
K
Q
Y
F
Site 51
S561
G
I
S
S
P
S
L
S
E
K
Q
Y
F
L
R
Site 52
Y565
P
S
L
S
E
K
Q
Y
F
L
R
W
M
E
W
Site 53
T588
R
L
R
Q
P
P
E
T
L
L
T
L
R
P
K
Site 54
T591
Q
P
P
E
T
L
L
T
L
R
P
K
H
G
G
Site 55
T600
R
P
K
H
G
G
T
T
D
V
G
E
P
L
W
Site 56
Y624
L
R
E
M
G
Q
F
Y
E
A
E
S
C
L
V
Site 57
S690
H
V
R
L
E
R
R
S
R
L
V
V
L
S
T
Site 58
T703
S
T
V
G
V
P
G
T
G
K
S
T
L
L
N
Site 59
T719
M
F
G
L
R
F
A
T
G
K
S
C
G
P
R
Site 60
S722
L
R
F
A
T
G
K
S
C
G
P
R
G
A
F
Site 61
S788
L
S
N
V
T
V
I
S
L
A
E
T
K
D
I
Site 62
T792
T
V
I
S
L
A
E
T
K
D
I
P
A
A
I
Site 63
T809
A
F
L
R
L
E
K
T
G
H
M
P
N
Y
Q
Site 64
Y815
K
T
G
H
M
P
N
Y
Q
F
V
Y
Q
N
L
Site 65
S826
Y
Q
N
L
H
D
V
S
V
P
G
P
R
P
R
Site 66
S846
L
D
P
P
G
D
L
S
R
A
A
A
Q
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation