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Updated November 2019
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Protein Info
Short Name:
CERK
Full Name:
Ceramide kinase
Alias:
Acylsphingosine kinase;Lipid kinase 4
Type:
Mass (Da):
59977
Number AA:
537
UniProt ID:
Q8TCT0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
G
A
A
E
P
L
Q
S
V
L
W
V
K
Q
Q
Site 2
S37
A
L
L
R
W
W
R
S
P
G
P
G
A
G
A
Site 3
T118
L
C
H
L
W
L
Q
T
L
R
E
M
L
E
K
Site 4
T127
R
E
M
L
E
K
L
T
S
R
P
K
H
L
L
Site 5
S128
E
M
L
E
K
L
T
S
R
P
K
H
L
L
V
Site 6
Y150
K
G
Q
G
K
R
I
Y
E
R
K
V
A
P
L
Site 7
Y181
N
Q
A
K
E
T
L
Y
E
I
N
I
D
K
Y
Site 8
T211
L
H
G
L
I
G
R
T
Q
R
S
A
G
V
D
Site 9
Y246
G
S
T
D
C
V
C
Y
S
T
V
G
T
S
D
Site 10
S247
S
T
D
C
V
C
Y
S
T
V
G
T
S
D
A
Site 11
T248
T
D
C
V
C
Y
S
T
V
G
T
S
D
A
E
Site 12
T251
V
C
Y
S
T
V
G
T
S
D
A
E
T
S
A
Site 13
S252
C
Y
S
T
V
G
T
S
D
A
E
T
S
A
L
Site 14
S272
D
S
L
A
M
D
V
S
S
V
H
H
N
S
T
Site 15
S273
S
L
A
M
D
V
S
S
V
H
H
N
S
T
L
Site 16
S278
V
S
S
V
H
H
N
S
T
L
L
R
Y
S
V
Site 17
T279
S
S
V
H
H
N
S
T
L
L
R
Y
S
V
S
Site 18
Y283
H
N
S
T
L
L
R
Y
S
V
S
L
L
G
Y
Site 19
S300
Y
G
D
I
I
K
D
S
E
K
K
R
W
L
G
Site 20
Y311
R
W
L
G
L
A
R
Y
D
F
S
G
L
K
T
Site 21
S321
S
G
L
K
T
F
L
S
H
H
C
Y
E
G
T
Site 22
T328
S
H
H
C
Y
E
G
T
V
S
F
L
P
A
Q
Site 23
T337
S
F
L
P
A
Q
H
T
V
G
S
P
R
D
R
Site 24
S340
P
A
Q
H
T
V
G
S
P
R
D
R
K
P
C
Site 25
S357
G
C
F
V
C
R
Q
S
K
Q
Q
L
E
E
E
Site 26
S403
M
S
C
A
C
R
R
S
P
R
G
L
S
P
A
Site 27
S408
R
R
S
P
R
G
L
S
P
A
A
H
L
G
D
Site 28
S418
A
H
L
G
D
G
S
S
D
L
I
L
I
R
K
Site 29
S427
L
I
L
I
R
K
C
S
R
F
N
F
L
R
F
Site 30
T439
L
R
F
L
I
R
H
T
N
Q
Q
D
Q
F
D
Site 31
T448
Q
Q
D
Q
F
D
F
T
F
V
E
V
Y
R
V
Site 32
S470
K
H
M
E
D
E
D
S
D
L
K
E
G
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation