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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PI4K2B
Full Name:
Phosphatidylinositol 4-kinase type 2-beta
Alias:
EC 2.7.1.67; FLJ11105; P4K2B; Phosphatidylinositol 4-kinase type II-beta; PI4KIIB; PIK42B
Type:
Kinase, lipid
Mass (Da):
54744
Number AA:
481
UniProt ID:
Q8TCG2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004430
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
D
P
S
E
P
D
R
L
A
S
Site 2
S12
S
E
P
D
R
L
A
S
A
D
G
G
S
P
E
Site 3
S17
L
A
S
A
D
G
G
S
P
E
E
E
E
D
G
Site 4
S45
P
R
R
G
A
P
G
S
A
V
R
L
L
D
A
Site 5
S74
P
P
G
D
V
G
V
S
R
S
S
S
A
E
L
Site 6
S76
G
D
V
G
V
S
R
S
S
S
A
E
L
D
R
Site 7
S77
D
V
G
V
S
R
S
S
S
A
E
L
D
R
S
Site 8
S78
V
G
V
S
R
S
S
S
A
E
L
D
R
S
R
Site 9
S84
S
S
A
E
L
D
R
S
R
P
A
V
S
V
T
Site 10
S89
D
R
S
R
P
A
V
S
V
T
I
G
T
S
E
Site 11
T91
S
R
P
A
V
S
V
T
I
G
T
S
E
M
N
Site 12
S127
G
I
F
P
E
R
I
S
Q
G
S
S
G
S
Y
Site 13
S130
P
E
R
I
S
Q
G
S
S
G
S
Y
F
V
K
Site 14
S131
E
R
I
S
Q
G
S
S
G
S
Y
F
V
K
D
Site 15
S133
I
S
Q
G
S
S
G
S
Y
F
V
K
D
P
K
Site 16
Y134
S
Q
G
S
S
G
S
Y
F
V
K
D
P
K
R
Site 17
S151
I
G
V
F
K
P
K
S
E
E
P
Y
G
Q
L
Site 18
Y155
K
P
K
S
E
E
P
Y
G
Q
L
N
P
K
W
Site 19
Y193
Y
L
S
E
A
G
A
Y
L
V
D
N
K
L
H
Site 20
S202
V
D
N
K
L
H
L
S
I
V
P
K
T
K
V
Site 21
Y219
L
V
S
E
T
F
N
Y
N
A
I
D
R
A
K
Site 22
S227
N
A
I
D
R
A
K
S
R
G
K
K
Y
A
L
Site 23
Y263
F
Q
L
F
V
E
G
Y
K
E
A
E
Y
W
L
Site 24
Y268
E
G
Y
K
E
A
E
Y
W
L
R
K
F
E
A
Site 25
S288
N
I
R
K
Q
F
Q
S
Q
F
E
R
L
V
I
Site 26
Y298
E
R
L
V
I
L
D
Y
I
I
R
N
T
D
R
Site 27
S375
P
Q
A
K
V
P
F
S
E
E
I
R
N
L
I
Site 28
Y400
Q
D
L
C
E
D
L
Y
E
L
F
K
T
D
K
Site 29
T405
D
L
Y
E
L
F
K
T
D
K
G
F
D
K
A
Site 30
T413
D
K
G
F
D
K
A
T
F
E
S
Q
M
S
V
Site 31
S416
F
D
K
A
T
F
E
S
Q
M
S
V
M
R
G
Site 32
T429
R
G
Q
I
L
N
L
T
Q
A
L
R
D
G
K
Site 33
S437
Q
A
L
R
D
G
K
S
P
F
Q
L
V
Q
I
Site 34
S452
P
C
V
I
V
E
R
S
Q
G
G
S
Q
G
R
Site 35
S456
V
E
R
S
Q
G
G
S
Q
G
R
I
V
H
L
Site 36
S464
Q
G
R
I
V
H
L
S
N
S
F
T
Q
T
V
Site 37
S466
R
I
V
H
L
S
N
S
F
T
Q
T
V
N
C
Site 38
T468
V
H
L
S
N
S
F
T
Q
T
V
N
C
R
K
Site 39
T470
L
S
N
S
F
T
Q
T
V
N
C
R
K
P
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation